Inhibition of bradykinin‐evoked trigeminal nerve stimulation by the non‐peptide bradykinin B2 receptor antagonist WIN 64338 in vivo and in vitro

British Journal of Pharmacology

Volumn 116, Issue 8, 1995, Pages 3164-3168

  Hall, Judith M ^a   Figini, Michela ^b   Butt, Semal K ^a   Geppetti, Pierangelo ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

B2 receptors; Bradykinin; bradykinin antagonist; iris sphincter; kinin; plasma extravasation; sensory nerves; trigeminal; WIN 64338

Indexed keywords

[[4 [2 [[BIS(CYCLOHEXYLAMINO)METHYLENE]AMINO] 3 (2 NAPHTHYL)PROPIONAMIDO]PHENYL]METHYL]TRIBUTYLPHOSPHONIUM CHLORIDE; BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; CAPSAICIN; EVANS BLUE; NEUROKININ A; SENKTIDE; SUBSTANCE P; SUBSTANCE P METHYL ESTER; TACHYKININ;

ANIMAL TISSUE; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; EXTRAVASATION; GUINEA PIG; MALE; MUSCLE CONTRACTION; NERVE ENDING; NERVE STIMULATION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RABBIT; SENSORY NERVE; SPHINCTER PUPILLAE MUSCLE; TRIGEMINAL NERVE;

ANIMALS; BRADYKININ; EYE; GUINEA PIGS; NAPHTHALENES; NASAL MUCOSA; ORGANOPHOSPHORUS COMPOUNDS; RABBITS; RECEPTORS, BRADYKININ; TRIGEMINAL NERVE;

EID: 0029617709     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb15119.x     Document Type: Article

References (26)

1. Involvement of neurogenic inflammation in antigeninduced bronchoconstriction in guinea pigs
2. Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea‐pig trachea
3. Bioregulation of kinins: kallikreins, kininogens and kininases
4. Bradykinin and inflammatory pain
5. Effects of a novel nonpeptide bradykinin B2 receptor antagonist on intestinal and airway smooth muscle: Further evidence for the tracheal B3 receptor
6. Involvement of tachykinins in plasma extravasation induced by bradykinin and low pH medium in the guinea‐pig conjunctiva
7. An in vitro study of the properties of single vagal afferents innervating guinea‐pig airways
8. Sensory neuropeptide release by bradykinin: Mechanisms and pathophysiological implications
9. Bradykinin receptors: Pharmacological properties and biological roles
10. Receptor function in the periphery
11. Receptor subtypes or species homologues: Relevance to drug discovery
12. Neurokinin receptors in rabbit iris sphincter characterised by novel, agonist ligands
13. Differences in affinities of bradykinin B2 receptor antagonists may be attributable to species
14. Tachykinin receptors mediating responses to sensory nerve stimulation and exogenous tachykinins and analogues in the rabbit isolated iris sphincter
15. Blockade by oral or parenteral RPR 100893 (a non‐peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea‐pig dura mater and conjunctiva
16. Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin‐sensitive trigeminal neurons
17. How should values of pA2 and affinity constants for pharmacological competitive antagonists be estimated?
18. Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin
19. Neurogenic plasma extravasation in the rat nasal mucosa is potentiated by peptidase inhibitors
20. Pharmacology of bradykinin and related kinins
21. Tachykinins and kinins in antigen‐evoked plasma extravasation of guinea‐pig nasal mucosa
22. Design of potent non‐peptide competitive antagonists of the human bradykinin B2 receptor
23. Vascular protein leakage in various tissues induced by substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge
24. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist
25. Capsaicin and bradykinin‐induced substance P‐ergic responses in the iris sphincter muscle of the rabbit
26. Non‐specific actions of the non‐peptide tachykinin receptor antagonists, CP‐96,345, RP 67580 and SR 48968, on neurotransmission