Intraindividual variability in red blood cell thiopurine methyltransferase activity

European Journal of Clinical Pharmacology

Volumn 50, Issue 3, 1996, Pages 217-220

  Giverhaug, T ^a   Klemetsdal, B ^a   Lysaa, R ^a   Aarbakke, J ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

6 mercaptopurine; Azathioprine; Leukaemia; circadian variation; Red blood cells; Thiopurine methyltransferase (TPMT); Variability

Indexed keywords

MERCAPTOPURINE; THIOPURINE METHYLTRANSFERASE;

ADULT; ARTICLE; CIRCADIAN RHYTHM; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL;

ADULT; CIRCADIAN RHYTHM; ERYTHROCYTES; FEMALE; HUMANS; MALE; METHYLTRANSFERASES; MIDDLE AGED; REPRODUCIBILITY OF RESULTS;

EID: 0030011484     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050095     Document Type: Article

References (29)

1. Zimmerman TP, Chu L-C, Buggé CJL, Nelson DJ, Lyon GM, Elion GB (1974) Identification of 6-methylmercaptopurine ribonucleoside 5′-diphosphate and 5′-triphosphate as metabolites of 6-mercaptopurine in man. Cancer Res 34:221-224
2. Szumlanski CL, Honchel R, Scott MC, Weinshilboum RM (1992) Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenctics 2:148-159
3. Woodson LC, Dunnette JH, Weinshilboum RM (1982) Pharmacogenetics of human thiopurine methyltransferase: kidney-erythrocyte correlation and immunotitration studies. J Pharmacol Exp Ther 222:174-181
4. McLeod HL, Relling MV, Liu Q, Pui C-H, Evans WE (1995) Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood 85:1897-1902
5. Weinshilboum RM, Sladek SL (1980) Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 32: 651-662
6. Klemetsdal B, Tollefsen H, Loennechen T, Johnsen K, Utsi E, Gisholt K, Wist E, Aarbakke J (1992) Interethnic difference in thiopurine methyltransferase activity. Clin Pharmacol Ther 51:24-31
7. McLeod HL, Lin J-S, Scott EP, Pui C-H, Evans WE (1994) Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharmacol Ther 55:15-20
8. Lee EJD, Kalow W (1993) Thiopurine S-methyltransferase activity in a Chinese population. Clin Pharmacol Ther 54: 28-33
9. Klemetsdal B, Straume B, Wist E, Aarbakke J (1993) Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 44:147-152
10. Klemetsdal B, Wist E, Aarbakke J (1993) Gender difference in red blood cell thiopurine methyltransferase activity. Scand J Clin Lab Invest 53:747-749
11. Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM (1990) Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 336: 225-229
12. Chocair PR, Duley JA, Simmonds HA, Cameron JS (1992) The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 53:1051-1056
13. Szumlanski CL, Weinshilboum RM (1995) Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 39:456-459
14. Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM (1983) Thiopurine methyltransferase: aromatic thiol substrates and inhibition by benzoic acid derivatives. Mol Pharm 24:471-478
15. Ames MM, Selassie CD, Woodson LC, Van Loon JA, Hansch C, Weinshilboum RM (1986) Thiopurine methyltransferase: structure-activity relationship for benzoic acid inhibitors and thiophenol substrates. J Med Chem 29:354-358
16. Lennard L, Van Loon JA, Weinshilboum RM (1989) Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 46:149-154
17. Lennard L, Gibson BES, Nicole T, Lilleyman JS (1993) Congenital thiopurine methyltransterase deficiency and 6- mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 69:577-579
18. Evans WE, Horner M, Qin Chu Y, Kalwinsky D, Roberts WM (1991) Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 119: 985-989
19. Schütz E, Gummert J, Mohr F, Oellerich M (1993) Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 341:436
20. McLeod HL, Miller DR, Evans WE (1993) Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 341:1151
21. Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM (1987) Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-hioguanine nucleotide concentrations. Clin Pharmacol Ther 41: 18-25
22. Weinshilboum RM, Raymond FA, Pazmiño PA (1978) Human erythrocyte thiopurine methyltransterase: radiochemical microassay and biochemical properties. Clin Chim Acta 85: 323-333
23. Klemetsdal B, Straume B, Lysaa R, Giverhaug T, Aarbakke J (1995) Erythrocyte fraction affects red blood cell thiopurine methyltransferase activity. Eur J Clin Pharmacol 48: 495-499
24. Lafolie P, Hayder S, Björk O, Peterson C (1991) Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia. Eur J Clin Pharmacol 40:599-601
25. Rivard GE, Infante-Rivard C, Hoyoux C, Champagne J (1985) Maintenance chemotherapy for childhood acute lymphoblastic leukaemia: better in the evening. Lancet 2:1264-1266
26. Balis FM, Jeffries SL, Lange B, Murphy RE, Doherty KM, Arndt CAS, Luery K, Poplack DG (1989) Chronopharmacokinetics of oral methotrexate and 6- mercaptopurine: is there diurnal variation in the disposition of antileukemic therapy? Am J Ped Hemat Oncol 11:324-326
27. Capdeville R, Mousson B, Bax G, Bertrand Y, Philippe N (1994) Interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity. Eur J Clin Pharmacol 46:385-386
28. McLeod HL (1995) Commentary on interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity. Eur J Clin Pharmacol 48:85-86
29. Capdeville R, Mousson B, Bax G (1995) Reply to Dr. McLeod's commentary on interactions between 6- mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity. Eur J Clin Pharmacol 48:87-88