Effects of overexpression of IL-1 receptor-associated kinase on NFχB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4

European Journal of Immunology

Volumn 28, Issue 10, 1998, Pages 3100-3109

  Knop, Johannes ^a   Wesche, Holger ^a,b   Lang, Detlef ^a   Martin, Michael U ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b AMGEN INC   (United States)

Author keywords

IL 1; IL 1 receptor associated kinase (IRAK); Signal transduction

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 2; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENZYME KINETICS; IMMUNOGENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS; NF-KAPPA B; PROTEIN KINASES; RECEPTORS, INTERLEUKIN-1; T-LYMPHOCYTES; TRANSFECTION;

EID: 0031714449     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199810)28:10<3100::AID-IMMU3100>3.0.CO;2-7     Document Type: Article

References (34)

1. Dinarello, C. A., Biologic basic for interleukin-1 in disease. Blood 1996. 87: 2095-2147.
2. van Lent, P. L., van de Loo, F. A., Holthuysen, A. E., van den Bersselaar, L. A., Vermeer, H. and van den Berg, W. B., Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J. Rheumatol. 1995. 22: 2250-2258.
3. Sims, J. E., March, C. J., Cosman, D. et al., cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 1988. 241: 585-589.
4. McMahan, C. J., Slack, J. L., Mosley, B. et al., A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 1991. 10: 2821-2832.
5. Greenfeder, S. A., Nunes, P., Kwee, L., Labow, M., Chizzonite, R. A. and Ju, G., Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 1995. 270: 13757-13765.
6. Korherr, C., Hofmeister, R., Wesche, H. and Falk, W., A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. Eur. J. Immunol. 1997. 27: 262-267.
7. Wesche, H., Korherr, C., Kracht, M., Falk, W., Resch, K. and Martin, M. U., The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J. Biol. Chem. 1997. 272: 7727-7731.
8. Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S. K., Sims, J. E. and Mantovani, A., Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 1993. 261: 472-475.
9. Sims, J. E., Gayle, M. A., Slack, J. L. et al., Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. USA 1993. 90: 6155-6159.
10. Martin, M. U. and Falk, W., The interleukin-1 receptor complex and interleukin-1 signal transduction. Eur. Cytokine Netw. 1997. 8: 5-17.
11. Martin, M., Bol, G. F., Eriksson, A., Resch, K. and Brigelius-Flohe, R., Interleukin-1-induced activation of a protein kinase co-precipitating with the type I interleukin-1 receptor in T cells. Eur. J. Immunol. 1994. 24: 1566-1571.
12. Croston, G. E., Cao, Z. and Goeddel, D. V., NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J. Biol. Chem. 1995. 270: 16514-16517.
13. Cao, Z., Henzel, W. J. and Gao, X., IRAK, a kinase associated with the interleukin-1 receptor. Science 1996. 271: 1128-1131.
14. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. and Goeddel, D. V., TRAF6 is a signal transducer for interleukin-1. Nature 1996. 383: 443-446.
15. Leung, K., Betts, J. C., Xu, L. and Nabel, G. J., The cytoplasmic domain of the interleukin-1 receptor is required for nuclear factor-kappa B signal transduction. J. Biol. Chem. 1994. 269: 1579-1582.
16. Bird, T. A., Schooley, K., Dower, S. K., Hagen, H. and Virca, G. D., Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit. J. Biol. Chem. 1997. 272: 32606-32612.
17. Brigelius-Flohe, R., Bilgin, B., Eickemeier, S., Hipskind, R., Singh, M., Szamel, M. and Resch, K., The NF kappa B heterodimer/homodimer balance and IL-1-stimulated IL-2 production in murine T lymphocytes. Biofactors 1995. 5: 169-174.
18. Lowenthal, J. W., Cerottini, J. C. and MacDonald, H. R., Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells. J. Immunol. 1986. 137: 1226-1231.
19. Huang, J., Gao, X., Li, S. and Cao, Z., Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997. 94: 12829-12832.
20. Korherr, C., Hofmeister, R. and Falk, W., The cytoplasmatic part of the IL-1 receptor accessory protein plays a critical role in IL-1 signaling and receptor internalisation. Immunobiology 1997. 197: 206 (Abstract F.11).
21. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. and Cao, Z., MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997. 7: 837-847.
22. Rothe, M., Wong, S. C., Henzel, W. J. and Goeddel, D. V., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75-kDa tumor necrosis factor receptor. Cell 1994. 78: 681-692.
23. Malinin, N. L., Boldin, P., Kovalenko, A. V. and Wallach, D., MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997. 385: 540-544.
24. Rothe, M., Sarma, V., Dixit, V. M. and Goeddel, D. V., TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 1995. 269: 1424-1427.
25. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z. and Rothe, M., Identification and characterization of an IkappaB kinase. Cell 1997. 90: 373-383.
26. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. and Karin, M., A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997. 388: 548-554.
27. Baeuerle, P. A. and Baltimore, D., NF-kappa B: ten years after. Cell 1996. 87: 13-20.
28. Reddy, S. A., Huang, J. H. and Liao, W. S., Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. J. Biol. Chem. 1997. 272: 29167-29173.
29. Muzio, M., Ni, J., Feng, P. and Dixit, V. M., IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997. 278: 1612-1615.
30. Yamin, T. T. and Miller, D. K., The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J. Biol. Chem. 1997. 272: 21540-21547.
31. Liu, Z. G., Hsu, H., Goeddel, D. V. and Karin, M., Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996. 87: 565-576.
32. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, G. A. and Struhl, K., (Eds.), Current Protocols in Molecular Biology. Greene Publishing Associates/Wiley & Sons, New York 1994.
33. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976. 72: 248-254.
34. Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970. 227: 680-685.