Novel Anti-Inflammatory Compounds Induce Shedding of L-Selectin and Block Primary Capture of Neutrophils under Flow Conditions

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4879-4885

  Endemann, Gerda ^a   Abe, Yasunori ^b   Bryant, Carmen M ^a   Feng, Ying ^a   Smith, C Wayne ^b   Liu, David Y ^a  

^a SCIOS INC   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DRUG DERIVATIVE; L SELECTIN; LEUCINE; N (9H (2,7 DIMETHYLFLUOREN 9 YLMETHOXY)CARBONYL)LEUCINE; N-(9H-(2,7-DIMETHYLFLUOREN-9-YLMETHOXY)CARBONYL)LEUCINE;

ARTICLE; CELL ADHESION; CYTOLOGY; FLOW KINETICS; HUMAN; METABOLISM; NEUTROPHIL; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS; CELL ADHESION; ENDOTHELIUM, VASCULAR; HUMANS; L-SELECTIN; LEUCINE; NEUTROPHILS; RHEOLOGY;

EID: 0031569967     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.158.10.4879     Document Type: Article

References (47)

1. Gallatin, W. M., I. L. Weissman, and E. C. Butcher. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304:30.
2. Jutila, M. A., L. Rott, E. L. Berg, and E. C. Butcher. 1989. Function and regulation of the neutrophil Mel-14 antigen in vivo: comparison with LFA-1 and Mac-1. J. Immunol. 143:3318.
3. Siegelman, M. H., M. Van de Rijn, and I. L. Weissman. 1989. Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains. Science 243:1165.
4. Lasky, L. A., M. S. Singer, T. A. Yednock, D. Dowbenko, C. Fennie, H. Rodriguez, T. Nguyen, S. Stachel, and S. D. Rosen. 1989. Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell 56:1045.
5. Baumhueter, S., M. S. Singer, W. Henzel, S. Hemmerich, M. Renz, SD. Rosen, and L. A. Lasky. 1993. Binding of L-selectin to the vascular sialomucin CD34. Science 262:436.
6. Puri, K. D., E. B. Finger, G. Gaudernack, and T. A. Springer. 1995. Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. J. Cell Biol. 131:261.
7. Berg, E. L., L. M. McEvoy, C. Berlin, R. F. Bargatze, and E. C. Butcher. 1993. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 366:695.
8. Picker, L. J., R. A. Warnock, A. R. Burns, C. M. Doerschuk, E. L. Berg, and E. C. Butcher. 1991. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66:921.
9. Ley, K., T. F. Tedder, and G. S. KS. 1993. L-selectin can mediate leukocyte rolling in untreated mesenteric venuies in vivo independent of E-or P-selectin. Blood 82:1632.
10. Abbassi, O., T. K. Kishimoto, L. V. McIntire, DC. Anderson, and C. W. Smith. 1993. E-selectin supports neutrophil rolling in vitro under conditions of flow. J. Clin. Invest. 92:2719.
11. X-dependent and -independent recognition pathways. Blood 82:182.
12. Smith, C. W., T. K. Kishimoto, O. Abbass, B. Hughes, R. Rothlein, L. V. McIntire, E. Butcher, and D. C. Anderson. 1991. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro. J. Clin. Invest. 87:609.
13. Ley, K., P. Gaehtgens, C. Fennie, M. S. Singer, L. A. Lasky, and S. D. Rosen. 1991. Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo. Blood 77:2553.
14. 2 integrins in vivo. Proc. Natl. Acad. Sci. USA 88:7538.
15. Lawrence, M. B., D. F. Bainton, and T. A. Springer. 1994. Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin. Immunity 1:137.
16. Hermanowski-Vosatka, A., J. A. G. Van Strijp, W. J. Swiggard, and S. D. Wright. 1992. Integrin modulating factor-1: a lipid that alters the function of leukocyte integrins. Cell 68:141.
17. Lawrence, M. B., and T. A. Springer. 1991. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65:859.
18. 2-integrin. J. Immunol. 155: 1502.
19. Kishimoto, T. K., M. A. Jutila, E. L. Berg, and E. C. Butcher. 1989. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245:1238.
20. Kahn, J., R. H. Ingraham, F. Shirley, G. I. Migaki, and T. K. Kishimoto. 1994. Membrane proximal cleavage of L-selectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin. J. Cell Biol. 125:461.
21. Tedder, T. F., D. A. Steeber, and P. Pizcueta. 1995. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181: 2259.
22. Mulligan, M. S., S. R. Watson, C. Fennie, and P. A. Ward. 1993. Protective effects of selectin chimeras in neutrophil-mediated lung injury. J. Immunol. 151: 6410.
23. Noronha-Blob, L., V. C. Lowe, L. Otterbein, L. Steranka, and R. M. Burch. 1993. NPC 15669 reduces mortality associated with sepsis in rats. J. Pharmacol. Exp. Ther. 267:664.
