Mechanisms of cardiac preconditioning: Ten years after the discovery of ischemic preconditioning

Journal of Surgical Research

Volumn 73, Issue 1, 1997, Pages 1-13

  Meldrum, Daniel R ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; NUCLEOTIDASE; PROTEIN KINASE C;

ADAPTATION; CALCIUM HOMEOSTASIS; CELL METABOLISM; CONDITIONING; ENZYME ACTIVATION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PRESERVATION; HEART PROTECTION; HEART TRANSPLANTATION; HUMAN; NONHUMAN; OXIDATIVE STRESS; PHOSPHATE METABOLISM; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031278003     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1997.5187     Document Type: Review

References (139)

1. 1. Murry, C., Jennings, R., and Reimer, K. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124, 1986.
2. 2. Yellon, D. M., Alkhulaifi, A., and Pugsley, W. B. Preconditioning the human myocardium. Lancet 342: 276, 1993.
3. 3. Kloner, R. A., and Shook, T. Previous angina alters in-hospital outcome in TIMI-4: A clinical correlate to preconditioning. Circulation 91: 37, 1995.
4. 4. Ottani, F., Galvani, M., Ferrini, D., Sorbello, F., Limonetti, P., Pantoli, D., and Rusticali, F. Prodromal angina limits infarct size. Circulation 91: 291, 1995.
5. 5. Andreotti, F., Pasceri, V., Hackett, D. R., Davies, G. J., Haider, A. W., and Maseri, A. Preinfarction angina as a predictor of more rapid coronary thrombolysis in patients with acute myocardial infarction. N. Engl. J. Med. 334: 7, 1996.
6. 6. Walker, D. M., Walker, J. M., Pugsley, W. B., Pattison, C. W., and Yellon, D. M. Preconditioning in isolated superfused human muscle. J. Mol. Cell. Cardiol. 27: 1349, 1995.
7. 7. Cleveland, J. C., Meldrum, D. R., Rowland, R. T., Banerjee, A., and Harken, A. H. Adenosine preconditioning of human myocardium is dependent upon the ATP-sensitive potassium channel. J. Mol. Cell. Cardiol. 29: 175, 1997.
8. 8. Cleveland, J. C., Wolmering, M., Meldrum, D. R., Rowland, R. T., Rehring, T. F., Sheridan, B. C., Harken, A. H., and Banerjee, A. Ischemic preconditioning in human and rat ventricle. Am. J. Physiol. 271: H1786, 1996.
9. 9. Gross, G. J., and Auchampach, J. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ. Res. 70: 223, 1992.
10. 10. Grover, G. J., Sleph, P. G., and Dzwoncyzk, S. The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs. Cardiovasc. Drugs Ther. 4: 465, 1990.
11. ATP blockade in type II diabetes and preconditioning in cardiovascular diseases. Circulation 94: 2297, 1996.
12. 12. Cleveland, J. C., Meldrum, D. R., Cain, B. S., Banerjee, A., and Harken, A. H. Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Circulation 1997, in press.
13. 13. Noble, R. L. The development of resistance by rats and guinea pigs to amounts of trauma usually fatal. Am. J. Physiol. 138: 346, 1943.
14. 14. Janoff, A., Weissmann, G., Zweifach, B. W., and Thomas, L. Pathogenesis of experimental shock. J. Exp. Med. 116: 451, 1962.
15. 15. Janoff, A. Alterations in lysosomes (intracellular enzymes) during shock: Effects of preconditioning (tolerance) and protective drugs. Int. Anesth. Clin. 2: 251, 1964.
16. 16. Brown, J. M., Grosso, M. A., Terada, L. S., Whitman, G. J., Banerjee, A., White, C. W., Harken, A. H., and Repine, J. E. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc. Natl. Acad. Sci. USA 86: 2516, 1989.
