Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas

Carcinogenesis

Volumn 17, Issue 10, 1996, Pages 2125-2129

  Probst Hensch, Nicole M ^a   Haile, Robert W ^a   Li, Donna S ^a   Sakamoto, Gordon T ^d   Louie, Andrew D ^d   Lin, Bruce K ^d   Frankl, Harold D ^b   Lee, Eric R ^c   Lin, Henry J ^d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Kaiser Permanente   (United States)

^c Harbor UCLA Medical Center ^*  (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE;

ACETYLATOR PHENOTYPE; ADENOMA; ADULT; AGED; ARTICLE; CANCER GENETICS; CASE CONTROL STUDY; COLORECTAL CANCER; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POINT MUTATION; POLYADENYLATION; PRIORITY JOURNAL; SIGMOIDOSCOPY;

ADENOMA; AGED; ARYLAMINE N-ACETYLTRANSFERASE; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; POLY A; POLYMORPHISM, GENETIC;

EID: 0029806517     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.10.2125     Document Type: Article

References (26)

1. Vatsis, K.P., Weber, W.W., Bell, D.A. et al. (1995) Nomenclature for N-acetyltransferases. Pharmacogenetics, 5, 1-17.
2. Lin, H.J., Han, C.-Y., Lin, B.K. and Hardy, S. (1994) Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics, 4, 125-134.
3. Kadlubar, F.F., Butler, M.A. Kaderlik, K.R., Chou, H.-C. and Lang, N.P. (1992) Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. Environ. Health Perspect., 98, 69-74.
4. Lang, N.P., Butler, M.A., Massengill, J., Lawson, M., Stotts, R.C., Hauer-Jensen, M. and Kadlubar, F.F. (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol. Biomarkers Prev., 3, 675-682.
5. Probst-Hensch, N.M., Haile, R.W., Ingles, S.A. et al. (1995) Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res., 55, 2017-2020.
6. Bell, D.A., Stephens, E.A., Castranio, T. et al. (1995) Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res., 55, 3537-3542.
7. Bell, D.A., Badawi, A.F. Lang, N.P., Ilett, K.F., Kadlubar, F.F. and Hirvonen, A. (1995a) Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res., 55, 5226-5229.
8. Badawi, A.F., Hirvonen, A., Bell, D.A., Lang, N.P. and Kadlubar, F.F. (1995c) Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Cancer Res., 55, 5230-5237.
9. Giovannucci, E. and Willett, W.C. (1994) Dietary factors and risk of colon cancer. Ann. Med., 26, 443-452.
10. Blum, M., Grant, D.M., McBride, W., Heim, M. and Meyer, U.A. (1990) Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell Biol., 9, 193-203.
11. Vatsis, K.P., Yao, Y. and Weber, W.W. (1994) Allelic variation at the NAT1 locus of N-acetyltransferase among Orientals. Am. J. Hum. Genet., 55 (Suppl.), A340.
12. Grant, D.M., Josephy, P.D., Lord, H.L. and Morrison, L.D. (1992) Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines. Cancer Res., 52, 3961-3964.
13. Minchin, R.F., Reeves, P.T., Teitel, C.H., McManus, M.E., Mojarrabi, B., Ilett, K.F. and Kadlubar, F.F. (1992) N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-I cells. Biochem. Biophys. Res. Commun., 185, 839-844.
14. Probst, M.R., Blum, M., Fasshauer, I., D'Orazio, D., Meyer, U.A. and Wild, D. (1992) The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Carcinogenesis, 13, 1713-1717.
15. Hein, D.W., Rustan, T.D., Ferguson, R.J., Doll, M.A. and Gray, K. (1994) Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch. Toxicol., 68, 129-133.
16. Turesky, R.J., Lang, N.P., Butler, M.A., Teitel, C.H. and Kadlubar, F.F. (1991) Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis, 12, 1839-1845.
17. Ilett, K.F., Ingram, D.M., Carpenter, D.S., Teitel, C.H., Lang, N.P., Kadlubar, F.F. and Minchin, R.F. (1994) Expression of monomorphic and polymorphic N-acetyltransferases in human colon. Biochem. Pharmacol., 47, 914-917.
18. Taylor, J.A., Umbach, D., Stephens, E., Paulson, D., Robertson, C., Mohler, J.L. and Bell, D.A. (1995) Role of N-acetylation polymorphisms at NAT1 and NAT2 in smoking- associated bladder cancer. Proc. Am. Assoc. Cancer Res., 36, 282.
19. Rex, D.K., Lehman, G.A., Ulbright, T.M. et al. (1993) Colonie neoplasia in asymptomatic persons with negative fecal occult blood tests: influence of age, gender, and family history. Am. J. Gastroenterol., 88, 815-831.
20. Potter, J.D., Slattery, M.L., Bostick, R.M. and Gapstur, S.M. (1993) Colon cancer: a review of the epidemiology. Epidemiol. Rev., 15, 499-545.
21. Oda, Y., Tanaka, M. and Nakanishi, I. (1994) Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas. Carcinogenesis, 15, 1365-1369.
22. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. (1995) Specific 5′-GGGA-3′ → 5′-GGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc. Natl Acad. Sci. USA, 92, 910-914.
23. Tachino, N., Hayashi, R., Liew, C., Bailey, G. and Dashwood, R. (1995) Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonie aberrant crypts in the rat. Mol. Carcinogenesis, 12, 187-192.
24. Yanagawa, Y., Sawada, M., Deguchi, T., Gonzalez, F.J. and Kamataki, T. (1994) Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Res., 54, 3422-3427.
25. Wild, D., Feser, W., Michel, S., Lord, H.L. and Josephy, P.D. (1995) Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. Carcinogenesis, 16, 643-648.
26. Yokoi, T., Sawada, M. and Kamataki, T. (1995) Polymorphic drug metabolism: studies with recombinant Chinese hamster cells and analyses in human populations. Pharmacogenetics, 5, S65-S69.