Role of kinins in airway diseases

Immunopharmacology

Volumn 22, Issue 1, 1991, Pages 1-20

  Farmer, Stephen G ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Airway hyperresponsiveness; Airway inflammation; Allergy; Asthma; Bradykinin; Bradykinin receptor; Bronchoconstriction; Kallinin; Kinin; Late asthmatic response; Smooth muscle; Thinitis

Indexed keywords

ACETYLCHOLINE; BRADYKININ; BRADYKININ ANTAGONIST; DEXTRO ARGINYLBRADYKININ[3 HYDROXYPROLINE 7 DEXTRO PHENYLALANINE]; KALLIDIN; KININ; NPC 16731; UNCLASSIFIED DRUG;

ADULT; ALLERGY; ANIMAL EXPERIMENT; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; REVIEW; RHINITIS; SMOOTH MUSCLE CONTRACTION;

AMINO ACID SEQUENCE; ANIMAL; ASTHMA; BRADYKININ; BRONCHOCONSTRICTION; HUMAN; KALLIDIN; MOLECULAR SEQUENCE DATA; RECEPTORS, BRADYKININ; RECEPTORS, NEUROTRANSMITTER;

EID: 0025838077     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(91)90051-Y     Document Type: Review

References (127)

1. Circulating plasma kinin in patients with bronchial asthma
2. Bradykinin antagonists in a sheep model of allergic asthma
3. Airway effects of inhaled bradykinin, substance P and neurokinin A in sheep
4. A bradykinin antagonists modifies allergen-induced mediator release and late bronchial responses in sheep
5. Pharmacology of bradykinin-induced bronchoconstriction in allergic sheep
6. Effect of kallidin, substance P and other basic polypeptides on the production of respiratory macromolecules
7. Bradykinin and respiratory mucous membranes. Analysis of bradykinin binding site distribution and secretory responses in vitro and in vivo
8. The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle
9. Plasma kallikrein during experimentally induced allergic rhinitis: role in kinin formation and contribution to TAME-esterase activity in nasal secretions
10. Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig lung
11. Action of some peptides on bronchial muscle
12. State of the art: bronchial hyperreactivity
13. The role of the epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro
14. The production of bradykinin during anaphylaxis
15. Bronchial hyperreactivity in patients who cough after receiving angiotensin converting enzyme inhibitors
16. Bradykinin receptor antagonists
17. Kinins are generated in nasal secretions during influenza A infections in ferrets
18. 2, bradykinin and histamine
19. Detection of tissue kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects
20. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells
21. Kinins and peripheral and central nervous system
22. Afferent pathways involved in reflex regulation of airway smooth muscle
23. An apparent bronchoconstrictor action of bradykinin and its suppression by some anti-inflammatory agents
24. Analgesic antipyretic drugs as antagonists of bradykinin
25. The bronchoconstrictor action of bradykinin in the guinea-pig
26. Kinins and ventilation of the lungs
27. Citric acid and bradykinin produce cough in allergic sheep
28. Bronchial motility regulation and bradykinin
29. Bradykinin-induced bronchoconstriction: Inhibition by nedocromil sodium and sodium cromoglycate
30. The effect of an angiotensin converting enzyme inhibitor, ramipril, on bronchial responses to inhaled histamine and bradykinin in asthmatic subjects
31. Prostaglandin E receptor subty[es in smooth muscle; agonist activities of stable prostacyclin analogues
32. Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C
33. Atropine modification of the pulmonary effects of chemical mediators in the guinea-pig
34. Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea
35. Airway pharmacology of bradykinin
36. The pharmacology of bradykinin receptors
37. 7]-substituted analogs of bradykinin inhibit vasopressin- and bradykinin-induced contractions of uterine smooth muscle
38. 3 receptors
39. 3 receptor
40. 3 receptors
41. Airway epithelial modulation of smooth muscle function: the evidence for epithelium-derived inhibitory factor
42. Effects of bradykinin receptor antagonists on antigen-induced airway hyperrespondiveness
43. 2
44. Modulation of bradykinin responses in airway smooth muscle by epithelial enzymes
45. Bradykinin-induced bronchoconstriction in humans: mode of action
46. Kinins as mediators of intestinal secretion
47. The pharmacology of airway hyperreactivity
48. Inflammation and mediators
49. The effects of captopril (SQ 14225) on bradykinin-induced bronchoconstriction in the anesthetized guinea pig
50. 2 release, and nociceptor stimulation and contraction of the iris sphincter muscle in the rabbit
51. Electrophysiological evidence for a role of bradykinin in chemical nociception in the rat
52. The effect of bradykinin, kallidin and eledoisin upon the pulmonary vascular bed of an isolated blood-perfused rabbit lung preparation
53. The effect of bradykinin aerosol in guinea-pigs and in man
54. Bradykinin and ethanol in bronchial asthma
55. A study of the efficacy of the bradykinin antagonist, NPC-567, in rhinovirus infections in human volunteers
56. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies
57. The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo
58. 2 receptor