17. 17. Maulik, N., Watanabe, M., Engelman, D., Engelman, R. M., Kagan, V. E., Kisin, E., Tyurin, V., Cordis, G. A., and Das, D. K. Myocardial adaptation to ischemia by oxidative stress induced by endotoxin. Am. J. Physiol. 269: C907, 1995.
18. 1-adrenoceptor mediated, protein synthesis independent mechanism. Am. J. Physiol. 272: R718, 1997.
19. 19. Meldrum, D. R., Cleveland, J. C., Rowland, R. T., Banerjee, A., Harken, A. H., and Meng, X. Early and delayed preconditioning: Differential mechanisms and additive protection. Am. J. Physiol. 42: H725, 1997.
20. 20. Meng, X., Brown, J. M., Ao, L., Franklin, W., Banerjee, A., and Harken, A. H. Heat shock protein 70 contributes to the induced cardiac resistance to bacterial lipopolysaccharide in the rat. Am. J. Physiol. 271: C1316, 1996.
21. 1-adrenoceptors. Cardiovasc. Res. 32: 374, 1996.
22. 22. Meldrum, D. R., Cleveland, J. C., Sheridan, B. C., Meng, X., Robertson, F., Cain, B. S., Harken, A. H., and Banerjee, A. Protein kinase C isoform diversity in preconditioning. J. Surg. Res. 69: 183, 1997.
23. 23. Meldrum, D. R., Cleveland, J. C., Sheridan, B. C., Rowland, R. T., Banerjee, A., and Harken, A. H. Differential effects of adenosine preconditioning on the post-ischemic rat myocardium. J. Surg. Res. 65: 156, 1996.
24. 24. Meldrum, D. R., and Harken, A. H. Preconditioning of skeletal muscle: Application to dynamic cardiomyoplasty. J. Card. Surg. 111: 109, 1996.
25. 25. Rehring, T. F., Friese, R. S., Cleveland, J. C., Meng, X., Gamboni, F., Harken, A. H., and Banerjee, A. Alpha-adrenergic preservation of myocardial pH during ischemia is PKC isoform dependent. J. Surg. Res. 63: 324, 1996.
26. 26. Zucchi, R., Ronca-Testoni, S., Gongyuan, Y., Galbani, P., Ronca, G., and Mariani, M. Postischemic changes in cardiac sarcoplasmic reticulum calcium channels: A possible mechanism of ischemic preconditioning. Circ. Res. 76: 1049, 1995.
27. 27. Banerjee, A., Gamboni, F., Mitchell, M. B., Rehring, T. F., Butler, K., Cleveland, J. C., Meldrum, D. R., Shapiro, J. I., and Meng, X. Stress induced cardioadaptation reveals a code linking hormone receptors and spatial distribution of PKC isoforms. Ann. NY Acad. Sci. 793: 226, 1996.
28. 28. Meldrum, D. R., Mitchell, M. B., Banerjee, A., and Harken, A. H. Cardiac preconditioning: Induction of endogenous tolerance to ischemia-reperfusion injury. Arch. Surg. 128: 1208, 1993.
29. 29. Nishizuka, Y. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607, 1992.
30. 30. Banerjee, A., Locke-Winter, C., Rogers, K. B., Mitchell, M. B., Bensard, D. D., Brew, E. C., Cairns, C. B., and Harken, A. H. Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha-1 adrenergic mechanism. Circ. Res. 73: 656, 1993.
31. 31. Cleveland, J. C., Meldrum, D. R., Rowland, R. T., Sheridan, B. C., Banerjee, A., and Harken, A. H. The obligate role of protein kinase C in mediating clinically accessible cardiac preconditioning. Surgery 120: 345, 1996.
32. 1-adrenoceptors. Am. J. Physiol. 1997, in press.
33. 2+ induced cardioadaptation to ischemia-reperfusion injury. Am. J. Physiol. 271: R1718, 1996.
34. 34. Meldrum, D. R., Cleveland, J. C., Sheridan, B. C., Rowland, R. T., Banerjee, A., and Harken, A. H. Cardiac preconditioning with calcium: Clinically accessible myocardial protection. J. Thorac. Cardiovasc. Surg. 112: 778, 1996.
