Disruption of M-T5, a novel myxoma virus gene member of the poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits

Journal of Virology

Volumn 70, Issue 7, 1996, Pages 4394-4410

  Mossman, Karen ^a   Lee, Siow Fong ^b   Barry, Michele ^a   Boshkov, Lynn ^b   McFadden, Grant ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; DELETION MUTANT; HELPER CELL; MONONUCLEAR CELL; MYXOMATOSIS; NONHUMAN; OPEN READING FRAME; POXVIRUS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RABBIT; VIRUS CELL INTERACTION; VIRUS REPLICATION;

EID: 8944257378     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.7.4394-4410.1996     Document Type: Article

References (55)

1. Ali, A. N., P. C. Turner, M. A. Brooks, and R. W. Moyer. 1994. The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation. Virology 202:305-314.
2. Barry, M., and G. McFadden. Virokines and viroceptors. In J. S. Friedland and D. G. Remick (ed.), Cytokines in health and disease, in press. Marcel Dekker, Inc., New York.
3. Boyle, D. B., and B. E. H. Coupar. 1988. A dominant selectable marker for the construction of recombinant poxviruses. Gene 65:123-128.
4. Buller, R. L. M., and G. J. Palumbo. 1991. Poxvirus pathogenesis. Microbiol. Rev. 55:80-122.
5. Chen, W., R. Drillien, D. Spehner, and R. M. L. Buller. 1993. In vitro and in vivo study of the ectromelia virus homolog of the vaccinia virus K1L host range gene. Virology 196:682-693.
6. Chou, J., J. Chen, M. Gross, and B. Roizman. 1995. Association of a Mr 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2α and premature shutoff of protein synthesis after infection with γ134.5′ mutants of herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 92:10516-10520.
7. Chou, J., and B. Roizman. 1992. The γ134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc. Natl. Acad. Sci. USA 89:3266-3270.
8. Clem, R. J., M. Fechheimer, and L. K. Miller. 1991. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254:1388-1390.
9. Drillien, R., D. Spehner, and A. Kirn. 1978. Host range restriction of vaccinia virus in Chinese hamster ovary cells: relationship to shutoff of protein synthesis. J. Virol. 28:843-850.
10. Falkner, F. G., and B. Moss. 1988. Escherichia coli gpt gene provides dominant selection for vaccinia virus open reading frame expression vectors. J. Virol. 62:1849-1854.
11. Fenner, F., and F. N. Ratcliffe (ed.). 1965. Myxomalosis. Cambridge University Press, Cambridge.
12. Fenner, F., and J. Ross. 1994. Myxomatosis, p. 205-239. In G. V. Thompson and C. King (ed.), The European rabbit. The history and biology of a successful colonizer. Oxford University Press, Oxford.
13. Gavriell, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
14. Goebel, S. J., G. P. Johnson, M. E. Perkus, S. W. Davis, J. P. Winslow, and E. Paoletti. 1990. The complete DNA sequence of vaccinia virus. Virology 179:247-266.
15. Gooding, L. R. 1992. Virus proteins that counteract the immune system. Cell 71:5-7.
16. Graham, K. A., A. Opgenorth, C. Upton, and G. McFadden. 1992. Myxoma virus ML ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence. Virology 191:112-124.
17. Gregory, C. D., C. Dive, S. Henderson, C. A. Smith, G. T. Williams, J. Gordon, and A. B. Rickinson. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from undergoing apoptosis. Nature (London) 349:612-614.
18. Howard, S. T., Y. C. Chan, and G. L. Smith. 1991. Vaccinia virus homologues of the Shope fibroma virus inverted terminal repeat proteins and a discontinuous ORF related to the tumor necrosis factor receptor family. Virology 180:633-647.
19. Hruby, D. E., D. L. Lynn, R. C. Condit, and J. R. Kates. 1980. Cellular differences in the molecular mechanisms of vaccinia virus host range restriction. J. Gen. Virol. 47:485-488.
20. Ink, B. S., C. S. Gilbert, and G. I. Evan. 1995. Delay of vaccinia virus-induced apoptosis in nonpermissive Chinese hamster ovary cells by the cowpox virus CHOhr and adenovirus E1B 19K genes. J. Virol. 69:561-668.
21. Kaschka-Dierich, C., F. J. Werner, I. Bauer, and B. Fleckenstein. 1982. Structure of nonintegrated, circular herpesvirus saimiri and herpesvirus ateles genomes in tumor cell lines and in vitro-transformed cells. J. Virol. 44:295-310.
22. Kerr, J. F. R., A. H. Wyllie, and A. R. Currie. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26:239-257.
23. Lambert, S., Y. Hullan, J. T. Prchal, J. Lawler, P. Ruff, D. Speicher, M. C. Cheung, Y. W. Kan, and J. Palek. 1990. cDNA sequence for human crythrocyte ankyrin. Proc. Natl. Acad. Sci. USA 87:1730-1734.
24. Lux, S. E., K. M. John, and V. Bennet. 1990. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature (London) 344:36-42.
25. Macen, J. L., K. A. Graham, S. F. Lee, M. Schrieber, L. K. Boshkov, and G. McFadden. 1996. Expression of the myxoma virus tumor necrosis factor receptor homologue (T2) and ML genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes. Virology 218:232-237.
