Pneumatically agitated bioreactors in industrial and environmental bioprocessing: Hydrodynamics, hydraulics, and transport phenomena

Applied Mechanics Reviews

Volumn 51, Issue 1, 1998, Pages 33-112

  Chisti, Yusuf ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOTECHNOLOGY; ENZYMES; FERMENTATION; HEAT TRANSFER; HYDRAULICS; HYDRODYNAMICS; MASS TRANSFER; MIXING; PLANT CELL CULTURE; SUSPENSIONS (FLUIDS); WASTEWATER TREATMENT;

AIRLIFT REACTORS; BIOPROCESSING; BIOTRANSFORMATION; GAS HOLDUP; LIQUID CIRCULATION; PNEUMATIC AGITATION;

BIOREACTORS;

EID: 0031648102     PISSN: 00036900     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.3098989     Document Type: Article

References (328)

1. Akita K and Yoshida F (1973), Gas holdup and volumetric mass transfer coefficient in bubble columns, Ind Eng Chem Process Des Develop 12, 76-80.
2. Akita K, Nakanishi O, and Tsuchiya K (1994), Turn-around energy losses in an extemal-loop airlift reactor, Chem Eng Sei 49,2521-2533.
3. Allsop PJ, Chisti Y, Moo-Young, M, and Sullivan, GR (1993), Dynamics of phenol degradation by Pseudomonas putida, Biotech Bioeng 41, 572-580.
4. Arathoon WR and Birch JR (1986), Large-scale cell culture in biotechnology, Science 232, 1390-1395.
5. Archambault J, Volesky B, and Kurz WGW (1990), Development of bioreactors for the culture of surface immobilized plant cells, Biotech Bioeng 35, 702-711.
6. Arters DC and Fan L-S (1986), Solid-liquid mass transfer in a gas-liquidsolid fluidized bed, Chem Eng Sei 41, 107-115.
7. Assa A and Bar R (1991), Biomass axial distribution in airlift bioreactor with yeast and plant cells, Biotech Bioeng 38, 1325-1330.
8. Ayazi Shamlou P, Pollard DJ, Ison AP, and Lilly MD (1994), Gas holdup and liquid circulation rate in concentric-tube airlift bioreactors, Chem Eng Sei 49, 303-312.
9. Backhurst JR and Harker JH (1973), Process Plant Design, Heinemann, London, p 108.
10. Bakker WAM, van Can HJL, Tramper J, and de Gooijer CD (1993), Hydrodynamics and mixing in a multiple air-lift loop reactor, Biotech Bioeng 42,994-1001.
11. Bakker WAM, Knitel JT, Tramper J, and de Gooijer CD (1994), Sucrose conversion by immobilized invertase in a multiple air-lift loop bioreactor, Biotech Prog 10, 277-283.
12. Bakker WAM, den Hartog M, Tramper J, and de Gooijer CD (1995), Oxygen transfer in a multiple air-lift loop reactor, Bioproc Eng 12, 167-172.
13. Bando Y, Nishimura M, Sota H, Toyoda K, Suzuki S, and Idota A (1992a), Flow characteristics of bubble column with perforated draft tube— Effects of equipment dimensions and gas dispersion, J Chem Eng Japan 25, 49-54.
14. Bando Y, Nishimura M, Sota H, Suzuki S, and Kawase N (1992b), Flow characteristics of countercurrent bubble column with perforated draft tube, Chem Eng Sei 47, 3371-3378.
15. Bando Y, Nishimura M, Hayashi A, Hiura S, Ido S, and Idota A (1995), Flow characteristics of bubble column with perforated draft tube in viscous liquid, J Chem Eng Japan 28, 225-227.
16. Bayer T, Zhou W, Holzhauer K, and Schügerl K (1989), Investigation of cephalosporin C production in an airlift tower loop reactor, Appl Microbiol Biotech 30,26-33.
17. Becker S, Sokolichin A, and Eigenberger G (1994), Gas-liquid flow in bubble columns and loop reactors: Part ü. Comparison of detailed experiments and flow simulations, Chem Eng Sei 49,5747-5762.
18. Bello RA (1981), A characterization study of airlift contactors for application to fermentations, PhD Thesis, Univ of Waterloo, Ontario, Canada.
19. Birch JR, Lambert K, Thompso PW, Kenney AC, and Wood LA (1987), Antibody production with airlift fermentors, in Large Scale Cell Culture Technology, Lydersen BK (ed), Hanser, New York, 1-20.
20. Blakebrough N, McManamay WJ, and Walker G (1983a), Heat transfer to fermentation systems in an air-lift fermenter. Part II: Osmotic effects on heat transfer, Chem Eng Res Des 61, 264-266.
21. Blakebrough N, Fatile LA, McManamay WJ, and Walker G (1983b), Heat transfer to fermentation systems in an air-lift fermenter. Part IB: Mechanism of heat transfer, Chem Eng Res Des 61, 383-387.
22. Blenke H (1979), Loop reactors, Adv Biochem Eng 13, 121-214.
23. Bonnarme P and Jeffries TW (1990), Selective production of extracellular peroxidases form Phanerochaete chrysosporium in an air-lift bioreactor, J Ferment Bioeng 70, 158-163.
24. Bonnarme P, Delattre M, Drouet H, Corrieu G, and Asther M (1993), Toward a control of lignin and manganese peroxidases hypersecretion by Phanerochaete chrysosporium in agitated vessels: Evidence of the superiority of pneumatic bioreactors on mechanically agitated bioreactors, Biotech Bioeng 41, 440-450.
25. Brandes L, Wu X, Bode J, Rhee JI, and Schügerl K (1993a), Fed-batch cultivation of recombinant Escherichia coli JM103 and production of the fusion protein SPA::EcoRI in a 60-L working volume airlift tower loop reactor, Biotech Bioeng 42, 205-214.
26. Brandes L, Wu X, Maschke HE, Jürgens H, Reinhardt B, and Schügerl K (1993b), Production of fusion protein SpA::£coRl in batch culture in a 60-L airlift tower loop reactor, Biotech Prog 9, 122-127.
27. Brandes L, Wu X, Maschke HE, and Schügerl IC (1993c), Overproduction of recombinant proteins by Escherichia coli—employing the combinations of two and three different types of multicopy plasmids—in a 60-litre working volume airlift tower loop reactor, Process Biochem 28, 161-169.
28. Brown KE (1967), Gas Lift Theory and Practice, Prentice-Hall, Englewood Cliffs.
29. Büch GW, Enders L, Berger RG, and Drawert F (1991), Modelling the growth of airlift cultured plant cells: Role of inoculum, invertase activity, and pÜ2, in Biochemical Engineering—Stuttgart, Reuss M, Chmiel H, Gilles E-D, and Knackmuss H-J (eds), Gustav Fischer, New York, pp. 232-235.
30. Buchholz H, Buchholz R, Lücke J, and Schügerl K (1978), Bubble swarm behaviour and gas absorption in non-Newtonian fluids in sparged columns, Chem Eng Sei 33, 1061 -1070.
31. Butler M (1987), Animal Cell Technology, Taylor and Francis, New York, P 5.
32. Byun SY and Pedersen H (1994), Two-phase airlift fermentor operation with elicitation for the enhanced production of benzophenanthridine alkaloids in cell suspensions of Escherichia califomica, Biotech Bioeng 44, 14-20.
33. Cai J and Nieuwstad TJ (1991), Hydrodynamic modelling and blank running of a pilot-scale internal loop airlift reactor for wastewater treatment, Env Tech 12, 637-653.
34. Cai J and Nieuwstad TJ (1992), Modelling the three-phase flow in a pilotscale airlift intemal-loop reactor for wastewater treatment, Env Tech 13, 101-113.
35. Cäi J, Nieuwstad TJ, and Kop JH (1992a), Fluidization and sedimentation of carrier material in a pilot-scale airlift intemal-loop reactor, Wat Sei Tech 26, 2481-2484.
