Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes

Japanese Journal of Cancer Research

Volumn 89, Issue 8, 1998, Pages 814-820

  Toyokuni, Shinya ^a   Okada, Kunihiko ^a,c   Kondo, Shohei ^a   Nishioka, Hiroaki ^a   Tanaka, Tomoyuki ^a   Nishiyama, Yasuyuki ^a   Hino, Okio ^b   Hiai, Hiroshi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Rat; Reactive oxygen species; Renal cell carcinoma; Tsc2; VHL

Indexed keywords

NITRILOTRIACETATE IRON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GRADING; CANCER INVASION; CONTROLLED STUDY; EXON; HETEROZYGOSITY LOSS; KIDNEY CARCINOMA; LUNG METASTASIS; MALE; MISSENSE MUTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

EID: 0031714758     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00633.x     Document Type: Article

References (36)

1. Anderson, R. L., Bishop, W. E. and Campbell, R. L. A review of the environmental and mammalian toxicology of nitrilotriacetic acid. Crit. Rev. Toxicol., 15, 1-102 (1985).
2. Ebina, Y., Okada, S., Hamazaki, S., Ogino, F., Li, J.-L. and Midorikawa, O. Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats. J. Natl. Cancer Inst., 76, 107-113 (1986).
3. Li, J.-L., Okada, S., Hamazaki, S., Ebina, Y. and Midorikawa, O. Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res., 47, 1867-1869 (1987).
4. Toyokuni, S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic. Biol. Med., 20, 553-566 (1996).
5. Okada, S. Iron-induced tissue damage and cancer: the role of reactive oxygen free radicals. Pathol. Int., 46, 311-332 (1996).
6. Toyokuni, S., Mori, T. and Dizdaroglu, M. DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int. J. Cancer. 57, 123-128 (1994).
7. Toyokuni, S., Mori, T., Hiai, H. and Dizdaroglu, M. Treatment of Wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes DNA-protein cross-linking between thymine and tyrosine in their renal chromatin. Int. J. Cancer, 62, 309-313 (1995).
8. Toyokuni, S., Okada, S., Hamazaki, S., Minamiyama, Y., Yamada, Y., Liang, P., Fukunaga, Y. and Midorikawa, O. Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res., 50, 5574-5580 (1990).
9. Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H. and Stadtman, E. R. Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc. Natl. Accid. Sci. USA, 91, 2616-2620 (1994).
10. 7-12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate. Free Radic. Biol. Med., 22, 1019-1027 (1997).
11. Uchida, K., Fukuda, A., Kawakishi, S., Hiai, H. and Toyokuni, S. A renal carcinogen ferric nitrilotriacetate mediates a temporary accumulation of aldehyde-modified proteins within cytosolic compartment of rat kidney. Arch. Biochem. Biophys., 317, 405-411 (1995).
12. Nishiyama, Y., Suwa, H., Okamoto, K., Fukumoto, M., Hiai, H. and Toyokuni, S. Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn. J. Cancer Res., 86, 1150-1158 (1995).
13. Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F. M., Orcutt, M. L., Stackhouse, T., Kuzmin, I., Modi, W., Geil, L., Schmidt, L., Zhou, F., Li, H., Wei, M. H., Chen, F., Glenn, G., Choyke, P., Walther, M. M., Weng, Y., Duan, D. R., Dean, M., Glavac, D., Richards, F. M., Crossey, P. A., Ferguson-Smith, M. A., Linehan, W. M., Zbar, B. and Lehman, M. I. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science, 260, 1317-1320 (1993).
14. Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F. M., Lubensky, I., Duan, D. R., Florence, C., Pozzatia, R., Walther, M. M., Bander, M. H., Grossman, H. B., Bauch, H., Brooks, J. D., Isaacs, W. B., Lerman, M. I., Zbar, B. and Linehan, W. M. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet., 7, 85-90 (1994).
15. Shuin, T., Kondo, K., Torigoe, S., Kishida, T., Kubota, Y., Hosaka, M., Nagashima, Y., Kitamura, H., Latif, F., Zbar, B., Lerman, M. I. and Yao, M. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res., 54, 2852-2855 (1994).
