A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues

Gene

Volumn 187, Issue 1, 1997, Pages 107-114

  Werner, Lisa A ^a   Manseau, Lynn J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Actin; Morphogenesis; Pleckstrin homology domain; Rho; Rho guanine nucleotide exchange factor; SH3 domain

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; PLECKSTRIN; RHO FACTOR;

ANIMAL TISSUE; ARTICLE; CELL SHAPE; DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; MORPHOGENESIS; NONHUMAN; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTO ONCOGENE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD PROTEINS; CHROMOSOME MAPPING; CLONING, MOLECULAR; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; NUCLEOPROTEINS; OOGENESIS; PHOSPHOPROTEINS; PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SRC HOMOLOGY DOMAINS;

ANIMALIA;

EID: 0031038716     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(96)00732-9     Document Type: Article

References (49)

1. Adams, J.M., Houston, H., Allen, J., Lints, T. and Harvety, R. (1992) The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) are involved in cytoskeletal organization. Oncogene 7, 611-618.
2. Bai, C., Li, Z. and Tolias, P.P. (1994) Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen. Mol. Cell. Biol. 14, 5123-5129.
3. Bar-Sagi, D., Rotin, D., Batzer, A., Mandiyan, V. and Schlessinger, J. (1993) SH3 domains direct cellular localization of signaling molecules. Cell 74, 83-91.
4. Castresana, J. and Saraste, M. (1995) Does Vav bind to F-actin through a CH domain? FEBS Letters 374, 149-151.
5. Chant, J. and Stowers, L. (1995) GTPase Cascades Choreographing Cellular Behavior: Movement, Morphogenesis, and More. Cell 81, 1-4.
6. Cohen, G.B., Ren, R. and Baltimore, D. (1995) Modular binding domains in signal transduction proteins. Cell 80, 237-238.
7. Costa, M., Sweeton, D. and Wieschaus, M. (1993) Gastrulation in Drosophila: cellular mechanisms of morphogentic movements. In: M. Bates and A. Martinez Arias (Eds.), The Development of Drosophila melanogaster. Cold Spring Harbor Press, Plainview, NY, pp. 425-465.
8. Eaton, S., Auvinen, P., Luo, L., Jan, Y.N. and Simons, K. (1995) Cdc42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J. Cell Biol. 131, 151-164.
9. Eva, A. and Aaronson, S.A. (1985) Isolation of a new human oncogene from a diffuse B-cell lymphoma. Nature 316, 273-275.
10. Eva, A., Vecchio, G., Diamond, M., Tronick, S.R., Ron, D., Cooper, G.M. and Aaronson, S.A. (1987) Independently activated dbl oncogenes exhibit similar yet distinct structural alterations. Oncogene 1, 355-360.
11. Eva, A., Vecchio, G., Rao, C.D., Tronick, S.R. and Aaronson, S.A. (1988) The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc. Natl. Acad. Sci. 85, 2061-2065.
12. Habets, G.G., Scholtes, E.H., Zuydgeest, D., Kammen, R.A. v.d., Stam, J.C., Berns, A. and Collard, J.G. (1994) Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell 77, 537-549.
13. Habets, G.G., Kammen, R.A. v.d., Stam, J.C., Michiels, F. and Collard, J.G. (1995) Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene 10, 1371-1376.
14. Harden, N., Loh, H.Y., Chia, W. and Lim, L. (1995) A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila. Development 121, 903-914.
15. Hariharan, I.K. and Adams, J.M. (1987) cDNA sequence for human bcr, the gene that translocates to the able oncogene in chronic myeloid leukaemia. EMBO J. 6, 115-119.
16. Hariharan, I.K., Hu, K.Q., Asha, H., Quintanilla, A., Ezzell, R.M. and Settleman, J. (1995) Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect. EMBO J. 14, 292-302.
17. Hart, M.J., Eva, A., Evans, T., Aaronson, S.A. and Cerione, R.A. (1991) Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354, 311-314.
18. Hart, M.J., Eva, A., Zangrilli, D., Aaronson, S.A., Evans, T., Cerione, R.A. and Zheng, Y. (1994) Cellular transformation and guanin nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J. Biol. Chem. 269, 62-65.
19. Heisterkamp, N., Stam, K., Groffen, J., Klein, A. de and Grosveld, G. (1985) Structural organization of the bcr gene and its role in the Ph′ translocation. Nature 315, 758-761.
20. Horii, Y., Beeler, J.F., Sakaguchi, K., Tachibana, M. and Miki, T. (1994) A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J. 1354, 4776-4786.
21. Hyvonen, M., Macias, M.J., Nilges, M., Oschkinat, H., Saraste, M. and Wilmanns, M. (1995) Structure of the binding site for inositol phosphates in a PH domain. EMBO J. 14, 4676-4685.
