β3-tubulin is directly repressed by the Engrailed protein in Drosophila

Development

Volumn 124, Issue 13, 1997, Pages 2527-2536

  Serrano, Nuria ^a,c   Brock, Hugh W ^b   Maschat, Florence ^a  

^a INSTITUT JACQUES MONOD   (France)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3 tubulin; Drosophila; Engrailed; Target genes

Indexed keywords

BETA TUBULIN; NUCLEAR PROTEIN; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; ENGRAIL PROTEIN, DROSOPHILA; HOMEODOMAIN PROTEIN; TUBULIN;

ARTICLE; BINDING SITE; DEVELOPMENTAL GENETICS; DROSOPHILA; ECTODERM; EMBRYO DEVELOPMENT; GENE LOCUS; GENE REPRESSION; INTRON; LARVA; MESODERM; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; ANIMAL; DIGESTIVE SYSTEM; GENE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; PRENATAL DEVELOPMENT; PROTEIN BINDING; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BINDING SITES; DIGESTIVE SYSTEM; DROSOPHILA; ECTODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENOMIC LIBRARY; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRONS; MESODERM; PROTEIN BINDING; TRANSCRIPTION FACTORS; TUBULIN;

EID: 0030609889     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Botas, J. and Auwers, L. (1996). Chromosomal binding sites of Ultrabithorax homeotic proteins. Mech. Dev. 56, 129-138.
2. Bourbon, H. M., Martin-Blanco, E., Rosen, D. and Kornberg, T. B. (1995). Phosphorylation of the Drosophila Engrailed protein at a site outside its homeodomain enhances DNA binding. J. Biol. Chem. 270, 11130-11139.
3. Bruhat, A., Tourmente, S., Chapel, S., Sobrier, M. L., Couderc, J. L. and Dastugue, B. (1990). Regulatory elements in the first intron contribute to transcriptional regulation of the β3-tubulin gene by 20-hydroxyecdysone in Drosophila Kc cells. Nucleic Acids Res. 18, 2861-2867.
4. Capovilla, M., Brandt, M. and Botas, J. (1994). Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila mitgut morphogenesis. Cell 76, 461-475.
5. Cleveland, D. W. (1987). The multitubulin hypothesis revisited: What have we learned? The J. Cell Biol. 104, 381-383.
6. Desplan, C., Theis, J. and O'Farrell, P. H. (1985). The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Nature 318, 630-635.
7. Eaton, S. and Kornberg, T. B. (1990). Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev. 4, 1068-1077.
8. Fjose, A., McGinnis, W. J. and Gehring, W. J. (1985). Isolation of a homeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature 313, 284-289.
9. Gasch, A., Hinz, U. and Renkawitz-Pohl, R. (1989). Intron and upstream sequences regulate expression of the Drosophila β3-tubulin gene in the visceral and somatic musculature, respectively. Proc. Natl. Acad. Sci. USA 86, 3215-3218.
10. Gay, N. J., Poole, S. J. and Kornberg, T. B. (1988). The Drosophila engrailed protein is phosphorylated by a serine-specific protein kinase. Nucleic Acids Res. 16, 6637-6647.
11. Glaser, R. L., Wolfner, M. F. and Lis, J.F. (1986). Spatial and temporal pattern of hsp26 expression during normal development. EMBO. J. 5, 747-754.
12. Gould, A. P., Brookman, J. J., Strutt, D. I. and White, R. A. H. (1990). Targets of homeotic gene control in Drosophila. Nature 348, 308-312.
13. Gould, A. P. and White, R. A. H. (1992). Connectin, a target of homeotic gene control in Drosophila. Development 116, 1163-1174.
14. Graba, Y., Aragnol, D., Laurenti, P., Garzino, V., Charmot, D., Berenger, H. and Pradel, J. (1992). Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins. EMBO J. 11, 3375-3384.
15. Graba, Y., Geiseler, K., Aragnol, D., Laurenti, P., Mariol, M.C., Berenger, H., Sagnier, T. and Pradel, J. (1995). DWnt-4, a novel Drosophila WM gene acts downstream of homeotic complex genes in visceral mesoderm. Development 121, 209-218.
16. Guillen, I., Mullor, J. L., Capdevila, J., Sanchez-Herrero, E. and Morata, G. (1995). The function of engrailed and the specification of Drosophila wing pattern. Development 121, 3447-3456.
17. Gustavson, E., Goldsbourough, A. S., Ali, Z. and Kornberg, T. B. (1996). The Drosophila engrailed and invected genes: partners in regulation, expression and function. Genetics 142, 893-906.
18. Hama, C., Ali, Z. and Kornberg, T. B. (1990). Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter. Genes Dev. 4, 1079-1093.
19. Heuer, J. G., Li, K. and Kaufman, T. C. (1995). The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis. Development 121, 3861-3876.
20. Hinz, U., Wolk, A. and Renkawitz-Pohl, R. (1992). Ultrabihorax is a regulator of β3-tubulin expression in the Drosophila visceral mesoderm. Development 116, 543-554.
21. Hoch, M. and Jäckle, H. (1993). Transcriptional regulation and spatial patterning in Drosophila. Curr. Opin. Gen. Dev. 3, 566-573.
22. Immerglück, K., Lawrence, P, A. and Bienz, M. (1990). Induction across germ layers in Drosophila mediated by a genetic cascade. Cell 62,261-268.
23. Ingham, P. W. (1988). The molecular genetics of embryonic pattern formation in Drosophila. Nature 335, 25-34.
24. Jaynes, J. B. and O'Farrell, P. H. (1988). Activation and repression of transcription by homeodomain-containing proteins that bind a common site. Nature 336, 744-749.
