Dexamethasone suppresses in vivo levels of bone collagen synthesis in neonatal mice

Bone

Volumn 20, Issue 1, 1997, Pages 41-46

  Advami, S ^a   Lafrancis, D ^a   Bogdanovic, E ^a   Taxel, P ^a   Raisz, L G ^a   Kream, B E ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Bone; COL1A1; Collagen synthesis; Dexamethasone; Glucocorticoids; Osteocalcin

Indexed keywords

CLOSTRIDIOPEPTIDASE A; COLLAGEN; DEXAMETHASONE; GLUCOCORTICOID; OSTEOCALCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALVARIA; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; ISOTOPE LABELING; MOUSE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; OSSIFICATION; PROTEIN SYNTHESIS; RNA ANALYSIS; WEIGHT GAIN; WEIGHT REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BONE DEVELOPMENT; COLLAGEN; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOCORTICOIDS; ISOTOPE LABELING; MICE; OSTEOCALCIN; PROLINE; RNA, MESSENGER; SKULL; TRANSCRIPTION, GENETIC; TRITIUM;

EID: 0031021653     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(96)00314-6     Document Type: Article

References (53)

1. Adinoff, A.D. and Hollister, J. R. Steroid-induced fractures and bone loss in patients with asthma. New Engl J Med 309:265-268; 1983.
2. Altman, A., Hockberg, Z., and Silbermann, M. Interactions between growth hormone and dexamethasone in skeletal growth and bone structure of the young mouse. Calcif Tissue Int 51:298-304; 1992.
3. Bellows, C. G., Aubin, J., and Heersche, J. N. M. Physiologic concentrations of glucocorticoids stimulate formation of bone nodules from isolated rat calvaria cells in vitro. Endocrinology 121:1985-1992; 1987.
4. Bogdanovic, Z., Bedalov, A., Krebsbach, P. H., Woody, C. O., Clark, S. H., Thomas, H. F., Rowe, D. W., Kream, B. E., and Lichtler, A. C. Upstream regulatory elements necessary for expression of theratCOL1A1 promoter in transgenic mice. J Bone Miner Res 9:285-292; 1993.
5. Bressot, C., Meunier, P. J., Chapuy, M. C., Lejeune, E., Edourd, C., and Darby, A. J. Histomorphometric profile, pathophysiology, and reversibility of corticosteroid-induced osteoporosis. Metab Bone Dis Rel Res 1:303-319; 1979.
6. Canalis, E. Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae. Endocrinology 112:931-939; 1983.
7. Canalis, E. Effect of Cortisol on periosteal and nonperiosteal collagen and DNA synthesis in cultured rat calvariae. Calcif Tissue Int 36:158-166; 1984.
8. Chen, T. L. and Feldman, D. Glucocorticoid receptors and actions in subpopulations of cultured rat bone cells. Mechanism of dexamethasone protentiation of parathyroid hormone-stimulated cyclic AMP production. J Clin Invest 63:750-758; 1979.
9. Cheng, S., Yang, J. W., Rifas, L., Zhang, S., and Avioli, L. Differentiation of human bone marrow osteogenic stromal cells in vitro: Induction of the osteoblast phenotype by dexamethasone. Endocrinology 134:277-286; 1994.
10. Chomczynski, P. and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:155-159; 1987.
11. Chyun, Y. S., Kream, B. E., and Raisz, L. G. Cortisol decreases bone formation by inhibiting periosteal cell proliferation. Endocrinology 114:477-480; 1984.
12. Cockayne, D., Sterling, K. M. Jr., Shull, S., Mintz, K.P., Illeyne, S., and Cutroneo, K. Glucocorticoids decrease the synthesis of type I procollagen mRNA. Biochemistry 25:3202-3209; 1986.
13. Cushing, H. The basophil adenomas of the pituitary and their clinical manifestations. Bull Johns Hopkins Hosp 50:137-195; 1932.
14. Delany, A. M., Gabbitas, B. Y., and Canalis, E. Cortisol downregulates osteoblast alphal (1) procollagen mRNA by transcriptional and posttranscriptional mechanisms. J Cell Biochem 57:488-494; 1995.
