Vitamin B12 deficiency in older people: Improving diagnosis and preventing disability

Journal of the American Geriatrics Society

Volumn 46, Issue 10, 1998, Pages 1317-1319

  Stabler, Sally P ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; METHYLMALONIC ACID;

AGED; BLOOD; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; HUMAN; NOTE; CLINICAL FEATURE; DIAGNOSTIC APPROACH ROUTE; DIFFERENTIAL DIAGNOSIS; EDITORIAL; GERIATRIC DISORDER; HEMATOCRIT; MEGALOBLASTIC ANEMIA; PHYSICAL DISABILITY;

AGED; AGED, 80 AND OVER; COGNITION DISORDERS; HUMANS; METHYLMALONIC ACID; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 0031595340     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1998.tb04554.x     Document Type: Editorial

References (21)

1. Stabler S P, Lindenbaum J, Allen RH,. Vitamin B12 deficiency in the elderly: Current dilemmas. Am J Clin Nutr 1997; 66: 741-749.
2. Carmel R,. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997; 66: 750-759.
3. Pennypacker LC, Allen RH, Kelly JP, et al,. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc 1992; 40: 1197-1204.
4. Lindenbaum J, Rosenberg I, Wilson P, et al,. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2-11.
5. 6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995; 346: 85-89.
6. Savage DG, Lindenbaum J, Stabler SP, Allen RH,. Sensitivity of serum MMA and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994; 96: 239-246.
7. Carmel R,. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996; 156: 1097-1100.
8. 12 deficiency on elderly veterans and its relationship to health. J Am Geriatr Soc 1998; 46: 1199-1206.
9. Stabler SP, Allen RH, Savage DG, Lindenbaum J,. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990; 76: 871-881.
10. Healton EB, Savage DG, Brust JCM, et al,. Neurologic aspects of cobalamin deficiency. Medicine 1991; 70: 229-245.
11. Carmel R, Gott PS, Waters CH, et al,. The frequently low cobalamin levels in dementia usually signify treatable metabolic, neurologic and electrophysiologic abnormalities. Eur J Haematol 1995; 54: 245-253.
12. 12: Effects of replacement therapy on dementia. J Neurol 1996; 243: 522-529.
13. 12 in Alzheimer-type dementia. Age Ageing 1984; 148: 1705-1707.
14. Kristensen MO, Gulmann NC, Christensen JEJ, et al,. Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand 1993; 87: 475-481.
15. Lindenbaum J, Stabler SP, Allen RH,. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990; 34: 99-107.
16. Kuzminski AM, Del Ciacco EJ, Allen RH, et al,. Effective treatment of cobalamin deficiency with oral cobalamin. Blood, 1998; 92: 1-9.
17. Rasmussen K, Vyberg B, Pedersen KO, Brochner-Mortensen J,. Methylmalonic acid in renal insufficiency: evidence of accumulation and implications for diagnosis of cobalamin deficiency. Clin Chem (letter) 1990; 36: 1523-1524.
18. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG,. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes. JAMA 1995; 274: 1049-1057.
19. Nygard O, Nordrehaug JE, Refsum H, et al,. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-236.
20. 12 deficiency. J Nutr 1996; 126: S1266-1272.
21. Koehler KM, Romero LJ, Stauber PM, et al,. Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J Am Coll Clin Nutr 1996; 15: 364-376.