Significance of cell type specific formation and elimination of DNA-adducts in respiratory tissues of hamster and rat induced by alkylating chemical carcinogens

Experimental and Toxicologic Pathology

Volumn 48, Issue 6, 1996, Pages 544-547

  Seiler, F ^a   Rehn, B ^a   Kamino, K ^b   Emuro, M ^a   Bruch, J ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

carcinogens, alkylating; diethylnitro samine; DNA adducts; ethylnitrosourea; O6 ethyldeoxyguanosine; respiratory tissue; tumour formation, species specific

Indexed keywords

ALKYLATING AGENT; CARCINOGEN; DIETHYLNITROSAMINE; ETHYLNITROSOUREA; GUANOSINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CARCINOGENESIS; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; DNA ADDUCT; HAMSTER; LUNG; LUNG PARENCHYMA; MALE; NONHUMAN; RAT; SPECIES DIFFERENCE; TRACHEA;

ANIMALIA; CRICETINAE;

EID: 0029827125     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(96)80079-0     Document Type: Conference Paper

References (4)

1. EBERLE G: Ph. D. Dissertation 1989; University of Essen, Essen, Germany.
2. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogens and therapeutic agents. Cancer Res 1990; 50: 6119-6129.
3. SEILER F, KIRSTEIN U, EBERLE E, et al.: Quantification of specific DNA O-alkylation products in individual cells by monoclonal antibodies and digital imaging of intensified nuclear fluorescence. Carcinogenesis 1993; 9: 1907-1913.
4. SCHMAHL D, HABS H: Carcinogenicity of N-Nitroso Compounds. Oncology 1980; 37: 237-242.