22. Ingley, E. and Hemmings, B.A. (1994) Pleckstrin homology (PH) domains in signal transduction. J. Cell. Biochem. 56, 436-443.
23. Jowett, T. (1986) Preparation of Nucleic Acids. Drosophila: A Practical Approach. IRL Press, Washington, DC, pp. 275-286.
24. Katzav, S., Martin-Zanca, D. and Barbacid, M. (1989) Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8, 2283-2290.
25. Lemmon, M., Ladbury, J., Mandiyan, V., Zhou, M. and Schlessinger, J. (1994) Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. J. Biol. Chem. 269, 31653-31658.
26. Lemmon, M.A., Ferguson, K.M. and Schlessinger, J. (1996) PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 85, 621-624.
27. Luo, L., Liao, Y.J., Jan, L.Y. and Jan, Y.N. (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787-1802.
28. Michiels, F., Habets, G.G.M., Stam, J.C., Kammen, R.A. v.d. and Collard, J.G. (1995) A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375, 338-340.
29. Miki, T., Smith, C.L., Long, J.E., Eva, A. and Fleming, T.P. (1993) Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362, 462-465.
30. Miyamoto, S., Ohya, Y., Ohsumi, Y. and Anraku, Y. (1987) Nucleotide sequence of the CLS4 (CDC24) gene of Saccharomyces cerevisiae. Gene 54, 125-132.
31. Murphy, A.M. and Montell, D. (1996) Cell type specific roles for Cdc42, Rac and RhoL in Drosophila oogenesis. J. Cell Biol. 133, 617-630.
32. Musacchio, A., Gibson, T., Lehto, V. and Saraste, M. (1992) SH3 -an abundant protein domain in search of a function (Review). FEBS Lett. 307, 55-61.
33. Musacchio, A., Gibson, T., Rice, P., Thompson, J. and Saraste, M. (1993) The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem. Sci. 18, 343-348.
34. Nobes, C.D., Hawkins, P., Stephens, L. and Hall, A. (1995) Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci. 108, 225-233.
35. Nomura, N., Miyajima, N., Sazuka, T., Tanaka, A., Kawarabayashi, Y., Nagase, T., Ishikawa, K., Seki, T. and Tabata, S. (1994) Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1, 27-35.
36. Ridley, A.J. and Hall, A. (1992) The small STP-binding protein rho regulates the assemble of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
37. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
38. Ron, D., Tronick, S.R., Aaronson, S.A. and Eva, A. (1988) Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells. EMBO J. 7, 2465-2473.
39. Ron, D., Graziani, G., Aaronson, S.A. and Eva, A. (1989) The N-terminal region of proto-dbl down regulates its transforming activity. Oncogene 4, 1067-1072.
40. Ron, D., Zannini, M., Lewis, M., Wickner, R.B., Hunt, L.T., Graziani, G., Tronick, S.R., Aaronson, S.A. and Eva, A. (1991) A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC224, and the human breakpoint cluster gene, bcr. New Biol. 3, 372-329.
41. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
42. Shaw, G. (1996) The pleckstrin homology domain: an intriguing multifunctional protein module. BioEssays 18, 35-46.
43. Takai, Y., Sasaki, T., Tanaka, K. and Nakanishi, H. (1995) Rho as a regulator of the cytoskeleton. Trends Biochem. Sci. 20, 227-231.
44. Tautz, D. and Pfeifle, C. (1989) A non-radioactive in situ hybridization protocol for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
45. Whitehead, I., Kirk, H. and Kay, R. (1995a) Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor. Oncogene 10, 713-721.
46. Whitehead, I., Kirk, H., Tognon, C., Trigo-Gonzalez, G. and Kay, R. (1995b) Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J. Cell Biol. 270, 18388-18395.
47. Wilson, R., Ainscough, R. anderson, K., Baynes, C., Berks, M., Bonfield, J., Burton, J., Connell, M., Copsey, T., Cooper, J., Coulson, A., Craxton, M., Dear, S., Du, Z., Durbin, R., Favello, A., Fulton, L., Gardner, A., Green, P., Hawkins, T., Hillier, L., Jier, M., Johnson, L., Jones, M., Kershaw, J., Kirsten, J., Laister, N., Latreille, P., Lightning, J., Lloyd, C., McMurray, A., Mortimore, B., O'Callaghan, M., Parsons, J., Percy, C., Rifken, L., Roopra, A., Saunders, D., Shownkeen, R., Smaldon, N., Smith, A., Sonnhammer, E., Staden, R., Sulson, J., Thierry-Mieg, J., Thomas, K., Vaudin, M., Vaughan, K., Waterston, R., Watson, A., Weinstock, L., Wilkinson-Sproat, J. and Wohldman, P. (1994) 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368, 32-38.
48. Zheng, Y., Cerione, R. and Bender, A. (1994) Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTpase activity by Bem3. J. Biol. Chem. 269, 2369-2372.
49. Zheng, Y., Olson, M.F., Hall, A., Cerione, R.A. and Toksov, D. (1995) Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J. Biol. Chem. 270, 9031-9034.