Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity

Leukemia Research

Volumn 20, Issue 2, 1996, Pages 119-126

  Andrivon, William ^a   Saucier, Jean Marie ^b   Auclair, Christian ^b   Monneret, Claude ^c   Florent, Jean Claude ^c   Guillosson, Jean Jacques ^a   Nafziger, Joëlle ^a  

^a UFR Sci Pharmaceutiques Biologiques ^*  (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c INSTITUT CURIE   (France)

Author keywords

DNA binding; DNA unwinding; Free radicals; New anthracycline derivative; Topoisomerase II

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTILEUKEMIC AGENT; DAUNORUBICIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; FREE RADICAL; MOFLOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DENATURATION; DNA STRAND BREAKAGE; DRUG DNA BINDING; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0029873324     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/0145-2126(95)00155-7     Document Type: Article

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