Depletion of CD8+ T Lymphocytes by Murine Monoclonal CD8 Antibodies and Restored Specific T Cell Proliferation in Vivo in a Patient with Chronic Hepatitis C

Journal of Immunology

Volumn 159, Issue 8, 1997, Pages 4064-4071

  Kiefersauer, Stefan ^a   Reiter, Christian ^a   Eisenburg, Josef ^b   Diepolder, Helmut Michael ^a   Rieber, Ernst P ^c   Riethmüller, Gert ^a   Gruber, Rudolf ^a,d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Urologische Abteilung   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIIDIOTYPIC ANTIBODY; ASPARTATE AMINOTRANSFERASE; CD8 ANTIGEN; MONOCLONAL ANTIBODY; VIRUS RNA;

ADULT; ANIMAL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CASE REPORT; CD8+ T LYMPHOCYTE; COMPLEMENT FIXATION TEST; ENZYMOLOGY; GENETICS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOLOGY; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; SOLUBILITY; T LYMPHOCYTE SUBPOPULATION;

ADULT; ALANINE TRANSAMINASE; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD8; ASPARTATE AMINOTRANSFERASES; CD8-POSITIVE T-LYMPHOCYTES; COMPLEMENT FIXATION TESTS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; RNA, VIRAL; SOLUBILITY; T-LYMPHOCYTE SUBSETS;