35. 35. Meldrum, D. R., Cleveland, J. C., Rowland, R. T., Banerjee, A., and Harken, A. H. Calcium induced inotropy is in part mediated by protein kinase C. J. Surg. Res. 63: 400, 1996.
36. 36. Meldrum, D. R., Cleveland, J. C., Mitchell, M. B., Rowland, R. T., Banerjee, A., and Harken, A. H. Constructive priming of myocardium against ischemia-reperfusion injury. Shock 6: 238, 1996.
37. 37. Mitchell, M. B., Meng, X., Parker, C. G., Harken, A. H., and Banerjee, A. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ. Res. 76: 73, 1995.
38. 2+ as a mediator of ischemic preconditioning. Circ. Res. 80: 790, 1997.
39. 39. Meldrum, D. R., Cleveland, J. C., Sheridan, B. C., Rowland, R. T., Banerjee, A., and Harken, A. H. Cardiac surgical implications of calcium dyshomeostasis in the heart. Ann. Thorac. Surg. 61: 1273, 1996.
40. 40. Baxter, G. F., Marber, M. S., Patel, V. C., and Yellon, D. M. Adenosine receptor involvement in a delayed phase of protection 24 hours following ischemic preconditioning. Circulation 90: 2993, 1994.
41. 41. Bouma, M. G., Wildenberg, F. A. J. V. D., and Buurman, W. A. Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells. Am. J. Physiol. 270: C522, 1996.
42. 42. Bullough, D. A., Magill, M. J., Firestein, G. S., and Mullane, K. M. Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated myocytes. J. Immunol. 155: 2579, 1995.
43. 43. Cave, A. C., Collis, C. C., and Downey, J. M. Improved functional recovery by ischemic preconditioning is not mediated by adenosine in the globally ischemic isolated rat heart. Cardiovasc. Res. 27: 663, 1993.
44. 44. Downey, J. M., Cohen, M. V., Ytrehus, K., and Liu, Y. Cellular mechanisms in ischemic preconditioning: The role of endogenous adenosine and PKC. Ann. NY Acad. Sci. 723: 82, 1994.
45. 45. Fralix, T. A., Murphy, E., London, R. E., and Steenbergen, C. Protective effects of adenosine in the reperfused rat heart: Changes in metabolism and intracellular ion homeostasis. Am. J. Physiol. 264: C986, 1993.
46. 46. Headrick, J. P. Ischemic preconditioning: Bioenergetic and metabolic changes and the role of endogenous adenosine. J. Mol. Cell. Cardiol. 28: 1227, 1996.
47. 47. Heads, R. J., Latchman, D. S., and Yellon, D. M. Differential stress protein mRNA expression during early ischemic preconditioning in the rabbit heart and its relationship to adenosine receptor function. J. Mol. Cell. Cardiol. 27: 2133, 1995.
48. 1-Adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs. Circ. Res. 60: 631, 1987.
49. 49. Kitakaze, M., Hori, M., and Kamada, T. Role of adenosine and its interaction with alpha-adrenoceptor activity in ischemic and reperfusion injury of the myocardium. Cardiovasc. Res. 27: 18, 1993.
50. 1 receptor mediated protection of the globally ischemic isolated rat heart. J. Mol. Cell. Cardiol. 22: 39, 1990.
51. 51. Li, Y., and Kloner, R. A. The cardioprotective effects of ischemic preconditioning are not mediated by adenosine in the rat. Circulation 87: 1642, 1992.
52. 52. Liu, G., Thornton, J., Van Winkle, D., Stanley, A., Olsson, R., and Downey, J. Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 84: 350, 1991.
53. 53. Parmely, M. J., Zhou, W. W., Edwards, C. K., Borcherding, D. R., Silverstein, R. S., and Morrison, D. C. Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-α production and protect mice against endotoxin challenge. J. Immunol. 151: 389, 1993.