36. Cai Z, Yang S, Kang R, Sun X, Liu W, Li G, and Wang Y (1992b), Studies on the performance of bioreactors used for the fermentation process with highly viscous broth, in Proc of Asia-Pacific Biochemical Engineering Conf 1992, Furusaki S, Endo I, and Matsuno R (eds), SpringerVerlag, Tokyo, 429-432.
37. Calderbank PH and Moo-Young MB (1961), Continuous phase heat and mass-transfer properties of dispersions, Chem Eng Sei 16, 39-54.
38. Capuder E and Koloini T (1984), Gas holdup and interfacial area in aerated suspensions of small particles, Chem Eng Res Des 62, 255-260.
39. Chakravarty M, Singh HD, Baruah JN, Iyengar MS, and Sinha AP (1971), Heat transfer in gas lift reactor, Paper presented at the 1st Natl Heat and Mass Transfer Conf, Madras, India. Paper no HMT-53-71.
40. Chang C-M, Lu WJ, Own KS, and Hwang S-J (1993), Operation conditions affecting the performance of airlift bioreactors for immobilized enzyme reactions, Biotech Techniques 7, 317-322.
41. Chang C-M, Lu WJ, Own KS, and Hwang S-J (1994), Comparison of airlift and stirred tank reactors for immobilized enzyme reactions, Process Biochem 29, 133-138.
42. Chaplin MF and Bucke C (1990), Enzyme Technology, Cambridge Univ Press, Cambridge, 167-196.
43. Chatteijee S, Grethlein AJ, Worden RM, and Jain MK (1996), Evaluation of support matrices for an immobilized cell gas lift reactor for fermentation of coal derived synthesis gas, J Ferment Bioeng 81, 158-162.
44. Chen J, Hu X, and Li Z (1994), Innovation of air-lift bioreactor for animal cell culture, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 405-407.
45. Cheng C-M, Lu WJ, Own KS, and Hwang S-J (1992), Application of airlift reactors for immobilized enzyme reactions, in Proc of Asia-Pacific Biochemical Engineering Conf 1992, Furusaki S, Endo I, and Matsuno R (eds), Springer-Verlag, Tokyo, 437-440.
46. Cherry RS (1993), Animal cells in turbulent fluids: Details of the physical stimulus and the biological response, Biotech Adv 11, 279-299.
47. Chiou T-W, Murakami S, Wang DIC, and Wu W-T (1991), Fiber-bed bioreactor for anchorage-dependent animal cell cultures: Part I. Bioreactor design and operation, Biotech Bioeng 37, 755-761.
48. Chisti Y (1989), Airlift Bioreactors, Elsevier, London.
49. Chisti Y (1992a), Build better industrial bioreactors, Chem Eng Progress 88(1), 55-58.
50. Chisti Y (1992b), Assure bioreactor sterility, Chem Eng Progress 88(9), 8085.
51. Chisti Y (1993), Animal cell culture in stirred bioreactors: Observations on scale-up, Bioproc Eng 9, 191-196.
52. Chisti Y and Moo-Young M (1986), Disruption of microbial cells for intracellular products, Enzyme Microb Technol 8, 194-204.
53. Chisti Y and Moo-Young M (1987a), Airlift reactors: Characteristics, applications and design considerations, Chem Eng Commun 60, 195-242.
54. Chisti Y and Moo-Young M (1987b), Pneumatically agitated bioreactor devices: effects of fluid height and flow area shape on hydrodynamic and mass transfer performance, in Bioreactors and Biotransformations, Moody GW and Baker PB (eds), Elsevier, London, 335-349.
55. Chisti Y and Moo-Young M (1988a), Prediction of liquid circulation velocity in airlift reactors with biological media, J Chem Tech Biotech 42, 211-219.
56. Chisti Y and Moo-Young M (1988b), Gas holdup in pneumatic reactors, Chem Eng J 38, 149-152.
57. Chisti Y and Moo-Young M (1988c), Gas holdup behaviour in fermentation broths and other non-newtonian fluids in pneumatically agitated reactors, Chem Eng J 39, B31-B36.
58. Chisti Y and Moo-Young M (1988d), Hydrodynamics and oxygen transfer in pneumatic bioreactor devices, Biotech Bioeng 31,487-494.
59. Chisti Y and Moo-Young M (1989), On the calculation of shear rate and apparent viscosity in airlift and bubble column bioreactors, Biotechnol Bioeng 34, 1391-1392.
60. Chisti Y and Moo-Young M (1991), Fermentation technology, bioprocessing, scale-up and manufacture, in Biotechnology: The Science and the Business, Moses V and Cape RE (eds), Harwood Academic Publ, New York, 167-209.
61. Chisti Y and Moo-Young M (1993a), Improve the performance of airlift reactors, Chem Eng Progress 89(6), 38-45.
62. Chisti Y and Moo-Young M (1993b), Airlift bioreactors with packed beds of immobilized biocatalysts: Theoretical evaluation of liquid circulation performance, Trans I Chem E 71C, 209-214.
63. Chisti Y and Moo-Young M (1994a), Anchorage dependent animal cell culture in packed beds with airlift driven liquid circulation: A theoretical analysis of oxygen transfer and comparison with stirred tank microcarrier culture system, Trans 1 Chem E 72C, 91 -94.
64. Chisti Y and Moo-Young M (1994b), Airlift bioreactors for treatment of hydrocarbon contaminated wastes, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 771-776.
65. Chisti Y and Moo-Young M (1994c), Liquid circulation in extemal-loop airlift reactors, J Chem Technol Biotechnol 59, 101-103.
66. Chisti Y and Moo-Young M (1994d), Clean-in-place systems for industrial bioreactors: Design, validation and operation, J Ind Microbiol 13, 201-207.
67. Chisti Y and Moo-Young M (1996), Bioprocess intensification through bioreactor engineering, Trans I Chem E 74A, 575-583.
68. Chisti Y, Fujimoto K, and Moo-Young M (1987), Hydrodynamic and oxygen mass transfer studies in bubble columns and airlift bioreactors, in Biotechnology Processes: Scale-up and Mixing, Ho CS and Oldshue JY (eds), American Institute of Chemical Engineers, New York, 72-81.
69. Chisti Y, Halard B, and Moo-Young M (1988), Liquid circulation in airlift reactors, Chem Eng Sci 43, 451 -457.
70. Chisti Y, Kasper M, and Moo-Young M (1990), Mass transfer in extemal-loop airlift bioreactors using static mixers, Can J Chem Eng 68,45-50.
71. Chisti Y, Wenge F, and Moo-Young M (1995), Relationship between riser and downcomer gas holdup in intemal-loop airlift reactors without gasliquid separators, Chem Eng J SI, B7-B13.
72. Choi KH and Lee WK (1990a), Comparison of probe methods for measurement of bubble properties, Chem Eng Commun 91, 35-47.
73. Choi KH and Lee WK (1990b), Recirculation and flow structures of gas in downcomer section of a concentric cylindrical airlift reactor, J Chem Tech Biotech 48, 81 -95.
74. Choi KH and Lee WK (1993), Circulation liquid velocity, gas holdup and volumetric oxygen transfer coefficient in extemal-loop airlift reactors, J Chem Tech Biotech 56, 51-58.
75. Choi KH, Chisti Y, and Moo-Young M (1995a), Influence of the gas-liquid separator design on hydrodynamic and mass transfer performance of split-channel airlift reactors, J Chem Tech Biotech 62, 327-332.
76. Choi KH, Chisti Y, and Moo-Young M (1995b), Split-channel rectangular airlift reactors: Enhancement of performance by geometric modifications, Chem Eng Commun 138, 171-181.
77. Choi KH, Chisti Y, and Moo-Young M (1996), Comparative evaluation of hydrodynamic and gas-liquid mass transfer characteristics in bubble column and airlift slurry reactor, Chem Eng J 62, 223-229.
78. Coulson JM and Richardson JF (1977), Chemical Engineering, vol 2, 3rd ed, Pergamon Press, Oxford, 126-132.
79. Dai X, Ouyang F, and Qi Y (1994), Preliminary investigation on anchorage-dependent cell culture by air-lift suspending microcarriers, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 408-410.
