Iron status and risk of cardiovascular disease

Annals of Epidemiology

Volumn 7, Issue 1, 1997, Pages 62-68

  Corti, Maria Chiara ^d   Gaziano, J Michael ^b,c   Hennekens, Charles H ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b VA BOSTON HEALTHCARE SYSTEM   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE

Author keywords

cardiovascular disease; coronary heart disease; ferritin; Iron; oxidative stress

Indexed keywords

FERRITIN; FREE RADICAL; IRON; TRANSFERRIN;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; DIETARY INTAKE; HUMAN; IRON BINDING CAPACITY; IRON OVERLOAD; IRON STORAGE; MORBIDITY; MORTALITY; OXIDATIVE STRESS; PHLEBOTOMY; PRIORITY JOURNAL;

ARTERIOSCLEROSIS; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; COHORT STUDIES; CORONARY DISEASE; FEMALE; FREE RADICALS; HUMANS; IRON; MALE; OXIDATIVE STRESS; RISK FACTORS;

EID: 0031049885     PISSN: 10472797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1047-2797(96)00112-3     Document Type: Article

References (48)

1. 1. Sullivan JL. The iron paradigm of ischemic heart disease. Am Heart J. 1989;117:1177-1188.
2. 2. Steinberg D. Lipoproteins and atherosclerosis. Atherosclerosis. 1983;3:283-301.
3. 3. Consensus Conference: Lowering blood cholesterol to prevent heart disease. JAMA. 1985;8:77-88.
4. 4. Steinberg D, Parthasarathy S, Carew T, Khoo J, Witztum J. Beyond cholesterol - modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
5. 5. Hessler JR, Morel DB, James LJ, Chisolm GM. Lipoprotein oxidation and lipoprotein-induced cytotoxicity. Arteriosclerosis. 1983;3: 215-222.
6. 6. Yagi K. Increased serum lipid peroxides initiate atherogenesis. Bioessays. 1984;1:58-60.
7. 7. Quinn MT, Parthasarathy S, Steinberg D. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low-density lipoprotein. Proc Natl Acad Sci USA. 1985;82:5949-5953.
8. 8. Schaffner T, Taylor K, Bartucci EJ, et al. Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages. Am J Pathol. 1980;100:57-73.
9. 9. Gerrity RG. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 1981;103:181-190.
10. 10. Fogelman AM, Schechter I, Hokom M, Child JS, Edwards PA. Malondialdehyde alteration of low density lipoproteins leads to cholesterol ester accumulation in human monocytemacrophages. Proc Natl Acad Sci USA. 1980;77:2214-2218.
11. 11. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA. 1979;76:333-337.
12. 12. Salonen T, Yla-Herttuala S, Yamamoto R, et al. Increased autoantibody titer to epitopes of oxidized LDL predicts progerssion of carotid atherosclerosis. Circulation 1991;84(4), suppl II.
13. 13. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620-1624.
14. 14. Marcus AJ, Silk ST, Safier LB, Ullman HL. Superoxide production and reducing activity in human platelets. J Clin Invest. 1977;59:149-158.
15. 2. Implications for the action of endothelium-derived relaxing factor (EDRF). Free Radic Res Commun. 1990;10:221-226.
16. 16. McCord JM. Is iron sufficiency a risk factor in ischemic heart disease? Circulation. 1991;83:1112-1113.
17. 17. Fong LG, Parthasarathy S, Witztum JL, Steinberg D. Nonenzymatic oxidative cleavage of peptide bonds in apoprotein B-100. J Lipid Res. 1987;28:1466-1477.
18. 18. Morel DW, DiCorleto PE, Chisolm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 1984;4:357-364.
19. 19. Cathcart MK, Morel DW, Chisolm GM. Monocytes and neutrophils oxidize low-density lipoproteins making it cytotoxic. J Leukocyte Biol. 1985;38:341-350.
20. 20. Araujo JA, Romano EL, Brito BE, et al. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler Throm Vasc Biol. 1995;15:1172-1180.
21. 21. Huebers HA, Finch CA. The physiology of transferrin and transferrin receptors. Physiol Rev. 1987;67:520-582.
22. 22. Hollan S, Johansen KS. Adequate iron stores and the 'Nil nocere' principle. Hematologia. 1993;25:69-84.
