No interaction between the APOE and the alpha-1-antichymotrypsin genes on risk for Alzheimer's disease

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 74, Issue 2, 1997, Pages 192-194

  Fallin, Danielle ^a,b   Reading, Sarah ^a   Schinka, John ^a   Hoyne, Jonathan ^a   Scibelli, Paul ^a   Gold, Michael ^a   Crawford, Fiona ^a   Mullan, Michael ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b NONE   (United States)

Author keywords

alpha 1 antichymotrypsin; Alzheimer's disease; apolipoprotein E

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; APOLIPOPROTEIN E4;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0030900984     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19970418)74:2<192::AID-AJMG15>3.0.CO;2-D     Document Type: Article

References (13)

1. Bennett C, Crawford F, Osborne A, Diaz P, Hoyne J, Lopez R, Roques P, Duara R, Rossor M, Mullan M, (1995): Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's disease but is not causative. AJMG 60:1-6.
2. Chartier-Harlin MC, Parfitt M, Legrain S, Perez-Tur J, Brousseau T, Evans A, Berr C, Vidal O, Roques P, Gourlet V, Fruchart JC, Delacourte A, Rossor M, Amouyel P, (1994): Apolipoproetin E ε4 as a major risk factor for sporadic early and late onset Alzheimer's disease: Analysis of the 19q13.2 chromosomal region. Hum Mol Genet, 3:569-574.
3. Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA, (1993): Alpha-1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro. J Neurochem 61:298-305.
4. Kamboh M, Sanghera D, Ferrell R, DeKosky S, (1995): APOE 4-associated Alzheimer's disease risk is modified by alpha-1-antichymotrypsin polymorphism. Nature Genet 10:486-488.
5. Licastro F, Parnetti L, Morini MC, Davis LJ, Cucinotta F, Gaiti A, Senin U, (1995): Acute phase reactant alpha-1-antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer's disease. Alzheimer's Dis Assoc Disor 9:112-118.
6. Ma J, Yee A, Brewer HB Jr, Das S, Potter H, (1994): Amyloid-associated proteins alpha-1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer's beta-protein into filaments. Nature 372:92-94.
7. Okuizumi K, Onodera O, Namba Y, Kazuhiko I, Yamamoto T, Seki K, Ueki A, Nanko S, Tanaka H, Takahashi H, Oyanagi K, Mizusawa H, Kanazawa I, Tsuji S, (1995): Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease. Nature Genet 11:207-209.
8. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S, (1993): Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342:697-699.
9. Relkin N, NIA/AA Conference Invited Researchers (1996): Apolipoprotein E genotyping in Alzheimer's disease. Lancet, 347:1091-1095.
10. Sambrook J, Fritsch E, Maniatis T, (1989): "Molecular Cloning: A Laboratory Manual." New York: Cold Spring Harbor Laboratory Press.
11. Schellenberg G, Deeb S, Boehnke M, Bryant E, Martin G, Lampe T, Birs T, (1987): Association of an apolipoprotein CII allele with familial Alzheimer's dementia of the Alzheimer type. J Neurogenet 4:97-108.
12. Strittmatter D, Saunders A, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses A, (1993): Apolipoprotein E: High-avidity binding to b-amyloid and increased frequency of type 4 allele in late onset Alzheimer's disease. Proc Natl Acad Sci 90:1977-1981.
13. Wenham PR, Blandell G, Price WH, (1991): Apolipoprotein genotyping by one-step PCR. Lancet 50:1158-1159.