80. de Boer JP, Teixeira de Mattos MJ, and Neijssel OM (1990), D(-)Lactic acid production by suspended and aggregated continuous cultures of Bacillus laevolacticus, Appl Microbiol Biotech 34, 149-153.
81. de Jong RJ, Breure AM, and van Andel JG (1991), Enhanced biodégradation of o-cresol by activated sludge in the presence of powdered activated carbon, Appl Microbiol Biotech 34,683-687.
82. Deckwer W-D (1985), Bubble column reactors, in Biotechnology, vol. 2, Rehm H-J and Reed G (eds), VCH, Weinheim, 445-464.
83. Deckwer W-D (1992), Bubble Column Reactors, John Wiley, New York.
84. Deckwer W-D and Schumpe A (1984), Transport phenomena in three-phase reactors with fiuidized solids, Ger Chem Eng 1, 168-177.
85. Deckwer W-D and Schumpe A (1987), Bubble columns—the state of the art and current trends, lnt Chem Eng 27,405-422.
86. Deckwer W-D and Schumpe A (1993), Improved tools for bubble column reactor design and scale-up, Chem Eng Sei 48, 889-911.
87. Deckwer W-D, Burckhart R, and Zoll G (1974), Mixing and mass transfer in tall bubble columns, Chem Eng Sei 29,2177-2188.
88. Dedek I (1990), Effect of bubbling regime and mode of mechanical agitation on the course of hydrogenation of vegetable oil, Coll Czech Chem Commun 55, 1721-1729.
89. Doran PM (1993), Design of reactors for plant cells and organs, Adv Bio-chem Eng Biotech 48, 115-168.
90. Douek RS and Livingsto AG (1994), Hydrodynamics and instability phenomena in an extemal-loop three phase air-lift (TPÄL) reactor, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 447-449.
91. Douek RS, Hewitt GF, and Livingston AG (1995), A hydrodynamic study of the riser zone in a three phase airlift (TPAL) reactor, Trans 1 Chem E, 73A, 336-340.
92. Dreveton E, Monot F, Lecourtier J, Ballerini D, and Choplin L (1996), Influence of fermentation hydrodynamics on gellan gum physico-chemical characteristics, J Ferment Bioeng, 82, 272-276.
93. Dunn IJ (1994), High-rate biofilm fiuidized bed reactors for specialized wastewater treatment, in Advances in Bioprocess Engineering, Galindo E and Ramirez OT (eds), Kluwer, Dordrecht, 365-378.
94. Fair JR, Lambright AJ, and Andersen JW (1962), Heat transfer and gas holdup in a sparged contactor, Ind Eng Chem Process Des Dev 1, 3336.
95. Ferschl A, Loidl M, Ditzelmüller G, Hinteregger C, and Streichsbier F (1991), Continuous degradation of 3-chloroaniline by calcium alginate-entrapped cells of Pseudomonas acidovorans CA28: Influence of additional substrates, Appl Microbiol Biotech 35, 544-550.
96. Fleishaker RJ and Sinskey AJ (1981), Oxygen demand and supply in cell culture, EurJ Appl Microbiol Biotechnol 12, 193-197.
97. Fouhy K (1992), Wastewater treatment reaches new heights, Chem Eng 99(12), 101-102.
98. Fraser RD and Hill GA (1993), Hydrodynamic characteristics of a spinning sparger, external loop airlift bioreactor, Can J Chem Eng 71,419-425.
99. Fraser RD, Ritchie BJ, and Hill GA (1994), Dynamic mixing and oxygen transfer in small, airlift loop bioreactors: Model and experimental verification, Biotech Prog 10, 543-547.
100. Fröhlich S, Lotz M, Korte T, Lübbert A, Schügerl K, and Seekamp M (1991a), Characterization of a pilot plant airlift tower loop reactor: I. Evaluation of the phase properties with model media, Biotech Bioeng 38,43-55.
101. Fröhlich S, Lotz M, Larson B, Lübbert A, Schügerl K, and Seekamp M (1991b), Characterization of a pilot plant airlift tower loop reactor: III. Evaluation of local properties of the dispersed gas phase during yeast cultivation and in model media, Biotech Bioeng 38, 56-64.
102. Ganzeveld KJ, Chisti Y, and Moo-Young M (1995), Hydrodynamic behaviour of animal cell microcarrier suspensions in split-cylinder airlift bioreactors, Bioproc Eng 12, 239-247.
103. García-Calvo E and Letón P (1996), Prediction of gas hold-up and liquid velocity in airlift reactors using two-phase flow friction coefficients, J Chem Tech Biotech 67, 388-396.
104. Gamier A, Chavarie C, Andre G, and Klvana D (1990), Inverse fluidization airlift bioreactor, part I: Hydrodynamic studies, Chem Eng Commun 98, 31-45.
105. Garrido F, Baneijee UC, Chisti Y, and Moo-Young M (1994), Disruption of a recombinant yeast for the release of P-galactosidase, Bioseparation 4, 319-328.
106. Garrido JM, van Benthum WAJ, van Loosdrecht MCM, and Heijnen JJ (1997), Influence of dissolved oxygen concentration on nitrite accumulation in a biofilm airlift suspension reactor, Biotech Bioeng 53, 168-178.
107. Gaspillo PD and Goto S (1991), Mass transfer in bubble slurry column with static mixer in draft tube, J Chem Eng Japan 24, 680-682.
108. Gavrilescu M and Tudose RZ (1995), Study of the liquid circulation velocity in extemal-loop airlift bioreactors, Bioproc Eng 14, 33-39.
109. Ghirardini M, Donati G, and Rivetti F (1992), Gas lift reactors: Hydrodynamics, mass transfer, and scale up, Chem Eng Sci 47, 2209-2214.
110. Ghosh TK and Bhattacharyya BC (1993), Effect of inlet oxygen concentration on continuous cultivation of baker’s yeast in a converging-diverging tube airlift fermentor, J Ferment Bioeng 76, 153-156.
111. Ghosh TK, Maiti BR, and Bhattachaiyya BC (1993a), Studies on mass transfer characteristics of a modified airlift fermenter, Bioproc Eng 9, 239-244.
112. Ghosh TK, Maiti BR, and Bhattacharyya BC (1993b), Gas hold-up in con-verging-diverging tube airlift fermenter, Biotech Techniques 7, 301-307.
113. Ghosh TK, Bhattacharyya BC, and Maiti BR (1994a), Residence time distribution in an external loop air-lift fermenter with a wavy riser, Indian Chem Eng, Section A, 36, 53-57.
114. Ghosh TK, Maiti BR, and Bhattacharyya BC (1994b), Performance characteristics of yeast growth in a modified airlift fermenter, Bioproc Eng 10,241-250.
115. Gjaltema A, Tijhuis L, van Loosdrecht MCM, and Heijnen JJ (1995), Detachment of biomass from suspended nongrowing spherical biofilms in airlift reactors, Biotech Bioeng 46,258-269.
116. Gjaltema A, Vinke JL, van Loosdrecht MCM, and Heijnen JJ (1997), Abrasion of suspended biofilm pellets in airlift reactors: Importance of shape, structure, and particle concentrations, Biotech Bioeng 53, 88-99.
117. Glasgow LA, Hua J, Yiin T-Y, Erickson LE (1992), Acoustic studies on interfacial effects in airlift reactors, Chem Eng Commun, 113, 155-181.
118. Glennon B, Al-Masry W, MacLoughlin PF, and Malone DM (1993), Hydrodynamic modelling in an air-lift loop reactor, Chem Eng Commun 121, 181-192.
119. Godbole SP, Schumpe A, Shah YT, and Carr NL (1984), Hydrodynamics and mass transfer in non-Newtonian solutions in a bubble column, AlChEJ 30,213-220.
120. Goto S and Gaspillo PD (1992), Effect of static mixer on mass transfer in draft tube bubble column and in external loop column, Chem Eng Sci 47, 3533-3539.
121. Goto S, Matsumoto Y, and Gaspillo P (1989), Mass transfer and reaction in bubble column slurry reactor with draft tube, Chem Eng Commun 85, 181-191.
