The genome of Treponema pallidum: New light on the agent of syphilis

FEMS Microbiology Reviews

Volumn 22, Issue 4, 1998, Pages 323-332

  Weinstock, George M ^a   Hardham, John M ^a   McLeod, Michael P ^a   Sodergren, Erica J ^a   Norris, Steven J ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Genome analysis; Molecular pathogenesis; Syphilis; Treponema pallidum; Virulence factor

Indexed keywords

VIRULENCE FACTOR;

BACTERIAL GENE; DNA SEQUENCE; GENOME; NONHUMAN; PATHOGENESIS; REVIEW; SYPHILIS; TREPONEMA DENTICOLA; TREPONEMA PALLIDUM;

GENES, BACTERIAL; GENOME, BACTERIAL; HEMOLYSIN PROTEINS; NUCLEAR PORE COMPLEX PROTEINS; PROTO-ONCOGENE PROTEINS; SYPHILIS; TREPONEMA PALLIDUM; VIRULENCE;

BACTERIA (MICROORGANISMS); TREPONEMA DENTICOLA; TREPONEMA PALLIDUM; TREPONEMA PALLIDUM SUBSP. PALLIDUM;

EID: 0031734391     PISSN: 01686445     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-6445(98)00017-5     Document Type: Review

References (50)

