Pneumocystis carinii telomere repeats are composed of TTAGGG and the subtelomeric sequence contains a gene encoding the major surface glycoprotein

Molecular Microbiology

Volumn 19, Issue 2, 1996, Pages 273-281

  Underwood, Anthony P ^a   Louis, Edward J ^b   Borts, Rhona H ^b   Stringer, James R ^c   Wakefield, Ann E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN;

ARTICLE; GENE EXPRESSION; GENE MAPPING; MOLECULAR CLONING; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; SEQUENCE ANALYSIS; YEAST;

ANIMALIA; PNEUMOCYSTIS CARINII; SACCHAROMYCES CEREVISIAE;

EID: 0030033311     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.374904.x     Document Type: Article

References (69)

1. Allshire, R.C., Gosden, J.R., Cross, S.H., Cranston, G., Rout, D., Sugawara, N., Szostak, J.W., Fantes, P.A., and Hastie, N.D. (1988) Telomeric repeat from T. thermophila cross hybridizes with human telomeres. Nature 332: 656-659.
2. Banerji, S., Wakefield, A.E., Allen, A.G., Maskell, D.J., Peters, S.E., and Hopkin, J.M. (1993) The cloning and characterization of the arom gene of Pneumocystis carinii. J Gen Microbiol 139: 2901-2914.
3. Banerji, S., Lugli, E.B., and Wakefield, A.E. (1994) Identification of two genetically distinct strains of Pneumocystis carinii in infected ferret lungs. J Euk Microbiol 41: 73S.
4. Banerji, S., Lugli, E.B., Miller, R.F., and Wakefield, A.E. (1995) Analysis of genetic diversity at the arom locus in isolates of Pneumocystis carinii. J Euk Microbiol 42: 675-679.
5. Blackburn, E.H. (1991) Telomeres. Trends Biochem Sci 16: 378-381.
6. Borts, R.H., Lichten, M., and Haber, J.E. (1986) Analysis of meiosis-defective mutations in yeast by physical monitoring of recombination. Genetics 113: 551-567.
7. Broun, P., Ganal, M.W., and Tanksley, S.D. (1992) Telomeric arrays display high levels of heritable polymorphism among closely related plant varieties. Proc Natl Acad Sci USA 89: 1354-1357.
8. Brown, W.R. (1989) Molecular cloning of human telomeres in yeast. Nature 338: 774-776.
9. de Bruin, D., Lanzer, M., and Ravetch, J.V. (1994) The polymorphic subtelomeric regions of Plasmodium falciparum chromosomes contain arrays of repetitive sequence elements. Proc Natl Acad Sci USA 91: 619-623.
10. Carlson, M., Celenza, J.L., and Eng, F.J. (1985) Evolution of the dispersed SUC gene family of Saccharomyces by rearrangements of chromosome telomeres. Mol Cell Biol 5: 2894-2902.
11. Cheng, J.-F., Smith, C.L., and Cantor, C.R. (1989) Isolation and characterisation of a human telomere. Nucl Acids Res 17: 6109-6127.
12. Cross, S.H., Allshire, R.C., McKay, S.J., McGill, N.I., and Cooke, H.J. (1989) Cloning of human telomeres by complementation in yeast. Nature 338: 771-774.
13. Cushion, M.T., Kaselis, M., Stringer, S.L., and Stringer, J.R. (1993a) Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infect Immun 61: 4801-4813.
14. Cushion, M.T., Zhang, J., Kaselis, M., Giuntoli, D., Stringer, S.L., and Stringer, J.R. (1993b) Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats. J Clin Microbiol 31: 1217-1223.
15. Edman, J.C., Kovacs, J.A., Masur, H., Santi, D.V., Elwood, H.J., and Sogin, M.L. (1988) Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature 334: 519-522.
16. Forney, J., Henderson, E.R., and Blackburn, E.H. (1987) Identification of the telomeric sequence of the acellular slime molds Didymium iridis and Physarum polycephalum. Nucl Acids Res 15: 9143-9152.
17. Gietz, D., St. Jean, A., Woods, R.A., and Schiestl, R.H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucl Acids Res 20: 1425.
18. Gigliotti, F., Harmsen, A.G., Haidaris, C.G., and Haidaris, P.J. (1993) Pneumocystis carinii is not universally transmissible between mammalian species. Infect Immun 61: 2886-2890.
19. Giuntoli, D., Stringer, S.L., and Stringer, J.R. (1994) Extra-ordinarily low number of ribosomal RNA genes in P. carinii. J Euk Microbiol 41: 88S.
20. Gottschling, D.E., Aparicio, O.M., Billington, B.L., and Zakian, V.A. (1990) Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63: 751-762.