26. Macen, J. L., C. Upton, N. Nation, and G. McFadden. 1993. SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation. Virology 195:348-363.
27. Massung, R. F., L. Liu, J. Qi, J. C. Knight, T. E. Yuran, A. R. Kerlavage, J. M. Parsons, J. C. Venter, and J. J. Esposito. 1994. Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975. Virology 201:215-240.
28. McFadden, G. 1988. Poxviruses of rabbits, p. 37-62. In G. Darai (ed.), Virus diseases in laboratory and captive animals. Martinus Nijhoff Publishers, Boston.
29. McFadden, G. 1994. Rabbit, hare, squirrel and swine poxviruses, p. 1153-1160. In R. Webster and A. Granoff (ed.), Encyclopedia of virology. Academic Press, Inc., San Diego, Calif.
30. McFadden, G. (ed.). 1995. Viroceptors, virokines and related immune modulators encoded by DNA viruses. R. G. Landes Co., Austin, Tex.
31. McFadden, G., and K. Graham. 1994. Modulation of cytokine networks by poxviruses: the myxoma virus model. Semin. Virol. 5:421-429.
32. McFadden, G., K. Graham, K. Ellison, M. Barry, J. Macen, M. Schreiber, K. Mossman, P. Nash, A. Lalani, and H. Everett. 1995. Interruption of cytokine networks by poxviruses: lessons from myxoma virus. J. Leukocyte Biol. 57:731-738.
33. McFadden, G., and K. Kane. 1994. How DNA viruses perturb functional MHC expression to alter immune recognition. Adv. Cancer Res. 63:117-209.
34. Moss, B. 1990. Poxviridae and their replication, p. 2079-2111. In B. N. Fields and D. M. Knipe (ed.), Virology. Raven Press, New York.
35. Mossman, K., P. Nation, J. Macen, M. Garbutt, A. Lucas, and G. McFadden. 1996. Myxoma virus M-T7, a secreted homolog of the interferon-γ receptor, is a critical virulence factor for the development of myxomatosis in European rabbits. Virology 215:17-30.
36. Oguiura, N., D. Spehner, and R. Drillien. 1993. Detection of a protein encoded by the vaccinia virus C7L open reading frame and study of its effect on virus multiplication in different cell lines. J. Gen. Virol. 74:1409-1413.
37. Opgenorth, A., K. Graham, N. Nation, D. Strayer, and G. McFadden. 1992. Deletion analysis of two tandemly arranged virulence genes in myxoma virus, ML and myxoma growth factor. J. Virol. 66:4720-4731.
38. Opgenorth, A., D. Strayer, C. Upton, and G. McFadden. 1992. Deletion of the growth factor gene related to EGF and TGFα reduces virulence of malignant rabbit fibroma virus. Virology 186:175-191.
39. Perkus, M. E., S. J. Goebel, S. W. Davis, G. P. Johnson, K. Limbach, E. K. Norton, and E. Paoletti. 1990. Vaccinia virus host range proteins. Virology 179:276-286.
40. Russell, R. J., and S. J. Robbing. 1989. Cloning and molecular characterization of the myxoma virus genome. Virology 170:147-159.
41. Shchelkunov, S. N., V. M. Blinov, and L. S. Sandakhchiev. 1993. Ankyrin-like proteins of variola and vaccinia viruses. FEBS Lett. 319:163-165.
42. Smith, G. L. 1994. Virus strategies for evasion of the host response to infection. Trends Microbiol. 2:81-88.
43. Spehner, D., S. Gillard, R. Drillien, and A. Kirn. 1988. A cowpox virus gene required for multiplication in Chinese hamster ovary cells. J. Virol. 62:1297-1304.
44. Spriggs, M. K. 1994. Poxvirus-encoded soluble cytokine receptors. Virus Res. 33:1-10.
45. Sutter, G., A. Ramsey-Ewing, R. Rosales, and B. Moss. 1994. Stable expression of the vaccinia virus K1L gene in rabbit cells complements the host range defect of a vaccinia virus mutant. J. Virol. 68:4109-4116.
46. Tewari, M., W. G. Tiford, R. A. Miller, and V. M. Dixit. 1995. CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte mediated apoptosis. J. Biol. Chem. 270:22705-22708.
47. Traktman, P. 1990. Poxviruses: an emerging portrait of biological strategy. Cell 62:621-626.
48. Turner, P. C., and R. W. Moyer. 1990. The molecular pathogenesis of poxviruses. Curr. Top. Microbiol. Immunol. 163:125-152.
49. Upton, C., A. M. DeLange, and G. McFadden. 1987. Tumorigenic poxviruses: genomic organization and DNA sequence of the telomeric region of the Shope fibroma virus genome. Virology 160:20-30.
50. Upton, C., J. L. Macen, M. Schreiber, and G. McFadden. 1991. Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence. Virology 184:370-382.
51. Upton, C., and G. McFadden. 1986. Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus. Virology 152:308-321.
52. Upton, C., K. Mossman, and G. McFadden. 1992. Encoding of a homolog of the IFN-γ receptor by myxoma virus. Science 258:1369-1372.
53. Walker, N. I., B. V. Harmon, G. C. Gobe, and J. F. R. Kerr. 1988. Patterns of cell death. Methods Achiev. Exp. Pathol. 13:18-54.
54. White, E., P. Sabbatini, M. Debbas, W. S. M. Wold, D. I. Kusher, and L. R. Gooding. 1992. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor α. Mol. Cell. Biol. 12:2570-2580.
55. Wyllie, A. H. 1980. Glucocortoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (London) 284:555-556.