Dynamics of HIV-1 replication in vivo

Journal of Clinical Investigation

Volumn 99, Issue 11, 1997, Pages 2565-2567

  Ho, David D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INDINAVIR; LAMIVUDINE; NEVIRAPINE; RITONAVIR; VIRUS DNA; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CELLULAR IMMUNITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE SUBPOPULATION; MATHEMATICAL MODEL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; VIREMIA; VIRION; VIRUS CELL INTERACTION; VIRUS REPLICATION; HUMAN; PHYSIOLOGY; VIROLOGY;

HIV INFECTIONS; HIV-1; HUMANS; VIRUS REPLICATION;

EID: 0031155367     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/jci119443     Document Type: Review

References (14)

1. Ho, D.D., T. Moudgil, and M. Alam. 1989. Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N. Engl. J. Med. 321: 1621-1625.
2. Piatak, M., M.S. Saag, L.C. Yang, S.J. Clark, J.C. Kappes, K.-C. Luk, B.H. Hahn, G.M. Shaw, and J.D. Lifson. 1993. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science (Wash. DC). 259:1749-1754.
3. Embretson, J., M. Zupancic, J.L. Ribas, A. Burke, P. Racz, K. Tenner-Racz, and A.T. Haase. 1993. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature (Land.). 362:359-362.
4. Pantaleo, G., C. Graziosi, J.F. Demarest, L. Butini, M. Montroni, C.H. Fox, J.M. Orenstein, D.P. Kotler, and A.S. Fauci. 1993. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature (Land.). 362:355-358.
5. Daar, E.S., T. Moudgil, R.D. Meyer, and D.D. Ho. 1991. Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N. Engl. J. Med. 324:961-964.
6. Koup, R.A., J.T. Safrit, Y. Cao, C.A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D.D. Ho. 1994. The initial control of viremia during primary HIV-1 syndrome is temporally associated with the presence of cellular immune responses. J. Virol. 68:4650-4655.
7. Mellors, J.W., C.R. Rinaldo, P. Gupta, R.M. White, J.A. Todd, and L.A. Kingsley. 1996. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science (Wash. DC). 272:1167-1170.
8. Ho, D.D. 1996. Viral counts count in HIV infection. Science (Wash. DC). 272:1124-1125.
9. Wei, X., S.K. Ghosh, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Deutsch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B.H. Hahn, et al. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.). 373:117-122.
10. Ho, D.D., A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (Lond.). 373:123-126.
11. Perelson, A.S., A.U. Neumann, M. Markowitz, J.M. Leonard, and D.D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science (Wash. DC). 271:1582-1586.
12. Perelson, A.S., P. Essunger, Y. Cao, M. Vesanen, A. Hurley, K. Saksela, M. Markowitz, and D.D. Ho. 1997. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature (Lond.). 387:188-192.
13. Mansky, L.M., and H.M. Temin. 1995. Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 60:5087-5094.
14. Ho, D.D. 1995. Time to hit HIV, early and hard. N. Engl. J. Med. 333: 450-451.