122. Griffiths JB (1992), Animal cell culture processes-batch or continuous, J Biotech 22,21-30.
123. Giinzel B, Yonsel S, and Deckwer W-D (1991), Fermentative production of 1,3-propanediol from glycerol by Clostridium butyricum up to a scale of 2 m, Appl Microbiol Biotech 36, 289-294.
124. Guo Y, Lou F, Peng Z-Y, Yuan Z-Y, and Korus RA (1990), Kinetics of growth and a-amylase production of immobilized Bacillus subtilis in an airlift bioreactor, Biotech Bioeng 35, 99-102.
125. Hamada T, Ishiyama T, and Motai H (1989), Continuous fermentation of soy sauce by immobilized cells of Zygosaccharomyces rouxii in an airlift reactor, Appl Microbiol Biotech 31, 346-350.
126. Hamada T, Sugishita M, Fukushima Y, Fukase T, and Motai H (1991), Continuous production of soy sauce by a bioreactor system, Process Biochem 26, 39-45.
127. Hano T, Matsumoto M, Kuribayashi K, and Hatate Y (1992), Biological nitrogen removal in a bubble column with a draught tube, Chem Eng Sci 47, 3737-3744.
128. Haque MW, Nigam KDP, and Joshi JB (1986), Hydrodynamics and mixing in highly viscous pseudo-plastic non-newtonian solutions in bubble columns, Chem Eng Sci 41, 2321 -2331.
129. Heck J and Onken U (1986), Hysterese-Effekte beim Suspendieren von Feststoffpartikeln in Blasensaule und Airlift-Schlaufenreaktor, Chem-Ing-Tech 58, 131-133.
130. Heck J and Onken U (1987), Hysteresis effects in suspended solid particles in bubble columns with and without draft tube, Chem Eng Sci 42, 1211-1212.
131. Heck J and Onken U (1988), Einfluss der Partikelform auf die Feststoffsuspendierung in Blasensaule und Airlift-Schlaufenreaktor, Chem-Ing-Tech 60,400-401.
132. Hegarty PK, Smart NJ, Scragg AH, and Fowler MW (1986), Aeration of C. roseus L. G. Don suspension cultures in airlift bioreactors: The inhibitory effect at high aeration rates on culture growth, J Exp Bot 37, 1911-1920.
133. Heijnen SJ, Mulder A, Weltevrede R, Hols PH, and van Leeuwen HUM (1990), Large-scale anaerobic/aerobic treatment of complex industrial wastewater using immobilized biomass in fluidized bed and air-lift suspension reactors, Chem Eng Tech 13,202-208.
134. Heijnen JJ, van Loosdrecht MCM, Mulder A, and Tijhuis L (1992), Formation of biofilms in a biofilm air-lift suspension reactor, Wat Sei Tech 26, 647-654.
135. Highfill JG, Haley SD, and Kompala DS (1996), Large-scale production of murine bone marrow cells in an airlift packed bed bioreactor, Biotech Bioeng 50, 514-520.
136. Hikita H, Asai S, Tanigawa K, Segawa K, and Kitao M (1980), Gas hold-up in bubble columns, Chem Eng J 20, 59-67.
137. Hills JH (1976), Operation of a bubble column at high throughputs I: Gas holdup measurements, Chem Eng J12, 89-99.
138. Hong YC, Labuza TP, and Harlander SK (1989), Growth kinetics of strawberry cell suspension cultures in shake flask, airlift, stirred-jar, and roller bottle bioreactors, Biotech Prog 5, 137-143.
139. Hopf NW, Yonsel S, and Deckwer W-D (1990), Ambruticin S production in air-lift and stirred tank bioreactors, Appl Microbiol Biotech 34, 350-353.
140. Hsiun D-Y and Wu W-T (1995), Mass transfer and liquid mixing in an airlift reactor with a net draft tube, Bioproc Eng 12, 221-225.
141. Hüppe P, Höke H, and Hempel DC (1990), Biological treatment of effluents from a coal tar refinery using immobilized biomass, Chem Eng Tech 13, 73-79.
142. Husemann W (1982), Photoautotrophic growth of cell suspension cultures from Chenopodium rubrum in an airlift reactor, Protoplasma 113, 214-220.
143. Ichii T, Takehara S, Konno H, Ishida T, Sato H, Suzuki A, and Yamazumi K (1993), Development of a new commercial-scale airlift fermentor for rapid growth of yeast, J Ferment Bioeng 75, 375-379.
144. Immich M and Onken U (1992), Prediction of minimum gas velocity in suspended bubble columns and airlift reactors, Chem Eng Sei 47, 3379-3386.
145. Jadhav SV and Pangarkar VG (1988), Particle-liquid mass transfer in three phase sparged reactor, Can J Chem Eng 66, 572-578.
146. Jäger AG and Wandrey C (1990), Immobilization of basidiomycete Phan-erochaete chrysosporium on sintered glass: Production of lignin peroxidase, in Physiology of Immobilized Cells, de Bont JAM, Vissert J, Mat-tiasson B, and Tramper J (eds), Elsevier, Amsterdam, 433-438.
147. Janssen AJH, Sleyster R, van der Kaa C, Jochemsen A, Bontsema J, and Lettinga G (1995), Biological sulphide oxidation in a fed-batch reactor, Biotech Bioeng 47, 327-333.
148. Jones AJ (1985), Liquid circulation in a draft-tube bubble column, Chem Eng Sei 40, 449-462.
149. Jong J-Z, Hsiun D-Y, Wu W-T, and Tzeng Y-M (1995), Fed-batch culture of Bacillus thuringiensis for thuringiensin production in a tower type bioreactor, Biotech Bioeng 48, 207-213.
150. Joshi JB, Ranade VV, Gharat SD, and Leie SS (1990), Sparged loop reactors, Can J Chem Eng 68, 705-741.
151. Karamanev DG, Nagamune T, and Endo I (1992), Hydrodynamic and mass transfer study of a gas-liquid-solid draft tube spouted bed bioreactor, Chem Eng Sei 47, 3581-3588.
152. Karamanev DG, Chavarie C, and Samson R (1996), Hydrodynamics and mass transfer in an airlift reactor with a semipermeable draft tube, Chem Eng Sei Si, 1173-1176.
153. Kato A, Kawazoe S, Iijima M, and Shimizu Y (1976), Continuous culture of tobacco cells, J Ferment Tech 54, 82-87.
154. Kautola H (1990), Itaconic acid production from xylose in repeated-batch and continuous bioreactors, Appl Microbiol Biotech 33, 7-11.
155. Kautola H, Rymowicz W, Linko Y-Y, and Linko P (1991), Production of citric acid with immobilized Yarrowia lipolytica, Appl Microbiol Biotech 35,447-449.
156. Kawasaki H, Hirano H, and Tanaka H (1994), Effects of multiple draft tubes with perforated plates on gas holdup and volumetric mass transfer coefficient in a bubble column, J Chem Eng Japan 27, 669-670.
157. Kawase Y (1990), Liquid circulation in extemal-loop airlift bioreactors, Biotechnol Bioeng 35, 540-546.
158. Kawase Y (1994), Design and scale-up of extemal-loop airlift bioreactor, in Advances in Bioprocess Engineering, Galindo E and Ramirez OT (eds), Kluwer, Dordrecht, 13-19.
159. Kawase Y and Moo-Young M (1986), Influence of non-newtonian flow behaviour on mass transfer in bubble columns with and without draft tubes, Chem Eng Commun 40, 67-83.
160. Kawase Y and Moo-Young M (1987), Theoretical prediction of gas hold-up in bubble columns with newtonian and non-newtonian fluids, Ind Eng Chem Res 26, 933-937.
161. Kawase Y and Moo-Young M (1989), Mixing time in bioreactors, J Chem Tech Biotech 44, 63-75.
162. Kawase Y and Moo-Young M (1990), Mathematical models for design of bioreactors: Applications of Kolmogoroff s theory of isotropic turbulence, Chem Eng J AS, B19-B41.
163. Kawase Y, Omori N, and Tsujimura M (1994), Liquid-phase mixing in extemal-loop airlift bioreactors, J Chem Tech Biotech 61, 49-55.
