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Volumn 47, Issue 11, 1998, Pages 1360-1365

Leptin does not affect adipocyte glucose metabolism: Studies in fresh and cultured adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR;

EID: 0031724190     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90305-5     Document Type: Article
Times cited : (27)

References (47)
  • 1
    • 0029739970 scopus 로고    scopus 로고
    • Identification of targets of leptin action in rat hypothalamus
    • Schwartz MW, Seeley RJ, Campfield A, et al: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106, 1996
    • (1996) J Clin Invest , vol.98 , pp. 1101-1106
    • Schwartz, M.W.1    Seeley, R.J.2    Campfield, A.3
  • 2
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, et al: Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3
  • 3
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 4
    • 0029859099 scopus 로고    scopus 로고
    • Leptin: The tale of an obesity gene
    • Caro JF, Sinha MK, Kolaczynski JW, et al: Leptin: The tale of an obesity gene. Diabetes 45:1455-1462, 1996
    • (1996) Diabetes , vol.45 , pp. 1455-1462
    • Caro, J.F.1    Sinha, M.K.2    Kolaczynski, J.W.3
  • 5
  • 7
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob/RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al: Leptin levels in human and rodent: Measurement of plasma leptin and ob/RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161, 1995
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 8
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • Halaas JL, Gajiwala KS, Maffei M, et al: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 9
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter MA, Cullen MJ, Baker MB, et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 10
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535, 1996
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 11
    • 0030600564 scopus 로고    scopus 로고
    • Do leptin receptors play a functional role in the endocrine pancreas?
    • Leclercq-Meyer V, Considine RV, Sener A, et al: Do leptin receptors play a functional role in the endocrine pancreas? Biochem Biophys Res Commun 229:794-798, 1996
    • (1996) Biochem Biophys Res Commun , vol.229 , pp. 794-798
    • Leclercq-Meyer, V.1    Considine, R.V.2    Sener, A.3
  • 12
    • 4244079188 scopus 로고    scopus 로고
    • Leptin: A potent inhibitor of insulin secretion
    • abstr
    • Fehmann H-C, Peiser C, Bode H-P, et al: Leptin: A potent inhibitor of insulin secretion. Diabetes 46:189A, 1997 (suppl 1, abstr)
    • (1997) Diabetes , vol.46 , Issue.1 SUPPL.
    • Fehmann, H.-C.1    Peiser, C.2    Bode, H.-P.3
  • 13
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • Emilsson V, Liu Y-L, Cawthorne MA, et al: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46:313-316, 1997
    • (1997) Diabetes , vol.46 , pp. 313-316
    • Emilsson, V.1    Liu, Y.-L.2    Cawthorne, M.A.3
  • 14
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen B, Novick D, Rubinstein M: Modulation of insulin activities by leptin. Science 274:1185-1188, 1996
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 15
    • 0030920217 scopus 로고    scopus 로고
    • Leptin receptor action in hepatic cells
    • Wang Y, Kuropatwinski KK, White DW, et al: Leptin receptor action in hepatic cells. J Biol Chem 272:16216-16223, 1997
    • (1997) J Biol Chem , vol.272 , pp. 16216-16223
    • Wang, Y.1    Kuropatwinski, K.K.2    White, D.W.3
  • 16
    • 0029952911 scopus 로고    scopus 로고
    • Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
    • Gainsford T, Willson TA, Metcalf D, et al: Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Cell Biol 93:14564-14568, 1996
    • (1996) Cell Biol , vol.93 , pp. 14564-14568
    • Gainsford, T.1    Willson, T.A.2    Metcalf, D.3
  • 17
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • Müller G, Ertl J, Gerl M, et al: Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272:10585-10593, 1997
    • (1997) J Biol Chem , vol.272 , pp. 10585-10593
    • Müller, G.1    Ertl, J.2    Gerl, M.3
  • 18
    • 85030343428 scopus 로고    scopus 로고
    • Effects of leptin and troglitazone on insulin action and leptin production in rat adipocytes
    • Minneapolis, MN, abstr P1-247
    • Shintani M, Nishimura H, Yamamoto Y, et al: Effects of leptin and troglitazone on insulin action and leptin production in rat adipocytes. Seventy-Ninth Annual Meeting of The Endocrine Society, Minneapolis, MN, 1997, p 196 (abstr P1-247)
    • (1997) Seventy-Ninth Annual Meeting of the Endocrine Society , pp. 196
    • Shintani, M.1    Nishimura, H.2    Yamamoto, Y.3
  • 19
    • 85030345832 scopus 로고    scopus 로고
    • Leptin decreases protein and mRNA levels of GLUT4 in rat adipocytes
    • abstr
    • Nishimura H, Shintani M, Yamamoto Y, et al: Leptin decreases protein and mRNA levels of GLUT4 in rat adipocytes. Diabetes 46:59A, 1997 (suppl 1, abstr)
    • (1997) Diabetes , vol.46 , Issue.1 SUPPL.
