Lipoprotein alterations in 10- and 20-week-old Zucker diabetic fatty rats: Hyperinsulinemic versus insulinopenic hyperglycemia

Metabolism: Clinical and Experimental

Volumn 47, Issue 11, 1998, Pages 1315-1324

  Sparks, Janet D ^a   Phung, Thuy L ^b   Bolognino, Mary ^b   Cianci, Joanne ^b   Khurana, Rohit ^b   Peterson, Richard G ^b   Sowden, Mark P ^b   Corsetti, James P ^b   Sparks, Charles E ^b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN C; APOLIPOPROTEIN E; CORTICOSTERONE; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROID HORMONE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLIPIDEMIA; HYPOINSULINEMIA; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; LIVER WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID HORMONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031724189     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90298-0     Document Type: Article

References (54)

1. Bray GA: The Zucker-fatty rat: A review. Fed Proc 36:148-153, 1977
2. Argiles JM: The obese Zucker rat: A choice for fat metabolism. 1968-1988: Twenty years of research on the insights of the Zucker mutation. Prog Lipid Res 28:53-66, 1989
3. Kava R, Greenwood MRC, Johnson PR: Zucker (fa/fa) rat. ILAR News 32:4-8, 1990
4. Clark JB, Palmer CJ, Shaw WN: The diabetic Zucker fatty rat. Proc Soc Exp Biol Med 173:68-75, 1983
5. Peterson RG, Shaw WN, Neel M-A, et al: Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. Inst Lab Anim Resources News 32:16-27, 1990
6. DeFronzo RA, Ferrannini E: Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991
7. 2. Clin Chem 29:2026-2030, 1983
8. Sparks JD, Bolognino M, Trax PA, et al: The production and utility of monoclonal antibodies to rat apolipoprotein B lipoproteins. Atherosclerosis 61:205-211, 1986
9. Hatch FT, Lees RS: Practical methods for plasma lipoprotein analysis. Adv Lipid Res 6:1-68, 1968
10. Markwell MK, Haas SM, Bieber LL, et al: A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 87:206-210, 1978
11. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
12. Sparks JD, Sparks CE: Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes. J Biol Chem 265:8854-8862, 1990
13. Sparks JD, Sparks CE: Chromatographic method for isolation and quantification of apolipoproteins B-100 and B-48. Methods Enzymol 263:104-121, 1996
14. Marsh JB, Sparks CE: Hepatic secretion of lipoproteins in the rat and the effect of experimental nephrosis. J Clin Invest 64:1229-1237, 1979
15. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
16. Sparks JD, Zolfaghari R, Sparks CE, et al: Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats. J Clin Invest 89:1418-1430, 1992
17. Smith HC, Kuo S-R, Backus JW, et al: In vitro apolipoprotein B mRNA editing: Identification of a 27S editing complex. Proc Natl Acad Sci USA 88:1489-1493, 1991
18. Phung TL, Sowden M, Sparks JD, et al: Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat. Metabolism 45:1056-1058, 1996
19. Schonfeld G, Pfleger B: Overproduction of very low-density lipoproteins by livers of genetically obese rats. Am J Physiol 220:1178-1181, 1971
20. Azain MJ, Fukuda N, Chao F-F, et al: Contributions of fatty acid and sterol synthesis to triglyceride and cholesterol secretion by the perfused rat liver in genetic hyperlipemia and obesity. J Biol Chem 260:174-181, 1985
21. Fukuda N, Azain MJ, Ontko JA: Altered hepatic metabolism of free fatty acids underlying hypersecretion of very low density lipoproteins in the genetically obese Zucker rat. J Biol Chem 257:14066-14072, 1982
22. McCaleb ML, Sredy J: Metabolic abnormalities of the hyperglycemic obese Zucker rat. Metabolism 41:522-525, 1992
23. Martin RJ, Wangsness PJ, Gahagan JH: Diurnal changes in serum metabolites and hormones in lean and obese Zucker rats. Horm Metab Res 10:187-192, 1978
24. Durbin-Naltchayan S, Bouhnik J, Michel R: Thyroid status in the obese syndrome of rats. Horm Metab Res 15:547-549, 1983
25. Schonfeld G, Felski C, Howald MA: Characterization of the plasma lipoproteins of the genetically obese hyperlipoproteinemic Zucker fatty rat. J Lipid Res 15:457-464, 1974
