Characterization of post-transcriptionally suppressed transgene expression that confers resistance to tobacco etch virus infection in tobacco

Plant Cell

Volumn 9, Issue 8, 1997, Pages 1411-1423

  Tanzer, Matthew M ^a,b   Thompson, William F ^a   Law, Marc D ^b   Wernsman, Earl A ^a   Uknes, Scott ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031420940     PISSN: 10404651     EISSN: None     Source Type: Journal    
DOI: 10.1105/tpc.9.8.1411     Document Type: Article

References (59)

1. Abler, M.L., and Green, P.J. (1996). Control of mRNA stability in higher plants. Plant Mol. Biol. 32, 63-78.
2. Allison, R., Johnston, R.E., and Dougherty, W.G. (1986). The nucleotide sequence of the coding region of tobacco etch virus genomic RNA: Evidence for the synthesis of a single polyprotein. Virology 154, 9-20.
3. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K., eds (1987). Current Protocols in Molecular Biology. (New York: John Wiley and Sons).
4. Baulcombe, D.C. (1996). Mechanisms of pathogen-derived resistance to viruses in transgenic plants. Plant Cell 8, 1833-1844.
5. Baulcombe, D.C., and English, J.J. (1996). Ectopic pairing of homologous DNA and post-transcriptional gene silencing in transgenic plants. Curr. Opin. Biotechnol. 7, 173-180.
6. Benfey, P.N., Ren, L., and Chua, N.-H. (1989). The CaMV 35S enhancer contains at least two domains which can confer different developmental and tissue-specific expression patterns. EMBO J. 8, 2195-2202.
7. Brawerman, G. (1993). mRNA degradation in eukaryotic cells: An overview. In Control of Messenger RNA Stability, J.G. Belasco and G. Brawerman, eds (San Diego, CA: Academic Press), pp. 149-159.
8. Carrazana, E.J., and Pasieka, K.B. (1988). The vasopressin mRNA poly(A) tract is unusually long and increases during stimulation of vasopressin gene expression in vivo. Mol. Cell. Biol. 8, 2267-2274.
9. Church, G.M., and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995.
10. Dean, C., Pichersky, E., and Dunsmuir, P. (1989). Structure, evolution, and regulation of rbcS genes in higher plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 40, 415-439.
11. de Carvalho, F., Gheysen, G., Kushnir, S., Van Montagu, M., Inzé, D., and Castresana, C. (1992). Suppression of β-1,3-glucanase transgene expression in homozygous plants. EMBO J. 11, 2595-2602.
12. De Rocher, E.J., Harkins, K.R., Galbraith, D.W., and Bohnert, H.J. (1990). Developmentally regulated systemic endopolyploidy in succulents with small genomes. Science 250, 99-101.
13. Dougherty, W.G., and Parks, T.D. (1995). Transgenes and gene suppression: Telling us something new? Curr. Opin. Cell Biol. 7, 399-405.
14. Dougherty, W.G., Lindbo, J.A., Smith, H.A., Parks, T.D., Swaney, S., and Proebsting, W.M. (1994). RNA-mediated virus resistance in transgenic plants: Exploitation of a cellular pathway possibly involved in RNA degradation. Mol. Plant-Microbe Interact. 7, 544-552.
15. Elmayan, T., and Vaucheret, H. (1996). Expression of single copies of a strongly expressed 35S transgene can be silenced post-transcriptionally. Plant J. 9, 787-797.
16. English, J.J., Mueller, E., and Baulcombe, D.C. (1996). Suppression of virus accumulation in transgenic plants exhibiting silencing of nuclear genes. Plant Cell 8, 179-188.
17. Flavell, R.B. (1994). Inactivation of gene expression in plants as a consequence of specific sequence duplication. Proc. Natl. Acad. Sci. USA 91, 3490-3496.
18. Galbraith, D.W., Harkins, K.R., and Knapp, S. (1991). Systemic endopolyploidy in Arabidopsis thaliana. Plant Physiol. 96, 985-989.
19. Gallie, D.R. (1996). Translational control of cellular and viral mRNAs. Plant Mol. Biol. 32, 145-158.
20. Gantt, J.S., and Key, J.L. (1987). Molecular cloning of a pea H1 histone cDNA. FEBS Lett. 106, 119-125.
