Molecular mechanisms linking thrombosis and angiogenesis in cancer

Trends in Cardiovascular Medicine

Volumn 7, Issue 2, 1997, Pages 52-59

  Shoji, Mamoru ^a,b   Abe, Keisuke ^a,b   Nawroth, Peter P ^c   Rickles, Frederick R ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; PROCOAGULANT; PROTEIN P53; THROMBOPLASTIN; THROMBOSPONDIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; BLOOD CLOTTING; CANCER; FIBRIN CLOT; HUMAN; HYPOXIA; METASTASIS; NONHUMAN; ONCOGENE; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PRIORITY JOURNAL; REVIEW; THROMBOGENESIS; TUMOR GROWTH; TUMOR THROMBUS; VASCULAR ENDOTHELIUM;

EID: 0030997222     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(96)00142-9     Document Type: Review

References (97)

1. Almoguera C, Shibata D, Forrester K, et al.: 1988. Most human carcinomas of exocrine pancreas contain mutant c-K-ras genes. Cell 53:549-554.
2. Altieri DC: 1995. Xa receptor EPR-1. FASEB J 9:860-865.
3. Banner DW, D'Arcy A, Chene, et al.: 1996. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380:41-46.
4. Bierhaus A, Zhang Y, Deng Y, et al.: 1996. TNFα induced endothelial cell expression of tissue factor depends on a concerted action of several members of the bZIP- and NF-κB-family in vitro and in vivo. J Biol Chem (in press).
5. Bornstein P: 1992. Thrombospondins: structure and regulation of expression. FASEB J 6:3290-3299.
6. Bromberg ME, Kongsberg WH, Madison JF, et al.: 1995. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation. Proc Natl Acad Sci USA 92:8025-8209.
7. Bruder JT, Heidecker G, Rapp UR: 1992. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev 6:545-556.
8. Bugge TH, Xiao Q, Kombrink KW, et al.: 1996. Fatal embryonic bleeding events in mice lacking tissue factor, the cell associated initiator of blood coagulation. Proc Natl Acad Sci USA 93:6258-6263.
9. Camerer E, Kolsto A-B, Prydz H: 1996. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 81:1-41. Cartwright CA, Kamps MP, Meisler AI, et al.: 1989. J Clin Invest 3:2025-2033.
10. Camerer E, Kolsto A-B, Prydz H: 1996. Cell biology of tissue factor, the principal initiator of blood coagulation. Thromb Res 81:1-41. Cartwright CA, Kamps MP, Meisler AI, et al.: 1989. J Clin Invest 3:2025-2033.
11. Cao X, Mahendran R, Guy GR, et al.: 1993. Detection and characterization of cellular EGR-1 binding to its recognition site. J Biol Chem 268:16,949-16,957.
12. Carmeliet P, Mackman N, Moons L, et al.: 1996. Role of tissue factor in embryonic blood vessel development. Nature 383:73-75.
13. c-src activation in human colon carcinoma. J Clin Invest 83: 2025-2033.
14. Chiao P, Wang W, Ellis L, et al.: 1996. NF-κB regulates VEGF gene expression in human pancreatic cancers [abst]. Proc Am Assoc Cancer Res 37:525.
15. Clauss M, Gerlach M, Gerlach H, et al.: 1990. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cells and monocyte procoagulant activity, and promotes monocytes migration. J Exp Med 172:1535-1545.
16. Cohen T, Nahari D, Cerem LW, et al.: 1996. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem 271:736-741.
17. Connoly DT, Heurelman DM, Nelson R, et al.: 1989. Tumor vascular permeability factor stimulates endothelial cell growth and angiogensis. J Clin Invest 84:1470-1478.
18. Contrino J, Goralnick S, Hair G, et al.: 1997. Fibrin induction of tissue factor expression in human vascular endothelial cells. Circulation (in press).
