Generation and analysis of conditional mutant mice

Research in Immunology

Volumn 148, Issue 7, 1997, Pages 475-480

  Betz, U A K ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

B lymphocyte; Forum; Gene targeting; KO mice; T lymphocyte

Indexed keywords

RECOMBINASE;

ANIMAL CELL; BACTERIOPHAGE; BINDING SITE; EXPRESSION VECTOR; GENE ACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE SPECIFICITY;

EID: 0031467520     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(97)82674-0     Document Type: Article

References (50)

1. Agah, R., Frenkel, P.A., French, B.A., Michael, L.H., Overbeek, P.A. & Schneider M.D. (1997), Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest., 100, 169-179.
2. Akagi, K., Sandig, V., Vooijs, M., Van der Valk, M., Giovannini, M., Strauss, M. & Berns, A. (1997), Cre-mediated somatic site specific recombination in mice. Nucleic. Acids. Res., 25, 1766-1773.
3. Araki, K., Araki, M., Miyazaki, J-I. & Vassalli P. (1995), Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Natl. Acad. Sci. USA, 92, 160-164.
4. Araki, K., Araki, M. & Yamamura, K.-I. (1997), Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic. Acids. Res., 25, 868-872.
5. Ashfield, R., Patel, A.J., Bossone, S.A., Brown, H., Campbell, R.D., Marcu, K.B. & Proudfoot, NJ. (1994), MAZ-dependent termination between closely spaced human complement genes. EMBO J., 13, 5656-5667.
6. Ayral, A.-M., Kolossov, E., Serwe, M. & Sablitzky, F. (1997), Reporter gene activation in transgenic mice mediated through induced Cre/loxP recombination. Transgenics, in press.
7. Barlow, C., Schroeder, M., Lekstrom-Himes, J., Kylefjord, H., Deng, C.X., Wynshaw-Boris, A., Spiegelman, B.M. & Xanthopoulos, K.G. (1997), Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP -flanked gene segments. Nucleic. Acids. Res., 25, 2543-2545.
8. Baubonis, W. & Sauer, B. (1993), Genomic targeting with purified Cre recombinase. Nucleic. Acids. Res. 21, 2025-2029.
9. Betz, U.A.K., Voßhenrich, C.A.J., Rajewsky, K. & Müller, W. (1996), Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr. Biol., 6, 1307-1316.
10. Brandon, E.P., Idzerda, R.L. & McKnight, G.S. (1995), Targeting the mouse genome: a compendium of knockouts. Curr. Biol., 5, 625-634.
11. Broach, J.R., Guarascio, V.R. & Jayaram, M. (1982), Recombination within the yeast plasmid 2μ circle is site-specific. Cell, 29, 227-234.
12. Brooks, A.I., Muhkerjee, B., Panahian, N., Cory-Slechta, D. & Federoff, H.J. (1997), Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of ere recombinase. Nat. Biotechnol., 15, 57-62.
13. Dymecki, S.M. (1996), Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl. Acad. Sci USA, 93, 6191-6196.
14. Feil, R., Brocard, J., Mascrez, B., LeMeur, M., Metzger, D. & Chambon, P. (1996), Ligand-activated site-specific recombination in mice. Proc. Natl. Acad. Sci. USA, 93, 10887-10890.
15. Furth, P.A., Stonge, L., Böger, H., Gruss, P., Gossen, M., Kistner, A., Bujard, H. & Henninghausen, L. (1994), Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA, 91, 9302-9306.
16. Gagneten, S., Le, Y., Miller, J. & Sauer, B. (1997), Brief expression of a GFPcre fusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletions. Nucleic. Acids. Res., 25, 3326-3331.
17. Golic, K.G. & Lindquist, S. (1989), The FLP recombinase of yeast catalyzes site-specific recombination in the drosophila genome. Cell, 59, 499-509.
18. Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. & Rajewsky, K. (1994), Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science, 265, 103-106.
19. Hennet, T., Hagen, F.K., Tabak, L.A. & Marth, J.D. (1996), T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA, 92, 12070-12074.
20. Imamoto, A. & Soriano, P. (1993), Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell, 73, 1117-1124.
21. Jiang, R. & Gridley, T. (1997), Gene targeting: Things go better with Cre. Curr. Biol., 7, R321-R323.
22. Kitamoto, T., Nakamura, K., Nakao, K., Shibuya, S., Shin, R.W., Gondo, Y., Katsuki, M. & Tateishi, J. (1996), Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse. Biochem. Biophys. Res. Commun., 222, 742-747.
23. Kühn, R., Schwenk, F., Aguet, M. & Rajewsky, K. (1995), Inducible gene targeting in mice. Science, 269, 1427-1429.
24. Kühn, R. & Schwenk, F. (1997), Advances in gene targeting methods. Curr. Opin. Immunol., 9, 183-188.
