Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice

Cancer Research

Volumn 56, Issue 9, 1996, Pages 2082-2085

  Morelli, Daniele ^a   Ménard, Sylvie ^a   Colnaghi, Maria I ^a   Balsari, Andrea ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; DRUG ANTIBODY; IMMUNOGLOBULIN G2A; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MAD11; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; DRUG ABSORPTION; DRUG EFFICACY; DRUG FORMULATION; FEMALE; GASTROINTESTINAL TOXICITY; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; DOXORUBICIN; FEMALE; GASTROINTESTINAL DISEASES; INTESTINAL MUCOSA; MICE; MICE, INBRED BALB C;

EID: 0029996467     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Goodman, M. Managing the side effects of chemotherapy. Semin. Oncol. Nurs., 5: 29-52, 1989.
2. Blijham, G. H. Prevention and treatment of organ toxicity during high-dose chemotherapy, an overview. Anti-Cancer Drugs, 4: 527-533, 1993
3. Wujcik, D. Current research in side effects of high-dose chemotherapy. Semin. Oncol. Nurs., 8: 102-112, 1992.
4. Cortes, E. P., Holland, J. F., and Glidewell, O. Amputation and Adriamycin in primary osteosarcoma: a five year report. Cancer Treat. Rep., 62: 271-277, 1978.
5. Yates, J W., Glidewell, O., Wiernik, P., Cooper, M. R. Steinberg, D., Dosik, H., Levy, R., Hoagland, C. Henry, P., Gottilieb, A , Cornell, C., Berenberg, J., Hurchison, J. L., Raich, P , Nissen, N., Ellison, R R., Frelick, R., James, G W., Falkson, G , Silver, R. T., Haurani, F., Green, M., Henderson, E., Leone, L , and Holland, J. F. Activity of daunorubicin vs Adriamycin induction and monthly vs bimonthly maintenance in acute myelocytic leukemia. Blood, 60. 454-462, 1982.
6. Tannock, I F., Boyd, N. F., DeBoer, G., Erlichman, C. Fine, S , Larocque, G., Mayers, C., Perrault, D , and Sutherland, H. A randomized trial of two dose levels of cyclophosphamide, methotrexate, and fluorouracil chemotherapy for patients with metastatic breast cancer. J Clin. Oncol., 6: 1377-1378, 1988
7. Bronchud, M. Can hematopoietic growth factors be used to improve the success of cytotoxic chemotherapy? Anti-Cancer Drugs, 4. 127-139, 1993.
8. Coiffier, B , Philip, T., Burnett, A. K., and Symann, M. L. Consensus conference on intensive chemotherapy plus hematopoietic stem-cell transplantation in malignancies. Lyon, France, June 4-6, 1993. J. Clin. Oncol., 12: 226-231, 1994.
9. Chabner, B A , and Myers, C. E. Antumor antibiotics. In: V. T. De Vita, S. Hellman, and S. A. Rosenberg (eds.), Cancer Principles & Practice of Oncology, pp. 374-384. Philadelphia: Lippincott, 1993.
10. Balsari, A., Ménard, S., Colnaghi, M. I., and Ghione, M. Anti-drug monoclonal antibodies antagonize toxic effect more than anti-tumor activity of doxonibicin. Int J. Cancer, 47: 889-892, 1991
11. Balsari, A. L., Morelli, D., Ménard, S., Veronesi, U., and Colnaghi, M. I Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies. FASEB J., 8: 226-230, 1994.
12. Hammarstrom, L., Gardulf, A , Hammarstrom, V., Janson, A , Lindberg, K., and Smith, C. I. E. Systemic and topical immunoglobulin treatment in immunocompromised patients Immunol. Rev , 139: 43-70, 1994.
13. Blum, P M., Phelps, D L., Ank, B. J , Krantman, H. J., and Stiehm, E. R Survival of oral human serum globulin in the gastrointestinal tract of low birth weight infants. Pediatr. Res., 15. 1256-1260, 1981.
14. Barnes, G L., Hewson, P H , McLellan, J A., Doyle, L. W., Knoches, A M L., Kitchen, W. H., and Bishop, R. F A randomized trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. Lancet, 2 1371-1373, 1982
15. Losonsky, G A , Johnson, J P., Winkelstein, J. A., and Yolken, R. H. Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. J. Clin. Invest. 76 2362-2367, 1985.
16. Melamed, I , Griffiths, A. M , and Roifman, C. M Benefit of oral immune globulin therapy in patients with immunodeficiency and chronic diarrhea. J. Pediatr , 3: 486-489, 1991.
17. Thakkar, N. S. and Potten, C S. Abrogation of Adnamycm toxicity in vivo by cycloheximide. Biochem Pharmacol. 43 1683-1691, 1992.
18. Anilkumar, T. V , Sarraf, C. E., Hunt, T , and Alison, M R The nature of cytotoxic drug-induced cell death in murine intestinal crypts Br J Cancer. 65: 552-558, 1992.
19. Sardini, A., Villa, E , Morelli, D., Ghione, M., Menard, S., Colnaghi, M I., and Balsari, A. An anti-doxorubicin monoclonal antibody modulates kinetic and dynamic characteristics of the drug Int J Cancer. 50 617-620, 1992
20. Bronchud, M H., Howell, A. Crowther, D., Hopwood, P., Souza, L. and Dexter, T. M The use of granulocyte colony-stimulating factor 10 increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer. Br. J Cancer. 60: 121-125, 1989
21. Gianni, A M , Bregni, M , Siena, S., Orazi, A., Stern, A. C., Gondola, L., and Bonadonna, G Recombinant human gronulocyte-macrophage colony-stimulating factor reduces hematologic toxicity and widens clinical applicability of high-dose cyclophosphamide treatment in breast cancer and non-Hodgkin's lymphoma. J. Clin. Oncol , 8. 761-764, 1990.
22. Castellino, S., Elion, G. B , Griffith, O. W., Dewhirst, M , Kurtzberg, J., Cattley, R. C , Scott, P., Bigner, D D. and Friedman, H. S. Development of a model of melphalan-induced gastrointestinal toxicity in mice. Cancer Chemother Pharmacol., 31 376-380, 1993.
23. Mahood, D J , Dose, A M , Loprinzi, C. L., Veeder, M H., Athmann, L M., Therneau, T M., Sorensen, J M , Gainey, D K , Mailliard, J A., Gusa, N. L , Finck, G. K., Johnson, C , and Goldber, R. M. Inhibition of fluorouracil-induced stomatitis by oral cryotherapy J Clin Oncol , 9 449-452, 1991
24. Sonis, S. T , Lindquist, L , Van Vugt, A , Stewart, A A., Stam, K., Qu, G-Y , Iwata, K K., and Haley, J D Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor β3 Cancer Res., 54. 1135-1138, 1994