164. Kawase Y, Tsujimura M, and Yamaguchi T (1995), Gas hold-up in exter-nal-loop airlift bioreactors, Bioproc Eng 12, 21-27.
165. Kelkar BG, Phulgaonkar SR, and Shah YT (1983), Effects of electrolyte solutions on hydrodynamic and backmixing characteristics in bubble columns, Chem EngJ 27, 125-133.
166. Kemblowski Z, Przywarski J, and Diab A (1993), Average gas hold-up and liquid circulation velocity in airlift reactors with external loop, Chem Eng Sci 48,4023-4035.
167. Keshavarz T, Eglin R, Walker E, Bucke C, Holt G, Bull AT, and Lilly MD (1990), Large-scale immobilization of Penicillium chrysogenum: Batch and continuous operation in an air-lift reactor, Biotech Bioeng 36, 763-770.
168. Kikuchi K-I, Takahashi H, and Takeda Y (1995), Measurement of local residence time of particles in a draft-tube slurry bubble column using magnetic tracer particles, J Chem Eng Japan 28, 483-486.
169. Koch B, Ostermann M, Hoke H, and Hempel D-C (1991), Sand and activated carbon as biofilm carriers for microbial degradation of phenols and nitrogen-containing aromatic compounds, Wat Res 25, 1-8.
170. Koide K, Sato H, and Iwamoto S (1983a), Gas holdup and volumetric liquid-phase mass transfer coefficient in bubble column with draught tube and with gas dispersion into annulus, J Chem Eng Japan 16, 407-413.
171. Koide K, Kurematsu K, Iwamoto S, Iwata Y, and Horibe K (1983b), Gas holdup and volumetric liquid-phase mass transfer coefficient in bubble column with draught tube and with gas dispersion into tube, J Chem Eng Japan 16,413-419.
172. Koide K, Iwamoto S, Takasaka Y, Matsuura S, Takahashi E, Kimura M, and Kubota H (1984a), Liquid circulation, gas holdup and pressure drop in bubble column with draught tube, J Chem Eng Japan 17, 611-618.
173. Koide K, Horibe K, Kawabata H, and Ito S (1984b), Critical gas velocity required for complete suspension of solid particles in solid-suspended bubble column with draught tube, J Chem Eng Japan 17, 368-374.
174. Koide K, Horibe K, Kitaguchi H, and Suzuki N (1984c), Contributions of annulus and draught tube to gas-liquid mass transfer in bubble columns with draught tube, J Chem Eng Japan 17, 547-549.
175. Koide K, Horibe K, Kawabata H, and Ito S (1985), Gas holdup and volumetric liquid-phase mass transfer coefficient in solid-suspended bubble column with draught tube, J Chem Eng Japan 18, 248-254.
176. Koide K, Terasawa M, and Takekawa H (1986), Critical gas velocity required for complete suspension of multicomponent solid particle mixture in solid-suspended bubble columns with and without draught tube, J Chem Eng Japan 19, 341 -344.
177. Koide K, Kimura M, Nitta H, and Kawabata H (1988), Liquid circulation in bubble column with draught tube, J Chem Eng Japan 21, 393-399.
178. Koide K, Shibata K, Ito H, Kim SY, and Ohtaguchi K (1992), Gas holdup and volumetric liquid-phase mass transfer coefficient in a gel-particle suspended bubble column with draught tube, J Chem Eng Japan 25, 1116.
179. Kracke-Helm HA, Rinas U, Hitzmann B, and Schilgerl K (1991), Cultivation of recombinant E. coli and production of fusion protein in 60-1 bubble column and airlift tower loop reactors, Enzyme Microb Tech 13, 554-564.
180. Kramer HW and Bailey JE (1991), Mass transfer characterization of an airlift probe for oxygenation and mixing cell suspensions in an NMR spectrophotometer, Biotech Bioeng 37, 205-209.
181. Kumar A and Shuler ML (1995), Model of a split-flow airlift bioreactor for attachment-dependent, baculovirus-infected insect cells, Biotech Prog 11,412-419.
182. Kushalkar KB and Pangarkar VG (1994), Particle-liquid mass transfer in a bubble column with a draft tube, Chem Eng Sci 49, 139-144.
183. Kwong C-W, Hsieh J-H, Syu M-J, and Chou S-S (1989), Anti-hepatitis B surface antigen monoclonal antibody IgM production in suspension and immobilized cell bioreactors, Biotech Lett 11, 377-382.
184. Laugero C, Sigoillot J-C, Moukha S, Frasse P, Bellon-Fontaine M-N, Bonnarme P, Mougin C, and Asther M (1996), Selective hyperproduction of manganese peroxidases by Phanerochaete chrysosporium 1-1512 immobilized on nylon net in a bubble-column reactor, Appl Microbiol Biotech 44, 717-723.
185. Lemcoff NO, Pereira Duarte SI, and Martinez OM (1990), Heat transfer in packed beds, Rev in Chem Eng 6, 229-292.
186. Li G-Q, Yang S-Z, Cai Z-L, and Chen J-Y (1993), Liquid phase axial backmixing in an airlift bioreactor with non-newtonian fluids, Chem Eng Commun 125, 13-26.
187. Li G-Q, Yang S-Z, Cai Z-L, and Chen J-Y (1995), Mass transfer and gasliquid circulation in an airlift bioreactor with viscous non-Newtonian fluids, Chem Eng J 56, B101-B107.
188. Linko S (1992), Production of Phanerochaete chrysosporium lignin peroxidase, Biotech Adv 10, 191-236.
189. Livingston AG and Zhang SF (1993), Hydrodynamic behaviour of three-phase (gas-liquid-solid) airlift reactors, Chem Eng Sei 48, 1641-1654.
190. Lu W-J, Hwang S-J, and Chang C-M (1993), Liquid mixing in two- and three-phase airlift reactors, Paper 706 presented at the AIChE 1993 Summer Natl Meeting, Seattle, Aug 15-18.
191. Lu W-J, Hwang S-J, and Chang C-M (1994), Liquid mixing in internal loop airlift reactors, lnd Eng Chem Res 33, 2180-2186.
192. Lu W-J, Hwang S-J, and Chang C-M (1995), Liquid velocity and gas holdup in three-phase internal loop airlift reactors with low-density particles, Chem Eng Sei 30, 1301-1310.
193. Lübbert A and Larson B (1990), Detailed investigations of the multiphase flow in airlift tower loop reactors, Chem Eng Sei 45, 3047-3053.
194. Lübbert A, Larson B, Wan LW, and Bröring S (1990), Local mixing behaviour of airlift multiphase chemical reactors, I Chem E Symp Ser 121, 203-213.
195. Maiorella B, Inlow D, Shauger A, and Harano D (1988), Large-scale insect cell-culture for recombinant protein production, Biotech 6, 1406-1410.
196. Mao HH, Chisti Y, and Moo-Young M (1992), Multiphase hydrodynamics and solid-liquid mass transport in an extemal-loop airlift reactor—A comparative study, Chem Eng Commun 113, 1-13.
197. Matthijs HCP, Balke H, Van Hes UM, Kroon BMA, Mur LR, and Binot RA (1996), Application of light-emitting diodes in bioreactors: Flashing light effects and energy economy in algal culture (Chlorella pyrenoi-dosa), Biotech Bioeng 50, 98-107.
198. Merchuk JC (1986), Hydrodynamics and hold-up in air-lift reactors, in Encyclopedia of Fluid Mechanics, Cheremisinoff NP ed, vol 3, Gulf Publ, Houston, 1485-1511.
199. Merchuk JC and Berzin I (1995), Distribution of energy dissipation in airlift reactors, Chem Eng Sei 50, 2225-2233.
200. Messing RA ed (1975), Immobilized Enzymes for Industrial Reactors, Academic Press, New York.
201. Metkin VP and Sokolov VN (1982), Hydraulic resistance to flow of gasliquid mixtures having non-Newtonian properties, J Appl Chem USSR 55, 558-563.
202. Miller WM, Wilke CR, and Blanch HW (1987), Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture, J Cell Physiol, 132, 524-530.
203. Miyahara T, Hamaguchi M, Sukeda Y, and Takehashi T (1986), Size of bubbles and liquid circulation in a bubble column with draught tube and sieve plate, Can J Chem Eng 64, 718-725.
