A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 346-355

  Smeets, Mariëlle ^a   Raymakers, Relnier ^a   Vierwinden, Gerty ^a   Pennings, Arie ^a   Van De Locht, Louis ^a   Wessels, Hans ^a   Boezeman, Jan ^a   De Witte, Theo ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

anthracyclines; haemopoietic progenitors; MDR1; P glycoprotein; rhodamine

Indexed keywords

ANTHRACYCLINE DERIVATIVE; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN P; RHODAMINE; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0031047395     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2024.x     Document Type: Article

References (45)

1. Alaoui Jamali, M.A., Yin, M.B., Mazzoni, A., Bankusli, I. & Rustum, V.M. (1989) Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933. Cancer Chemotherapy and Pharmacology, 25, 77-83.
2. Bailly, J.D., Muller, C., Jaffrezou, J.P., Demur, C., Gassar, G., Bordier, C. & Laurent, C. (1995) Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia, 9, 799-807.
3. Bartlett, N.L., Lum, B.L., Fisher, G.A., Brophy, N.A., Ehsan, M.N., Halsey, J. & Siklc, B.I. (1994) Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance. Journal of Clinical Oncology, 12, 835-842.
4. Bertolini, F., de Monte, L., Corsini, C., Lazzari, L., Lauri, E., Soligo, D., Ward, M., Bank, A. & Malavasi, F. (1994) Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells. British Journal of Haematolagy, 88, 318-324.
5. Bertoncello, I., Hodgson, G.S. & Bradley, T.R. (1985) Multiparameter analysis of transplantable hemopoietic stem cells. I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence. Experimental Hematology, 13, 999-1006.
6. Boesch, D. & Loor, F. (1994) Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents. Anticancer Drugs, 5, 229-238.
7. Brophy, N.A., Marie, J.P., Rojas, V.A., Warnke, R.A., McFall, P.J., Smith, S.D. & Sikic, B.I. (1994) Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques. Leukemia, 8, 327-335.
8. Chaudhary, P.M., Mechetner, E.B. & Roninson, I.B. (1992) Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood, 80, 2735-2739.
9. Chaudhary, P.M. & Roninson, I.B. (1991) Expression and activity of P-glycoprotein. a multidrug efflux pump, in human hematopoietic stem cells. Cell, 66, 85-94.
10. Cordon Cardo, C., O'Brien, J.P., Casals, D., Rittman Grauer, L., Biedler, J.L., Melamed, M.R. & Bertino, J.R. (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proceedings of the National Academy of Sciences of the United States of America, 86, 695-698.
11. Darzynkiewicz, Z., Staiano Coico, L. & Melamed, M.R. (1981) Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation. Proceedings of the National Academy of Sciences of the United States of America, 78, 2383-2387.
12. Drach, D., Zhao, S., Drach, J., Mahadevia, R., Gattringer, C. Huber, H. & Andreeff, M. (1992) Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood, 80, 2729-2734.
13. Efferth, T., Lohrke, H. & Volm, M. (1989) Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors. Anticancer Research, 9, 1633-1637.
14. Figueredo, A., Arnold, A., Goodyear, M., Findlay, B., Neville, A., Normandeau, R. & Jones, A. (1990) Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer: a phase I/II study. Cancer, 65, 1895-1902.
15. + T cells: a role in cytotoxic effector function. Journal of Clinical Immunology, 12, 451-458.
16. Hegewisch Becker, S., Fliegner, M., Tsuruo, T., Zander, A., Zeller, W. & Hossfeld, D.K. (1993) P-glycoprotein expression in normal and reactive bone marrows. British Journal of Cancer, 67, 430-435.
17. Hofmann, J., Wolf, A., Spitaler, M., Bock, G., Drach, J., Ludescher, C. & Grunicke. H. (1992) Reversal of multidrug resistance by B859-35, a metabolite of B859-35, niguldipine, verapamil and nitrendipine. Journal of Cancer Research and Clinical Oncology, 118, 161-366.
18. Klimecki, W.T., Futscher, B.W., Grogan, T.M. & Dalton, W.S. (1994) P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood, 83, 2451-2458.
19. Krishan, A., Sauerteig, A. & Stein, J.H. (1991) Comparison of three commercially available antibodies for flow cytometric monitoring of P-glycoprotein expression in tumor cells. Cytometry, 12, 731-742.
20. Licht, T., Pastan, I., Gottesman, M. & Herrmann, F. (1994) P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells. Annals of Hematology, 69, 159-171.
21. Ling, V. (1992) Charles F. Kettering Prize. P-glycoprotein and resistance to anticancer drugs. Cancer, 69, 2603-2609.
22. Ludescher, C., Thaler, J., Drach, D., Drach, J., Spitaler, M., Gattringer, C., Huber, H. & Hofmann, J. (1992) Detection of activity of P-glycoprotein in human tumour samples using rhodamine 123. British Journal of Haematology, 82, 161-168.