19. Contrino J, Hair G, Kreutzer DL, et al.: 1996. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 2:209-215.
20. Cui M-Z, Parry GCN, Edgington TS, et al.: 1994. Regulation of tissue factor gene expression in epithelial cells: induction by serum and phorbol 12-myristate 13-acetate. Arterioscler Thromb 14:807-814.
21. Cui M-Z, Parry GCN, Oeth P, et al.: 1996. Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and FGR-1. J Biol Chem 271:2731-2739.
22. Dameron KM, Volpert OV, Tainsky MA, et al.: 1994. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265:1582-1584.
23. Drake TA, Morrissey JH, Edgington TS: 1989. Selective cellular expression of tissue factor in human tissues. Am J Pathol 134:1087-1097.
24. Edwards RL, Rickles FR: 1996. Thrombosis and cancer. In Hull R, Pineo GF, eds. Disorders of Thrombosis. Philadelphia, WB Saunders, pp 374-382.
25. Ellis LM, Staley CE, Parikh N, et al.: 1996. Down regulation of vascular endothelial growth factor (VEGF) in human colon carcinoma by src antisense transfection [abst]. Proc Am Assoc Cancer Res 37:59.
26. Finkenzeller G, Marme D, Weich HA, et al.: 1992. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor is mediated by protein kinase C. Cancer Res 52:4821-4823.
27. Fisher EG, Ruf W, Mueller BM: 1995. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. Cancer Res 55:1629-1632.
28. Folkman J: 1996. Tumor angiogenesis and tissue factor. Nat Med 2:167-168.
29. Forrester K, Almoguera C, Han K, et al.: 1987. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327:298-303.
30. Frank S, Hubner G, Breier G, et al.: 1995. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem 270:12,607-12,613.
31. Good DJ, Polverini PJ, Rastinejad F, et al.: 1990. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 87:6624-6628.
32. Groupp ER, Donovan-Peluso M: 1996. Lipopolysaccharide induction of THP-1 cells activates binding of c-Jun, Ets, and Egr-1 to the tissue factor promoter. J Biol Chem 271: 12,423-12,430.
33. Grugel S, Finkenzeller G, Weindel K, et al.: 1995. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J Biol Chem 270: 25,915-25,919.
34. Harlos K, Martin DMA, O'Brien DP, et al.: 1994. Crystal structure of the extracellular region of human tissue factor. Nature 370:662-666.
35. Hartzell S, Ryder K, Lanahan A, et al.: 1989. A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol 9:2567-2573.
36. Henkel T, Machleidt T, Alkalay I, et al.: 1993. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365:182-185.
37. Huang R-P, Adamson ED: 1994. The phosphorylated forms of transcription factor, Egr-1, bind to DNA more efficiently than non-phosphorylated. Biochem Biophys Res Commun 200:1271-1276.
38. Ikeda E, Achen MG, Breier G, et al.: 1995. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270:19,761-19,766.
39. Imler JL, Schatz C, Wasylyk C, et al.: 1988. A Harvey-ras responsive transcription element is also responsive to a tumor-promoter and to serum. Nature 332:275-285.
40. Kaibuchi K, Fukumoto Y, Oku N, et al.: 1989. Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C. J Biol Chem 264:20,855-20,858.
41. Kaplan DR, Whitman M, Schaffhausen B, et al.: 1987. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021-1029.
42. Kieser A, Weich HA, Brandner G, et al.: 1994. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene 9:963-969.
43. Kim KJ, Li B, Winer J, et al.: 1993. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 362:841-844.
44. Kobayashi E, Nakamo H, Morimoto M, et al.: 1989. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159:548-553.
45. Kolch W, Heldecker G, Kochs G, et al.: 1993. Protein kinase Cα activates Raf-1 by direct phosphorylation. Nature 364:249-252.
46. Kramer B, Meichle A, Hensel G, et al.: 1994. Characterization of an Krox-24/Egr-1- responsive element in the human tumor necrosis factor promoter. Biochim Biophys Acta 1219:413-421.