204. Mojovic L, Siler-Marinkovic S, Kukic G, Bugarski B, and Vunjak-Novako-vic G (1994), Rhizopus arrhizus lipase-catalysed interesterification of palm oil midfraction in a gas-lift reactor, Enzyme Microb Tech 16, 159-162.
205. Molina Grima E, Sánchez Pérez JA, García Camacho F, García Sánchez JL, Acién Fernández FG, and López Alonso D (1994), Outdoor culture of Isochrysis galbana ALU-4 in a closed tubular photobioreactor, J Biotech 31, 159-166.
206. Molina Grima E, Sánchez Pérez JA, Garcia Camacho F, Fernández Sevilla JM, Acién Fernández FG, and Urda Cardona J (1995), Biomass and icosapentaenoic acid productivities from an outdoor batch culture of Phaeodactylum tricornutum UTEX 640 in an airlift tubular photobioreactor, Appl Microbiol Biotech 42, 658-663.
207. Molina Grima E, Chisti Y, and Moo-Young M (1997), Characterization of shear rates in airlift bioreactors for animal cell culture, J Biotech 54, 195-210.
208. Moo-Young M and Chisti Y (1988), Considerations for designing bioreactors for shear-sensitive culture, Biotech 6(11), 1291-1296.
209. Moo-Young M and Chisti Y (1994), Bioreactor applications in waste treatment, Res Cons Recycl 11,13-24.
210. Moo-Young M, Halard B, Allen DG, Burrell R, and Kawase Y (1987), Oxygen transfer to mycelial fermentation broths in an airlift fermentor, Biotech Bioeng 30, 746-753.
211. Moo-Young M, Chisti Y, and Vlach D (1994), Fermentation of cellulosic materials to mycoprotein foods, Biotechnol Adv, 11,469-479.
212. Mota MJ and Teixeira JA (1990), Utilization of an external loop bioreactor for the isolation of a flocculating strain of Kluyveromyces marxianus, Curr Microbiol 20, 209-214.
213. Murakami S, Chiou T-W, and Wang DIC (1991), A fibre-bed bioreactor for anchorage-dependent animal cell cultures: Part II. Scaleup potential, Biotech Bioeng 37, 762-769.
214. Murdin AD, Thorpe JS, Kirkby N, Groves DJ, and Spier RE (1987), Immobilization and growth of hybridomas in packed beds, in Bioreactors and Biotransformations, Moody GW and Baker PB (eds), Elsevier, London, 99-110.
215. Murhammer DW and Goochee CF (1988), Scaleup of insect cell cultures: Protective effects of Pluronic F-68, Biotech 6, 1411-1418.
216. Murhammer DW and Goochee CF (1990), Sparged animal cell bioreactors: Mechanism of cell damage and Pluronic F-68 protection, Biotech Prog 6,391-397.
217. Nishii K, Sode K, and Karube I (1989), Microbial conversion of dihy-drooxoisophorone (DOIP) to 4-hydroxy-2,2,6-trimethylcyclohexanone (4-HTMCH) by thermophilic bacteria, J Biotech 9, 117-128.
218. Nishikawa M, Kato H, and Hashimoto K (1977), Heat transfer in aerated tower filled with non-Newtonian liquid, lnd Eng Chem Process Des Develop 16, 133-137.
219. Ohashi H, Sugawara T, and Kikuchi K (1981), Mass transfer between particles and liquid in solid-liquid two-phase upflow in the low-velocity region through vertical tubes, J Chem Eng Japan 14, 489-491.
220. Ohashi H, Sugawara T, Kikuchi K, and Takeda M (1982), Mass transfer between particles and liquid in solid-liquid two-phase flow through horizontal tubes, J Chem Eng Japan 15, 311-313.
221. Okada K, Shibano S, and Akagi Y (1993), Turbulent properties in bubble-flow region in extemal-loop airlift bubble column, J Chem Eng Japan 26, 637-643.
222. Onken U and Weiland P (1983), Airlift fermenters: Construction behaviour and uses, in Mizrahi A and van Werzel L (eds), Advances in Biotechnological Processes, vol. 1, Liss, New York, 67-95.
223. Opie R (1993), Repeat order, World Water and Environmental Engineer, Jan/Feb, pp 16-17.
224. Ouyoung PK, Chisti Y, and Moo-Young M (1989), Heat transfer in airlift reactors, Trans I Chem E 67, 451-456.
225. Papoutsakis ET (1991), Fluid-mechanical damage of animal cells in bioreactors, Trends Biotech 9,427-437.
226. Park YS, Ohta N, and Okabe M (1994), Neomycin production by partial immobilization Streptomyces fradiae on cellulose beads in an air-lift bioreactor, J Ferment Bioeng 78,265-268.
227. Pavlica RT and Olson JH (1970), Unified design method for continuous-contact mass transfer operations, lnd Eng Chem 62(72), 45-48.
228. Petrovic D, Posarac D, and Skala D (1989), Hysteresis effects of minimum fluidization velocity in a draft tube airlift reactor, Chem Eng Sci 44, 996-998.
229. Petrovic DL, Posarac D, Dudukovic A, and Skala D (1990), Mixing time in gas-liquid-solid draft tube airlift reactors, Chem Eng Sci 45,2967-2970.
230. Petrovic DL, Posarac D, Dudukovic A, and Skala D (1991), Hydrodynamics and mass transfer in a draft tube bubble column, J Serb Chem Soc 56, 227-240.
231. Petrovic DL, Posarac D, Dudukovic A, and Skala D (1993), Minimum fluidization velocity of large particles in a draft tube airlift reactor, Chem Eng Sci 48,2663-2667.
232. Petrovic DL, Posarac D, and Dudukovic A (1995), Prediction of mixing time in airlift reactors, Chem Eng Commun 133, 1-9.
233. Pigache S, Trystram G, and Dhoms P (1992), Oxygen transfer modeling and simulations for an industrial continuous airlift fermentor, Biotech Bioeng 39, 923-931.
234. Pollard DJ, Ison AP, Ayazi Shamlou P, and Lilly MD (1994), Examination of bioreactor heterogeneity with Theological different fermentation broths, in Advances in Bioprocess Engineering, Galindo E and Ramirez OT (eds), Kluwer, Dordrecht, 163-170.
235. Posarac D and Petrovic D (1988), Experimental study of the minimum fluidization velocity in a three-phase extemal-loop air-lift reactor, Chem Eng Sci 43, 1161-1165.
236. Posarac D and Petrovic DL (1991), Prediction of the gas holdup and liquid recirculation velocity in an external loop airlift reactor, J Serb Chem Soc 56,359-369.
237. Potucek F (1990), Specific interfacial area in an airlift tower reactor, Coll Czech Chem Commun 55, 981 -986.
238. Redman J (1987), Deep shaft treatment for sewage, Chem Eng (Lond) 441, 12-13.
239. Reinhard E, Kreis W, Barthlen U, and Helmbold U (1989), Semicontinuous cultivation of Digitalis lanata cells: Production of p-methyldigoxin in a 300-L airlift bioreactor, Biotech Bioeng 34, 502-508.
240. Reuss M, Debus D, and Zoll G (1982), Rheological properties of fermentation fluids, Chem Eng (Lond) 381, 233-236.
241. Reuveny S (1990), Microcarrier culture systems, in Large-Scale Mammalian Cell Culture Technology, Lubiniecki AS (ed), Marcel Dekker, New York, 271-341.
242. Rhodes M and Birch J (1988), Large-scale production of proteins from mammalian cells, Biotech 6, 518-523.
243. Ritchie BJ and Hill GA (1995), Biodégradation of phenol-polluted air using an extemal-loop airlift bioreactor, J Chem Techn Biotech 62, 339-344.
244. Roca E, Ghommidh C, Navarro JM, and Lema JM (1995), Hydraulic model of a gas-lift bioreactor with flocculating yeast, Bioproc Eng 12, 269-272.
245. Rodriguez-Mendiola MA, Stafford A, Cresswell R, and Arias-Castro C (1991), Bioreactors for growth of plant roots, Enzyme Microb Tech 13, 697-702.