24. Burch, R. M., L. Noronha-Blob, J. M. Bator, V. C. Lowe, and J. P. Sullivan. 1993. Mice treated with a leumedin or antibody to Mac-1 to inhibit leukocyte sequestration survive endotoxin challenge. J. Immunol. 150:3397.
25. Bator, J. M., A. M. Gillinov, K. J. Zehr, J. M. Redmond, I. C. Wilson, A. Herskowitz, J. R. Connor, R. M. Burch, and D. E. Cameron. 1993. NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs. Mediat. Inflamm. 2:135.
26. Noronha-Blob, L., V. C. Lowe, R. O. Muhlhauser, and R. M. Burch. 1993. NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. Gastroenterology 104:1021.
27. Burch, R. M., J. R. Connor, J. M. Bator, M. Weitzberg, K. Laemont, L. Noronha-Blob, J. P. Sullivan, and L. R. Steranka. 1992. NPC 15669 inhibits the reversed passive Arthus reaction in rats by blocking neutrophil recruitment. J. Pharmacol. Exp. Ther. 263:933.
28. Jorens, P. G., J. B. Y. Richman-Eisenstat, B. P. Housset, P. P. Massion, I. Ueki, and J. A. Nadel. 1994. Pseudomonas-induced neutrophil recruitment in the dog airway in vivo is mediated in part by IL-8 and inhibited by a leumedin. Eur. Respir. J. 7:1925.
29. Kaneko, T., P. G. Jorens, J. B. Y. Richman-Eisenstat, P. F. Dazin, and J. A. Nadel. 1994. Leumedin NPC 15669 inhibits antigen-induced recruitment of inflammatory cells into the canine airways. Am. J. Physiol. 267:L250.
30. Bator, J. M., M. Weitzberg, and R. M. Burch. 1992. N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine, NPC 15669, prevents neutrophil adherence to endothelium and inhibits CD11b/CD18 upregulation. Immunopharmacology 23:139.
31. Hamilton, G. S., R. E. Mewshaw, C. M. Bryant, Y. Feng, G. Endemann, K. S. Madden, J. E. Janczak, J. Perumattam, L. W. Stanton, X. Yang, Z. Yin, B. Venkataramen, and D. Y. Liu. 1995. Fluorenylalkanoic and benzoic acids as novel inhibitors of cell adhesion processes in leukocytes. J. Med. Chem. 38:1650.
32. 2 (Mac-1)-dependent neutrophil adhesion without blocking activation-induced changes in Mac-1. J. Pharmacol. Exp. Ther. 276:5.
33. Entman, M. L., K. Youker, S. B. Shappell, C. Siegel, R. Rothlein, W. J. Dreyer, F. C. Schmalstieg, and C. W. Smith. 1990. Neutrophil adherence to isolated adult canine myocytes: evidence for a CD18-dependent mechanism. J. Clin. Invest. 85:1497.
34. Kishimoto, T. K., M. A. Jutila, and E. C. Butcher. 1990. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci. USA 87:2244.
35. 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am. J. Physiol. 263:H1034.
36. Diamond, M. S., and T. A. Springer. 1993. A subpopulation of Mac-1 (CD11b/ CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J. Cell Biol. 120:545.
37. Schumann, M. A., P. Gardner, and T. A. Raffin. 1993. Recombinant human tumor necrosis factor induces calcium oscillations and calcium-activated chloride current in human neutrophils. J. Biol. Chem. 268:2134.
38. Grinstein, S., W. Furuya, and G. P. Downey. 1992. Activation of permeabilized neutrophils: role of anions. Am. J. Physiol. 263:C78.
39. Olson, S. C., and J. D. Lambeth. 1996. Biochemistry and cell biology of phospholipase D in human neutrophils. Chem. Phys. Lipids 80:3.
40. Kolesnick, R., and D. W. Golde. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77:325.
41. Stephens, L., P. T. Hawkins, A. Eguinoa, and F. Cooke. 1996. A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors. Philos. Trans. R. Soc. Lond-Biol. Sci. 351:211.
42. Knall, C., S. Young, J. A. Nick, A. M. Buhl, G. S. Worthen, and G. L. Johnson. 1996. Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem. 271:2832.
43. Laudanna, C., J. J. Campbell, and E. C. Butcher. 1996. Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271:981.
44. 2 functions. J. Immunol. 152:5836.
45. McCafferty, D.-M., P. Kubes, and J. L. Wallace. 1993. Inhibition of platelet-activating factor-induced leukocyte adhesion in vivo by a leumedin. Eur. J. Pharmacol. 232:169.
46. Gonzalez-Alvaro, I., L. Carmona, F. Diaz-Gonzalez, R. Gonzalez-Amaro, F. Mollinedo, F. Sanchez-Madrid, A. Laffon, and R, Garcia-Vicuna. 1996. Aceclofenac, a new nonsteroidal antiinflammatory drug, decreases the expression and function of some adhesion molecules on human neutrophils. J. Rheumatol. 23: 723.
47. Diaz-Gonzalez, F., I. Gonzalez-Alvaro, M. R. Campanero, F. Mollinedo, M. A. del Pozo, C. Munoz, J. P. Pivel, and F. Sanchez-Madrid. 1995. Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs. J. Clin. Invest. 95:1756.