25. Jaynes, J. B. and O'Farrell, P. H. (1991). Active repression of transcription by the Engrailed homeodomain protein. EMBO J. 10, 1427-1433.
26. Kimble, M., Incardona, J. P. and Raff, E. C. (1989). A variant β-Tubulin isoform of Drosophila melanogaster (β3) is expressed primarily in tissues of mesodermal origin in embryos and pupae, and is utilized in populations of transient microtubules. Dev. Biol. 131, 415-429.
27. Kimble, M., Dettman, R. W. and Raff, E. C. (1990). The β3-tubulin gene of Drosophila melanogaster is essential for viability and fertility. Genetics 126, 991-1005.
28. Kornberg, T. (1981). engrailed : A gene controlling compartment and segment formation in Drosophila. Proc. Natl. Acad. Sci. USA 78, 1095-1099.
29. Kornberg, T. B. and Tabata, T. (1993). Segmentation of the Drosophila embryo. Curr. Opin. Gen. Dev. 3, 585-593.
30. Kuner, J., Nakanishi, M., Ali, Z., Drees, B., Gustavson, E., Theis, J., Kauvar, L., Kornberg, T. and O'Farrell, P. (1985). Molecular cloning of engrailed, a gene involved in the development of pattern in Drosophila melanogaster. Cell 42, 309-316.
31. Lawrence, P. A. and Morata, G. (1976). Compartments in the wing of Drosophila, a study of the engrailed gene. Dev. Biol. 50, 321-337.
32. Lawrence, P. A. and Morata, G. (1994). Homeobox genes: their function in Drosophila segmentation and pattern formation. Cell 78, 181-189.
33. Lawrence, P. A., Johnston, P. and Vincent, J. P. (1994). Wingless can bring about a mesoderm-to-ectoderm induction in Drosophila. Development 120, 3355-3359.
34. Maschat, F., Dubertret, M.L., Lepesant, J-A. (1991). Mapping of essential sequences for a correct developmental regulation of the ecdysterone inducible P1 gene of Drosophila. Mol. cell. biol. 11, 2913-2917.
35. Mastick, G. S., McKay, R., Oligino, T., Donovan, K. and Lopez, A. J. (1995). Identification of target genes regulated by homeotic proteins in Drosophila melanogaster through genetic selection of Ultrabithorax protein-binding sites in yeast. Genetics 139, 349-363.
36. Mann, R. S. (1994). engrailed-medialea repression of Ultrabithorax is necessary for the parasegment 6 identity in Drosophila. Development 120, 3205-3212.
37. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
38. Morata, G. and Lawrence, P, A. (1975). Control of compartment development by the engrailed gene in Drosophila. Nature 255, 614-617.
39. Ohkuma, Y., Horikoshi, M., Roeder, R. G. and Desplan, C. (1990). Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID. Proc. Natl. Acad. Sci. USA 87, 2289-2293.
40. O'Neill, J. W. and Bier, E. (1994). Double label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques 17, 870-875.
41. Patel, N. H., Martin-Blanco, E., Coleman, K. J., Poole, S. J., Ellis, M. C., Kornberg, T. B. and Goodman, C. S. (1989). Expression of Engrailed proteins in arthropods, annelids and chordates. Cell 58, 955-968.
42. Poole, S. and Kornberg, T. B. (1988). Modifying expression of the engrailed gene of Drosophila melanogaster. Development 104 Supplement 85-93.
43. Poole, S. J., Kauvar, L. M., Drees, B. and Kornberg, T. ( 1985). The engrailed locus of Drosophila: structural analysis of an embryonic transcript. Cell 40, 37-43.
44. Raftery, L. A., Sanicola, M., Blackman, R. K. and Gelbart, W. M. (1991). The relationship of decapentaplegic and eng railed expression in Drosophila imaginai disks: do these genes mark the anterior-posterior compartment boundary? Development 113, 27-33.
45. Saenz-Robles, M. T., Maschat, F., Tabata, T., Scott, M. P. and Kornberg, T. B. (1995). Selection and characterization of sequences with high affinity for the Engrailed protein of Drosophila. Mech. Dev. 53. 185-195.
46. Schwartz, C., Locke, J., Nishida, C. and Kornberg, T. B. (1995). Analysis of cubitus interruptus regulation in Drosophila embryos and imaginai disks. Development 121, 1626-1635.
47. Serrano, N., Brock, H. W., Demeret, C., Dura, J. M., Randsholt, N. B., Kornberg, T. B. and Maschat, F. (1995). polyhomeotic appears to be a target of Engrailed regulation in Drosophila. Development 121, 1691-1703.
48. Staehling-Hampton, K., Hoffmann, F. M., Baylies, M. K., Rushton, E. and Bate, M. (1994). dpp induces mesodermal gene expression in Drosophila. Nature 372, 783-786.
49. Sullivan, W., Fogarty, P. and Theurkauf, W. (1993). Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos. Development 118, 1245-1254.
50. Tabata, T., Eaton, S. and Kornberg, T. B. (1992). The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6, 2635-2645.
51. Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T. B. (1995). Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis. Development 121, 3359-3369.
52. Xiong, W. C. and Montell, C. (1993). tramtrack is a transcriptionnal repressor required for cell fate determination in the Drosophila eye. Genes Dev. 7, 1085-1096.
53. Yanicostas, C. and Lepesant, J. A. (1990). Transcriptional and translational cis-regulatory sequences of the spermatocyte-specific Drosophila janusB gene are located in the 3′ exonic region of the overlapping janusA gene. Mol. Gen. Genet. 224, 450-458.
54. Zink, B. and Paro, R. (1989). In vivo binding pattern of a trans-regulator of the homeotic genes in Drosophila melanogaster. Nature 337, 468-471.