Iron and heart disease: The epidemiologic data

Nutrition Reviews

Volumn 54, Issue 3, 1996, Pages 73-84

  Sempos, Christopher T ^a   Looker, Anne C ^b   Gillum, Richard F ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NATIONAL CENTER FOR HEALTH STATISTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FREE RADICAL; IRON;

DIETARY INTAKE; FERRITIN BLOOD LEVEL; FINLAND; HEART INFARCTION; HUMAN; IRON STORAGE; ISCHEMIC HEART DISEASE; OXIDATIVE STRESS; REVIEW; RISK ASSESSMENT;

EID: 0029938109     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.1996.tb03875.x     Document Type: Review

References (99)

1. Harman D. Aging: a theory based on free radical and radiation chemist. J Gerontol 1956;11:298-300
2. Harman D. Prolongation of the normal lifespan and inhibition of spontaneous cancer by antioxidants. J Gerontol 1961;16:247-54
3. Graham S. Results of case-control studies of diet and cancer in Buffalo, New York. Cancer Res 1983;2409s-13s
4. Ziegler RG. Vegetables, fruits and carotenoids and the risk of cancer. Am J Clin Nutr 1991;53:251s-9s
5. Hennekens CH. Antioxidant vitamins and cancer. Am J Med 1994;97:3A-2s-4s
6. Krinsky NI, Sies H, eds. Antioxidant vitamins and β-carotene in disease prevention. Am J Clin Nutr 1995;62(6s):1299s-540s
7. Block G, Patterson B, Subar A. Fruit, vegetables and cancer prevention: a review of the epidemiologic evidence. Nutr Cancer 1992;18:1-29
8. Steinberg D. Metabolism of lipoproteins and their role in the pathogenesis of atherosclerosis. In: Gotto Am Jr, Paoletti R, eds. Atherosclerosis Reviews, Vol 18, Stokes J, Mancini M, eds. Hypercholesterolemia: Clinical and Therapeutic Implications. 1988:1-23
9. Jha P, Flather M, Lonn E, Farkouh M, Yusuf S. The antioxidant vitamins and cardiovascular disease. A critical review of epidemiologic and clinical trial data. Ann Intern Med 1995;123:860-72
10. McCord JM. Effects of positive iron status at a cellular level. Nutr Rev 1996;54:85-8
11. Cross CE, Halliwell B, Borish ET, et al. Oxygen radicals and human disease. Ann Intern Med 1987;107: 526-45
12. Beard JL. Are we at risk for heart disease because of normal iron status? Nutr Rev 1993;51:112-5
13. Diplock AT. Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr 1991;53:189s-93s
14. Dormandy TL. Free-radical oxidation and antioxidants. Lancet 1978;1:647-50
15. Glavind J, Hartman S, Clemmesen J, Jessen KE, Dam H. Studies on the role of lipoperoxides in human pathology, II: the presence of peroxidized lipids in the atherosclerotic aorta. Acta Pathol Microbiol Scan 1952;30:1-6
16. Ray BR, Davisson EO, Crespi HL. Experiments in the degradation of lipoproteins from serum. J Phys Chem 1954;58:841-6
17. Peng SK, Taylor CB. Atherogenic effect of oxidized cholesterol. In: Perkins EG, Visek WJ, eds. Dietary Fats and Health. Champaign: American Oil Chemists' Society, 1983:919-33
18. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-24
19. Esterbaurer H, Gebicki J, Phul H, Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 1992;13: 341-90
20. Smith C, Mitchinson MJ, Auroma OI, Halliwell B. Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions. Biochem J 1992;286:901-5
21. McCord JM. Is iron sufficiency a risk factor for ischemic heart disease? Circulation 1991;83:1112-4
22. Grech ED, Dodd NJF, Bellamy CM, Perry RA, Morrison WL, Ramsdale DR. Free-radical generation during angioplasty repurfusion for acute myocardial infarction. Lancet 1993;341:990-1
23. Hoffman RM, Garewal HS. Antioxidants and the prevention of coronary heart disease. Arch Intern Med 1995;155:241-6
