Molecular processes and radiosensitivity

Strahlentherapie und Onkologie

Volumn 173, Issue 9, 1997, Pages 457-461

  Zdzienicka, M Z ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

DNA double strand breaks; Homologous and non homologous recombination; Radiosensitivity

Indexed keywords

DNA; RECOMBINANT DNA;

DNA DAMAGE; DNA REPAIR; HUMAN; MOLECULAR BIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; REVIEW;

DNA; DNA DAMAGE; DNA REPAIR; DNA, RECOMBINANT; HUMANS; MOLECULAR BIOLOGY; RADIATION INJURIES; RADIATION TOLERANCE;

EID: 0031230507     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03038184     Document Type: Article

References (48)

1. Ajimura, M;, S. H. Leem, H. Ogawa: Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133 (1993), 51-66.
2. Anderson, C. W.: DNA damage and the DNA-activated protein kinase. Trends Biochem. Sei. 18 (1993), 433-437.
3. Beau, E. L;, D. C. Rio: Drosophila IRBP/Ku p70 corresponds to the mutagen-sensitive mus309 gene and is involved in P-element excision in vivo. Genes and Develop. 10 (1996), 921-933.
4. Biedermann, K. A;, J. Sung, A. J. Giaccia et al.: Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. nat. Acad. Sei. (Wash.) 88 (1991), 1394-1397.
5. Blunt, T;, N. J. Finnic, G. E. Taccioli et al.: Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine seid mutation. Cell SO (1995), 813-823.
6. Blunt, T;, D. Gell, M. Fox et al.: Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. nat. Acad. Sei. (Wash.) 93 (1996), 10285-10290.
7. Bosma, M. J;, A. M. Carroll: The SCID mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 9 (1991), 323-350.
8. Bosma, G. C, R. P. Custer, M. J. Bosma: A severe combined immunodeficiency mutation in the mouse. Nature 301 (1983), 527-530.
9. Boulton, S. J;, S. P. Jackson: Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15 (1996), 5093-5103.
10. Danska, J. S;, D. P. Holland, S. Mariathasan et al.: Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Molec. Cell. Biol. 16 (1996), 5507-5517.
11. Dolganov, G. M;, R. S. Maser, A. Novikov et al.: Human Rad50 is physically associated with human Mrell: Identification of a conserved multiprotein complex implicated in recombinational DNA repair. Molec. cell. Biol. 16 (1996), 4832-4841.
12. Errami, A;, V. Smider, W. K. Ralhmell et al.: Ku86 defines the defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Molec. cell. Biol. 13 (1996), 3464-3471.
13. Feldmann, H;, E. L. Winnacker: A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J. biol. Chem. 268 (1993), 12895-12900.
14. Friedberg, E. C;, G. C. Walker, W. Siede: DNA repair and mutagenesis, American Society for Microbiology, Washington, DC 1995.
15. Fulop, G. M;, R. A. Phillips: The seid mutation in mice causes a general defect in DNA repair Nature 347 (1990), 479-482.
16. Gaccia, A;, R. Weinstein, J. Hu et al.: Cell cycle-dependent repair of double-strand breaks in a ray-sensitive Chinese hamster cell. Somatic Cell Molec. Genet. 11 (1985), 485-491.
17. Game, J. C.: DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces. Semin. Cancer Biol. 4 (1993), 73-83.
18. IS. Gotlieb, T. M;, S. P. Jackson: The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72 (1993), 131-142.
19. Hartley, K. O;, D. Gell, G. C. M. Smith et al.: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and ataxia telangiectasia gene product. Cell 82 (1995), 849-856.
20. Hendrickson, E. A;, X. Q. Qin, E. A. Bump et al.: A link between double-strand break related repair and V(D)J recombination: the seid mutation. Proc. nat. Acad. Sei. (Wash.) 88 (1991), 4061-4065.
21. Jackson, S. P;, P. A. Jeggo: DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends biochem. Sei. 20 (1995), 412-415.
22. Jacoby, D. B;, P. C. Wensink: DNA binding specificities of YPF1, a drosophila homolog to the DNA binding subunit of human DNA-dependent protein kinase, Ku. J. biol. Chem. 28 (1996), 16827-16832.