54. 1 selective adenosine analogues protects the heart against infarction. Circulation 85: 659, 1992.
55. ATP channels. Am. J. Physiol. 272: H334, 1997.
56. 56. Thornton, J., Striplin, S., Liu, G. S., Swafford, A., Stanley, A. W. H., Van Winkle, D. M., and Downey, J. M. Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. Am. J. Physiol. 259: H1822, 1990.
57. + channel? Circ. Res. 77: 1030, 1995.
58. 58. Asimakis, G. K., Inners-McBride, K., and Conti, V. R. Attenuation of postischemic dysfunction by ischemic preconditioning is not mediated by adenosine in the isolated rat heart. Cardiovasc. Res. 27: 1522, 1993.
59. 59. Winter, C. B., Cleveland, J. C., Butler, K. L., Bensard, D. B., Mitchell, M. B., Harken, A. H., and Banerjee, A. Facilitative interactions between noradrenergic and purinergic signaling during preconditioning of the rat heart. J. Mol. Cell. Cardiol. 29: 163, 1997.
60. 60. Liu, Y., and Downey, J. M. Ischemic preconditioning protects against infarction in rat heart. Am. J. Physiol. 263: H1107, 1992.
61. 61. Cleveland, J. C., Meldrum, D. R., Rowland, R. T., Banerjee, A., and Harken, A. H. Preconditioning and hypothermic cardioplegia protect human heart equally against ischemia. Ann. Thorac. Surg. 63: 147, 1997.
62. 62. Poggetti, R. S., Moore, E. E., Moore, F. A., Bensard, D. D., Parsons, P., Anderson, B. O., and Banerjee, A. Gut and liver coordinated metabolic response following major torso injury. J. Surg. Res. 52: 27, 1992.
63. 63. Poggetti, R. S., Moore, E. E., Moore, F. A., Koike, K., Tuder, R., Anderson, B. O., and Banerjee, A. Quantifying oxidative injury in the liver. Am. J. Physiol. 268: G471, 1995.
64. 64. Berridge, M. J. Inositol triphosphate and calcium signalling. Nature 361: 315, 1993.
65. 65. Ashraf, M., Suleiman, J., and Ahmad, M. Calcium preconditioning elicits a unique protection against the calcium paradox injury in rat heart: Role of adenosine. Circ. Res. 74: 360, 1994.
66. 66. Shen, A., and Jennings, R. Myocardial calcium and magnesium in acute ischemic injury. Am. J. Pathol. 67: 417, 1972.
67. 67. Sayeed, M. M., and Maitra, S. R. Effect of diltiazem on altered cellular calcium regulation during endotoxic shock. Am. J. Physiol. 253: R549, 1987.
68. 68. Sayeed, M. M. Alterations in cellular calcium regulation in the liver in endotoxic shock. Am. J. Physiol. 250: R884, 1986.
69. 69. Chaudry, I. H., Ayala, A., Ertel, W., and Stephan, R. N. Hemorrhage and resuscitation: Immunological aspects. Editorial Review. Am. J. Physiol. 259: R663, 1990.
70. 70. Chaudry, I. H. Cellular mechanisms in shock and ischemia and their correction. Am. J. Physiol. 245: R117, 1983.
71. 71. Steenbergen, C., Perlman, M. E., London, R. E., and Murphy, E. Mechanism of preconditioning: Ionic alterations. Circ. Res. 72: 112, 1993.
72. 72. Steenbergen, C., Fralix, T., and Murphy, E. Role of increased cytosolic calcium concentration in myocardial ischemic injury. Basic Res. Cardiol. 88: 456, 1993.
73. 73. Banerjee, A., Gamboni, F., and Harken, A. H. Selection of isoforms by cardioadaptive preconditioning. FASEB J. 9: A932, 1995.
74. + channel blocker. Circulation 90: 700, 1994.
75. 75. Klimt, C. R., Knautterud, G. L., Meinert, C. L., and Prout, T. E. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. Diabetes 19: 747, 1970.