24. Jeroudi MO, Hartley CJ, Bolli R. Myocardial repurfusion injury: role of oxygen radicals and potential therapy with antioxidants. Am J Cardiol 1994;73:2B-7B
25. Sullivan JL. Iron and the sex difference in heart disease risk. Lancet 1981;1:1293-4
26. Sullivan JL. The iron paradigm of ischemic heart disease. Am Heart J 1989;117:1177-88
27. Stevens RG, Beasley RP, Blumberg BS. Iron-binding proteins and risk of cancer in Taiwan. JNCI 1986;76: 605-10
28. Stevens RG, Jones DY, Micozzi MS, Taylor PR. Body iron stores and the risk of cancer. N Engl J Med 1988;319:1047-52
29. Salonen JT, Nyyssönen K, Korpela H, Tuomilehto J, Seppänen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992;86:803-11
30. Beaton GH, Corey PN, Steele C. Conceptual and methodological issues regarding the epidemiology of iron deficiency and their implications for studies of the functional consequences of iron deficiency. Am J Clin Nutr 1989;50:575-88
31. Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974;27:681-7
32. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med 1974;290:1213-6
33. Huebers HA, Finch CA. The physiology of transferrin and transferrin receptors. Physiol Rev 1987;67:520-82
34. Bothwell T, Charlton R, Cook J, Finch C. Iron Metabolism in Man. Oxford, England: Blackwell Scientific, 1979
35. Herbert V. Everyone should be tested for iron disorders. J Am Diet Assoc 1992;92:1502-9
36. Custer EM, Finch CA, Sobel RE, Zettner A. Populations norms for serum ferritin. J Lab Clin Med 1995;126:88-94
37. Sempos CT, Looker AC, Gillum RF, Makuc DM. Body iron stores and the risk of coronary heart disease. [Reply] N Engl J Med 1994;331:1160
38. Peter F, Wang S. Serum iron and total iron-binding capacity compared with serum ferritin in assessment of iron deficiency. Clin Chem 1981;27:276-9
39. Craig WY, Poulin SE, Palomaki GE, Neveux LM, Ritchie RF, Ledue TB. Oxidation-related analytes and lipid and lipoprotein concentrations in healthy subjects. Arterioscler Thromb Vasc Biol 1995;15:733-9
40. Gordeuk V, Mukiibi J, Hasstedt SJ, et al. Iron overload in Africa. Interaction between a gene and dietary iron content. N Engl J Med 1992;326:95-100
41. Yip R, Dallman PR. The roles of inflammation and iron deficiency as causes of anemia. Am J Clin Nutr 1988;48:1295-1300
42. Birgegård G, Hällgren R, Venge P, Wide L. Serum ferritin during inflammation. A study on myocardial infarction. Acta Med Scan 1979;206:361-6
43. Griffiths JD, Campbell LJ, Woodruff IW, et al. Acute changes in iron metabolism following myocardial infarction. Am J Clin Pathol 1985;84:649-54
44. Schouw YT van der, Veek PMWC van der, Kok FJ, Koster JF, Schouten EG, Hofman A. Iron status in the acute phase and six weeks after myocardial infarction. Free Radic Biol Med 1990;8:47-53
45. Lilienfeld AM, Lilienfeld DE. Foundations of Epidemiology, 2nd ed. New York, NY: Oxford University Press, 1980
46. Magnusson MK, Sigfusson N, Sigvaldason H, Johannesson GM, Magnusson S, Thorgeirsson G. Low iron-binding capacity as a risk factor for myocardial infarction. Circulation 1994;89:102-8
47. Stampfer MJ, Grodstein F, Rosenberg I, Willett W, Hennekens C. A prospective study of plasma ferritin and risk of myocardial infarction in US physicians. [Abstract] Circulation 1993;87:688
48. Mänttäri M, Manninen V, Huttunen JK, et al. Serum ferritin and ceruloplasmin as coronary risk factors. Eur Heart J 1994;15:1599-603
49. Frey GH, Krider DW. Serum ferritin and myocardial infarct. W V Med J 1994;90:13-5
