Diminished Class II-Associated Ii Peptide Binding to the Juvenile Dermatomyositis HLA-DQα1*0501/DQβ1*0301 Molecule

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 6260-6265

  Reed, Ann M ^a   Collins, Edward J ^a   Shock, Lisa P ^a   Klapper, David G ^a   Frelinger, Jeffrey A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DQALPHA ANTIGEN; HLA DQBETA ANTIGEN; HLA-DQALPHA ANTIGEN; HLA-DQBETA ANTIGEN; PEPTIDE;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; DERMATOMYOSITIS; GENETICS; HUMAN; IMMUNOLOGY; INVARIANT CHAIN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING;

ALLELES; AMINO ACID SEQUENCE; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; DERMATOMYOSITIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DQ ANTIGENS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING;

EID: 0031573669     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.159.12.6260     Document Type: Article

References (20)

1. Van De Wal, Y., Y. M. C. Kooy, J. W. Drijfhout, R. Amons, and F. Koning. 1996. Peptide binding characteristics of the coeliac disease-associated DQ(α1*0501, β1*0201) molecule. Immunogenetics 44:246.
2. Buckner, J., W. W. Kwok, B. Nepom, and G. T. Nepom. 1996. Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions. J. Immunol. 157:4940.
3. Vandal, P., B. H Johansen, T. Freide, C. J. Thorpe, S. Stevanovic, J. E. Eriksen, K. Sletten, E. Thorsby, H. G. Rammensee, and L. M. Sollid. 1996. The peptide binding motif of the disease associated HLA-DQ (α1*0501,β1*0201) molecule. Eur. J. Immunol. 26:2764.
4. Avva, R. R., and P. Cresswell. 1994. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. Immunity 1:763.
5. Sette, A., S. Cerman, R. T. Kubo, K. Sakaguchi, E. Apella, D. F. Hunt, T. A. Davis, H. Michel, J. Shabanowitz, R. Rudersdorf, H. M. Grey, and R. DeMars. 1992. Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 258:1801.
6. Roche, P. A., and P. Cresswell. 1990. Invariant chain association with HLA-DR Molecules inhibits immunogenic peptide binding. Nature 345:615.
7. Newcomb, J. R., and P. Cresswell. 1993. Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo. J. Immunol. 151:4153.
8. Chicz, R. M., W. S. Lane, R. A. Robinson, M. Trucco, J. L. Strominger, and J. C. Gorga. 1994. Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8. Int. Immunol. 6:1639.
9. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class IIαβ dimers and facilitates peptide loading. Cell 82:155.
10. Reed, A. M., and J. D. Stirling. 1995. Association of the HLA-DQA1*0501 allele in multiple racial groups with juvenile dermatomyositis. Hum. Immunol. 44:131.
11. O'Sullivan, D., J. Sidney, E. Appella, L. Walker, L. Phillips, S. M. Colon, C. Miles, R. W. Chesnut, and A. Sette. 1990. Characterization of the specificity of peptide binding to four DR haplotypes. J. Immunol. 145:1799.
12. Giles, R. C., G. Nunez, C. K. Hurley, A. Nunez-Roldan, R. Winchester, P. Stastny, and J. D. Capra. 1983. Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity. J. Exp. Med. 157:1461.
13. 131I-labeled human growth hormone of high specific radioactivity. Biochem. J. 89:114.
14. Machamer, C. E., and P. Cresswell. 1982. Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens. J. Immunol. 29:2564.
15. Ghosh, P., M. Amaya, E. Mellins, and D. C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457.
16. Jones, T. A., J. Y. Zou, S. W. Cowan, and M. Kjeldgaard. 1991. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A47:110.
17. Dunbrack, R. L., Jr., and M. Karplus. 1994. Conformational analysis of the backbone-dependent rotomer preferences of protein sidechains. Nat. Struct. Biol. 5: 334.
18. Falk, K., O. Rotzschke, S. Stevanovic, G. Jung, and H. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
19. Kwok, W. W., M. E. Domeier, F. C. Raymond, P. Byers, and G. T. Nepom. 1996. Allele-specific motifs characterized HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J. Immunol. 156:2171.
20. Zhong, G., F. Castellino, P. Romagnoli, and R. N. Germain. 1996. Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP). J. Exp. Med. 184:2061.