47. Lawler J: 1995. Thrombospondins. In High KA, Roberts HR, eds. Molecular Basis of Thrombosis and Hemostasis. New York, Marcel Dekker, pp 621-638.
48. Levy AP, Levy NS, Goldberg MA: 1996. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271:2746-2753.
49. Li J, Perrella MA, Tsai J-C, et al.: 1995. Induction of vascular growth factor gene expression by interleukin-1β in rat aortic smooth muscle cells. J Biol Chem 270:308-312.
50. Luther T, Flossel C, Albrecht S, et al.: 1996. Tissue factor expression in normal and abnormal mammary gland. Nat Med 2:491.
51. Mackman N: 1994. Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers. J Biol Chem 269:26,363-26,367.
52. Mackman N: 1995. Regulation of tissue factor gene. FASEB J 9:883-889.
53. Margolis B, Rhee SG, Felder S, et al.: 1989. EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell 57:1101-1107.
54. Martiny-Baron G, Marme D: 1995. VEGF-mediated tumor angiogenesis: a new target for cancer therapy. Curr Opin Biotech 6:675-680.
55. Mazure NM, Chen EY, Yeh P, et al.: 1996. Induction of vascular endothelial growth factor by hypoxia is modulated by a Ras and PI 3-kinase [abst]. Proc Am Assoc Cancer Res 37:41.
56. Meisenhelder J, Suh P-G, Rhee SG, et al.: 1989. Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell 57:1109-1122.
57. Minchenko A, Salceda S, Bauer T, et al.: 1994. Hypoxia regulatory elements of human vascular endothelial growth factor gene. Cell Mol Biol Res 40:35-39.
58. Morrison DK, Kaplan DR, Escobedo JA, et al.: 1989. Direct activation of the serine-threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF b-receptor. Cell 58:649-657.
59. Mueller BM, Reisfeld RA, Edgington TS, et al.: 1992. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci USA 89: 11,832-11,836.
60. Mukhopadhyay D, Tsiokas L, Zhou X-M, et al.: 1995a. Hypoxia induction of human vascular endothelial growth factor expression through c-Src activation. Nature 375:577-581.
61. Mukhopadhyay D, Tsiokas L, Sukhatme VP: 1995b. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res 55:6161-6165.
62. Namiki A, Brogi E, Kearney M, et al.: 1995. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 270:31,189-31,195.
63. Nierodzik ML, Kelpfish A, Karpatkin S.: 1995. Role of platelets, thrombin, integrin IIb-IIIa, fibronectin and von Willebrand factor on tumor adhesion in vitro and metastasis in vivo. Thromb Haemost 74:282-290.
64. Nishibe S, Wahl MI, Rhee SG, et al.: 1989. Tyrosine Phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. J Biol Chem 264:10,335-10,338.
65. Nomura M, Yamagishi S, Harada S, et al.: 1995. Possible participation of autocrine and paracrine vascular endothelial growth factor in hypoxia-induced proliferation of endothelial cells and pericytes. J Biol Chem 270:28,316-28,324.
66. Oeth PA, Parry GCN, Kunsch C, et al.: 1994. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel-p65 heterodimers to a κB-like site. Mol Cell Biol 14:3772-3781.
67. Ottenhoff-Kalff AE, Rijksen G, van Beurden EACM, et al.: 1992. Characterization of protein tyrosine kinases from human breast cancer: involvement of the C-SRC oncogene product. Cancer Res 52:4773-4778.
68. Pertovaara L, Kaipainen A, Mustonen T, et al.: 1994. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269:6271-6294.
69. Plate KH, Risau W: 1995. Angiogenesis in malignant gliomas. Glia 15:339-347.
70. Pulverer BJ, Kyriakis JM, Avruch J, et al.: 1991. Phosphorylation of c-jun mediated by MAP kinases. Nature 353:670-674.