50. Salonen JT, Nyyssönen K, Salonen R. Body iron stores and the risk of coronary heart disease. [Letter] N Engl J Med 1994;331:1159
51. Weiss G, Fuchs D, Wachter H. High stored iron levels and the risk of myocardial infarction. [Letter] Circulation 1993;87:1425
52. MacDonald HB. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. [Letter] Circulation 1993;87:2063
53. Borch-Iohnsen B, Halvorsen R. High stored iron levels. [Letter] Circulation 1993;87:2064-5
54. Giles WH, Anda RF, Williamson DF, Yip R, Marks J. Iron and ischemic heart disease. [Letter] Circulation 1993;87:2065-6
55. Salonen JT, Nyyssönen K, Korpela H, Salonen R, Tuomilehto J, Seppänen R. High stored iron levels and the risk of myocardial infarction. [Reply] Circulation 1993;87:1425-6
56. Salonen JT, Nyyssönen K, Korpela H, Salonen R, Tuomilehto J, Seppänen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. [Reply] Circulation 1993;87:2063-4
57. Salonen JT, Nyyssönen K, Korpela H, Salonen R, Tuomilehto J, Seppänen R. High stored iron levels. [Reply] Circulation 1993;87:2065
58. Salonen JT, Nyyssönen K, Korpela H, Salonen R, Tuomilehto J, Seppänen R. Iron and ischemic heart disease. [Reply] Circulation 1993;87:2066
59. Clayton D, Hills M. Statistical methods in epidemiology. Oxford: Oxford University Press, 1993:329
60. Sempos CT, Looker AC, Gillum RF, Makuc DM. Body iron stores and the risk of coronary heart disease. N Engl J Med 1994;330:1119-24
61. Liao Y, Cooper RS, McGee DL. Iron status and coronary heart disease: negative findings from the NHA-NES I epidemiologic follow-up study. Am J Epidemiol 1994;139:704-12
62. Baer DM, Tekawa IS, Hurley LB. Iron stores are not associated with acute myocardial infarction. Circulation 1994;89:2915-8
63. Reunanen A, Takkunen H, Knekt P, Seppänen R, Aromaa A. Body iron stores, dietary iron intake and coronary heart disease mortality. J Intern Med 1995;238:223-30
64. Asperen IA van, Feskensens EJM, Bowels CH, Kromhout D. Body iron stores and mortality due to cancer and ischemic heart disease: a 17-year follow-up study of elderly men and women. Int J Epidemiol 1995;24:665-70
65. Morrison HI, Semenciw RM, Mao Y, Wigle DT. Serum iron and fatal acute myocardial infarction. Epidemiology 1994;5:243-6
66. Gillum RF, Sempos CT, Makuc DM, Looker AC, Chien CY, Ingram DD. Serum transferrin saturation and stroke incidence and mortality in women and men: the NHANES I epidemiologic follow-up study. Am J Epidemiol, in press, 1996
67. Ascherio A, Hunter DJ. Iron and myocardial infarction. Epidemiology 1994;5:135-6
68. Ascherio A, Willett WC. Are body iron stores related to the risk of coronary heart disease? N Engl J Med 1994;330:1152-4
69. Ascherio A, Willett WC, Rimm EB, Giovannucci EL, Stampfer MJ. Dietary iron and risk of coronary heart disease among men. Circulation 1994;89:969-74
70. Rauramaa R, Väisänen S, Mercuri M, Rankinen T, Penttila I, Bond MG. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged eastern Finnish men. Eur Heart J 1994;15: 1020-7
71. Moore M, Folsom AR, Barnes RW, Eckfeldt JH. No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 1995;141:719-23
72. Bothwell TH. Overview and mechanisms of iron regulation. Nutr Rev 1995;53:237-45
73. McGee D, Reed D, Yano K. The results of logistic analyses when the variables are highly correlated: an empirical example using diet and CHD incidence. J Chron Dis 1984;37:713-9
74. Reed D, McGee D, Yano K, Hankin J. Diet, blood pressure and multicollinearity. Hypertension 1985;7: 405-10