    • Nishimura, H.1    Shintani, M.2    Yamamoto, Y.3
  • 20
    • 0023731797 scopus 로고
    • Preservation of intermediary metabolism in saponin-permeabilized rat adipocytes
    • Mick GJ, Bonn T, Steinberg J, et al: Preservation of intermediary metabolism in saponin-permeabilized rat adipocytes. J Biol Chem 263:10667-10673, 1988
    • (1988) J Biol Chem , vol.263 , pp. 10667-10673
    • Mick, G.J.1    Bonn, T.2    Steinberg, J.3
  • 21
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system
    • Marshall S, Bacote V, Traxinger RR: Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. J Biol Chem 266:4706-4712, 1991
    • (1991) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 22
    • 0028147169 scopus 로고
    • Persistence of disturbed adipocyte metabolism in streptozocin-induced diabetic rats despite near-euglycemia with phlorizin
    • Mick GJ, Hingre K, Benedict M, et al: Persistence of disturbed adipocyte metabolism in streptozocin-induced diabetic rats despite near-euglycemia with phlorizin. Biochim Biophys Acta 1226:315-322, 1994
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 315-322
    • Mick, G.J.1    Hingre, K.2    Benedict, M.3
  • 23
    • 0025945017 scopus 로고
    • Diminished in situ glucose6-phosphate flux in permeabilized adipocytes from streptozocin-induced diabetic rats
    • Mick GJ, Tousley K, McCormick K: Diminished in situ glucose6-phosphate flux in permeabilized adipocytes from streptozocin-induced diabetic rats. Diabetes 40:1517-1524, 1991
    • (1991) Diabetes , vol.40 , pp. 1517-1524
    • Mick, G.J.1    Tousley, K.2    McCormick, K.3
  • 25
    • 0031584837 scopus 로고    scopus 로고
    • Augmentation of obese (OB) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats)
    • Hiraoka J, Hosoda K, Ogawa Y, et al: Augmentation of obese (OB) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats). Biochem Biophys Res Commun 231:582-585, 1997
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 582-585
    • Hiraoka, J.1    Hosoda, K.2    Ogawa, Y.3
  • 26
    • 0030597308 scopus 로고    scopus 로고
    • Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal adenocarcinoma cells, ACHN
    • Takahashi Y, Okimura Y, Mizuno I, et al: Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal adenocarcinoma cells, ACHN. Biochem Biophys Res Commun 228:859-864, 1996
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 859-864
    • Takahashi, Y.1    Okimura, Y.2    Mizuno, I.3
  • 27
    • 15844410399 scopus 로고    scopus 로고
    • Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
    • Bai Y, Zhang S, Kim K-S, et al: Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 271:13939-13942, 1996
    • (1996) J Biol Chem , vol.271 , pp. 13939-13942
    • Bai, Y.1    Zhang, S.2    Kim, K.-S.3
  • 28
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • Shimabukuro M, Koyama K, Chen G, et al: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 29
    • 0030847432 scopus 로고    scopus 로고
    • Acute stimulation of glucose metabolism in mice by leptin
    • Kamohara S, Burcelin R, Halaas JL, et al: Acute stimulation of glucose metabolism in mice by leptin. Nature 389:374-377, 1997
    • (1997) Nature , vol.389 , pp. 374-377
    • Kamohara, S.1    Burcelin, R.2    Halaas, J.L.3
  • 30
    • 0031467631 scopus 로고    scopus 로고
    • Direct effects of leptin in brown and white adipose tissue
    • Seigrist-Kaiser CA, Pauli V, Juge-Aubry CE, et al: Direct effects of leptin in brown and white adipose tissue. J Clin Invest 100:2858-2864, 1997
    • (1997) J Clin Invest , vol.100 , pp. 2858-2864
    • Seigrist-Kaiser, C.A.1    Pauli, V.2    Juge-Aubry, C.E.3
  • 31
    • 0030737573 scopus 로고    scopus 로고
    • Effects of leptin on insulin sensitivity in normal rats
    • Sivitz WI, Walsh SA, Morgan DA, et al: Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138:3395-3401, 1997
    • (1997) Endocrinology , vol.138 , pp. 3395-3401
    • Sivitz, W.I.1    Walsh, S.A.2    Morgan, D.A.3
  • 32
    • 0030784253 scopus 로고    scopus 로고
    • Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
    • Rossetti L, Massillon D, Barzilai N, et al: Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272:27758-27763, 1997
    • (1997) J Biol Chem , vol.272 , pp. 27758-27763
    • Rossetti, L.1    Massillon, D.2    Barzilai, N.3
  • 33
    • 0031439778 scopus 로고    scopus 로고
    • Leptin selectively decreases visceral adiposity and enhances insulin action
    • Barzilai N, Wang J, Massilon D, et al: Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100:3105-3110, 1997
    • (1997) J Clin Invest , vol.100 , pp. 3105-3110
    • Barzilai, N.1    Wang, J.2    Massilon, D.3
  • 34
    • 0031939588 scopus 로고    scopus 로고
    • Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance
    • Carantoni M, Abbasi F, Azhar S, et al: Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance. Diabetes 47:244-247, 1998