23. Kirchgessner, C. U;, C. K. Patil, J. W. Evans et al.: DNA dependent kinase (p350) is a candidate gene for murine seid defect. Science 267 (1995), 1178-1183.
24. Lewis, S. M.: The mechanisms of V(D)J rejoining: lessons from molecular, immunological, and comparative analysis. Adv. Immunol. 56 (1994), 27-149.
25. Li, Z;, T. Otevrel, Y. Gao et al.: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83 (1995), 1079-1089.
26. Lin, F-L;, K. Sperle, and N. Sternberg: Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. Molec. cell. Biol. 4 (1984), 1020-1034.
27. Mages, G. J;, H. M. Feldman, E. L. Winnacker: Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination. J. biol. Chem. 271 (1996), 7910-7915.
28. Meyn, M. S.: Ataxia-telangiectasia and cellular responses to DNA damage. Cancer Res. 55 (1995), 5991-6001.
29. Milne, G. T;, S. Jin, K. B. Shannon et al.: Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Molec. cell. Biol. 16 (1996), 4189-4198.
30. Mimori, T;, J. A. Hardin, J. A. Steitz: Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. biol. Chem. 26 (1986), 2274-2278.
31. Mimori, T;, Y. Ohosone, N. Hama, A. Smva et al.: Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/pSO) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. Proc. nat. Acad. Sei. (Wash.) 87 (1990), 1777-1781.
32. Mizuta, R;, G. E. Taccioli, F. W. Alt: The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the KuSO gene. Int. Immunol. 8 (1996), 1467-1471.
33. Moore, J. K;, J. E. Haber: Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks of Saccharomyces cerevisiae. Molec. cell. Diol. 16 (1996), 2164-2173.
34. Nussenzwieg, A;, C. Chen, V. da Costa Soares et al.: Requirement for KuSO in growth and immunoglobulin V(D)J recombination. Nature 382 (1996), 551-555.
35. Pergola F;, M. Z. Zdzienicka, M. R. Lieber: V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Molec. cell. Bio!. 13 (1993), 3464-3471.
36. Price, A.: The repair of ionising radiation-induced damage to DMA. Semin. Cancer Biol. 4 (1993) 61-71.
37. Roth, D. B;, J. H. Wilson: Illegitimate recombination in mammalian cells. In: Kucherlapati, R;, G. R. Smith (eds.): Genetic recombination. American Society for Microbiology, Washington DC 1988, p. 621-653.
38. Savitsky, K;, A. Bar-Shira, S. Gilad et al.: A single ataxia-telangiectasia gene with a product similar to PI-3 kinase. Sciences 268 (1995), 1749-1753.
39. Shiloh, Y.: Ataxia-telangiectasia: closer to unravelling the mystery. Europ. J. Hum. Genet. 3 (1995), 116-138.
40. Siede, W;, A. A. Friedl, I. Dianova et al.: The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142 (1996), 91-102.
41. Taccioli, G. E;, G. Rathbun, E. Oltz et al.: Impairment of V(D)J recombination in double-strand break repair mutants. Science 260 (1993), 207-210.
42. TsukSmoto, Y;, J. Kato, H. Ikeda: Hsfl, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination. Nucl. Acid Res. 24 (1996), 2067-2072.
43. Verhaegh, G. W. C. T;, W. Jongmans, N. G. J. Jaspers et al.: A gene which regulates DNA replication in response to DNA damage is located on human chromosome 4q. Amer. J. Hum. Genet. 57 (1995), 1095-1103.
44. Weaver, D. T.: What to do at an end: DNA double-strand-break repair. Trends in Genet. 11 (1995), 388-392.
45. Weemaes, C. M;, D. F. C. Smeets, C. J. A. M. van der Burgt: Nijmegen Breakage syndrome: a progress report. Int. J. Radial. Biol. 66 (1994), S185-S188.
46. Zdzienicka, M. Z.: Mammalian X-ray-sensitive mutants: a tool for the elucidation of the cellular response to ionising radiation. In: Tooze (ed.): Cancer surveys. Vol. 28: Genetic instability and cancer (ed. by Lindahl). Cold Spring Harbor Laboratory Press, New York 1966, p. 281-293.
47. Zdzienicka, M. Z.: Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutât. Res. 336 (1995), 203-213.
48. Zhu, C, M. A. Bogue, D.-S. Lim et al.: Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86 (1996), 379-389.