21. Guzman, P.A., and Sanchez, J.G. (1994) Characterization of telomeric regions from Ustilago maydis. Microbiology 140: 551-557.
22. Horowitz, H., Thorburn, P., and Haber, J.E. (1984) Rearrangements of highly polymorphic regions near telomeres of Saccharomyces cerevisiae. Mol Cell Biol 4: 2509-2517.
23. Hughes, W.T. (1987) Pneumocystis carinii Pneumonitis. Boca Raton, FL: CRC Press, Inc.
24. Hughes, W.T., Bartley, D.L., and Smith, B.M. (1983). A natural source of infection due to Pneumocystis carinii. J Inf Dis 147: 595.
25. Kovacs, J.A., Powell, F., Edman, J.C., Lundgren, B., Martinez, A., Drew, B., and Angus, C.W. (1993) Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. J Biol Chem 268: 6034-6040.
26. 1-3 repeats. Genes Dev 7: 2345-2356.
27. Lee, C.H., Lu, J.J., Bartlett, M.S., Durkin, M.M., Liu, T.H., Wang, J., Jiang, B., and Smith, J.W. (1993) Nucleotide sequence variation in Pneumocystis carinii strains that infect humans. J Clin Microbiol 31: 754-757.
28. Liu, Y., and Leibowitz, M.J. (1993) Variation and in vitro splicing of group I introns in rRNA genes of Pneumocystis carinii. Nucl Acids Res 21: 2415-2421.
29. Louis, E.J., and Haber, J.E. (1989) Nonrecombinant meiosis I nondisjunction in Saccharomyces cerevisiae induced by tRNA ochre suppressors. Genetics 123: 81-95.
30. Louis, E.J., and Haber, J.E. (1990a) Mitotic recombination among subtelomeric Y′ repeats in Saccharomyces cerevisiae. Genetics 124: 547-559.
31. Louis, E.J., and Haber, J.E. (1990b) The subtelomeric Y′ repeat family in Saccharomyces cerevisiae: an experimental system for repeated sequence evolution. Genetics 124: 533-545.
32. Louis, E.J., Naumova, E.S., Lee, A., Naumov, G., and Haber, J.E. (1994) The chromosome end in yeast: its mosaic nature and influence on recombinational dynamics. Genetics 136: 789-802.
33. Lu, J.J., Bartlett, M.S., Queener, S.F., Shaw, M.M., Smith, J.W., Ortiz-Rivera, M., Liebowitz, M.J., and Lee, C.H. (1994) Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes. J Clin Microbiol 32: 2904-2912.
34. McEachern, M.J., and Hicks, J.B. (1993) Unusually large telomeric repeats in the yeast Candida albicans. Mol Cell Biol 13: 551-560.
35. Matsumoto, T., Fukui, K., Niwa, O., Sugawara, N., Szostak, J.W., and Yanagida, M. (1987) Identification of healed terminal DNA fragments in linear minichromosomes of Schizosaccharomyces pombe. Mol Cell Biol 7: 4424-4430.
36. n among vertebrates. Proc Natl Acad Sci USA 86: 7049-7053.
37. Michels, C.A., Read, E., Nat, K., and Charron, M.J. (1992) The telomere-associated MAL3 locus of Saccharomyces is a tandem array of repeated genes. Yeast 8: 655-665.
38. Murray, A.W., Schultes, N.P., and Szostak, J.W. (1986) Chromosome length controls mitotic chromosome segregation in yeast. Cell 45: 529-536.
39. Peters, S.E., Wakefield, A.E., Sinclair, K., Millard, P.R., and Hopkin, J.M. (1992) A search for Pneumocystis carinii in post-mortem lungs by DNA amplification. J Pathol 166: 195-198.
40. Pixley, F.J., Wakefield, A.E., Banerji, S., and Hopkin, J.M. (1991) Mitochondrial gene sequences show fungal homology for Pneumocystis carinii. Mol Microbiol 5: 1347-1351.
41. Pryde, F.E., Huckle, T.C., and Louis, E.J. (1995) Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Yeast 11: 371-382.
42. Roder, M.S., Lapitan, N.L., Sorrells, M.E., and Tanksley, S.D. (1993) Genetic and physical mapping of barley telomeres. Mol Gen Genet 238: 294-303.
43. Rose, M.D., Winston, F., and Hieter, P. (1990) Methods in Yeast Genetics: A Laboratory Course Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
44. Sadhu, C., McEachern, M.J., Rustchenko, B.E., Schmid, J., Soll, D.R., and Hicks, J.B. (1991) Telomeric and dispersed repeat sequences in Candida yeasts and their use in strain identification. J Bacteriol 173: 842-850.
45. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
46. Schechtman, M.G. (1990) Characterization of telomere DNA from Neurospora crassa. Gene 88: 159-165.
47. Shampay, J., Szostak, J.W., and Blackburn, E.H. (1984) DNA sequences of telomeres maintained in yeast. Nature 310: 154-157.
48. Sikorski, R.S., and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