21. Gerez, L., Arad, G., Efrat, S., Ketzinel, M., and Kaempfer, R. (1995). Post-transcriptional regulation of human interleukin-2 gene expression at processing of precursor transcripts. J. Biol. Chem. 270, 19569-19575.
22. Gilbertson, R.L., and Lucas, W.J. (1996). How do viruses traffic on the 'vascular highway'? Trends Plant Sci. 1, 260-267.
23. Goodwin, J., Chapman, K., Swaney, S., Parks, T.D., Wernsman, E.A., and Dougherty, W.G. (1996). Genetic and biochemical dissection of transgenic RNA-mediated virus resistance. Plant Cell 8, 95-105.
24. Hart, C.M., Fischer, B., Neuhaus, J.M., and Meins, F. (1992). Regulated inactivation of homologous gene expression in transgenic Nicotiana sylvestris plants containing a defense-related tobacco chitinase gene. Mol. Gen. Genet. 235, 179-188.
25. Jackson, A.O., and Larkins, B.A. (1976). Influence of ionic strength, pH, and chelation of divalent metals on isolation of polyribosomes from tobacco leaves. Plant Physiol. 57, 5-10.
26. Jorgensen, R.A. (1995). Cosuppression, flower color patterns, and metastable gene expression states. Science 268, 686-691.
27. Kozak, M. (1991). An analysis of vertebrate mRNA sequences: Intimations of translational control. J. Cell Biol. 115, 887-903.
28. Lagrimini, L.M., Burkhart, W., Moyer, M., and Rothstein, S. (1987). Molecular cloning of complementary DNA encoding the lignin-forming peroxidase from tobacco: Molecular analysis and tissue-specific expression. Proc. Natl. Acad. Sci. USA 84, 7542-7546.
29. Larkins, B.A., and Davies, E. (1975). Polyribosomes from peas. Plant Physiol. 55, 749-756.
30. Lindbo, J.A., and Dougherty, W.G. (1992a). Pathogen-derived resistance to a potyvirus: Immune and resistant phenotypes in transgenic tobacco expressing altered forms of a potyvirus coat protein nucleotide sequence. Mol. Plant-Microbe Interact. 5, 144-153.
31. Lindbo, J.A., and Dougherty, W.G. (1992b). Untranslatable transcripts of the tobacco etch virus coat protein gene sequence can interfere with tobacco etch virus replication in transgenic plants. Virology 189, 725-733.
32. Lindbo, J.A., Silva-Rosales, L., Proebsting, W.M., and Dougherty, W.G. (1993). Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus resistance. Plant Cell 5, 1749-1759.
33. Linder, M.C., Nagel, G.N., Roboz, M., and Hungerford, D.M.J. (1981). The size and shape of heart and muscle ferritins analyzed by sedimentation, gel filtration, and electrophoresis. J. Biol. Chem. 256, 9104-9110.
34. Mahajan, S., Dolja, V.V., and Carrington, J.C. (1996). Roles of the sequence encoding tobacco etch virus capsid protein in genome amplification: Requirements for the translation process and a cis-active element. J. Virol. 70, 4370-4379.
35. Martienssen, R. (1996). Epigenetic phenomena: Paramutation and gene silencing in plants. Curr. Biol. 6, 810-813.
36. Matthews, R.E.F. (1991). Transmission, movement, and host range. In Plant Virology, 3rd ed (San Diego, CA: Academic Press), pp. 369-371.
37. Meins, F.J., and Kunz, C. (1994). Silencing of chitinase expression in transgenic plants. In Homologous Recombination and Gene Silencing in Plants, J. Paszkowski, ed (Dordrecht, The Netherlands: Kluwer Academic Publishers), pp. 335-348.
38. Metzlaff, M., O'Dell, M., Cluster, P.D., and Flavell, R.B. (1997). RNA-mediated RNA degradation and chalcone synthase A silencing in petunia. Cell 88, 845-854.
39. Mol, J.N.M., Van Blockland, R., De Lange, P., Stam, M., and Kooter, J.M. (1994). Post-transcriptional inhibition of gene expression: Sense and antisense genes. In Homologous Recombination and Gene Silencing in Plants, J. Paszkowski, ed (Dordrecht, The Netherlands: Kluwer Academic Publishers), pp. 309-334.
40. Pang, S.-Z., Jan, F.-J., Carney, K., Stout, J., Tricoli, D.M., Quemada, H.D., and Gonsalves, D. (1996). Post-transcriptional transgene silencing and consequent tospovirus resistance in transgenic lettuce are affected by transgene dosage and plant development. Plant J. 9, 899-909.