76. 76. Rytter, L., Troelsen, S., and Beck-Nielsen, H. Prevalence and mortality of acute myocardial infarction in patients with diabetes. Diabetes Care 8: 230, 1985.
77. 77. Kitakaze, M., Node, K., Komamura, K., Minamino, T., Inoue, M., Hori, M., and Kamada, T. Evidence for nitric oxide generation in the cardiomyocytes: Its augmentation by hypoxia. J. Mol. Cell. Cardiol. 27: 2149, 1995.
78. 78. Kitakaze, M., Node, K., Minamino, T., Komamura, K., Funaya, H., Shinozaki, Y., Chujo, M., Mori, H., Inoue, M., Hori, M., and Kamada, T. Role of activation of protein kinase C in the infarct size limiting effect of ischemic preconditioning through the activation of 5′-nucleotidase. Circulation 93: 781, 1996.
79. 79. Kitakaze, M., Minamino, T., Node, K., Komamura, K., and Hori, M. Activation of ecto-5′-nucleotidase and cardioprotection by ischemic preconditioning. Basic Res. Cardiol. 91: 23, 1996.
80. 80. Minamino, T., Kitakaze, M., Morioka, T., Node, K., Komamura, K., Takeda, H., Inoue, M., Hori, M., and Kamada, T. Cardioprotection due to preconditioning correlates with increased ecto-5′-nucleotidase activity. Am. J. Physiol. 270: H238, 1996.
81. 81. Yellon, D. M., and Baxter, G. F. A second window of protection or delayed preconditioning: Future horizons for myocardial protection? J. Mol. Cell. Cardiol. 27: 1023, 1995.
82. 82. Goto, M., Liu, Y., Yang, X. M., Ardell, J. L., Cohen, M. V., and Downey, J. M. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts. Circ. Res. 77: 611, 1995.
83. 83. Brew, E. B., Mitchell, M. B., Rehring, T. F., Gamboni-Robertson, F., Mcintyre, R. C., Harken, A. H., and Banerjee, A. The role of bradykinin in cardiac functional protection after global ischemia-reperfusion in the rat heart. Am. J. Physiol. 269: H1370, 1995.
84. 84. Brown, J. M., White, C. W., Terada, L. S., Grosso, M. A., Shanley, P.F., Mulvin, D. W., Banerjee, A., Whitman, G. J., Harken, A. H., and Repine, J. E. Interleukin-1 pretreatment decreases ischemia/reperfusion injury. Proc. Natl. Acad. Sci. USA 87: 5026, 1990.
85. 85. Donnelly, T., Sievers, R., Vissern, F., Welch, W., and Wolfe, C. Heat shock protein induction in rat hearts: A role for improved myocardial salvage after ischemia and reperfusion? Circulation 85: 769, 1992.
86. 86. Szekeres, L., Papp, J. G., Szilvássy, Z., Udvary, E., and Vegh, A. Moderate stress by cardiac pacing may induce both short term and long term cardioprotection. Cardiovasc. Res. 27: 593, 1993.
87. 87. Marber, M., Latchman, D., Walker, J., and Yellon, D. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88: 1264, 1993.
88. 88. Brown, J. M., Anderson, B. O., Repine, J., Shanley, P., White, C., Grosso, M. A., Banerjee, A., Bensard, D., and Harken, A. H. Neutrophils contribute to TNF induced myocardial tolerance to ischemia. J. Mol. Cell. Cardiol. 24: 485, 1992.
89. 89. Nelson, D. W., Brown, J. M., Banerjee, A., Bensard, D. D., Rogers, K. B., Locke-Winter, C. R., Anderson, B. O., and Harken, A. H. Pretreatment with a nontoxic derivative of endotoxin (MPL) induces functional protection against cardiac ischemia reperfusion injury. Surgery 110: 365, 1991.
