Human osteoclast formation and activity in vitro: Effects of alendronate

Journal of Bone and Mineral Research

Volumn 13, Issue 11, 1998, Pages 1721-1729

  Breuil, V ^a,b   Cosman, F ^a,c   Stein, L ^a   Horbert, W ^a   Nieves, J ^a,c   Shen, V ^a,c   Lindsay, R ^a,c   Dempster, D W ^a,c  

^a HELEN HAYES HOSPITAL   (United States)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCITRIOL; DEXAMETHASONE; RECOMBINANT COLONY STIMULATING FACTOR 1; SALCATONIN;

ADULT; AGED; ARTICLE; BONE REMODELING; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; HUMAN TISSUE; MONONUCLEAR CELL; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; POSTMENOPAUSE OSTEOPOROSIS; TISSUE CULTURE;

AGED; ALENDRONATE; ANALYSIS OF VARIANCE; BONE AND BONES; BONE RESORPTION; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MONOCYTES; OSTEOCLASTS; POSTMENOPAUSE; STROMAL CELLS;

EID: 0031722177     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.11.1721     Document Type: Article

References (38)

1. Arnett TR, Dempster DW 1987 A comparative study of disaggregated chick and rat osteoclasts in vitro: Effects of calcitonin and prostaglandins. Endocrinology 120:602-608.
2. Murrills RJ, Dempster DW 1990 The effects of stimulators of intracellular cyclic AMP on rat and chick osteoclasts in vitro: Validation of a simplified light microscope assay of bone resorption. Bone 11:333-344.
3. Nicholson GC, Moseley JM, Sexton PM, Martin TJ 1987 Chicken osteoclasts do not possess calcitonin receptors. J Bone Miner Res 2:53-59.
4. Dempster DW, Murrills RJ, Horbert WR, Arnett TR 1987 Biological activity of chicken calcitonin: effects on neonatal rat and embryonic chick osteoclasts. J Bone Miner Res 2:443-448.
5. Murrills RJ, Stein L, Horbert WR, Dempster DW 1992 Effects of phorbol myristate acetate on rat and chick osteoclasts. J Bone Miner Res 7:415-423.
6. Dempster DW, Stein L, Horbert W, Chowdhury M, Hamada C, Murills RJ 1990 Contrasting effects of glucocorticoids on rat and chick osteoclasts. J Bone Miner Res 5 (Suppl 2):S95 (abstract).
7. Moonga BS, Stein L, Kilb JM, Dempster DW 1996 Effects of diacylglycerols on osteoclastic bone resorption. Calcif Tissue Int 59:105-108.
8. Flanagan AM, Horton MA, Dorey EL, Collins DA, Evely RS, Mosely JM, Firkin FC, Chambers TJ, Helfrich MH, Martin TJ 1992 An assessment of the ability of human bone marrow culture to generate osteoclasts. Int J Exp Pathol 73:387-401.
9. Roodman GD 1995 Application of bone marrow cultures to the study of osteoclast formation and osteoclast precursors in man. Calcif Tissue Int 56 (Suppl 1):S22-S23.
10. Sarma U, Flanagan AM 1996 Macrophage-colony stimulating factor (M-CSF) induces substantial osteoclast generation and bone resorption in human marrow cultures. Blood 88:2531-2540.
11. Fujikawa Y, Quinn JMW, Sabokbar A, Mc Gee JO'D, Athanasou NA 1996 The human osteoclast precursor circulates in the monocyte fraction. Endocrinology 137:4058-4060.
12. Matayoshi A, Brown C, DiPersio JF, Haug J, Abu-Amer Y, Liapis H, Kuestner R, Pacifici R 1996 Human blood mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stroma cells. Proc Natl Acad Sci USA 93:10785-10790.
13. Murrills RJ, Shane E, Lindsay R, Dempster DW 1989 Bone resorption by isolated human osteoclasts in vitro: Effects of calcitonin. J Bone Miner Res 4:259-268.
14. Davies J, Warwick J, Tutty N, Philip R, Helfrich M, Horton M 1989 The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 109:1817-1826.
15. Schenk R 1976 Basic stereological principles. In: Jaworski ZFG (ed.) Proceedings of the First Workshop on Bone Morphometry. University of Ottawa Press, Ottawa, Ontario, Canada, pp. 21-23.
16. Nicholson GC, Moseley JM, Sexton PM, Mendelsohn FAO, Martin TJ 1986 Abundant calcitonin receptors in isolated rat osteoclasts: Biochemical and autoradiographic characterization. J Clin Invest 78:355-360.
