Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms

Nature Medicine

Volumn 3, Issue 6, 1997, Pages 671-674

  Davis, Karen D ^a   Taub, Ethan ^a   Houle, Sylvain ^a   Lang, Anthony E ^b   Dostrovsky, Jonathan O ^c   Tasker, Ronald R ^a   Lozano, Andres M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AKINESIA; ARTICLE; BASAL GANGLION; BRADYKINESIA; BRAIN BLOOD FLOW; BRAIN CORTEX; CLINICAL ARTICLE; ELECTROSTIMULATION; FEMALE; GLOBUS PALLIDUS; HUMAN; MALE; MOTOR PERFORMANCE; MOTOR SYSTEM; PARKINSON DISEASE; PARKINSONISM; POSITRON EMISSION TOMOGRAPHY; PREMOTOR CORTEX; PRIORITY JOURNAL; RIGIDITY; THALAMUS;

AGED; BRAIN; ELECTRIC STIMULATION THERAPY; FEMALE; GLOBUS PALLIDUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOVEMENT DISORDERS; PARKINSON DISEASE; PARKINSON DISEASE, SECONDARY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030941260     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0697-671     Document Type: Article

References (29)

1. Filion, M. & Tremblay, L. Abnormal spontaneous activity of globus pallidus neurons in monkeys with MPTP-induced parkinsonism. Brain Res. 547, 142-151 (1991).
2. Bergman, H., Wichmann, T., Karmon, B. & DeLong, M.R. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J. Neurophysiol. 72, 507-520 (1994).
3. DeLong, M.R. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 13, 281-285 (1990).
4. Hutchison, W.D. et al. Differential neuronal activity in segments of globus pallidus in Parkinson's disease patients. Neuroreport 5, 1533-1537 (1994).
5. Lozano, A. et al. Methods for microelectrode-guided posteroventral pallidotomy. J. Neurosurg. 84, 194-202 (1996).
6. Beric, A. et al. Characteristics of pallidal neuronal discharges in Parkinson's disease patients. Adv. Neurol. 69, 123-128 (1996).
7. Eidelberg, D. et al. The metabolic topography of parkinsonism. J. Cereb. Blood Flow Metab. 14, 783-801 (1994).
8. Rascol, O., Sabatini, U. & Chollet, F. Supplementary and primary sensory motor area activity in Parkinson's disease: Regional cerebral blood flow changes during finger movements and effects of apomorphine. Arch. Neurol. 49, 144-148 (1992).
9. Playford, E.D., Jenkins, I.H., Passingham, R.E., Frackowiak, R.S.J. & Brooks, D.J. Impaired activation of frontal areas during movement in Parkinson's disease: A PET study. Adv. Neurol. 60, 506-510 (1993).
10. Svennilson, E. et al. Treatment of parkinsonism by stereotactic thermolesions in the pallidal region: A clinical evaluation of 81 cases. Acta Psychiatr. Neurol. Scand. 35, 358-377 (1960).
11. Laitinen, L.V., Bergenheim, A.T. & Hariz, M.I. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J. Neurosurg. 76, 53-61 (1992).
12. Dogali, M. et al. Stereotactic ventral pallidotomy for Parkinson's disease. Neurology 45, 753-761 (1995).
13. Lozano, A.M. et al. Effect of GPi pallidotomy on motor function in Parkinson's disease. Lancet 346, 1383-1387 (1995).
14. Siegfried, J. & Lippitz, B. Bilateral chronic electrostimulation of ventroposterolateral pallidum: A new therapeutic approach for alleviating all parkinsonian symptoms. Neurosurgery 35, 1126-1129 (1994).
15. Jenkins, I.H. et al. Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine. Ann. Neurol. 32, 749-757 (1992).
16. Deiber, M.-P. et al. Thalamic stimulation and suppression of parkinsonian tremor: Evidence of a cerebellar deactivation using positron emission tomography. Brain 116, 267-279 (1993).
17. Colebatch, J.G., Findley, L.J., Frackowiak, R.S., Marsden, C.D. & Brooks, D.J. Preliminary report: Activation of the cerebellum in essential tremor. Lancet 336, 1028-1030 (1990).
18. Cridland, R.A. & Henry, J.L. N- and C-terminal fragments of substance P: Spinal effects in the rat tail flick test. Brain Res. Bull. 20, 429-432 (1988).
19. Ekblom, A. & Hansson, P. Pain intensity measurements in patients with acute pain receiving afferent stimulation. J. Neurol. Neurosurg. Psychiatry 51, 481-486 (1988).
20. Benabid, A.L. et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J. Neurosurg. 84, 203-214 (1996).
21. Ceballos-Baumann, A.O. et al. Restoration of thalamocortical activity after posteroventral pallidotomy in Parkinson's disease [Letter]. Lancet 344, 814 (1994).
22. Grafton, S.T., Waters, C., Sutton, J., Lew, M.F. & Couldwell, W. Pallidotomy increases activity of motor association cortex in Parkinson's disease: A positron emission tomographic study. Ann. Neurol. 37, 776-783 (1995).
23. Eidelberg, D. et al. Regional metabolic correlates of surgical outcome following unilateral pallidotomy for Parkinson's disease. Ann. Neurol. 39, 450-459 (1996).
24. Parent, A. Carpenter's Human Neuroanatomy (Williams & Wilkins, Media, PA, 1996).
25. Langston, J.W. et al. Core assessment program for intracerebral transplantations (CAPIT). Movement Disord. 7, 2-13 (1992).
26. Galvez-Jimenez, N. et al. Deep brain stimulation in Parkinson's disease: New methods of tailoring functional surgery to patient needs and response. Neurology 46 (Suppl.), A402 (1996).
27. 15O. I. Theory and error analysis. J. Nucl. Med. 24, 782-789 (1983).
28. Friston, K.J., Frith, C.D., Liddle, P.F. & Frackowiak, R.S.J. Comparing functional (PET) images: The assessment of significant change. J. Cereb. Blood Flow Metab. 11, 690-699 (1991).
29. Talairach, J. & Tournoux, P. Co-Planar Stereotaxic Atlas of the Human Brain (Thieme Medical Publ., New York, 1988).