49. Sinclair, K., Wakefield, A.E., Banerji, S., and Hopkin, J.M. (1991) Pneumocystis carinii organisms derived from rat and human hosts are genetically distinct. Mol Biochem Parasitol 45: 183-184.
50. Sloand, E., Laughon, B., Armstrong, M., Bartlett, M.S., Blumenfeld, W., Cushion, M., Kalica, A., Kovacs, J.A., Martin, W., Pitt, E., Pesanti, E.L., Richards, F., Rose, R., and Walzer, P. (1993) The challenge of P. carinii culture. J Euk Microbiol 40: 188-195.
51. Starling, J.A., Maule, J., Hastie, N.D., and Allshire, R.C. (1990) Extensive telomere repeat arrays in mouse are hypervariable. Nucl Acids Res 18: 6881-6888.
52. de Steensma, H., de Jonge, P., Kaptein, A., and Kaback, D.B. (1989) Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: localization of a repeated sequence containing an acid phosphatase gene near a telomere of chromosome I and chromosome VIII. Curr Genet 16: 131-137.
53. Stringer, J.R. (1993) The identity of Pneumocystis carinii: not a single protozoan, but a diverse group of exotic fungi. Inf Agents Dis 2: 109-117.
54. Stringer, J.R., Stringer, S.L., Zhang, J., Baughman, R., Smulian, A.G., and Cushion, M.T. (1993) Molecular genetic distinction of Pneumocystis carinii from rats and humans. J Euk Microbiol 40: 733-741.
55. Sunkin, S.M., and Stringer, J.R. (1996) Translocation of surface antigen genes to a unique telomeric expression site in Pneumocystis carinii. Mol Microbiol 19: 283-295.
56. Sunkin, S.M., Stringer, S.L., and Stringer, J.R. (1994) A tandem repeat of rat-derived Pneumocystis carinii genes encoding the major surface glycoprotein. J Euk Microbiol 41: 292-300.
57. Turakainen, H., Naumov, G., Naumova, E., and Korhola, M. (1993) Physical mapping of the MEL gene family in Saccharomyces cerevisiae. Curr Genet 24: 461-464.
58. Underwood, A.P., Louis, E.J., Borts, R.H., and Wakefield, A.E. (1994) A technique for cloning the telomeres and subtelomeric regions from Pneumocystis carinii. J Euk Microbiol 41: 113S.
59. Van der Ploeg, L., Gottesdiener, K., and Lee, M.G. (1992) Antigenic variation in African trypanosomes. Trends Genet 8: 452-457.
60. Van der Ploeg, L., Liu, A.Y., and Borst, P. (1984) Structure of the growing telomeres of Trypanosomes. Cell 36: 459-468.
61. Vernick, K.D., Walliker, D., and McCutchan, T.F. (1988) Genetic hypervariability of telomere-related sequences is associated with meiosis in Plasmodium falciparum. Nucl Acids Res 16: 6973-6985.
62. Viswanathan, M., Muthukumar, G., Cong, Y.S., and Lenard, J. (1994) Seripauperins of Saccharomyces cerevisiae: a new multigene family encoding serine-poor relatives of serine-rich proteins. Gene 148: 149-153.
63. Wada, M., Kitada, K., Saito, M., Egawa, K., and Nakamura, Y. (1993) cDNA sequence diversity and genomic clusters of major surface glycoprotein genes of Pneumocystis carinii. J Inf Dis 168: 979-985.
64. Wakefield, A.E., Peters, S.E., Banerji, S., Bridge, P.D., Hall, G.S., Hawksworth, D.L., Guiver, L.A., Allen, A.G., and Hopkin, J.M. (1992) Pneumocystis carinii shows DNA homology with the ustomycetous red yeast fungi. Mol Microbiol 6: 1903-1911.
65. Wakefield, A.E., Fritscher, C.C., Malin, A.S., Gwanzura, L., Hughes, W.T., and Miller, R.F. (1994) Genetic diversity in human-derived Pneumocystis carinii isolates from four geographical locations shown by analysis of mitochondrial rRNA gene sequences. J Clin Microbiol 32: 2959-2961.
66. Weinberg, G.A., and Durant, P.J. (1994) Genetic diversity of Pneumocystis carinii derived from infected rats, mice, ferrets, and cell cultures. J Euk Microbiol 41: 223-228.
67. Weinberg, G.A., Edlind, T.D., Lu, J.J., Lee, C.H., Bauer, N.L., and Durant, P.J. (1994) Genetic diversity of Pneumocystis carinii from different host species at the beta-tubulin gene locus and at the internal transcribed spacer regions of the rRNA gene cluster. J Euk Microbiol 41: 118S.
68. Zakian, V.A. (1989) Structure and function of telomeres. Annu Rev Genet 23: 579-604.
69. Zhang, J., Cushion, M.T., and Stringer, J.R. (1993) Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats. J Clin Microbiol 31: 244-248.