71. Qi J, Kreutzer DL: 1995. Fibrin activation of vascular endothelial cells: induction of IL-8 expression. J Immunol 155:867-876.
72. Rak JN, Mitsuhashi Y, Bayko L, et al.: 1995. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res 55:4575-4580.
73. Rickles FR, Edwards RL: 1994. Leukocytes and tumor cells in thrombosis. In Coleman R, Hirsh J, Marder VJ, Saltzman EN, eds. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia, JB Lippincott, pp 1164-1179.
74. Rickles FR, Levine M, Edwards RL: 1992. Hemostatic alterations in cancer patients. Cancer Metastasis Rev 11:237-248.
75. 2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby caine kidney cells and in human endothelial cells induced to synthesize tissue factor. J Biol Chem 270:4650-4660.
76. Roy S, Haas PE, Bourell JH, et al.: 1991. Lysine residues 165 and 166 are essential for the cofactor function of tissue factor. J Biol Chem 266:22,063-22,066.
77. Ruf W, Edgington TS: 1991. An anti-tissue factor monoclonal antibody which inhibits TF-VIIa complex is a potent anticoagulant in plasma. Thromb Haemost 66:529-533.
78. Ruf W, Miles DJ, Rehemtulla A, et al.: 1992. Cofactor residues lysine 165 and 166 are critical for protein substrate recognition by the tissue factor-factor VIIa protease complex. J Biol Chem 267:6375-6381.
79. ras-GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc Natl Acad Sci USA 87:7926-7929.
80. Shingu T, Bornstein P: 1994. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin-1 gene. J Biol Chem 269:32,551-32,557.
81. Shoji M, Casper K, Micko C, et al.: 1996. Coexpression of tissue factor and VEGF in human melanoma [abst]. Proc Am Assoc Cancer Res 37:61.
82. Sidransky D, Mikkelsen T, Schwechheimer K, et al.: 1992. Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature 355:846-847.
83. Spicer EK, Horton R, Bloem L, et al.: 1987. Isolation of cDNA clones coding for human tissue factor: primary structure of protein and cDNA. Proc Natl Acad Sci USA 84:5148-5152.
84. Terry CM, Callahan KS: 1996. Protein kinase C regulates cytokine-induced tissue factor transcription and procoagulant activity in human endothelial cells. J Lab Clin Med 127:81-93.
85. Tischer E, Mitchell R, Hartman T, et al.: 1991. The human gene for vascular endothelial growth factor: multiple proteins are encoded through alternative exon splicing. J Biol Chem 266:11,947-11,954.
86. Tolsma SS, Volpert OV, Good DJ, et al.: 1993. Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-antiogenic activity. J Cell Biol 122:497.
87. Trahey M, McCormick F: 1987. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542-545.
88. Vu T-KH, Hung DT, Wheaton VI, et al.: 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
89. Waleh NS, Brody MD, Knapp MA, et al.: 1995. Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res 55:6222-6226.
90. Walz DA: 1992. Thrombospondin as a mediator of cancer adhesion in metastasis. Cancer Metastasis Rev 11:313-324.
91. Walz DA, Fenton JW: 1994-1995. The role of thrombin in tumor cell metastasis. Invasion Metastasis 14:303-308.
92. Warren RS, Yuan H, Matli MR, et al.: 1995. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 95:1789.
93. Wasylyk C, Wasylyk B, Heidecker G, et al.: 1989. Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol 9:2247-2250.
94. Zacharski LR, Wojtukiewicz MZ, Costantini V, et al.: 1992. Pathways of coagulation/fibrinolysis activation in malignancy. Semin Thromb Hemost 18:104-116.
95. Zhang Y, Deng Y, Luther T, et al.: 1994. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 94:1320-1327.
96. Zhang Y, Deng Y, Wendt T, et al.: 1996. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse Meth-A sarcoma. J Clin Invest 97:2213-2224.
97. Zioncheck TF, Roy S, Vehar GA: 1992. The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism. J Biol Chem 267:3561-3564.