59. Bradykinin-induced bronchoconstriction in guinea pig in vivo: role of neural mechanisms
60. Nasal challenge with cold, dry air induces a late-phase reaction
61. Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs
62. 2 receptor antagonist
63. Release of kallikrein from guinea-pig lung during anaphylaxis
64. Effect of prolonged inhibition of angiotensin converting enzyme on MK-447. Studies on the irritant induced cough and bronchoconstriction in guinea-pigs
65. Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs
66. Bradykinin-induced airway hyperreactivity in a perfused bronchial artery preparation
67. Biological activity of synthetic polypeptides with bradykinin-like properties
68. The contact activation system of plasma: biochemistry and pathophysiology
69. Design and conformational analysis of several highly potent bradykinin antagonists
70. The effects of peptides and mediators on mucus secretion and smooth muscle tone in the ferret trachea
71. Damage of the airway epithelium and bronchial reactivity in patients with asthma
72. 2 release by canine tracheal epithelium
73. New, long-acting bradykinin antagonists
74. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants
75. Pharmacology of kinins: their relevance to tissue in injury and inflammation
76. Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases
77. Pharmacology of airway secretion
78. Sensory nerves containing tachykinins and CGRP in the lower airways
79. Release of intracellular calcium by two different second messengers in airway epithelium
80. Neurogenic inflammation in the respiratory tract: actions of sensory nerve mediators on blood vessels and epithelium of the airway mucosa
81. Neurogenic inflammation in the rat trachea I Changes in venules leucocytes and epithelial cells
82. Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability
83. Effects of peptides and amines on isolated guinea pig trachea as influenced by inhibitors of the metabolism of arachidonic acid
84. Angiotensin-converting enzyme and the cough reflex
85. Pharmacology of the late response to allergen and its relevance to asthma prophylaxis
86. Pathogenesis of airway hyperreactivity
87. Inflammatory mediators in late antigen-induced rhinitis
88. Bradykinin and human airways
89. Late asthmatic responses
90. Bradykinin and substance P potentiate acetylcholine-induced bronchoconstriction in guinea-pig
91. Neuropeptides and inflammation: The role of substance P
92. 3 receptors in vitro
93. Inhaled bradykinin accelerates tracheobronchial clearance in normal human airways
94. 9]-bradykinin in normal and asthmatic subjects
95. Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthmatic asthma
96. Kininis in rhinitis
97. Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen
98. Kinin formation: mechanisms and role in inflammatory disorders
99. Nasal provocation with bradykinin induces symptoms of rhinitis and a sore throat
100. Kinins are generated in nasal secretions during natural rhinovirus colds
101. Identification of human lung mast cell kininogenase as tryptase and relevance of tryptase kininogenase activity
102. Luminal receptors for bradykinin on the canine tracheal epithelium: functional subtyping
103. B receptors can modulate release of substance P from capsaicin-sensitive neurons in rat trachea
104. Peptide receptors in the airways
105. Pharmacology of bradykinin and related kinins
106. Bradykinin antagonism: Differentiation between peptide antagonists and anti-inflammatory agents
107. Reflex tracheal contraction induced by stimulation of bronchial C-fibers in dogs
108. Bradykinin-induced plasma extravasation in guinea-pig airways: involvement of platelet-activating factor
109. 2 generation and the effect of aspirin
110. Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge
111. Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation
112. Interrelationship between the kallikrein-kinin system and hypertension: a review
113. In vivo and in vitro effect of bradykinin on bronchial motor tone in normal subjects and patients with airways obstruction
114. A bradykinin antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep
115. Bradykinin antagonists in pain and inflammation
116. 2 bradkinin receptors
117. Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions
118. Captopril-induced cough
119. Die Wirkung von Bradykinin-Aerosol auf die Atmung des Menschen und des Meerschweinchens und derEinfluss verschneidener Substanzen auf den experimentellen Bradykinin-Bronchospasmus
120. Characterization of the arachidonic acid metabolites mediating bradykinin and noradrenaline hyperalgesia
121. Effect of bradykinin on airway ciliary motility and its modulation by neutral endopeptidase
122. Nasal challenge with cold, dry air results in release of inflammatory mediators: possible mast cell involvement
123. The effect of inhalations of bradykinin on healthy and atopic (asthmatic) children
124. The effect of bradykinin in an isolated perfused dog lung preparation
125. Electrolyte transport by airway epithelia
126. Physiology of airway epithelia
127. Regulatory pathways for the stimulation of canine tracheal ciliary beat frequency by bradykinin