Cellular electrophysiological effects of chronic fluoxetine and duloxetine administration on serotonergic responses in the aging hippocampus

Synapse

Volumn 30, Issue 3, 1998, Pages 318-328

  Smith, Jane E ^a,b   Lakoski, Joan M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Aging; Duloxetine; Electrophysiology; Fluoxetine; Hippocampus; Serotonin

Indexed keywords

DULOXETINE; FLUOXETINE; SEROTONIN RECEPTOR;

AGING; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; FEMALE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEROTONIN UPTAKE; SEROTONINERGIC NERVE;

AGING; ANIMALS; ANTIDEPRESSIVE AGENTS; DRUG ADMINISTRATION SCHEDULE; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; FEMALE; FLUOXETINE; HIPPOCAMPUS; PYRAMIDAL CELLS; RATS; RATS, INBRED F344; SEROTONIN; THIOPHENES;

EID: 0031712098     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199811)30:3<318::AID-SYN9>3.0.CO;2-E     Document Type: Article

References (75)

1. Andrade, R., and Nicoll, R.A. (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J. Physiol., 394:99-124.
2. 1A-mediated responses in CA1 and CA3 hippocampal subfields with aging. Soc. Neurosci. Abstr., 19:1060.
3. 3H-paroxetine binding in the rat brain: Effect of imipramine and tetrahydroacridine. Life Sci., 52:1767-1775.
4. Arranz, B., Eriksson, A., Mellerup, E., Plenge, P., and Marcusson, J. (1993) Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. Brain Res., 620:163-166.
5. Azmitia, E.C., and Whitaker-Azmitia, P.M. (1991) Awakening the sleeping giant: Anatomy and plasticity of the brain serotonergic system. J. Clin. Psychiatry, 52:4-16.
6. Baldessarini, R.J. (1990) Drugs and the treatment of psychiatric disorders. In: The Pharmacological Basis of Therapeutics, Vol. 8. A.G. Gilman, T.W. Rail, A.S. Nies, and P. Taylor, eds. Pergamon Press, New York, pp. 383-435.
7. Blazer, D., and Williams, C.D. (1980) Epidemiology of dysphoria and depression in the elderly population. Am. J. Psychiatry, 137:439-444.
8. Blier, P., and de Montigny, C. (1994) Current advances and trends in the treatment of depression. Trends Pharmacol. Sci., 15:220-226.
9. Blier, P., de Montigny, C., and Chaput, Y. (1987) Modifications of the serotonin system by antidepressant treatments: Implications for the therapeutic response in major depression. J. Clin. Psychopharmacol., 7:24S-35S.
10. Briley, M., and Moret, C. (1993) 5-HT and antidepressants: In vitro and in vivo release studies. Trends Pharmacol. Sci., 14:396-397.
11. 4 receptors. Br. J. Pharmacol. 110:10P.
12. 2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age. Neurosci. Lett., 178:85-89.
13. Casey, D.A. (1994) Depression in the elderly. South. Med. J., 87:559-563.
14. 1A binding in rat brain - A combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res., 561:51-60.
15. Chaput, Y., de Montigny, C., and Blier, P. (1986) Effects of a selective 5-HT reuptake blocker, citalopram. on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain. Naunyn Schmiedebergs Arch. Pharmacol., 333:342-348.
16. Coppen, A. (1967) The biochemistry of affective disorders. Br. J. Psychiatry, 113:1237-1264.
17. de Montigny, C., and Aghajanian, G.K. (1977) Preferential action of 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and 5-HT. Neuropharmacology, 16:811-818.
18. de Montigny, C., Wang, R.Y., Reader, T.A., and Aghajanian, G.K. (1980) Monoaminergic denervation of the rat hippocampus: Microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Res., 200:363-376.
19. de Montigny, C., Chaput, Y, and Blier, P. (1990) Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. J. Clin. Psychiatry, 51:4-8.
20. Dugar, A., and Lakoski, J.M. (1997) Serotonergic function of aging hippocampal CA3 pyramidal neurons: Electrophysiological assessment following administration of 5,7-dihydroxytryptamine in the fimbria-fornix and cingulum bundle. J. Neurosci. Res., 47:58-67.
21. Finch, C.E., Felicio, L.S., Mobbs, C.V., and Nelson, J.F. (1984) Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocr. Rev., 5:467-497.
22. Fuller, R.W., Hemrick-Luecke, S.K., and Snoddy, H.D. (1995) Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice. J. Pharmacol. Exp. Ther., 269:132-136.