246. Roy PK, Khan AW, Kumar J, Chopra SDK, and Basu SK (1992), Steroid transformation in a laboratory-scale glass air-lift fermenter, World J Microbiol Biotech 8, 399-401.
247. Rüffer HM, Wan L, Lilbbert A, and Schügerl K (1994), Interpretation of gas residence time distributions in large airlift tower loop reactors, Bioproc Eng 11, 153-159.
248. Rüffer HM, Bröring S, and Schügerl K (1995), Fluiddynamic characterization of airlift tower loop bioreactors with and without motionless mixtures, Bioproc Eng 12, 119-130.
249. Russell AB, Thomas CR, and Lilly MD (1994), Influence of vessel height and top-section size on the hydrodynamic characteristics of airlift fermentors, Biotech Bioeng 43, 69-76.
250. Russell AB, Thomas CR, and Lilly MD (1995), Oxygen transfer measurements during yeast fermentations in a pilot scale airlift fermenter, Bioproc Eng 12, 71-79.
251. Sajc L, Vunjak-Novakovic G, Grubisic D, Kovacevic N, Vukovic D, and Bugarski B (1995a), Production of anthraquinones by immobilized Frangula alnus Mill, plant cells in a four-phase air-lift bioreactor, Appl Microbiol Biotech 43, 416-423.
252. Sajc L, Obradovic B, Vukovic D, Bügarski B, Grubisic D, and Vunjak-Novakovic G (1995b), Hydrodynamic and mass transfer in a four-phase external loop air lift bioreactor, Biotech Prog 11, 420-428.
253. Sano Y, Yamaguchi N, and Adachi T (1974), Mass transfer coefficients for suspended particles in agitated vessels and bubble columns, J Chem Eng Japan 7, 255-261.
254. Schmidt J, Nassar R, and Lübbert A (1992), Influence of the wakes in bubble driven multiphase flow systems, Chem Eng Sci 47,2295-2300.
255. Schorr-Galindo S, Ghommidh C, and Guiraud JP (1995), Inulin enrichment by fermentation in a flocculating yeast reactor, Biotech Lett 17, 1305-1310.
256. Schügerl K (1990), Comparison of the performance of stirred tank and airlift tower loop reactors, J Biotech 13, 251 -256.
257. Schügerl K, Lücke J, and Oels U (1977), Bubble column bioreactors, Adv Biochem Eng 7, 1 -84.
258. Schumpe A and Deckwer W-D (1987), Viscous media in tower bioreactors: Hydrodynamic characteristics and mass transfer properties, Bioproc Eng 2, 79-94.
259. Scragg AH, Cresswell RC, Ashton S, York A, Bond PA, and Fowler MW (1989), Growth and alkaloid production in bioreactors by a selected Catharanthus roseus cell line. Enzyme Microb Tech 11, 329-333.
260. Sharp JM and Doran PM (1990), Characteristics of growth and tropane alkaloid synthesis in Atropa belladonna roots transformed by Agrobacterium rhizogenes, J Biotech 16, 171-186.
261. Shah YT (1979), Gas-Liquid Solid Reactor Design, McGraw-Hill, New York, 351.
262. Shah YT, Kelkar BG, Godbole SP, and Deckwer W-D (1982), Design parameter estimations for bubble column reactors, AIChE J, 28, 353-379.
263. Shetty SA, Kantak MV, and Kelkar BG (1992), Gas-phase backmixing in bubble-column reactors, AIChE J 38, 1013-1026.
264. Shi LK, Riba JP, and Angelino H (1990), Estimation of effective shear rate for aerated non-Newtonian liquids in airlift bioreactor, Chem Eng Commun 89, 25-35.
265. Smart NJ and Fowler MW (1984), An airlift column bioreactor suitable for large scale cultivation of plant cell suspensions, J Exp Bot 35, 531 -537.
266. Smith BC and Skidmore DR (1990), Mass transfer phenomena in an airlift reactor: Effects of solids loading and temperature, Biotech Bioeng 35, 483-491.
267. Snape JB and Thomas NH (1992), Modeling of particle transport by bubbles for performance guidelines in airlift fermentors, Biotechnol Bioeng 40, 337-345.
268. Snape JB, Fialova M, Zahradnik J, and Thomas NH (1992), Hydrodynamic studies in an external loop airlift reactor containing aqueous electrolyte and sugar solutions, Chem Eng Sci 47, 3387-3394.
269. Sokolichin A and Eigenberger G (1994), Gas-liquid flow in bubble columns and loop reactors: Part I. Detailed modelling and numerical simulation, Chem Eng Sci 49, 5735-5746.
270. Sokolov VN and Metkin VP (1981), Turbulent flow of pseudoplastic liquids in tubes, Zh Prikl Khim, 54, 1321-1326; J Appl Chem USSR 54, 1103-1107.
271. Spieler H, Alfermann W, and Reinhard E (1985), Biotransformation of ß-methyldigitoxin by cell cultures of Digitalis lanata in airlift and stirred tank reactors, Appl Microbiol Biotech 23, 1-4.
272. Spier RE and Whiteside JP (1976), Production of foot-and-mouth disease virus from BHK 21 C 13 cells grown on the surface of glass spheres, Biotech Bioeng 18, 649-657.
273. Srivastava P and Kundu S (1995), Laboratory air lift bioreactor for cepha-losporin-C production using Cephalosporium acremonium, Indian Chem Eng, Section A, 37, 136-139.
274. Stasinopoulos SJ and Seviour RJ (1992), Exopolysaccharide production by Acremonium persicinum in stirred-tank and air-lift fermentors, Appl Microbiol Biotech 36,465-468.
275. Stejskal J and Potucek F (1985), Oxygen transfer in liquids, Biotechnol Bioeng 27, 503-508.
276. Steiner R (1987), Operating characteristics of special bubble column reactors, Chem Eng Process 21, 1-8.
277. Suh I-S, Schumpe A, Deckwer W-D, and Kulicke W-M (1991), Gas-liquid mass transfer in the bubble column with viscoelastic liquid, Can J Chem Eng 69, 506-512.
278. Suh I-S, Schumpe A, and Deckwer W-D (1992), Xanthan production in bubble column and air-lift reactors, Biotech Bioeng 39, 85-94.
279. Sukan SS and Vardar-Sukan F (1987), Mixing performance of air-lift fermenters against working volume and draft tube dimensions, Bioproc Eng 2, 33-38.
280. Suzuki T, Matsuo T, Ohtaguchi K, and Koide K (1995), Gas-sparged bioreactors for CO2 fixation by Dunaliella tertiolecta, J Chem Tech Biotech 62,351-358.
281. Svendsen HF, Jakobsen HA, and Torvik R (1992), Local flow structures in internal loop and bubble column reactors, Chem Eng Sci 47, 3297-3304.
282. Tan WS, Dai GC, Ye W, and Shen JP (1995), Local flow behavior of the liquid phase in an airlift bioreactor for potential use in animal cell suspension cultures, Chem Eng J 57, B31-B36.
283. Tijhuis L, Zwols H, van Meekeren K-H, van Loosdrecht MCM, and Heijnen JJ (1994a), Dynamics of biofilm formation on small suspended particles in airlift reactors, in Progress in Biotechnology, voi 9, Proc of 6th European Congress on Biotechnology, Alberghina L, Frontali L, and Sensi P (eds), Elsevier, Amsterdam, 953-956.
284. Tijhuis L, van Benthum WAJ, van Loosdrecht MCM, and Heijnen JJ (1994b), Solids retention time in spherical biofilms in a biofilm airlift suspension reactor, Biotech Bioeng 44, 867-879.
285. Tijhuis L, van Loosdrecht MCM, and Heijnen JJ (1994c), Formation and growth of heterotrophic aerobic biofilms on small suspended particles in airlift reactors, Biotech Bioeng 44, 595-608.
286. Tijhuis L, Huisman JL, Hekkelman HD, van Loosdrecht MCM, and Heijnen JJ (1995a), Formation of nitrifying biofilms on small suspended particles in airlift reactors, Biotech Bioeng 47, 585-595.