23. 23. Johnson MA, Fisher JG, Bowman BA, Gunter EW. Iron nutriture in elderly individuals. FASEB J. 1994;8:609-621.
24. 24. Finch CA, Gollnik PD, Hlastala MP, et al. Lactic acidosis as a result of iron deficiency. J Clin Invest. 1979;64:129-137.
25. 25. Mehta BC, Panjwani DD, Jhala DA. Electrophysiology abnormalities of heme in iron deficiency anemia; effect of iron therapy. Acta Hematologica (Basel). 1983;70:189-193.
26. 26. Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates. FEBS Lett. 1978;92:321-326.
27. 27. Fairbanks VF. Iron in medicine and nutrition. In: Shils ME, Olson JA, Shike M, eds. Modern nutrition in health and disease. Philadelphia: Lea and Febiger; 1994:185-213.
28. 28. Bridges KR, Bunn HF. Anemias with distrubed iron metabolism. In: Wilson JD et al., eds. Harrison's Principles of Internal Medicine. 12th ed. New York: McGraw Hill 1991:1518-1523.
29. 29. Willett W. Nutritonal Epidemiology. New York: Oxford University Press, 1990:179-180.
30. 30. Beaton GH, Corey PN, Steele C. Conceptual and methodological issues regarding the epidemiology of iron deficiency and their implications for studies of the functional consequencs of iron deficiency. Am J Clin Nutr. 1989;50:575-588.
31. 31. Lauffer RB. Iron stores and the international variation in mortality from coronary heart disease. Medical Hypotheses. 1990;35:96-102.
32. 32. Salonen JT, Nyssonen K, Korpela H, et al. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 1992;86:803-811.
33. 33. Sullivan JL. Stored iron and ischemic heart disease. Empirical support for a new paradigm. Circulation. 1992;86:1036-1037.
34. 34. Morrison HI, Semenciw RM, Wigle DT. Serum iron and risk of fatal acute myocardial infarction. Epidemiology. 1994;5:243-246.
35. 36. Sempos CT, Locker AC, Gillum RF, Makuc DM. Body iron stores and the risk of coronary heart disease. N Engl J Med. 1994;330:1119-1124.
36. 36. Liao Y, Cooper RS, Mc Gee DL. Iron status and coronary heart diease: negative findings from the NHANES I Epidemiologic Follow-up Study. Am J. Epidemiol. 1994;139:704-712.
37. 37. Stampfer MJ, Grodstein F, Rosenberg I, Willett W, Hennekens C. A prospective study of plasma ferritin and risk of myocardial infarction in U.S. physicans (abstract). Circulation. 1993;87:688.
38. 38. Cook JK, Skikne BS, Lynch SR, et al. Estimates of iron sufficiency in the U.S. population. Blood. 1986;68:726-731.
39. 39. Magnusson MK, Sigfusson N, Sigvaldason H, et al. Low iron binding capacity as a risk factor for myocardial infarction. Circulation. 1994;89:102-108.
40. 40. Takkunen H, Reunanen A, Knekt P, Aromaa A. Body iron stores and the risk of cancer (letter). N Engl J Med. 1989;320:1013-1014.
41. 41. Mänttäi M, Manninen V, Huttunen JK, Heininen OP, Frick MH. Serum ferritin and ceruloplasmin as coronary risk factors: A nested case control study in Helsinki Heart Study population. Circulation 1993;83:70.
42. 42. Moore M, Folsom A, Barnes RW, et al. No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol. 1995;141: 719-723.
43. 43. Ascherio A, Willett WC, Rimm EB, Giovannucci EL, Stampfer MJ. Dietary iron intake and risk of coronary heart disease among men. Circulation. 1994;89:969-974.
44. 44. Burt MJ, Hallyday JW, Powell LW. Iron and coronary heart disease. Iron's role is undecided. BMJ. 1993;307:575-576.
45. 45. Olson LJ, Edwards WD, Holmes DR, et al. Endomyocardial biopsy in hemochromatosis: clinicopathologic correlates in six cases. J Am Coll Cardiol. 1989;13:116-120.
46. 46. Miller M, Grover M, Hutchins MD: Hemocromatosis, multiorgan hemosiderosis, and coronary artery disease. JAMA. 1994;272:231-233.
47. 47. Stevens RG, Jones DY, Micozzi MS, et al. Body iron stores and the risk of cancer. N Engl J Med. 1988;319:1047-1052.
48. 48. Corti M-C, Guralnik JM, Salive ME, Ferrucci L, Pahor M, Wallace RB, Hennekens CH. Serum iron level, coronary artery disease and all-cause mortality in older men and women. Am J Cardiol. 1997; January, in press.