23. Godbout, R., Chaput, Y., Blier, P., and de Montigny, C. (1991) Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine-I. Effects of acute and long-term administration of tandospirone of serotonin neurotransmission. Neuropharmacology, 30:676-690.
24. 2 and β-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination. J. Neurochem., 62:2262-2268.
25. Gozlan, H., Daval, G., Vergé, D., Spampinato, U., Fattaccini, C. M., Gallissot, M.C., El Mestikawy, S., and Hamon. M. (1990) Aging associated changes in serotoninergic and dopaminergic pre- and postsynaptic neurochemical markers in the rat brain. Neurobiol. Aging, 11:437-449.
26. 4 receptors in guinea-pig and rat brain. J. Pharmacol., 109:618-624.
27. 3H]8-Hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem., 44:1685-1696.
28. Heils, A., Teufel, A., Petri, S., Seemann, M., Bengel, D., Balling, U., Riederer, P., and Lesch, K.P. (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J. Neural Transm., 102:247-254.
29. Hensler, J.G., Ferry, R.C., Labow, D.M., Kovachich, G.B., and Frazer, A. (1994) Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse, 17:1-15.
30. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R., and Humphrey, P.P.A. (1994) International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46:157-203.
31. 2 receptors in rat brain: An autoradiographic study. Synapse, 14:324-331.
32. Invernizzi, R., Bramante, M., and Samanin, R. (1995) Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain Res., 696:62-66.
33. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J. Pharmacol. Exp. Ther., 268:1432-1443.
34. Kasamo, K., Blier, P., and de Montigny, C. (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brain. J. Pharmacol. Exp. Ther., 277:278-286.
35. Khan, A., Mirolo, H., Mirolo, M.H., and Dobie, D.J. (1993) Depression in the elderly: A treatable disorder. Geriatrics, 48:14-17.
36. Kihara, T., and Ikeda, M. (1995) Effects of duloxetine, a new serotonin and norepinephrine uptake inhibitor, on extracellular monoamine levels in rat frontal cortex. J. Pharmacol. Exp. Ther., 272:177-183.
37. 2 receptors in the rat brain. J. Psychiatry Neurosci., 19:63-67.
38. Koenig, H., and Blazer, D. (1992) Epidemiology of geriatric affective disorders. Clin. Geriatr. Med., 8:235-251.
39. Kohler, K.C., and Steinbusch, H. (1982) Identification of serotonin and non-serotonin-containing neurons in the midbrain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain. Neuroscience, 7:951-975.
40. Kreiss, D.S., and Lucki, I. (1995) Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J. Pharmacol. Exp. Ther., 274:866-876.
41. Lakoski, J.M. (1989) Cellular electrophysiological approaches to the central regulation of female reproductive aging. In: Neural Control of Reproductive Function. J.M. Lakoski, J.R. Perez-Polo, and D.A. Rassin, eds. Alan R. Liss, New York, pp. 209-220.
42. Lakoski, J.M. (1994) Neuroendocrinology of aging at the cellular level: Membranes to neural circuits. Neurobiol. Aging, 15:519-520.
43. Lesch, K.P., Aulakh, C.S., Wolozin, B.L., Tolliver, T.J., Hill, J.L., and Murphy, D.L. (1993) Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Mol. Brain Res., 17:31-35.
44. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H., and Murphy, D.L. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274:1527-1531.
45. Lippa, A.S., Critchett, D.J., Ehlert, F., Yamamura, H.I., Enna, S.J., and Bartus, R.T. (1981) Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis. Neurobiol. Aging, 2:3-8.
46. Lopez, J.F., Chalmers, D.T., Vazquez, D.M., Watson, S.J., and Akil, H. (1994) Serotonin transporter mRNA in rat brain is regulated by classical antidepressants. Biol. Psychiatry, 35:287-290.
47. Maggi, A., U'Prichard, D.C., and Enna, S.J. (1980) Differential effects of antidepressant treatment on brain monoaminergic receptors. Eur. J. Pharmacol., 61:91-98.
48. Marcusson, J., Oreland, L., and Winblad, B. (1984) Effect of age on human brain serotonin (S-1) binding sites. J. Neurochem., 43:1699-1705.
49. Meister, B., Johnson, H., and Ulfhake, B. (1995) Increased expression of serotonin transporter messenger RNA in raphe neurons of the aged rat. Mol. Brain Res., 33:87-96.