    • (1998) Diabetes , vol.47 , pp. 244-247
    • Carantoni, M.1    Abbasi, F.2    Azhar, S.3
  • 35
    • 0030895726 scopus 로고    scopus 로고
    • 12 myotubules: Evidence for a PI3-kinase mediated effect
    • 12 myotubules: Evidence for a PI3-kinase mediated effect. Diabetologia 40:606-609, 1997
    • (1997) Diabetologia , vol.40 , pp. 606-609
    • Berti, L.1    Kellerer, M.2    Capp, E.3
  • 36
    • 0015090889 scopus 로고
    • The effect of insulin upon glucose metabolism by adipose cells of different size
    • Salans LB, Dougherty JW: The effect of insulin upon glucose metabolism by adipose cells of different size. J Clin Invest 50:1399-1410, 1971
    • (1971) J Clin Invest , vol.50 , pp. 1399-1410
    • Salans, L.B.1    Dougherty, J.W.2
  • 37
    • 0031975899 scopus 로고    scopus 로고
    • Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
    • Zierath JR, Frevert EU, Ryder JW, et al: Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes 47:1-4, 1998
    • (1998) Diabetes , vol.47 , pp. 1-4
    • Zierath, J.R.1    Frevert, E.U.2    Ryder, J.W.3
  • 38
    • 0030804112 scopus 로고    scopus 로고
    • Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice
    • Surwit RS, Petro AE, Parekh P, et al: Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice. Diabetes 46:1516-1520, 1997
    • (1997) Diabetes , vol.46 , pp. 1516-1520
    • Surwit, R.S.1    Petro, A.E.2    Parekh, P.3
  • 39
    • 0031054698 scopus 로고    scopus 로고
    • Depot- and sex-specific differences in human leptin mRNA expression. Implications for the control of regional fat distribution
    • Montague CT, Prins JB, Sanders L, et al: Depot- and sex-specific differences in human leptin mRNA expression. Implications for the control of regional fat distribution. Diabetes 46:342-347, 1997
    • (1997) Diabetes , vol.46 , pp. 342-347
    • Montague, C.T.1    Prins, J.B.2    Sanders, L.3
  • 40
    • 0029090011 scopus 로고
    • Human obese gene expression: Adipocyte-specific expression and regional differences in adipose tissue
    • Masuzaki H, Ogawa Y, Isse N, et al: Human obese gene expression: Adipocyte-specific expression and regional differences in adipose tissue. Diabetes 44:855-858, 1995
    • (1995) Diabetes , vol.44 , pp. 855-858
    • Masuzaki, H.1    Ogawa, Y.2    Isse, N.3
  • 41
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • Lonnqvist F, Arner P, Nordfors L, et al: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1:950-956, 1995
    • (1995) Nat Med , vol.1 , pp. 950-956
    • Lonnqvist, F.1    Arner, P.2    Nordfors, L.3
  • 42
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah AH, Krakower GR: Regional adiposity and morbidity. Physiol Rev 74:761-811, 1994
    • (1994) Physiol Rev , vol.74 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 43
    • 0031014894 scopus 로고    scopus 로고
    • Glucose metabolism in identical twins discordant for obesity. The critical role of visceral fat
    • Ronnemaa T, Koskenvuo M, Marniemi J, et al: Glucose metabolism in identical twins discordant for obesity. The critical role of visceral fat. J Clin Endocrinol Metab 82:383-387, 1997
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 383-387
    • Ronnemaa, T.1    Koskenvuo, M.2    Marniemi, J.3
  • 44
    • 0029859209 scopus 로고    scopus 로고
    • Leptin: A significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women
    • Dua A, Hennes MI, Hoffmann RG, et al: Leptin: A significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women. Diabetes 45:1635-1637, 1996
    • (1996) Diabetes , vol.45 , pp. 1635-1637
    • Dua, A.1    Hennes, M.I.2    Hoffmann, R.G.3
  • 45
    • 0031031622 scopus 로고    scopus 로고
    • Effect of regional fat distribution and Prader-Willi syndrome on plasma leptin levels
    • Weigel DS, Ganter SL, Kuijper JL, et al: Effect of regional fat distribution and Prader-Willi syndrome on plasma leptin levels. J Clin Endocrinol Metab 82:566-570, 1997
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 566-570
    • Weigel, D.S.1    Ganter, S.L.2    Kuijper, J.L.3
  • 46
    • 0031587418 scopus 로고    scopus 로고
    • In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin
    • Fruhbeck G, Aguado M, Martinez JA: In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 240:590-594, 1997
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 590-594
    • Fruhbeck, G.1    Aguado, M.2    Martinez, J.A.3
  • 47
    • 0031764763 scopus 로고    scopus 로고
    • Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells
    • Ranganathan S, Ciaraldi TP, Henry RR, et al: Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells. Endocrinology 139:2509-2513, 1998
    • (1998) Endocrinology , vol.139 , pp. 2509-2513
    • Ranganathan, S.1    Ciaraldi, T.P.2    Henry, R.R.3


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