287. Tijhuis L, van Loosdrecht MCM, and Heijnen JJ (1995b), Dynamics of biofilm detachment in biofilm airlift suspension reactors, Biotech Bioeng 45,481-487.
288. Townsley PM and Webster F (1983), Recycling airlift transfer fermenter for plant cells, Biotechnol Let, 5, 13-18.
289. Trilleros JA and Recio A (1990), Mixing phenomena in airlift loop reactors, I Chem E Symp Ser 121, 215-239.
290. Tyagi RD, Couillard D and Tran FT (1991), Comparative study of bacterial leaching of metals from sewage sludge in continuous stirred tank and air-lift reactors, Process Biochem 26, 47-54.
291. Tzeng Y-M and Young Y-H (1996), Production of thuringiensin from Bacillus thuringiensis using a net-draft-tube, modified airlift reactor, World J Microbiol Biotech 12, 32-37.
292. Ulonska A, Deckwer W-D, and Hecht V (1995), Degradation of quinoline by immobilized Comamonas acidovorans in a three-phase airlift reactor, Biotech Bioeng 46, 80-87.
293. van Benthum WAJ, Garrido-Femändez JM, Tijhuis L, van Loosdrecht MCM, and Heijnen JJ (1996), Formation and detachment of biofilms and granules in a nitrifying biofilm airlift suspension reactor, Biotech Prog 12, 764-772.
294. van Houten R, Hulshoff Pol LW, and Lettinga G (1994), Biological sulphate reduction using gas-lift reactors fed with hydrogen and carbon dioxide as energy and carbon source, Biotech Bioeng 44, 586-594.
295. van Loosdrecht MCM and Heijnen SJ (1993), Biofilm bioreactors for waste-water treatment, Trends Biotech 11, 117-121.
296. van Sonsbeek HM, Verlaan P, and Tramper J (1990a), Hydrodynamics, mixing and oxygen transfer in liquid-impelled loop reactors, I Chem E Symp Ser 121,259-268.
297. van Sonsbeek HM, Verdurmen REM, Verlaan P, and Tramper J (1990b), Hydrodynamic model for liquid-impelled loop reactors, Biotech Bioeng 36, 940-946.
298. van Sonsbeek HM, van der Tuin SP, and Tramper J (1992), Mixing in liquid-impelled loop reactors, Biotech Bioeng 39,707-716.
299. Verlaan P, Tramper J, Van’t Riet K, and Luyben KChAM (1986), Hydrodynamic model for an airlift-loop bioreactor with external loop, Chem EngJ 33, B43-B53.
300. Verlaan P, Vos J-C, and van’t Riet K (1989a), Axial dispersion and oxygen transfer in the transition from bubble column to an airlift-loop reactor, J Chem Tech Biotech 45, 181-190.
301. Verlaan P, Vos J-C, and van’t Riet K (1989b), Hydrodynamics of the flow transition from a bubble column to an airlift-loop reactor, J Chem Tech Biotech 45, 109-121.
302. Verlaan P, Van Eijs AMM, Tramper J, Van’t Riet K, and Luyben KChAM (1989c), Estimation of axial dispersion in individual sections of an airlift-loop reactor, Chem Eng Sci 44, 1139-1146.
303. Vicente AA and Teixeira JA (1995), Hydrodynamic performance of a three-phase airlift bioreactor with an enlarged degassing zone, Bioproc Eng 14, 17-22.
304. Vilchez C and Vega JM (1995), Nitrate uptake by immobilized Chlamydo-monas reinhardtii cells growing in airlift reactors, Enzyme Microb Tech 17,386-390.
305. Wachi S, Jones AG, and Elson TP (1991), Flow dynamics in a draft-tube bubble column using various liquids, Chem Eng Sci 46, 657-663.
306. Wagner K and Hempel DC (1988), Biodégradation by immobilized bacteria in an airlift-loop reactor—Influence of biofilm diffusion limitation, Biotech Bioeng 31, 559-566.
307. Weiland P (1984), Influence of draft tube diameter on operation behaviour of airlift loop reactors, Ger Chem Eng 7, 374-385.
308. Wenge F, Chisti Y, and Moo-Young M (1995), New method for the measurement of solids holdup in gas-liquid-solid three-phase systems, Ind Eng Chem Res 34, 928-935.
309. Wenge F, Chisti Y, and Moo-Young M (1996), Split-cylinder airlift reactors: Hydraulics and hydrodynamics of a new mode of operation, Chem Eng Commun 155, 19-44.
310. Whiteside JP and Spier RE (1981), Scale-up from 0.1 to 100 liter of a unit process system based on 3-mm-diameter glass spheres for the production of four strains of FMDV from BHK monolayer cells, Biotech Bioeng IS, 551-556.
311. Whitney PJ (1992), Novel bioreactors for the growth of roots transformed by Agrobacterium rhizogenes, Enzyme Microb Tech 14, 13-17.
312. Winkler MA (1981), Biological Treatment o/Waste-Water, Ellis Horwood, Chichester, 146-163.
313. Wöhler W, Rüdiger HW, and Passarge E (1972), Large scale culturing of normal diploid cells on glass beads using a novel type of culture vessel, Exptl Cell Res 74,571-573.
314. Wu J, King G, Daugulis AJ, Faulkner P, Bone DH, Goosen MFA (1990), Adaptation of insect cells to suspension culture, J Ferment Bioeng 70, 90-93.
315. Wu J-T and Jong J-Z (1994), Liquid-phase dispersion in an airlift reactor with a net draft tube, Bioproc Eng 11, 43-47.
316. Wu J-Y and Wu W-T (1991), Fed-batch culture of Saccharomyces cere-visiae in an airlift reactor with net draft tube, Biotech Prog 7, 230-233.
317. Wu J-Y and Wu W-T (1992), Glutamic acid production in an airlift reactor with net draft tube, Bioproc Eng 8, 183-187.
318. Wu W-T and Wu J-Y (1990), Airlift reactor with net draught tube, J Ferment Bioeng 70,359-361.
319. Wu W-T, Wu J-Y, and Jong J-Z (1992), Mass transfer in an airlift reactor with a net draft tube, Biotech Prog 8, 465-468.
320. Yamashita F (1993), Effects of partition plates on gas holdup in a bubble column with and without a draught tube, J Chem Eng Japan 26, 742-744.
321. Yonsel S, Langer B, and Deckwer W-D (1991), Bioreactor comparisons— Equi-inocular cultivation of Trichosporon cutaneum in stirred tank and airlift reactors, in Biochemical Engineering—Stuttgart, Reuss M, Chmiel H, Gilles E-D, and Knackmuss H-J (eds), Gustav Fischer, New York, 192-195.
322. Yuan N, Gu X, Li 1, Zhu D, and Ding F (1994), Study on an airlift loop reactor with membraneous gas distributor and its application in fermentations of baker’s yeast, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 426-428.
323. Zenz FA (1993), Explore the potential of air-lift pumps and multiphase, Chem Eng Progress 89(5), 51-56.
324. Zenz FA and Othmer DF (1960), Fluidization and Fluid-Particle Systems, Reinhold, New York, 427-433; 467-470.
325. Zhang Z, Chisti Y, and Moo-Young M (1995), Effects of the hydrodynamic environment and shear protectants on survival of erythrocytes in suspension, J Biotech 43, 33-40.
326. Zhao M, Niranjan K, and Davidson JF (1994), Mass transfer to viscous liquids in bubble columns and air-lift reactors: Influence of baffles, Chem Eng Sci 49,2359-2369.
327. Zhou W, Holzhaur-Rieger K, and Schügerl K (1993), Cephalosporin C production by a highly productive Cephalosporium acremonium strain in an airlift tower loop reactor with static mixers, J Biotech 28, 165-177.
328. Zhou SQ, Tang LM, Lai GZ, Feng PS, and Yao RH (1994), Fields of flow, pressure and shear stress in downcomer of an internal airlift loop reactor based on computational hydrodynamics, in Better Living Through Biochemical Engineering, Teo WK, Yap MGS, and Oh SKW (eds), Univ of Singapore, Singapore, 477-479.