Recombinant measles viruses with mutations in the C, V, or F gene have altered growth phenotypes in vivo

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 7754-7761

  Valsamakis, Alexandra ^a   Schneider, Henriette ^b   Auwaerter, Paul G ^a   Kaneshima, Hideto ^c   Billeter, Martin A ^b   Griffin, Diane E ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE MUTATION; GENE STRUCTURE; MEASLES VIRUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; THYMOCYTE; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0031682557     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.7754-7761.1998     Document Type: Article

References (52)

1. Aldrovandi, G. M., and J. A. Zack. 1996. Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J. Virol. 70:1505-1511.
2. Auwaerter, P. G., H. Kaneshima, J. M. McCune, G. Wiegand, and D. E. Griffin. 1996. Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. J. Virol. 70:3734-3740.
3. Bellini, W. J., G. Englund, S. Rozenblatt, H. Arnheiter, and C. D. Richardson. 1985. Measles virus P gene codes for two proteins. J. Virol. 53:908-919.
4. Bonyhadi, M. L., L. Rabin, S. Salimi, D. A. Brown, J. Kosek, J. M. McCune, and H. Kaneshima. 1993. HIV induces thymus depletion in vivo. Nature 363:728-732.
5. Brown, J. M., H. Kaneshima, and E. Mocarski. 1995. Dramatic intrastrain differences in the replication of human CMV in SCID-hu mice. J. Infect. Dis. 171:1599-1603.
6. Cadd, T., D. Garcin, C. Tapparel, M. Itoh, M. Homma, L. Roux, J. Curran, and D. Kolakofsky. 1996. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in promoter-specific fashion. J. Virol. 70:5067-5074.
7. Calain, P., and L. Roux. 1993. The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. J. Virol. 67:4822-4830.
8. Cathomen, T., D. J. Buchholz, P. Spielhofer, and R. Cattaneo. 1995. Preferential initiation at the second AUG of the measles virus F mRNA: a role for the long untranslated region. Virology 214:628-632.
9. Cattaneo, R., K. Kaelin, K. Baczko, and M. A. Billeter. 1989. Measles virus editing provides an additional cysteine-rich protein. Cell 56:759-764.
10. Cattaneo, R., and J. K. Rose. 1993. Cell fusion by the envelope glycoproteins of persistent measles viruses which caused lethal human brain diseases. J. Virol. 67:1493-1502.
11. Coben, J. I., and K. E. Seidel. 1994. Absence of varicella-zoster virus (VZV) glycoprotein V does not alter growth of VZV in vitro or sensitivity to heparin. J. Gen. Virol. 75:3087-3093.
12. Curran, J., M. DeMelo, S. Moyer, and D. Kolakofsky. 1991. Characterization of the Sendai virus V protein with an anti-peptide antiserum. Virology 184:108-116.
13. Curran, J. A., and D. Kolakofsky. 1988. Ribosomal initiation from an ACG codon in the Sendai virus P/C mRNA. EMBO J. 7:245-251.
14. Delenda, C., S. Hausmann, D. Garcin, and D. Kolakofsky. 1997. Normal cellular replication of Sendai virus without the trans-frame, nonstructural V protein. Virology 228:55-62.
15. Enders, J. F., and T. C. Peebles. 1954. Propagation in tissue cultures of cytopathic agents from patients with measles. Proc. Soc. Exp. Biol. Med. 86:277-286.
16. Evans, S. A., G. J. Belsham, and T. Barrett. 1990. The role of the 5′ nontranslated regions of the fusion protein mRNAs of canine distemper virus and rinderpest virus. Virology 177:317-323.
17. Garcin, D., M. Itoh, and D. Kolakofsky. 1997. A point mutation in the Sendai virus accessory C protein attenuates virulence for mice, but not virus growth in cell culture. Virology 238:424-431.
18. Gupta, K. C., and S. Patwardhan. 1988. ACG, the initiator codon for a Sendai virus protein. J. Biol. Chem. 263:8553-8556.
19. Horikami, S. M., R. E. Hector, S. Smallwood, and S. A. Moyer. 1997. The Sendai virus C protein binds the L polymerase protein to inhibit viral RNA synthesis. Virology 235:261-270.
20. Horikami, S. M., S. Smallwood, and S. A. Moyer. 1996. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication. Virology 222:383-390.
21. Jamieson, B. D., G. M. Aldrovandi, V. Planelles, J. B. M. Jowett, L. Guo, L. Bloch, and J. A. Zack. 1994. Requirement of human immunodeficiency virus type 1 Nef for in vivo replication and pathogenicity. J. Virol. 68:3478-3485.
22. Jamieson, B. D., G. M. Aldrovandi, and J. A. Zack. 1996. The SCID-hu mouse: an in vivo model for HIV-1 pathogenesis and stem cell gene therapy for AIDS. Semin. Immunol. 8:215-221.
23. Kato, A., K. Kiyotani, Y. Sakai, T. Yoshida, and Y. Nagai. 1997. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis. EMBO J. 16:578-587.
24. Kato, A., K. Kiyotani, Y. Sakai, T. Yoshida, T. Shioda, and Y. Nagai. 1997. Importance of the cysteine-rich carboxy-terminal half of V protein for Sendai virus pathogenesis. J. Virol. 71:7266-7272.