26. O'Looney P, Irwin D, Briscoe P, et al: Lipoprotein composition as a component in the lipoprotein clearance defect in experimental diabetes. J Biol Chem 260:428-432, 1985
27. Elovson J, Chatterton JE, Bell GT, et al: Plasma very low density lipoproteins contain a single molecule of apolipoprotein B. J Lipid Res 29:1461-1473, 1988
28. Kotite L, Bergeron N, Havel RJ: Quantitation of apolipoproteins B-100, B-48, and E in human triglyceride-rich lipoproteins. J Lipid Res 36:890-900, 1995
29. Bar-On H, Roheim PS, Eder HA: Serum lipoproteins and apolipoproteins in rats with streptozotocin-induced diabetes. J Clin Invest 57:714-721, 1976
30. Li X, Grundy SM, Patel SB: Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. J Lipid Res 38:1277-1288, 1997
31. Reaven GM, Mondon CE: Effect of in vivo plasma insulin levels on the relationship between perfusate free fatty acid concentration and triglyceride secretion by perfused rat livers. Horm Metab Res 16:230-232, 1984
32. Witztum JL, Schonfeld G: Lipoproteins in the plasma and hepatic perfusates of the Zucker fatty rat. Diabetes 28:509-516, 1979
33. Redgrave TG: Catabolism of chylomicron triacylglycerol and cholesteryl ester in genetically obese rats. J Lipid Res 18:604-612, 1977
34. Wang C-S, Fukuda N, Ontko JA: Studies on the mechanism of hypertriglyceridemia in the genetically obese Zucker rat. J Lipid Res 25:571-579, 1984
35. Ito Y, Azrolan N, O'Connell A, et al: Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science 249:790-793, 1990
36. de Silva HV, Lauer SJ, Wang J, et al: Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J Biol Chem 269:2324-2335, 1994
37. Windler E, Chao Y-S, Havel RJ: Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins. J Biol Chem 255:8303-8307, 1980
38. Shelburne F, Hanks J, Meyers W, et al: Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat. J Clin Invest 65:652-658, 1980
39. Windler E, Havel RJ: Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J Lipid Res 26:556-565, 1985
40. Kowal RC, Herz J, Weisgraber KH, et al: Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem 265:10771-10779, 1990
41. Sparks JD, Sparks CE, Bolognino M, et al: Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes. J Clin Invest 82:37-43, 1988
42. Yamane M, Jiao S (Nokboru Sho), Kihara S, et al: Increased proportion of plasma apo B-48 to apo B-100 in non-insulin-dependent diabetic rats: Contribution of enhanced apo B mRNA editing in the liver. J Lipid Res 36:1676-1685, 1995
43. Davidson NO, Carlos RC, Sherman HL, et al: Modulation of apolipoprotein B-100 mRNA editing: Effects on hepatic very low density lipoprotein assembly and intracellular apoB distribution in the rat. J Lipid Res 31:899-908, 1990
44. Thorngate FE, Raghow R, Wilcox HG, et al: Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing. Proc Natl Acad Sci USA 91:5392-5396, 1994
45. Sparks CE, Hnatiuk O, Marsh JB: Hepatic and intestinal contribution of two forms of apolipoprotein B to plasma lipoprotein fractions in the rat. Can J Biochem 59:693-699, 1981
46. Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870, 1995
47. Iida M, Murakami T, Ishida K, et al: Substitution at codon 269 (glutamine - proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 224:597-604, 1996
48. Shimabukuro M, Koyama K, Chen G, et al: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641, 1997
49. Bai Y, Zhang S, Kim K-S, et al: Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 271:13939-13942, 1996
50. Terauchi Y, Iwamoto K, Tamemoto H, et al: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99:861-866, 1997
51. Anai M, Funaki M, Ogihara T, et al: Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47:13-23, 1998
52. Hirose H, Lee YH, Inman LR, et al: Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes. J Biol Chem 271:5633-5637, 1996
53. Peterson RG, Shaw WN, Little LA, et al: The obese female ZDF rat as an inducible NIDDM model. Obes Res 3:362, 1995 (suppl 3, abstr)
54. Reaven GM: Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988