EID: 0031572572     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Hasan, F., L. J. Jeffers, M. De Medina, K. R. Reddy, T. Parker, E. R. Schiff, M. Houghton, Q. L. Choo, and G. Kuo. 1990. Hepatitis C-associated hepatocellular carcinoma. Hepatology 12:589.
2. Choo, Q.-L., G. Kuo, A. Weiner, L. Overby, and M. Houghton. 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244:359.
3. Olynyk, J., and B. Bacon. 1995. Hepatitis C. Postgrad. Med. 98:79.
4. Davis, G. L., L. A. Balart, E. R. Schiff, K. Lindsay, H. C. Bodenheimer, Jr., R. P. Perrillo, W. Carey, I. M. Jacobson, J. Payne, J. L. Dienstag, D. H. Van Thiel, C. Tamburro, et al. 1989. Treatment of chronic hepatitis C with recombinant interferon alpha: a multicenter randomized, controlled trial. N. Engl. J. Med. 321:1501.
5. Fried, M., and J. Hoofnagle. 1995. Therapy of hepatitis C. Semin. Liver Dis. 15:82.
6. van der Poel, C. L., H. T. Cuypers, and H. W. Reesink. 1994. Hepatitis C virus six years on. Lancet 344:1475.
7. Simmonds, P. 1995. Variability of hepatitis C virus. Hepatology 21:570.
8. Koziel, M., D. Dudley, and J. Wong. 1992. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J. Immunol. 149: 3339.
9. Autschbach, F., S. Meuer, U. Moebius, et al. 1991. Hepatocellular expression of lymphocyte function-associated antigen 3 in chronic hepatitis. Hepatology 14: 223.
10. Walker, C. 1996. Cytotoxic T-lymphocyte responses to the hepatitis C virus in humans and chimpanzees. Semin. Virol. 7:13.
11. Leist, T. P., E. Rüedi, and R. M. Zinkernagel. 1988. Virus-triggered immune suppression in mice caused by virus-specific cytotoxic T cells. J. Exp. Med. 167:1749.
12. Dunlop, M., and R. Blanden. 1977. Mechanisms of suppression of cytotoxic T-cell responses in murine lymphocytic choriomeningitis virus infection. J. Exp. Med. 145:1131.
13. Moreland, L., R. Bucy, A. Tilden, et al. 1993. Use of chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis. Arthritis Rheum. 36:307.
14. Reiter, C., B. Kakavand, E. P. Rieber, M. Schattenkirchner, G. Riethmüller, and K. Krüger. 1991. Treatment of rheumatoid arthritis with monoclonal CD4 antibody M-T151: clinical results and immunopharmacological effects in an open study, including repeated administration. Arthritis Rheum. 34:525.
15. Isaacs, J. D., M. R. Clark, J. Greenwood, and H. Waldmann. 1992. Therapy with monoclonal antibodies: an in vivo model for the assessment of therapeutic potential. J. Immunol. 148:3062.
16. Brett, S., G. Baxter, H. Cooper, M. Johnston, J. Tite, and N. Rapson. 1996. Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody, CAMPATH-1H. Immunology 88:13.
17. Bartholomew, M., S. Brett, K. Barber, C. Rossman, S. Crowe, and J. Tite. 1995. Functional analysis of the effects of a fully humanized anti-CD4 antibody on resting and activated human T cells. Immunology 85:41.
18. Knapp, W., B. Dörken, W. Gilks, et al. 1989. Leukocyte Typing IV. Oxford University Press, New York.
19. Reinherz, E., B. Haynes, L. Nadler, and I. Bernstein. 1986. Leukocyte Typing II. Springer Verlag, New York.
20. Bicker, U., W. Dippold, F. Emmrich, et al. 1978. Empfehlungen für die Herstellung und Prüfung in vivo applizierbarer monoklonaler Antikörper. Dtsch. Med. Wochenschr. 112:194.
21. Gruber, R., E. Felber, G. Pape, R. Zachoval, W. Höchtlen-Vollmar, and G. Riethmüller. 1994. Detection of autoantibodies against M2, LKM-1, and SLA in liver disease by standardized and improved ELISA techniques. J. Clin. Lab. Anal. 8:284.
22. Geiger, C., and C. Caselmann. 1992. Non-radioactive hybridization with hepatitis C virus-specific probes created during polymerase chain reaction: a fast and simple procedure to verify hepatitis C virus infection. J. Hepatol. 15:387.
23. + lymphocytes expressing CD45RO and CD45RA. J. Immunol. Methods 163:173.
24. Landay, A. L., and D. A. Muirhead. 1989. Procedural guidelines for performing immunophenotyping by flow cytometry. Clin. Immunol. Immunopathol. 52:48.
25. Zinkernagel, R. 1996. Immunology taught by viruses. Science 271:173.
26. Koziel, M. J., D. Dudley, N. Afdhal, et al. 1993. Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J. Virol. 67:7522.
27. Cerny, A., J. G. McHutchison, C. Pasquinelli, et al. 1995. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J. Clin. Invest. 95:521.
28. Nelson, D., C. Marousis, G. Davis, et al. 1997. The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J. Immunol. 158:1473.
29. Odermatt, B., M. Eppler, T. P. Leist, H. Hengartner, and R. M. Zinkernagel. 1991. Virus-triggered acquired immunodeficiency by cytotoxic Tcell dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl. Acad. Sci. USA 88:8252.
30. Lanford, R., D. Chavez, F. Chisari, and C. Sureau. 1995. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J. Virol. 69:8079.
31. Lerat, H., F. Berby, M. A. Trabaud, et al. 1996. Specific detection of hepatitis C virus minus strand RNA in hematopoietic cells. J. Clin. Invest. 97:845.
32. Sansonno, D., A. R. Iacobelli, V. Cornacchiulo, G. Iodice, and F. Dammacco. 1996. Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients. Clin. Exp. Immunol. 103:414.
33. Fink, P., H. Rammensee, and M. Bevan. 1984. Cloned cytolytic T cells can suppress primary cytotoxic responses directed against them. J. Immunol. 133: 1775.
34. Fink, J., R. P. Shimonkevitz, and M. J. Bevan. 1988. Veto cells. Annu. Rev. Immunol. 6:115.
35. Qi, Y., R. Berg, M. Singleton, J. Debrick, and U. Staerz. 1996. Hybrid antibody mediated veto of cytotoxic T lymphocyte responses. J. Exp. Med. 183:1973.
36. Tsai, S. L., P. J. Chen, L. H. Hwang, et al. 1993. Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection. J. Hepatol. 21:403.
37. Rice, C., and C. Walker. 1995. Hepatitis C virus-specific T lymphocyte responses. Curr. Opin. Immunol. 7:532.
38. Diepolder, H., R. Zachoval, R. Hoffmann, et al. 1995. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346:1006.
39. Fung-Leung, W., M. Schilham, A. Rahemtulla, et al. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443.
40. Adleman, L., and D. Wofsy. 1996. Blind T-cell homeostasis in CD4-deficient mice. J. Acquired Immune Defic. Syndr. 11:334.
41. Margolick, J., A. Donnenberg, and A. Munoz. 1994. T lymphocyte homeostasis after HIV seroconversion. J. Acquired Immune Defic. Syndr. 7:415.
42. Adleman, L., and D. Wofsy. 1993. T-cell homeostasis: implications in HIV infection. J. Acquired Immune Defic. Syndr. 6:144.
43. Riethmüller, G., E. Rieber, S. Kiefersauer, et al. 1992. From antilymphocyte serum to therapeutic monoclonal antibodies: first experiences with a chimeric CD4 antibody in the treatment of autoimmune disease. Immunol. Rev. 129:81.
44. Lubbe van der, P. A., A. M. Miltenburg, and F. C. Breedveld. 1991. Anti-CD4 monoclonal antibody for relapsing polychondrilis. Lancet 337:1349.
45. + T cells and inversion of the CD4/CD8 ratio induced by anti-CD4 therapy. J. Rheumatol. 19:1845.
46. Chatenoud, L., M. Jonker, F. Villemain, G. Goldstein, and J. F. Bach. 1986. The human immune response to the OKT3 monoclonal antibody is oligoclonal. Science 232:1406.
47. Brüggemann, M., G. Winter, H. Waldmann, and M. S. Neuberger. 1989. The immunogenicity of chimeric antibodies. J. Exp. Med. 170:2153.