Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions

Developmental Dynamics

Volumn 213, Issue 2, 1998, Pages 159-169

  Hudson, Rhea ^a   Taniguchi Sidle, Aiko ^a   Boras, Kata ^a   Wiggan, O'Neil ^a   Hamel, Paul A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alx 4; Epithelialmesenchymal interactions; LEF 1; Murine embryonic development; PL homeodomain protein

Indexed keywords

LYMPHOID ENHANCER FACTOR 1; TRANSACTIVATOR PROTEIN; TRANSACTIVATOR PROTEIN ALX 4; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL INTERACTION; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM CELL; HAIR; MAMMARY GLAND; MESENCHYME; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOOTH PAPILLA;

ANIMALS; BONE AND BONES; COS CELLS; DNA; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HAIR FOLLICLE; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; LYMPHOID ENHANCER-BINDING FACTOR 1; MAMMARY GLANDS, ANIMAL; MESODERM; MICE; MICE, KNOCKOUT; PREGNANCY; PROMOTER REGIONS (GENETICS); TOOTH; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; MAMMALIA; MURINAE; RODENTIA;

EID: 0031671277     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0177(199810)213:2<159::AID-AJA1>3.0.CO;2-F     Document Type: Article

References (37)

1. Cadigan KM, Nusse R. Wnt signaling: A common theme in animal development. Genes Dev. 1996;11:3286-3305.
2. Chen Y, Bei M, Woo I, Satokata I, Maas R. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 1996; 122:3035-3044.
3. Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN. MHox: A mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 1992;115:1087-1101.
4. Cunha GR, Hom YK. Role of mesenchymal-epithelial interactions in mammary gland development. J. Mamm. Gland Biol. Neo. 1996;1: 21-35.
5. Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BLM. Haploinsufficient phenotypes in BMP4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 1997;188:235-247.
6. Forsthoelfel PF. Genetics and manifold effects of Strong's luxoid gene in the mouse, including its interactions with Green's luxoid and Carter's luxate genes. J. Morphol. 1962;110:391-420.
7. Gaunt SJ, Blum M, De Robertis E. Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall. Development 1993;117:769-778.
8. Gurdon JB. The generation of diversity and pattern in animal development. Cell 1992;68:185-199.
9. Hardy MH. The secret life of the hair follicle. Trends Genet. 1992;8: 55-61.
10. Hogan BLM. Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 1996a;6:432-438.
11. Hogan BLM. Bone morphogenic proteins: multifunctional regulators of vertebrate development. Genes Dev. 1996b;10:1580-1594.
12. Kaufman MH. The Atlas of Mouse Development. San Diego: Academic Press Limited, 1995.
13. Kongsuwan K, Webb E, Housiaux P, Adams JM. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. EMBO J. 1988;7:2131-2138.
14. Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 1986;44:283-292.
15. Kratochwil K, Dull M, Farinas I, Galceran J, Grosschedl R. Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev 1996;10: 1382-94.
16. Kuhl M, Wedlich D. Wnt signalling goes nuclear. Bioessays 1997;19: 101-104.
17. McBurney MW. P19 embryonal carcinoma cells. Int J Dev Biol 1993;37:135-140.
18. Oosterwegel M, van de Wetering M, Timmerman J, Kruisbeek A, Destree O, Meijlink F, Clevers H. Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. Development 1993;118:439-48.
19. Qu S, Niswender KD, Ji Q, van der Meer R, Keeney D, Magnuson MA, Wisdom R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development 1997;124:3999-4008.
20. Riese J, Yu X, Munnerlyn A, Eresh S, Hsu S-C, Grosschedl R, Bienz M. LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 1997;88:777-787.
21. Rivera PJ, Mallo M, Gendron MM, Gridley T, Behringer RR. Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development 1995; 121:3005-3012.
22. Rudnick A, Ling TY, Odagiri H, Rutter WJ, German MS. Pancreatic beta cells express a diverse set of homeobox genes. Proc. Natl. Acad. Sci. USA 1994;91:12203-12207.
23. Rudnicki MA, McBurney MW. Cell culture methods and induction of differentiation of embryonyl carcinoma cell lines In: Teratocarcinomas and embryonic stem cells: a practical approach. Robertson, EJ, ed. 1988;19-49.
24. Schneitz K, Spielmann P, Noll M. Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes Dev. 1993;7:114-129.
25. Sidle A, Palaty C, Dirks P, Wiggan O, Kiess M, Gill RM, Wong AK, Hamel PA. Activity of the retinoblastoma-family proteins, pRB, p107 and p130, during cellular proliferation and differentiation. Crit. Rev. Biochem. Mol. Biol. 1996;31:237-271.
26. Thesleff I, Nieminen P. Tooth morphogenesis and cell differentiation. Curr. Opin. Cell. Biol. 1996;8:844-850.
27. Travis A, Amsterdam A, Belanger C, Grosschedl R. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function. Genes Dev. 1991;5:880-894.
28. van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, Grosschedl R. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994;8:2691-2703.
29. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
30. Wiggan O, Taniguchi-Sidle A, Hamel PA. Interaction of the pRB-family proteins with paired-like homeodomains. Oncogene 1998;16: 227-236.
31. Wilson DS, Guenther B, Desplan C, Kuriyan J. High resolution structure of a paired (Pax) class cooperative homeodimer on DNA. Cell 1995;82:709-719.
32. Yamada G, Mansouri A, Torres M, Stuart ET, Blum M, Schultz M, De Robertis E, Gruss P. Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death. Development 1995;121:2917-2922.
33. Yang TT, Cheng L, Kain SR. Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein. Nuc. Acid. Res. 1996;24:4592-4593.
34. Zhao GQ, Zhou X, Eberspaecher H, Solursh M, deCrombrugghe B. Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes. Proc. Natl. Acad. Sci. USA 1993:90:8633-8637.
35. Zhao Q. Behringer RR, de Crombrugghe B. Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the cart-1 homeobox gene. Nature Genetics 1996;13:275-284.
36. Zhou J, Olsen EN. Dimerization through the helix-loop-helix motif enhances phosphorylation of the transcription activation domains of myogenin. Mol. Cell. Biol. 1994;14:6232-6243.
37. Zhou P, Byrne C, Jacobs J, Fuchs E. Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev. 1995;9:700-713.