23. Marie, J.P., Brophy, N.A., Ehsan, M.N., Aihara, Y., Mohamed, N.A., Cornbleet, J., Chao, N.J. & Sikic, B.I. (1992) Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells. British Journal of Haematology, 81, 145-152.
24. Mulder, A.H. & Visser, J.W. (1987) Separation and functional analysis of bone marrow cells separated by rhodamine-123 fluorescence. Experimental Hematology, 15, 99-104.
25. Murphy, L.D., Herzog, C.E., Rudick, J.B., Fojo, A.T. & Bates, S.E. (1990) Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry, 29, 10351-10356.
26. Nakarai, T. & Koizumi, S. (1990) Effects of calcium antagonists on anti-cancer drug toxicity to hematopoietic progenitor cells in normal bone marrow. Lukemia Research, 14, 401-404.
27. Neyfakh, A.A. (1988) Use of fluorescent dyes as molecular probes for the study of multidrug resistance. Experimental Cell Research, 174, 168-176.
28. Neyfakh, A.A., Serpinskaya, A.S., Chervonsky, A.V, Apasov, S.G. & Kazarov, A.R. (1989) Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection. Experimental Cell Research, 185, 496-505.
29. Noonan, K.E., Beck, C., Holzmayer, T.A., Chin, J.E., Wunder, J.S., Andrulis, I.L. Gazdar, A.F., Willman, C.L., Griffith, B., Von Hoff, D.D. & Roninson, I.B. (1990) Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America, 87, 7160-7164.
30. Nussler, V., Pelka Fleischer, R., Zwierzina, H., Nerl, C., Beckert, B., Gullis, E., Gieseler, F., Bock, S., Bartl, R., Petrides, P.E. & Wilmanns, W. (1994) Clinical importance of P-glycoprotein-related resistance in leukemia and myelodysplastic syndromes: first experience with their reversal. Annals of Hematology, 69, (Suppl. 1), S25-S29.
31. Ploemacher, R.E. & Brons, N.H. (1988) Cells with marrow and spleen repopulating ability and forming spleen colonies on day 16, 12, and 8 are sequentially ordered on the basis of increasing rhodamine 123 retention. Journal of Cell Physiology, 136, 531-556.
32. Puissant, C. & Houdebine, L.M. (1990) An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biotechniques, 8, 148-149.
33. Scheithauer, W., Kornek G., Globits, S., Raderer, M. & Funovics, J. (1993) Phase I/II study of d-verapamil (dvpm), epirubicin and GmCSF in advanced pancreatic cancer. (Abstract). Proceedings of the American Society for Clinical Oncology, 12, 205.
34. Schmkel, A.H., Roelofs, E.M. & Borst, P. (1991) Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies. Cancer Research, 51, 2628-2635.
35. Slater, L.M., Sweet, P., Stupecky, M. & Gupta, S. (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. Journal of Clinical Investigation, 77, 1405-1408.
36. Speth, P.A., Raijmakers, R.A., Boezeman, J.B., Linssen, P.C., de Witte, T.J., Wessels, H.M. & Haanen, C. (1988) In vivo cellular adriamycin concentrations related to growth inhibition of normal and leukemic human bone marrow cells. European Journal of Cancer and Clinical Oncology, 24, 667-674.
37. Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S. & Mori, S. (1988) Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Research, 48, 1926-1929.
38. Udomsakdi, C., Eaves, C.J., Sutherland, H.J. & Lansdorp, P.M. (1991) Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123. Experimental Hematology, 19, 338-342.
39. Ueda, K., Cornwell, M.M., Gottesman, M.M., Pastan, I., Roninson, I.B., Ling, V. & Riordan, J.R. (1986) The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochemical and Biophysical Research Communications, 141, 956-962.
40. Van Acker, K.L., Van Hove, L.M. & Boogaerts, M.A. (1993) Evaluation of flow cytometry for multidrug resistance detection in low resistance K562 cells using daunorubicin and monoclonal antibodies. Cytometry, 14, 736-746.
41. van der Valk, P., van Kalken, C.K., Ketelaars, H., Broxterman, H.J., Scheffer, G., Kuiper, C.M., Tsuruo, T., Lankelma, J., Meijer, C.J., Pinedo, H.M. & Scheper, R.J. (1990) Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues: analysis with three monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule. Annals of Oncology, 1, 56-64.
42. Visani, G., Fogli, M., Tosi, P., Ottaviani, E., Gamberi, B., Cenacchi, A., Manfroi, S. & Tura, S. (1993) Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors. Annals of Hematology, 66, 273-276.
43. + cells. Blood, 84, 1408-1414.
44. Weaver, J.L., Szabo, G., Jr, Pine, P.S., Gottesman, M.M., Goldenberg, S. & Aszalos, A. (1993) The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multidrug transporter. International Journal of Cancer, 54, 456-461.
45. Zhou, D.C., Marie, J.P., Suberville, A.M. & Zittoun, R. (1992) Relevance of mdr1 gene expression in acute myeloid leukemia and comparison of different diagnostic methods. Leukemia, 6, 879-885.