15. Dempster, D. W. Bone histomorphology in glucocorticoid-induced osteoporosis. J Bone Miner Res 4:137-141; 1989.
16. Dempster, D. W., Arlot, M. A., and Meunier, P. J. Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosis. Calcif Tissue Int 35:410-417; 1983.
17. Diegelmann, R. F. and Peterkofsky, B. Collagen biosynthesis during connective tissue development in chick embryo. Dev Biol 28:443-453; 1972.
18. Dietrich, J. W., Canalis, E. M.. Maina, D. M., and Raisz, L. G. Effects of glucocorticoids on fetal rat bone collagen synthesis in vitro. Endocrinology 104:715-721; 1978.
19. Doherty, W. J., DeRome, M. E., McCarthy, M. B., and Gronowicz, G. A. The effect of glucocorticoids on osteoblast function: The effect of corticosterone on osteoblast expression of beta-1 integrins. J Bone Joint Surgery 77:396-404; 1995.
20. Eastell, R. Management of corticosteroid-induced osteoporosis. J Int Med 237:439-447; 1995.
21. Genovese, C., Rowe, D., and Kream, B. Construction of DNA sequences complementary to rat α1 and α2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1.25-dihydroxyvitamin D. Biochemistry 23:6210-6216; 1984.
22. Gohel, A. R., Hand, A. R., and Gronowicz, G. A. Immunogold localization of β1-integrin in bone: Effect of glucocorticoids and insulin-like growth factor on integrins and osteocyte formation. J Histochem Cytochem 43:1085-1096; 1995.
23. Gronowicz, G. A., DeRome, M. E., and McCarthy, M.-B. Glucocorticoids inhibit fibronectin synthesis and messenger ribonucleic acid levels in cultured fetal rat parietal bones. Endocrinology 128:1107-1114; 1991.
24. 2 stimulates preosteoblast replication: An autoradiographic study in cultured fetal rat calvariae. Exp Cell Res 212:314-320; 1994.
25. Gronowicz, G. A. and McCarthy, M. B. Glucocorticoids inhibit the attachment of osteoblasts to bone extracellular matrix proteins and decrease β1-integrin levels. Endocrinology 136:598-608; 1995.
26. Hahn, T. J., Westbrook, S. L., and Halstead, L. R. Cortisol modulation of osteoblast metabolic activity in cultured neonatal rat bone. Endocrinology 114:1864-1870; 1984.
27. Hamalainen, L., Oikarinen, J., and Kivirikko, K. I. Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem 260:720-725; 1985.
28. Hodge, B. O. and Kream, B. E. Variable effects of dexamethasone on protein synthesis in clonal rat osteosarcoma cells. Endocrinology 122:2127-2133; 1988.
29. 3 analogs and dexamethasone on the expression of osteocalcin gene in rat tibiae in vivo. Biochem Biophys Res Commun 189:1231-1235; 1992.
30. 3 interaction with dexamethasone and retinoic acid: Effects on procollagen messenger ribonucleic acid levels in rat osteoblast-like cells. Mol Endocrinol 3:97-104; 1989.
31. Kream, B. E., LaFrancis, D., Petersen, D. N., Woody, C., Clark, S., Rowe, D. W., and Lichtler, A. Parathyroid hormone represses α1 I collagen promoter activity in cultured calvariae from neonatal transgenic mice. Mol Endocrinol 7:399-408; 1993.
32. Kream, B. E., Petersen, D. N., and Raisz, L. G. Cortisol enhances the anablic effects of insulin-like growth factor I on collagen synthesis and procollagen messenger ribonucleic acid levels in cultured 21 day fetal rat calvariae. Endocrinology 126:1576-1583; 1990.
33. Kream, B. E., Rowe, D., Smith, M. D., Maher, V., and Majeska, R. Hormonal regulation of collagen synthesis in a clonal rat osteosarcoma cell line. Endocrinology 119:1922-1928; 1986.
34. Luengo, M., Picado, C., Del-Rio, L., Guanabens, N., Monsterrat, J. M., and Setoain, J. Treatment of steroid-induced osteopenia with calcitonin incorticosteroid-dependent asthma: A one-year follow-up study. Am Rev Respir Dis 142:104-107; 1990.