1. Cartwright, F.F. (1972) Disease and History. Dorset Press, New York.
2. Quétel, C. (1990) History of Syphilis. Johns Hopkins University Press, Baltimore, MD.
3. Pusey, W.A. (1933) The History and Epidemiology of Syphilis. Charles C. Thomas, Springfield, IL.
4. Barondes, S.H. (1993) Molecules and Mental Illness. Scientific American Library, New York.
5. Schaudinn, F. (1905) Korrespondenzen. Deut. Med. Wochenschr. 31, 1728.
6. Schaudinn, F. and Hoffman, E. (1905) Vorlaufiger bericht uber das vorkommen fur spirochaeten in syphilitischen krankheitsprodukten und be papillomen. Arb. Gesundh. Amt. Berlin 22, 528-534.
7. Centers for Disease Control and Prevention (1996). Morbid. Mortal. Weekly Rep. 44, 75.
8. Robinson, E.N., Jr., Hitchcock, P.J., et al. (1993) Syphilis: disease with a history. In: Mechanisms of Microbial Disease, (Schaechter, M., Medoff, G. and Eisenstein, B.I., Eds.), pp. 334-342. Williams and Wilkins, Baltimore, MD.
9. Sell, S. and Norris, S.J. (1983) The biology, pathology, and immunology of syphilis. Int. Rev. Exp. Pathol. 24, 204-276.
10. Fieldsteel, A.H., Cox, D.L. and Moeckli, R.A. (1981) Cultivation of virulent Treponema pallidum in tissue culture. Infect. Immun. 32, 908-915.
11. Norris, S.J. and Edmondson, D.G. (1986) Factors affecting the multiplication and subculture of Treponema pallidum subsp. pallidum in a tissue culture system. Infect. Immun. 53, 534-539.
12. Cox, D.L. (1994) Culture of Treponema pallidum. Methods Enzymol. 236, 390-405.
13. Schell, R.F. and Musher, D.M. (1983) Pathogenesis and Immunology of Treponemal Infection. Marcel Dekker, New York.
14. Norris, S.J. and The Treponema pallidum Polypeptide Research Group (1993) Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunological roles. Microbiol. Rev. 57, 750-779.
15. Radolf, J.D., Norgard, M.V. and Shulz, W.W. (1989) Outer membrane ultrastructure explains the limited antigenicity of virulent Treponema pallidum. Proc. Natl. Acad. Sci. USA 86, 2051-2055.
16. Walker, E.M., Borenstein, L.A., Blanco, D.R., Miller, J.N. and Lovett, M.A. (1991) Analysis of outer membrane ultra-structure of pathogenic Treponema and Borrelia species by freeze-fracture electron microscopy. J. Bacteriol. 173, 5585-5588.
17. Cox, D.L., Chang, P., McDowall, A.W. and Radolf, J.D. (1992) The outer membrane, not a coat of host proteins, limits antigenicity of virulent Treponema pallidum. Infect. Immun. 60, 1076-1083.
18. Fraser, C.M., Norris, S.J., Weinstock, G.M., et al. (1998) The genome sequence of Treponema pallidum, the syphilis spirochete. Science, in press.
19. Fleischmann, R.D. et al. (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269, 496-512.
20. Fraser, C.M. et al. (1995) The minimal gene complement of Mycoplasma genitalium. Science 270, 397-403.
21. Bult, C.J. et al. (1996) Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science 273, 1058-1073.
22. Tomb, J.F. et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547.
23. Klenk, H.P. et al. (1997) The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus. Nature 390, 364-370.
24. Fraser, C.M. et al. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390, 580-586.
25. Riley, M. (1993) Functions of the gene products of Escherichia coli. Microbiol. Rev. 57, 862-952.
26. Salzberg, S.L., Deicher, A.L., Kasif, S. and White, O. (1998) Microbial gene identification using interpolated Markov models. Nucleic Acids Res. 26, 544-548.
27. Sonnhammer, E.L., Eddy, S.R. and Durbin, R. (1997) Pfam: a comprehensive database of protein domain families based on seed alignments. Proteins 28, 405-420.
28. Sonnhammer, E.L., Eddy, S.R., Birney, E., Bateman, A. and Durbin, R. (1998) Pfam: multiple sequence alignments and HMM-profiles of protein domains. Nucleic Acids Res. 26, 320-322.
29. Claros, M.G. and von Heijne, G. (1994) TopPred II: an improved software for membrane protein structure predictions. Comput. Appl. Biosci. 10, 685-686.
30. Nielsen, H., Engelbrecht, J., Brunak, S. and von Heijne, G. (1997) Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 10, 1-6.
31. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W. and Lipman, D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389-3402.
32. Henikoff, S., Pietrokovski, S. and Henikoff, J.G. (1998) Superior performance in protein homology detection with the Blocks Database servers. Nucleic Acids Res. 26, 309-312.
33. Corpet, F., Gouzy, J. and Kahn, D. (1998) The ProDom database of protein domain families. Nucleic Acids Res. 26, 323-326.
34. Tatusov, R.L., Koonin, E.V. and Lipman, D.J. (1997) A genomic perspective on protein families. Science 278, 631-637.
35. Haapasalo, M., Muller, K.H., Uitto, V.J., Leung, W.K. and McBride, B.C. (1992) Characterization, cloning, and binding properties of the major 53-kilodalton Treponema denticola surface antigen. Infect. Immun. 60, 2058-2065.
36. Fenno, J.C., Muller, K.H. and McBride, B.C. (1996) Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola. J. Bacteriol. 178, 2489-2497.
37. Fenno, J.C., Wong, G.W., Hannam, P.M., Muller, K.H., Leung, W.K. and McBride, B.C. (1997) Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp. J. Bacteriol. 179, 1082-1089.
38. Mathers, D.A., Leung, W.K., Fenno, J.C., Hong, Y. and McBride, B.C. (1996) The major surface protein complex of Treponema denticola depolarizes and induces ion channels in HeLa cell membranes. Infect. Immun. 64, 2904-2910.
39. Fitzgerald, T.J., Repesh, L.A. and Oakes, S.G. (1982) Morphological destruction of cultured cells by the attachment of Treponema pallidum. Br. J. Vener. 58, 1-11.
40. Oakes, S.G., Repesh, L.A., Pozos, R.S. and Fitzgerald, T.J. (1982) Electrophysiological dysfunction and cellular disruption of sensory neurones during incubation with Treponema pallidum. Br. J. Vener. Dis. 58, 220-227.
41. Wong, G.H., Steiner, B.M. and Graves, S. (1983) Inhibition of macromolecular synthesis in cultured rabbit cells by Treponema pallidum (Nichols). Infect. Immun. 41, 636-643.
42. Baida, G.E. and Kuzmin, N.P. (1995) Cloning and primary structure of a new hemolysin gene from Bacillus cereus. Biochim. Biophys. Acta 1264, 151-154.
43. ter Huurne, A.A., Muir, S., van Houten, M., van der Zeijst, B.A., Gaastra, W. and Kusters, J.G. (1994) Characterization of three putative Serpulina hyodysenteriae hemolysins. Microbial Pathogen. 16, 269-282.
44. Baida, G.E. and Kuzmin, N.P. (1996) Mechanism of action of hemolysin III from Bacillus cereus. Biochim. Biophys. Acta 1284, 122-124.
45. Williams, S.G., Attridge, S.R. and Manning, P.A. (1993) The transcriptional activator HlyU of Vibrio cholerae: nucleotide sequence and role in virulence gene expression. Mol. Microbiol. 9, 751-760.
46. Stebeck, C.E., Shaffer, J.M., Arroll, T.W., Lukehart, S.A. and Van Voorhis, W.C. (1997) Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue. FEMS Microbiol. Lett. 154, 303-310.
47. Mellors, A. and Lo, R.Y. (1995) O-sialoglycoprotease from Pasteurella haemolytica. Methods Enzymol. 248, 728-740.
48. Watt, M.A., Mellors, A. and Lo, R.Y. (1997) Comparison of the recombinant and authentic forms of the Pasteurella haemolytica Al glycoprotease. FEMS Microbiol. Lett. 147, 37-43.
49. Dedhar, S. and Hannigan, G.E. (1996) Integrin cytoplasmic interactions and bidirectional transmembrane signalling. Curr. Opin. Cell Biol. 8, 657-669.
50. Peters, L.L. et al. (1995) Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. J. Cell Biol. 130, 313-330.