25. Kestler, H. W., D. J. Ringler, M. Kazuyasu, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers, 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
26. Lin, G. Y., R. G. Paterson, and R. A. Lamb. 1997. The RNA binding region of the paramyxovirus SV5 V and P proteins. Virology 238:460-469.
27. Liston, P., and D. J. Briedis. 1994. Measles virus V protein binds zinc. Virology 198:399-404.
28. Liston, P., C. DiFlumeri, and D. J. Briedis. 1995. Protein interactions entered into by the measles virus P, V, and C proteins. Virus Res. 38:241-259.
29. Manservigi, R., P. Spear, and A. Buchan. 1977. Cell fusion induced by herpes simplex virus is promoted and supported by different glycoproteins. Proc. Natl. Acad. Sci. USA 74:3913-3917.
30. Mocarski, E. S., M. Bonyhadi, J. M. McCune, and H. Kaneshima. 1993. Human CMV in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication. Proc. Natl. Acad. Sci. USA 90:104-108.
31. Moffat, J. F., M. D. Stein, H. Kaneshima, and A. M. Arvin. 1995. Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice. J. Virol. 69:5236-5242.
32. Moffat, J. F., L. Zerboni, P. R. Kinchington, C. Grose, H. Kaneshima, and A. M. Arvin. 1998. Attenuation of the vaccine Oka strain of varicella-zoster virus and role of glycoprotein C in alphaherpesvirus virulence demonstrated in the SCID-hu mouse. J. Virol. 72:965-974.
33. Namikawa, R., K. N. Weilbaecher, H. Kaneshima, E. J. Lee, and J. M. McCune. 1989. Long-term human hematopoiesis in the SCID-hu mouse. J. Exp. Med. 172:1055-1063.
34. 33a.Naniche, D. Personal communication.
35. Numazaki, K., H. Goldman, I. Wong, and M. A. Wainberg. 1989. Replication of measles virus in cultured human thymic epithelial cells. J. Med. Virol. 27:52-58.
36. Paterson, R. G., G. P. Leser, M. A. Shaughnessy, and R. A. Lamb. 1995. The paramyxovirus SV5 V protein hinds two atoms of zinc and is a structural component of virions. Virology 208:121-131.
37. Patwardhan, S., and K. C. Gupta. 1988. Translation initiation potential of the 5' proximal AUGs of the polycistronic P/C mRNA of Sendai virus: a multipurpose vector of site-specific mutagenesis. J. Biol. Chem. 263:4907-4913.
38. Precious, B., D. F. Young. A. Bermingham, R. Fearns, M. Ryan, and R. E. Randall. 1995. Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions. J. Virol. 69:8001-8010.
39. Radecke. F., and M. A. Billeter. 1996. The nonstructural C protein is not essential for multiplication of Edmonston B strain measles virus in cultured cells. Virology 217:418-421.
40. Radecke, F., P. Spielhofer, H. Schneider, K. Kaelin, M. Huber, C. Dotsch, CJ. Christiansen, and M. A. Billeter. 1995. Rescue of measles virus from cloned DNA. EMBO J. 14:5773-5784.
41. Randall, R. E., and A. Bermingham. 1996. NP:P and NP:V interactions of the paramyxovirus simian virus 5 examined using a novel protein:protein capture assay. Virology 224:121-129.
42. Richardson, C., D. Hull, P. Greer, K. Hasel, A. Berkovich, G. Englund, W. Bellini, B. Rima, and R. Lazzarini. 1986. The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston strain): a comparison of fusion proteins from several different paramyxoviruses. Virology 155:508-523.
43. Sakaguchi, M., Y. Yoshikawa, K. Yamanouchi, T. Sata, K. Nagashima, and K. Takeda. 1986. Growth of measles virus in epithelial and lymphoid tissues of cynomolgus monkeys. Microbiol. Immunol. 30:1067-1073.
44. Schneider, H., K. Kaelin, and M. A. Billeter. 1997. Recombinant measles virus defective for RNA editing and V protein synthesis are viable in cultured cells. Virology 227:314-322.
45. Takeuchi, K., K. Tanabayashi, M. Hishiyama, Y. Yamada, A. Yamada, and A. Sugiura. 1990. Detection and characterization of mumps virus V protein. Virology 178:247-253.
46. Tapparel, C., S. Hausmann, T. Pelet, J. Curran, D. Kolakofsky, and L. Roux. 1997. Inhibition of Sendai virus genome replication due to promoter-increased selectivity: a possible role for the accessory C protein. J. Virol. 71:9588-9599.
47. Thomas, S. M., R. A. Lamb, and R. G. Paterson. 1988. Two mRNAs that differ by two nontemplaled nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54:891-902.
48. Valsamakis, A., F. Mustafa, D. E. Griffin, and H. L. Robinson. Unpublished data.
49. Vidal, S., J. Curran, and D. Kolakofsky. 1990. Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity. J. Virol. 64:239-246.
50. Wardrop, E. A., and D. J. Briedis. 1991. Characterization of V protein in measles virus-infected cells. J. Virol. 65:3421-3428.
51. White, R. G., and J. F. Boyd. 1986. The effect of measles on the thymus and other lymphoid tissues. Clin. Exp. Immunol. 30:1067-1073.
52. Yamada, H., T. Omata-Yamada, J. Taira, K. Mizumoto, and K. Iwasaki. 1990. Association of the Sendai virus C protein with nucleocapsids. Arch. Virol. 113:245-253.