75. Gordeuk VR, Devee Boyd R, Brittenham GM. Dietary iron overload persists in rural Sub-Saharan Africa. Lancet 1986;1:1310-3
76. Lynch SR. Iron overload: prevalence and impact on health. Nutr Rev 1995;53:255-60
77. Miller M, Hutchins GM. Hemochromatosis, multiorgan hemosiderosis, and coronary heart disease. JAMA 1994;272:231-3
78. Aronow WS. Serum ferritin is not a risk factor for coronary artery disease in men and women aged ≥ 62 years. Am J Cardiol 1993;72:347-80
79. Solymoss BC, Marcil M, Gilfix BM, Gelinas F, Poitras AM, Campeau L. The place of ferritin among risk factors associated with coronary artery disease. Coron Artery Dis 1994;5:231-5
80. Kiechl S, Aichner F, Gerstenbrand F, et al. Body iron stores and presence of carotid atherosclerosis. Results from the Bruneck Study. Arterioscler Thromb 1994;14:1625-30
81. Miller DM, Buettner GR, Aust SD. Transition metals as catalysts of "autoxidation" reactions. Free Radic Biol Med 1990;8:95-108
82. De Silva DM, Aust SD. Ferritin and ceruloplasmin in oxidative damage: review and recent findings. Can J Physiol Pharmacol 1993;71:715-20
83. Gutteridge JMC, Stocks J. Caeruloplasmin: physiological and pathological perspectives. CRC Crit Rev Clin Lab Sci 1981;14:257-329
84. Kok FJ, Van Duijn CM, Hofman A, et al. Serum copper, and zinc and the risk of death from cancer and cardiovascular disease. Am J Epidemiol 1988;128: 352-9
85. Salonen JT, Salonen R, Korpela H, Suntioinen S, Tuomilehto J. Serum copper and the risk of acute myocardial infarction: a prospective study in men in eastern Finland. Am J Epidemiol 1991;134:268-76
86. Salonen JT, Ylä-Herttuala S, Yamamoto R, et al. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet 1992;339:883-7
87. Manthey J, Stoeppler M, Morgenstern W, et al. Magnesium and trace metals: risk factors for coronary heart disease? Circulation 1981;64:722-9
88. Reunanen A, Knekt P, Aaran RK. Serum ceruloplasmin level and the risk of myocardial infarction and stroke. Am J Epidemiol 1992;136:1082-90
89. Salonen JT, Salonen R, Seppänen K, Kantola M, Suntioinen S, Korpela H. Interactions of serum copper, selenium, and low density lipoprotein cholesterol in atherogenesis. BMJ 1991;302:756-60
90. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993;87[suppl II]:II-56-65
91. Kromhout D, Wibowo AAE, Herber RFM, et al. Trace metals and coronary heart disease risk indicators in 152 elderly men (The Zutphen Study). Am J Epidemiol 1985;122:378-85
92. Vallee BL. The time course of serum copper concentrations of patients with myocardial infarctions. I. Metabolism 1952;1:420-34
93. Adelstein SJ, Coombs TL, Vallee BL. Metalloenzymes and myocardial infarction. I. The relation between serum copper and ceruloplasmin and its catalytic activity. N Engl J Med 1956;255:105-9
94. Versieck J, Barbier F, Speecke A, Hoste J. Influence of myocardial infarction on serum magnesium, copper, and zinc concentrations. Clin Chem 1975;21: 578-81
95. Sullivan JL. Stored iron and ischemic heart disease. Empirical support for the new paradigm. Circulation 1992;86:1036-7
96. Steinberg D. The cholesterol controversy is over. Why did it take so long? Circulation 1989;80:1070-8
97. Joint National Committee. The Fifth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressue. Arch Intern Med 1993;153:154-83
98. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA 1993;269: 3015-23
99. National Cholesterol Education program. Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction. Circulation 1991;83:2154-232