90. 90. Meng, X., Ao, L., Brown, J. M., Meldrum, D. R., Sheridan, B. C., Cain, B. S., Banerjee, A., and Harken, A. H. LPS induces delayed cardiac functional protection against ischemia independent of cardiac and circulating TNFα. Am. J. Physiol. 273: H1894, 1997.
91. ATP channels mediate late preconditioning against infarction produced by monophosphoryl lipid A. Am. J. Physiol. 271: H2723, 1996.
92. + channels underlies relaxation to bacterial lipopolysaccharide in rat aorta. Biochem. Biophys. Res. Commun. 224: 184, 1996.
93. 93. Schultz, J. E., Hsu, A. K., and Gross, G. J. Morphine mimics the cardioprotective effects of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circ. Res. 78: 1100, 1996.
94. + channels: A possible mechanistic link to ischemic preconditioning. Circ. Res. 79: 399, 1996.
95. 95. Baxter, G. F., Goma, F. M., and Yellon, D. M. Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium. Br. J. Pharmacol. 115: 222, 1995.
96. 96. Meng, X., Ao, L., Banerjee, A., and Harken, A. H. Sympathetic signal transduction induces two distinct phases of cardioprotection by activation of protein kinase C. Circulation 94:I-184, 1996.
97. 97. Plumier, J. L., Ross, B. M., Currie, R. W., Angelidis, C. E., Kazlaris, H., Kollias, G., and Pagoulatos, G. N. Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J. Clin. Invest. 95: 1854, 1995.
98. 98. Marber, M. S., Mestril, R., Chi, S.-H., Sayen, M. R., Yellon, D.M., and Dillmann, W. H. Overexpression of the rat 70 kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J. Clin. Invest. 95: 1446, 1995.
99. 99. Shen, H. M., Sha, L. X., Kennedy, J. L., and Ou, D. W. Adrenergic receptors regulate macrophage secretion. Int. J. Immunopharmacol. 16: 905, 1994.
100. 100. Matsumori, A., Ono, K., Sato, Y., Shioi, T., Nose, Y., and Sasayama, S. Differential modulation of cytokine production by drugs: Implications for therapy in heart failure. J. Mol. Cell. Cardiol. 28: 2491, 1996.
101. 101. VanderPoll, T., Coyle, S. M., Barbosa, K., Braxton, C. C., and Lowry, S. F. Epinephrine inhibits tumor necrosis factor-α and potentiates interleukin 10 production during human endotoxemia. J. Clin. Invest. 97: 713, 1996.
102. 102. Schoenberg, M. H., Poch, B., Moch, D., Marzinzig, M., Marzinzig, E., Mattfeldt, T., Gruber, H., and Beger, H. G. Effect of acadesine treatment on postischemic damage to the small intestine. Am. J. Physiol. 269: H1752, 1995.
103. 103. Denlinger, L. C., Fisette, P. L., Garis, K. A., Kwon, G., Vasquez-Torres, A., Simon, A. D., Nguyen, B., Proctor, R. A., Bertics, P. J., and Corbett, J. A. Regulation of inducible nitric oxide synthase expression by macrophage purinoceptors and calcium. J. Biol. Chem. 271: 337, 1996.
104. 104. Meldrum, D. R., Ayala, A., and Chaudry, I. H. Energetics of defective macrophage antigen presentation following hemorrhage. Surgery 112: 150, 1992.
105. 105. Hutter, M. M., Sievers, R. E., Barbosa, V., and Wolfe, C. L. Heat shock protein induction in rat hearts: A direct correlation between the amount of heat shock protein induced and the degree of myocardial protection. Circulation 89: 355, 1994.
106. 106. Wakabayashi, G., Cannon, J. G., Gelfand, J. A., Clark, B. D., Aiura, K., Burke, J. F., Wolffe, S. M., and Dinarello, C. A. Altered IL-1 and TNF production and secretion during pyogenic tolerance to LPS in rabbits. Am. J. Physiol. 267: R329, 1994.