35. Lukert, B., Mador, A., Raisz, L. G., and Kream, B. E. The role of DNA synthesis in the responses of fetal rat calvariae to cortisol. J Bone Miner Res 6:453-460; 1991.
36. Lukert, B. P., Johnson, B. E., and Robinson, R. G. Estrogen and progesterone replacement therapy reduces glucocorticoid-induced bone loss. J Bone Miner Res 7:1063-1069; 1992.
37. Lukert, B. P. and Raisz, L. G. Pathogenesis and management of glucocorticoid-induced osteoporosis. Adv Endocrinol Metab 5:97-135; 1994.
38. Manning, P. J., Evans, M. C., and Reid, I. R. Normal bone mineral density following cure of Cushing's syndrome. Clin Endocrinol 36:229-234; 1992.
39. McCulloch, C. A., Strugurescu, M., Hughes, F., Melcher, A. H., and Aubin, J. E. Osteogenic progenitor cells in rat bone morrow stromal populations exhibit self-renewal in culture. Blood 77:1906-1911; 1991.
40. McCulloch, C. A. G. and Tenenbaum, H. C. Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue culture. Anat Rec 215:397-402; 1986.
41. Meunier, P. J., Biracon, D., Chavassieux, P., Edouard, C., Boivin, G. T. C., Marcelli, C., Pastoureau, P., Delmas, P. D., and Casez, J. P. Treatment with fluroide: Bone histomorphometric findings. Christiansen, C., Johansen, J. S., and Riis, B. J., Eds. Osteoporosis. Copenhagen Osteopress; 1987; 824-828.
42. Ng, K. W., Manji, S. S., Young, M. F., and Findlay, D. M. Opposing influences of glucocorticoid and retinoic acid on transcriptional control in preosteoblasts. Mol Endocrinol 3:2079-2085; 1989.
43. Nielsen, H. K., Charles, P., and Mosekilde, L. The effect of single oral doses of prednisone on the circadian rhythm of serum osteocalcin in normal subjects. J Clin Endo Metab 67:1025-1030; 1988.
44. Peterkofsky, B. and Diegelmann, R. Use of a mixture of proteinase-free colagenases for the specific assay of radioactive collagen in the presence of other hormones. Biochemistry 6:988-994; 1971.
45. Petersen, D. N., Blaine, T., Lichtler, A., Rowe, D. W., and Kream, B. E. Glucocorticoid regulation of alpha 1 (I) collagen promoter constructs in stably transfected osteoblastic Py-1a cells. J Bone Miner Res 6(Suppl. 1):S204; 1991.
46. Pocock, N. A., Eisman, J. A., Dunstan, C. R., Evans, R. A., Thomas, D. H., and Hug, N. L. Recovery from steroid-induced osteoporosis. Ann Intern Med 107:319-323; 1987.
47. Quarles, L. D. Prednisone-induced osteopenia in beagles: Variable effects mediated by differential suppression of bone formation. Am J Physiol Endocrinol Metab 263:E136-E141; 1992.
48. Raghow, R., Gossage, D., and Kang, A. H. Pretranslational regulation of type I collagen, fibronectin, and a 50 kilodalton noncollagenous extracellular protein by dexamethasone in rat fibroblasts. J Biol Chem 261:4677-4684; 1986.
49. Rickard, D. J., Sullivan, T. A., Shenker, B. J., Leboy, P. S., and Kazhdan, I. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 161:218-228; 1994.
50. Rizzato, G. and Montemurro, L. Reversibility of exogenous corticosteroid-induced bone loss. European Respiratory J 6:116-199; 1993.
51. Struys, A., Anneke, A., Snelder, R. N., and Mulder, H. Cyclic ethidronate reverses bone loss of the spine and proximal femur in patients with established corticosteroid-induced osteoporosis. Am J Med 99:235-242; 1995.
52. Tenenbaum, H. C. and Heersche, J. N. M. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology 117:2211-2217; 1985.
53. Turner, R. T., Hannon, K. S., Greene. V. S., and Bell, N. H. Prednisone inhibits formation of cortical bone in sham-operated and ovariectomized female rats. Calcif Tissue Int 56:311-315; 1995.