25. Lakso, M., Pichel, J.G., Gorman, J.R., Sauer, B., Okamoto, Y., Lee, E., Alt, F.W. & Westphal, H. (1996), Efficient in vivo manipulation of mouse genomic sequences at the zygotic stage. Proc. Natl. Acad. Sci. USA, 93, 5860-5865.
26. Lakso, M., Sauer, B., Mosinger Jr., B., Lee, E.J., Manning, R.W., Yu, S-H., Mulder, K.L. & Westphal, H. (1992), Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci., USA, 89, 6232-6236.
27. Lewandoski, M., Wassarman K.M. & Martin G.R. (1997), Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr. Biol., 7, 148-151.
28. Marshall, E. (1997), The mouse that prompted a roar. Science, 277, 24-25.
29. Marth, J.D. (1996), Recent advances in gene mutagenesis by site-directed recombination. J. Clin. Invest., 97, 1999-2002.
30. Odell, J.T., Hoopes, J.L. & Vermerris, W. (1994), Seed-specific gene activation mediated by the Cre/lox site -specific recombination system. Plant. Physiol., 106, 447-458.
31. Orban, P.C., Chui, D. & Marth, J.D. (1992), Tissue- and site-specific DNA recombination in transgenic mice. Proc. Natl. Acad. Sci. USA, 89, 6861-6865.
32. Pham, C.T.N., MacIvor, D.M., Hug, B.A., Heusel, J.W. & Ley, T.J. (1996), Long-range disruption of gene expression by a selectable marker cassette. Proc. Natl. Acad. Sci. USA, 93, 13090-13095.
33. Rajewsky, K., Gu, H., Kühn, R., Betz, U.A.K., Müller, W., Roes, J. & Schwenk, F. (1996), Conditional gene targeting. J. Clin. Invest. 98, 600-603.
34. Rickert, R.C., Roes, J. & Rajewsky, K. (1997), B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic. Acids. Res., 25, 1317-1318.
35. Rohlmann, A., Gotthardt, M., Willnow, T.E., Hammer, R.E. & Herz, J. (1996), Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nature Biotechnol., 14, 1562-1565.
36. Rossant, J. & Nagy, A. (1995), Genome engineering: the new mouse genetics. Nature Med., 1, 592-594.
37. Sakai, K. & Miyazaki, J-I. (1997), A Transgenic Mouse Line That Retains Cre Recombinase Activity in Mature Oocytes Irrespective of the ere Transgene Transmission. Biochem. Biophys. Res. Commun., 237, 318-324.
38. Sauer, B. & Henderson, N. (1988), Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. USA, 85, 5166-5170.
39. Schwenk, F., Baron, U. & Rajewsky, K. (1995), A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic. Acids. Res., 23, 5080-5081.
40. Schwenk, F., Sauer, B., Kukoc, N., Hoess, R., Müller, W., Kocks, C., Kühn, R. & Rajewsky, K. (1997), Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains. J. Immunol. Meth., 207, 203-212.
41. St-Onge, L., Furth, P.A. & Gruss, P. (1996), Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter. Nucleic. Acids. Res., 24, 3875-3877.
42. Sternberg, N. & Hamilton, D. (1981), Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J. Mol. Biol., 150, 467-486.
43. Tarutani, M., Itami, S., Okabe, M., Ikawa, M., Tezuka, T., Yoshikawa, K., Kinoshita, T. & Takeda, J. (1997), Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc. Natl. Acad. Sci. USA, 94, 7400-7405.
44. Thomas, K.R. & Capecchi, M.R. (1987), Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell, 51, 503-512.
45. Thorey, I.S., Muth, K., Russ, A.P., Otte, J., Reffelmann, A. & von Melchner, H. Selective disruption of genes transiontly induced during early mouse development using gene trap mutagenesis and site specific recombination, manuscript in preparation.
46. Tsien, J.Z., Chen, D.F., Gerber, D., Tom, C., Mercer, E.H., Anderson, D.J., Mayford, M., Kandel, E.R. & Tonegawa, S. (1996), Subregion- and cell type-restricted gene knockout in mouse brain. Cell, 87, 1317-1326.
47. Tsien, J.Z., Huerta, P.T. & Tonegawa, S. (1996), The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell, 87, 1327-1338.
48. Wang, Y., Krushel, L.A. & Edelman, G.M. (1996), Targeted DNA recombination in vivo using an adenovirus carrying the Cre recombinase gene. Proc. Natl. Acad. Sci. USA, 93, 3932-3936.
49. Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., Hirabayashi, T., Yoneda, Y., Tanaka, K., Wang, W.-Z., Mori, C., Shiota, K., Yoshida, N. & Kishimoto, T. (1996), Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA, 93, 407-411.
50. Zhang, Y., Riesterer, C., Ayrall, A.-M., Sablitzky, F., Littlewood, T.D. & Reth, M. (1996), Inducible site-directed recombination in mouse embryonic stem cells. Nucleic. Acids. Res., 24, 543-548.