107. 107. Ayala, A., Kisala, J. M., Felt, J. A., Perrin, M. M., and Chaudry, I. H. Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin 1, interleukin 6, or tumor necrosis factor) during sepsis? Arch. Surg. 127: 191, 1992.
108. 108. Dinarello, C. A., Dempsey, R. A., Allegretta, M., Parkinson, D. R., and Mier, J. W. Inhibitory effects of elevated temperature on human monokine production and natural killer cell activity. Cancer Res. 46: 6236, 1986.
109. 109. Fouqueray, B., Philippe, C., Amrani, A., Perez, J., and Baud, L. Heat shock prevents LPS-induced TNF-α synthesis by rat mononuclear phagocytes. Eur. J. Immunol. 22: 2983, 1992.
110. 110. Hall, T. J. Role of hsp70 in cytokine production. Experientia 50: 1048, 1994.
111. 111. Buchman, T. G. Manipulation of stress gene expression: A novel therapy for the treatment of sepsis? Crit. Care Med. 22: 901, 1994.
112. 112. Zuckerman, S. H., Evans, G. F., and Butler, L. D. Endotoxin tolerance: Independent regulation of IL-1 and TNF expression. Infect. Immun. 41: 2774, 1991.
113. 113. Brown, J. M., Grosso, M. A., Terada, L. S., Beehler, C. J., Toth, K. M., Whitman, G. J., and Harken, A. H. Erythrocytes decrease myocardial hydrogen peroxide levels and reperfusion injury. Am. J. Physiol. 256: H584, 1989.
114. 114. Brown, J. M., Buehler, G. J., Berger, E. M., Grosso, M. A., Whitman, G. J., Terada, L. S., Leff, J., Harken, A. H., and Repine, J. E. Albumin decreases hydrogen peroxide and reperfusion injury in isolated rat hearts. Inflammation 13: 583, 1989.
115. 115. Brown, J. M., Terada, L. S., Grosso, M. A., Whitman, G. J., Velasco, S. E., Patt, A., Harken, A. H., and Repine, J. E. Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic isolated rat hearts. J. Clin. Invest. 81: 1297, 1988.
116. 116. Meldrum, D. R., Sheridan, B. C., Cleveland, J. C., Fullerton, D. A., Banerjee, A., and Harken, A. H. Neutrophils are required for endotoxin induced myocardial cross-tolerance to ischemia-reperfusion injury. Arch. Surg. 131: 1203, 1996.
117. 117. Brown, J. M., Grosso, M. A., Terada, L. S., Banerjee, A., and Harken, A. H. Endotoxin induces in vivo myocyte HSP-70 expression and protection from cardiac ischemic injury. J. Cell Biochem. 195: 17, 1993.
118. 118. Meldrum, D. R., Cleveland, J. C., Moore, E. E., Partrick, D. A., Banerjee, A., and Harken, A. H. Adaptive and maladaptive mechanisms of cellular priming. Ann. Surg. 1997, in press.
119. 119. Rowland, R. T., Brown, J. M., Meng, X., Terada, L. S., and Harken, A. H. The mechanism of immature myocardial tolerance to ischemia: Phenotypic differences in antioxidants, stress proteins and oxidases. Surgery 118: 446, 1995.
120. 120. Cumming, D. V. E., Heads, R. J., Watson, A., Latchman, D. S., and Yellon, D. M. Differential protection of primary rat cardiomyocytes by transfection of specific heat stress proteins. J. Mol. Cell. Cardiol. 28: 2343, 1996.
121. 121. Suzuki, K., Sawa, Y., Kaneda, Y., Ichikawa, H., Shirakura, R., and Matsuda, H. In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in the rat. J. Clin. Invest. 99: 1645, 1997.
122. 122. Nakano, M., Mann, D. L., and Knowlton, A. A. Blocking the endogenous increase in HSP72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiomyocytes. Circulation 95: 1523, 1997.
123. 123. Feinstein, D. L., Galea, E., Aquino, D. A., Li, G. C., Xu, H., and Reis, D. J. Heat shock protein 70 suppresses astroglial-inducible nitric oxide synthase expression by decreasing NFkB activation. J. Biol. Chem. 271: 17724, 1996.