50. Meltzer, H.Y., and Lowy, M.T. (1987) The serotonin hypothesis of depression. In: Psychopharmacology: The Third Generation of Progress. H.Y. Meltzer, ed. Raven Press, New York, pp. 513-526.
51. Moretti, A., Carfagna, N., and Trunzo, F. (1987) Effect of aging on monoamines and their metabolites in the rat brain. Neurochem. Res., 12:1035-1039.
52. Murphy, D.L., Cambell, I., and Costa, J.L. (1978) Current status of the indoleamine hypothesis of the affective disorders. In: Psychopharmacology: A Generation of Progress. M.A. Lipton, A. DiMascio, and K.F. Killam, eds. Raven Press, New York, pp. 1235-1247.
53. 2C serotonin receptors by fluoxetine (Prozac). Proc. Natl. Acad. Sci. USA, 94:2036-2040.
54. Olpe, H.R., and Steinmann, M.W. (1982) The effect of vincamine, hydergine and piracetam on the firing rate of locus coeruleus neurons. J. Neural Trans., 55:101-109.
55. Paxinos, G., and Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
56. Peroutka, S.J., and Snyder, S.H. (1980) Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science, 210:88-90.
57. Pineyro, G., Blier, P., Dennis, T., and de Montigny, C. (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J. Neurosci., 14:3036-3047.
58. Ponzio, F., Calderini, G., Lomuscio, G., Vantini, G., Toffano, G., and Algeri, S. (1982) Changes in monoamines and their metabolite levels in some brain regions of aged rats. Neurobiol. Aging, 3:23-29.
59. Richelson, E. (1991) Biological basis of depression and therapeutic relevance. J. Clin. Psychiatry, 52:4-10.
60. Salmoiraghi, G.C., and Weight, F. (1967) Micromethods in neuropharmacology: An approach to the study of anesthetics. Anesthesiology, 28:54-64.
61. Schlicker, E., Betz, T., and Gothert, M. (1989) Investigation into the age-dependence of release of serotonin and noradrenaline in the rat brain cortex and or autoreceptor-mediated modulation of release. Neuropharmacology, 28:811-815.
62. Siever, L.J., Coccaro, E.F., Benjamin, E., Rubinstein, K., and Davis, K.L. (1986) Adrenergic and serotonergic receptor responsiveness in depression. In: Antidepressants and Receptor Function. R. Porter, G. Bock, and S. Clark, eds. John Wiley & Sons, New York, pp. 148-169.
63. Slotkin, T.A., Whitmore, W.L., Barnes, G.A., Ranga, K., Krishnan, R., Blazer, D.G., Knight, D.L., and Nemeroff, C.B. (1989) Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression. Biol. Psychiatry, 25:687-691.
64. Smith, J.E., and Lakoski, J.M. (1997a) Electrophysiological effects of fluoxetine and duloxetine in the dorsal raphe nucleus and hippocampus. Eur. J. Pharmacol. 323:69-73.
65. Smith, J.E., and Lakoski, J.M. (1997b) Electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus. Pharmacology, 55:66-77.
66. Stober, G., Heils, A., and Lesch, K.P. (1996) Serotonin transporter gene polymorphism and affective disorder. Lancet, 347:1340-1341.
67. Sur, C., Betz, H., and Schloss, P. (1996) Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience, 73:217-231.
68. Tanila, H., Taira, T., Piepponen, T.P., and Honkanen, A. (1994) Effect of sex and age on brain monoamines and spatial learning in rats. Neurobiol. Aging, 15:733-741.
69. Venero, J.L., de la Roza, C., Machado, A., and Cano, J. (1993) Age-related changes on monoamine turnover in hippocampus of rats. Brain Res., 631:89-96.
70. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci., 6:3473-3482.
71. Watchel, H. (1989) Dysbalance of neuronal second messenger function in the etiology of affective disorders: A pathophysiological concept hypothesizing defects beyond first messenger receptors. J. Neural Transm., 75:21-29.
72. Weissman, M.M., and Olfson, M. (1995) Depression in women: Implications for health care research. Science, 269:799-801.
73. Wester, P., Hardy, J.A., Marcusson, J., Nyberg, P., and Winblad, B. (1984) Serotonin concentrations in normal aging human brains: Relation to serotonin receptors. Neurobiol. Aging, 5:199-203.
74. Wise, P.M. (1983) Aging of the female reproductive system. Rev. Biol. Res. Aging, 1:195-222.
75. Wong, D.T., Bymaster, P.P., Mayle, D.A., Reid, L.R., Krushinski, J.H., and Robertson, D.W. (1993) LY248686, a new inhibitor of serotonin and norepinephrine uptake. Neuropsychopharmacology, 8:23-33.