16. Whaley, J. M., Naglich, J., Gelbert, L., Hsia, Y. E., Lamiell, J. M., Green, J. S., Collins, D., Neumann, H. P., Laidlaw, J., Li, F. P., Klein-Szanto, A. J. P., Seizinger, B. R. and Kley, N. Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma. Am. J. Hum. Genet., 55, 1092-1102 (1994).
17. Kobayashi, T., Hirayama, Y., Kobayashi, E., Kubo, Y. and Hino, O. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat. Genet., 9, 70-74 (1995).
18. Yeung, R. S., Xiao, G. H., Jin, F., Lee, W. C., Testa, J. R. and Knudson, A. G. Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. Proc. Natl. Acad. Sci. USA, 91, 11413-11416 (1994).
19. Osaka, M., Matsuo, S., Koh, T. and Sugiyama, T. Specific N-ras mutation in bone marrow within 48 h of 7,12-dimethylbenz[a]anthracene treatment in Huggins-Sugiyama rat leukemogenesis. Mol. Carcinog., 16, 126-131 (1996).
20. Toyokuni, S., Tanaka, T., Nishiyama, Y., Okamoto, K., Nakashima, Y., Hamazaki, S., Okada, S. and Hiai, H. Induction of renal cell carcinoma in male Wistar rats treated with cupric nitrilotriacetate. Lab. Invest., 75, 239-248 (1996).
21. Japanese Urological Association, the Japanese Society of Pathology, and Japanese Radiological Society. "General Rule for Clinical and Pathological Studies on Renal Cell Carcinoma" (1996). Kanehara Publication Co., Ltd., Tokyo.
22. Kikuchi, Y., Kobayashi, E., Nishizawa, M., Hamazaki, S., Okada, S. and Hino, O. Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas. Jpn. J. Cancer Res., 86, 905-909 (1995).
23. Kobayashi, T., Urakami, S., Hirayama, Y., Yamamoto, T., Nishizawa, M., Takahara, T., Kubo, Y. and Hino, O. Intragenic Tsc2 somatic mutations at Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model. Jpn. J. Cancer Res., 88, 254-261 (1997).
24. Nasdy, T., Bane, B. L. and Silva, F. G. Adult renal diseases. In " Diagnostic Surgical Pathology," ed. S. S. Sternberg, pp. 1711-1739 (1994). Raven Press, New York.
25. Urakami, S., Tokuzen, R., Tsuda, H., Igawa, M. and Hino, O. Somatic mutation of the tuberous sclerosis (Tsc2) tumor suppressor gene in chemically induced rat renal carcinoma cell. J. Urol. 158, 275-278 (1997).
26. Knudson, A. G., Jr., Hethcote, H. W. and Brown, B. W. Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc. Natl. Acad. Sci. USA, 72, 5116-5120 (1975).
27. Kobayashi, T., Nishizawa, M., Hirayama, Y., Kobayashi, E. and Hino, O. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Nucleic Acids Res., 23, 2608-2613 (1995).
28. Wienecke, R., Konig, A. and DeClue, J. E. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J. Biol. Chem., 270, 16409-16414 (1995).
29. Tsuchiya, H., Orimoto, K., Kobayashi, K. and Hino, O. Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model. Cancer Res., 56, 429-433 (1996).
30. The European Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell, 75, 1305-1315 (1993).
31. Kim, K. K., Pajak, L., Wang, H. and Field, L. J. Cloning, developmental expression, and evidence for alternative splicing of the murine tuberous sclerosis (TSC2) gene product. Cell. Mol. Biol. Res., 41, 515-526 (1995).
32. Everitt, J. I., Goldsworthy, T. L., Wolf, D. C. and Walker, C. L. Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome. J. Urol., 148, 1932-1936 (1992).
33. Hino, O., Mitani, H., Kalsuyama, H. and Kubo, Y. A novel cancer predisposition syndrome in the Eker rat model. Cancer Lett., 83, 117-121 (1994).
34. Walker, C., Ahn, Y. T., Everitt, J. and Yuan, X. Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. Mol. Carcinog., 15, 154-161 (1996).
35. Basu, A. K., Loechler, E. L., Leadon, S. A. and Essigmann, J. M. Genetic effets of thymine glycol: site-specific mutagenesis and molecular modeling studies. Proc. Natl. Acta. Sci. USA, 86, 7677-7681 (1989).
36. Uchida, T., Wada, C., Wang, C., Egawa, S., Ohtani, H. and Koshiba, K. Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. Cancer Res., 54, 3682-3685 (1994).