17. McDonald BR, Takahashi N, McManus LM, Holahan J, Mundy GR, Roodman GD 1987 Formation of multinucleated cells that respond to osteotropic hormones in long term human bone marrow cultures. Endocrinology 120:2326-2333.
18. Hughes DE, Mac Donald BR, Russell RGG, Gowen M 1989 Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83:1930-1935.
19. Azria M, Avioli LV 1996 Calcitonin. In: JP Bilezikian, LG Raisz, GA Rodan (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, U.S.A., pp. 1083-1097.
20. Flanagan AM, Tinkler SMB, Horton MA, Williams DM, Chambers TJ 1988 The multinucleate cells in giant cell granulomas of the jaw are osteoclasts. Cancer 62:1139-1145.
21. Liberman UA, Weiss SR, Bröll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales Downs RW Jr, Dequekker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC II, Lombardi A, Shah RV, Hirsch LJ, Karpf DB 1995 Effect of oral alendronate on bone mineral density and incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437-1443.
22. Tucci JR, Tonino RP, Emkey RD, Peverly CA, Kher U, Santora AC II 1996 Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis. Am J Med 101:488-501.
23. Black DM, Cummings SR, Karpf DB, cauley JA, Thompson JE, Nevitt MC, Bauer DC, Genant HK, Haskell WL, Marcus R, Ott SM, Torner JC, Quandt SA, Reiss TF, Ensrud KE, for the Fracture Intervention Trial Research Group 1996 Randomized trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348:1535-1541.
24. Ensrud KE, Black DM, Palermo L, Bauer DC, Barrett-Connor E, Quandt SA, Thompson DE, Karpf DB 1997 Treatment with alendronate prevents fractures in women at highest risk. Arch Intern Med 157:2617-2624.
25. Rodan GA, Fleisch HA 1996 Bisphosphonates: Mechanisms of action. J Clin Invest 12:2692-2696.
26. Schmidt A, Rutledge SU, Endo N, Opas EE, Tanaka H, Wesolowski G, Leu CT, Huang Z, Ramachandaran C, Rodan SB, Rodan GA 1996 Protein-tyrosine phosphatase activity regulates osteoclast formation and function: Inhibition by alendronate. Proc Natl Acad Sci USA 93:3068-3073.
27. Van Beek ER, Lowik CWG, Papapoulos SE 1997 Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice. Bone 20:335-340.
28. Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson D, Golub E, Rodan GA 1991 Bisphosphonate action: Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88:2095-2105.
29. Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S, Nakamura I, Zhang D, Barbier A, Suda T 1995 A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having a ruffled border. Bone 17:137-144.
30. Vitte C, Fleisch H, Guenther HL 1996 Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption. Endocrinology 137:2324-2333.
31. Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF 1995 Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-1487.
32. Owens JM, Fuller K, Chambers TJ 1997 Osteoclast activation: Potent inhibition by the bisphosphonate Alendronate through a nonresorptive mechanism. J Cell Physiol 172:79-86.
33. Sato M, Grasser W 1990 Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy. J Bone Miner Res 5:31-40.
34. Zimolo Z, Wesolowski G, Rodan GA 1995 Acid extrusion is induced by osteoclast attachment to bone: inhibition by alendronate and calcitonin. J Clin Invest 96:2277-2283.
35. Selander K, Lehenkari P, Vaananen HK 1994 The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 55:368-375.
36. Piper K, Boyde A, Jones J 1994 The effect of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) on the resorptive function of osteoclasts of known nuclear number. Calcif Tissue Int 54:56-61.
37. Murrills RJ, Dempster DW, Arnett TR 1998 Isolation and culture of osteoclasts and osteoclast resorption assays. In Arnett TR, Henderson B (eds.) Methods in Bone Biology. Chapman and Hall, London, U.K., pp. 64-99.
38. Apone S, Lee MY, Eyre DR 1997 Osteoclasts generate cross-linked collagen N-telopeptides (NTx) but not free pyridinolines when cultured on human bone. Bone 21:129-136.