Decreased substrate affinity upon alteration of the substrate-docking region in cytochrome P450(BM-3)

FEBS Letters

Volumn 414, Issue 2, 1997, Pages 213-218

  Maves, Shelley A ^a   Yeom, Hyeyeong ^a,b   McLean, Mark A ^a   Sligar, Stephen G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Carbon monoxide geminate kinetics; Random mutagenesis; Regiospecificity; Substrate binding

Indexed keywords

CYTOCHROME P450 ISOENZYME;

ARTICLE; BACILLUS MEGATERIUM; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ISOLATION; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; MUTAGENESIS; PRIORITY JOURNAL;

ARGININE; BACTERIAL PROTEINS; BINDING SITES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; GLUTAMINE; KINETICS; LAURIC ACIDS; MIXED FUNCTION OXYGENASES; MODELS, STRUCTURAL; MUTAGENESIS, SITE-DIRECTED; MYRISTIC ACID; MYRISTIC ACIDS; PALMITIC ACID; POINT MUTATION; PROLINE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

BACILLUS MEGATERIUM;

EID: 0031559918     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00999-X     Document Type: Article

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