Blind T-cell homeostasis in CD4-deficient mice

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 11, Issue 4, 1996, Pages 334-340

  Adleman, Leonard M ^a,c   Wofsy, David ^b  

^a University of Southern California ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

CD4 lymphocytes; CD8 lymphocytes; HIV; HIV infections; T lymphocytes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HOMEOSTASIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOTHESIS; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030009729     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199604010-00003     Document Type: Article

References (17)

1. Adleman LM, Wofsy D. T-Cell homeostasis: implications in HIV infection. J Acquir Immune Defic Syndr 1993;6:144-52.
2. - populations suggest regulatory responses linked to loss of CD4 lymphocytes. J Acquir Immune Defic Syndr 1993;6:153-61.
3. Stanley SK, Fauci AS. T cell homeostasis in HIV infection: part of the solution or part of the problem? [Editorial.] J Acquir Immune Defic Syndr 1993;6:142-3.
4. Reddy MM, Goetz RR, Gorman JM, Grieco MH, Chess L, Lederman S. Human immunodeficiency virus type-1 infection of homosexual men is accompanied by a decrease in circulating B cells. J Acquir Immune Defic Syndr 1991;4:428-34.
5. Giorgi JV, Detels R. T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study. Clin Immunol Immunopathol 1989;52:10-8.
6. Giorgi J, Nishanian PG, Schmid I, Hultin LE, Cheng H, Detels R. Selective alterations in immunoregulatory lymphocyte subsets in early HIV (human T-lymphotropic virus type III/lymphadenopathy-associated virus) infection. J Clin Immunol 1987;7:140-50.
7. Landay A, Ohlsson-Wilhelm B, Giorgi JV. Applications of flow, cytometry to the study of HIV infection [Editorial review]. AIDS 1990;4:479-97.
8. Margolick JB, Munroz A, Donnenberg AD, et al., for the Multicenter Aids Cohort Study. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. Nature Med 1995;1:674-80.
9. Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA. Treatment of autoimmune MRL/lpr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J Immunol 1983;130:1713-8.
10. Bonyhadl ML, Rabin L, Sallmi S, et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-32.
11. Clement LT, Giorgi JV, Plaeger-Marshall S, Haas A, Stiehm ER, Martin AM. Abnormal differentiation of immunoregulatory T-lymphocytes subpopulations in the major histocompatibility complex (MHC) class II antigen deficiency syndrome. J Clin Immunol 1988;8:6:503-12.
12. + cells but markedly decreased helper cell activity in mice lacking CD4 [Letter]. Nature 1991;353:180-4.
13. Fung-Leung W-P, Schilham MW, Rahemtulla A, et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 1991;65:443-9.
14. Cheynier R, Henrichwark S, Hadida F, et al. HIV and T cell expansion in splenic white pulp is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes. Cell 1994;78:373-87.
15. + lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients. Am J Pathol 1993;142:1750-8.
16. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-22.
17. Ho DD, Neumann AU, Perelson AS, Chan W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.