p59fyn-p125FAK cooperation in Development of CD4+CD8+ Thymocytes

Blood

Volumn 87, Issue 3, 1996, Pages 865-870

  Kanazawa, Satoshi ^b   Ilić, Duško ^b   Hashiyama, Motohiro ^b   Noumura, Tetsuo ^b   Yamamoto, Tadashi ^b   Suda, Toshio ^b   Aizawa, Shinichi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL ADHESION MOLECULE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; FYN PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, MOUSE; DNA FRAGMENT;

ANIMAL; ARTICLE; ATROPHY; CELL DIFFERENTIATION; CYTOLOGY; GENOTYPE; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; THYMUS; ANIMAL CELL; ANIMAL TISSUE; CELL MATURATION; DNA DETERMINATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE MUTATION; HETEROZYGOSITY; HISTOLOGY; HOMOZYGOSITY; IMMUNOBLOTTING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FAMILY; THYMOCYTE;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; ATROPHY; BASE SEQUENCE; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENOTYPE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 0029664666     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.3.865.bloodjournal873865     Document Type: Article

References (30)

1. Weiss A, Littman DR: Signal transduction by lymphocyte antigen receptors. Cell 76:263, 1994
2. Lancki DW, Quian D, Fields P, Gajewski T, Fitch FW: Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1. J Immunol 154:4363, 1995
3. fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70:741, 1992
4. fyn. Cell 70:751, 1992
5. Yagi T, Shigetani Y, Okada N, Tokunaga T, Ikawa Y, Aizawa S: Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ. Oncogene 8:3343, 1993
6. FAK. Mol Cell Biol 14:147, 1994
7. Thomas SM, Soriano P, Imamoto A: Specific and redundant roles of Src and Fyn in organizing cytoskeleton. Nature 376:267, 1995
8. Kanner SB, Reynolds AB, Vines RR, Parsons JT: Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci USA 87:3328, 1990
9. FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 89:5192, 1992
10. Hanks SK, Calalb MB, Harper MC, Patel SK Focal adhesion protein-kinase phosphorylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA 89:8487, 1992
11. Andre E, Becker-Andre M: Expression of an N-terminally truncated form of human focal adhesion kinase in brain. Biochem Biophys Res Commun 190:140, 1993
12. FAK. DNA Cell Biol 12:823, 1993
13. Choi K, Kennedy M, Keller G: Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal- and adult-derived heinatopoietic lineages. Proc Natl Acad Sci USA 90:5747, 1993
14. Ilić D, Furuta Y, Suda T, Atsumi T, Fujimoto J, Ikawa Y, Yamamoto T, Aizawa S: Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochem Biophys Res Commun 209:300, 1995
15. Furuta Y, Ilić D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S: Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11:1989, 1995
16. Kanazawa S, Ilić D, Noumura T, Yamamoto T, Aizawa S: Integrin-stimulation decreases tyrosine phosphorylation and activity of focal adhesion kinase in thymocytes. Biochem Biophys Res Commun 215:438, 1995
17. Ilić D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Nakatsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T, Aizawa S: Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377:539, 1995
18. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S: Roles of adhesion molecules in T-cell recognition: Fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol Rev 114:109, 1990
19. 1, defines a unique stage of human thymocyte development. J Exp Med 179:1573, 1994
20. Yagi T, Shigetani Y, Furuta Y, Nada S, Okado N, Ikawa Y, Aizawa S: Fyn expression during early neurogenesis in mouse embryos. Oncogene 9:2433, 1994
21. Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S: Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73:1125, 1993
22. Tsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, Matsuo I, Ikawa Y, Aizawa S: Enchanced proliferative potential in culture of cells from p53-deficient mice. Oncogene 8.3313, 1993
23. Okada S, Nagayoshi K, Nakauchi H, Nishikawa S, Miura Y, Suda T: Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells. Blood 81:1720, 1993
24. Guidos CJ, Danska JS, Fathman CG, Weissman IL: T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med 172:835, 1990
25. Bendelac A, Matzinger P, Seder RA, Paul WE, Schwartz RH: Activation events during thymic selection. J Exp Med 175:731, 1992
26. Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D: Another view of the selective model of thymocyte selection. Cell 73-225, 1993
27. Grant SGN, Karl KA, Kiebler, Kandel ER: Focal adhesion kinase in the brain: Novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev 9:1909, 1995
28. + thymocytes by csk-"knock-in" into fyn locus. (Submitted)
29. Clark EA, Brugge JS: Integrins and signal transduction pathways: The road is taken. Science 268:233, 1995
30. Calalb MB, Polte TR, Hanks SK: Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol Cell Biol 15:954, 1995