124. 124. Ribeiro, S. P., Villar, J., Downey, G. P., Edelson, J. D., and Slutsky, A. S. Effects of the stress response in septic rats and LPS-stimulated alveolar macrophages: Evidence for TNFα posttranslational regulation. Am. J. Respir. Crit. Care Med. 154: 1843, 1996.
125. 125. Brown, J. M., Harken, A. H., and Sharefkin, J. B. Recombinant DNA and surgery. Ann. Surg. 212: 178, 1990.
126. 126. Rowland, R. T., Cleveland, J. C., Meng, X., Harken, A. H., and Brown, J. M. Potential gene therapy strategies in the treatment of cardiovascular disease. Ann. Thorac. Surg. 60: 721, 1995.
127. 127. Muller, J. M., Ziegler-Heitbrock, H. W., and Baeuerle, P. A. Nuclear factor kappa B, a mediator of LPS effects. Immunobiology 187: 233, 1993.
128. 128. Barnes, P. J., and Karvin, M. Nuclear factor kappa B: A pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336: 1066, 1997.
129. 129. Meldrum, D. R., Shenkar, R., Sheridan, B. C., Cain, B. S., and Harken, A. H. Hemorrhage activates myocardial NFkB and increases tumor necrosis factor in the heart. J. Mol. Cell. Cardiol. 1997, in press.
130. 130. Meldrum, D. R., Cleveland, J. C., Sheridan, B. C., Rowland, R. T., Selzman, C. H., Banerjee, A., and Harken, A. H. Alpha-adrenergic activation of myocardial NFkB during hemorrhage. J. Surg. Res. 69: 268, 1997.
131. 131. Schmidt, K. N., Traenckner, E. B., Meier, B., and Baeuerle, P. A. Induction of oxidative stress by okadaic acid is required for activation of transcription factor NFkB. J. Biol. Chem. 270: 27136, 1995.
132. 132. Mihm, S., Galter, D., and Droge, W. Modulation of transcription factor NFkB activity by intracellular glutathione levels and by variations of the extracellular cysteine supply. FASEB J. 9: 246, 1995.
133. 133. LeTulzo, Y., Shenkar, R., Kaneko, D., Moine, P., Fantuzzi, G., Dinarello, C. A., and Abraham, E. Hemorrhage increases cytokine expression in lung mononuclear cells in mice: Involvement of catecholamines in nuclear factor kappa B regulation and cytokine expression. J. Clin. Invest. 99: 1516, 1997.
134. 134. Walker, G., Kunz, D., Pignat, W., vandenBosch, H., and Pfeilshifter, J. Pyrrolidine dithiocarbamate differentially affects cytokine-and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells. FEBS Lett. 8: 218, 1995.
135. 135. Kawai, M., Nishikomori, R., Jung, E. Y., Tai, G., Yamanaka, C., Mayumi, M., and Heike, T. Pyrrolidine dithiocarbamate inhibits intracellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. J. Immunol. 154: 2333, 1995.
136. 136. Liu, S. L., Esposti, S. D., Yao, T., Diehl, A. M., and Zern, M. A. Vitamin E therapy of acute CC14-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. Hepatology 22: 1474, 1995.
137. 137. Banerjee, A., Grosso, M. A., Rogers, K. B., Brown, J. M., and Whitman, G. J. R. Oxygen metabolite effects on creatine kinase and cardiac energetics after reperfusion. Am. J. Physiol. 261: H590, 1991.
138. 138. Cleveland, J. C., Meldrum, D. R., Rowland, R. T., Banerjee, A., and Harken, A. H. Optimal myocardial preservation: Cooling, cardioplegia and conditioning. Ann. Thorac. Surg. 61: 760, 1996.
139. 139. Meldrum, D. R. Tumor necrosis factor in the heart. (Invited Review). Am. J. Physiol. 1997. [in press]