41. Papp, I., Iglesias, V.A., Moscone, E.A., Michalowski, S., Spiker, S., Park, Y.-D., Matzke, M.A., and Matzke, A.J.M. (1996). Structural instability of a transgene locus in tobacco is associated with aneuploidy. Plant J. 10, 469-478.
42. Park, Y.D., Papp, I., Moscone, E.A., Iglesias, V.A., Vaucheret, H., Matzke, A.J.M., and Matzke, M.A. (1996). Gene silencing mediated by promoter homology occurs at the level of transcription and results in meiotically heritable alterations in methylation and gene activity. Plant J. 9, 183-194.
43. Pascal, E., Goodlove, P.E., Wu, L.C., and Lazarowitz, S.G. (1993). Transgenic tobacco plants expressing the geminivirus BL1 protein exhibit symptoms of viral disease. Plant Cell 5, 795-807.
44. Penman, S., Vesco, C., and Penman, M. (1968). Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells. J. Mol. Biol. 34, 49-69.
45. Qian, R.L., Chen, Y.D., Hu, Y.L., Li, M.Q., Wang, Z.H., and Xu, Y.L. (1993a). Interaction between HMG proteins (1+2) and the negative regulatory region 1 (NCR1) in the 5′-flanking sequence of the human β-globin gene. Sci. China Ser. B 36, 933-939.
46. Qian, R.L., Chen, Y.D., Song, Q.B., and Hu, Y.L. (1993b). Binding of HMG proteins to the 5′-flanking sequence of human β-globin gene. Sci. China Ser. B 36, 81-88.
47. Reddy, R., Singh, R., and Shimba, S. (1992). Methylated cap structures in eukaryotic RNAs: Structure, synthesis and function. Pharmacol. Ther. 54, 249-267.
48. Ross, J. (1988). Messenger RNA turnover in eukaryotic cells. Mol. Biol. Med. 5, 1-14.
49. Sachs, A.B. (1993). Messenger RNA degradation in eukaryotes. Cell 74, 413-421.
50. Scheid, O.M., Jakovleva, L., Afsar, K., Maluszynska, J., and Paszkowski, J. (1996). A change in ploidy can modify epigenetic silencing. Proc. Natl. Acad. Sci. USA 93, 7114-7119.
51. Sherwood, J.L. (1988). Mechanisms of cross protection between virus strains. In Plant Resistance to Viruses, D. Evered and S. Harnett, eds (Chichester, UK: John Wiley and Sons), pp. 144-157.
52. Shirley, B.W., Ham, D.P., Senecoff, J.F., Berry-Lowe, S.L., Zurfluh, L.L., Shah, D.M., and Meagher, R.B. (1990). Comparison of the expression of two highly homologous members of the soybean ribulose-1,5-bisphosphate carboxylase small subunit gene family. Plant Mol. Biol. 14, 909-925.
53. Smith, H.A., Swaney, S.L., Parks, T.D., Wernsman, E.A., and Dougherty, W.G. (1994). Transgenic plant virus resistance mediated by untranslatable sense RNAs: Expression, regulation, and fate of nonessential RNAs. Plant Cell 6, 1441-1453.
54. Tanzer, M.M., and Meagher, R.B. (1994). Faithful degradation of soybean rbcS messenger RNA in vitro. Mol. Cell. Biol. 14, 2640-2650.
55. Tanzer, M.M., and Meagher, R.B. (1995). Degradation of the soybean ribulose-1,5-bisphosphate carboxylase small-subunit mRNA SRS4, initiates with endonucleolytic cleavage. Mol. Cell. Biol. 15, 6641-6652.
56. Thompson, D.M., and Meagher, R.B. (1990). Transcriptional and post-transcriptional processes regulate expression of RNA encoding the small subunit of ribulose-1,5-bisphosphate carboxyl-ase differently in petunia and in soybean. Nucleic Acids Res. 18, 3621-3629.
57. Thompson, D.M., Tanzer, M.M., and Meagher, R.B. (1992). Degradation products of the mRNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean and transgenic petunia. Plant Cell 4, 47-58.
58. Uknes, S., Dincher, S., Friedrich, L., Negrotto, D., Williams, S., Thompson-Taylor, H., Potter, S., Ward, E., and Ryals, J. (1993). Regulation of pathogenesis-related protein-1A gene expression in tobacco. Plant Cell 5, 159-169.
59. Van Blokland, R., Van der Geest, N., Mol, J.N.M., and Kooter, J.M. (1994). Transgene-mediated suppression of chalcone synthase expression in Petunia hybrida results from an increase in RNA turnover. Plant J. 6, 861-877.