Transforming growth factor-β receptors: Role in physiology and disease

Journal of Biomedical Science

Volumn 3, Issue 3, 1996, Pages 143-158

  Kim, David H ^a   Kim, Seong Jin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Microsatellite instability; Mutation; Receptor; Transcription; Transforming growth factor ; Tumor suppressor gene; Tumorigenesis

Indexed keywords

DNA; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA REPLICATION; EXTRACELLULAR MATRIX; GENE MUTATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

VERTEBRATA;

EID: 0029782780     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02253095     Document Type: Review

References (6)

1. Aaltonen L, Peltomäki P, Leach F, Sistonen P, Pylkkanen L, Jarvinen H, Powell S, Jen J, Hamilton S, Petersen G, Kinzler K, Vogelstein B, de la Chapelle A. Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816;1993.
2. Damstrup L, Rygaard K, Spang-Thomsen M, Poulson H. Expression of transforming growth factor-β (TGFβ) receptors and expression of TGF-β1, TGF-β2, TGF-β3 in human small cell lung cancer cell lines. Br J Cancer 67:1015-1021;1993.
3. Ito N, Kawata S, Tamura S, Takaishi K, Shirai Y, Kiso S, Yabuuchi I, Matsudo Y, Nishioka M, Tarui S. Elevated levels of transforming growth factor-β messenger RNA and its polypeptide in human hepatocellular carcinoma. Cancer Res 51:4080-4083;1991.
4. Lafyatis R, Thompson N, Remmers E, Flanders K, Roche N, Kim SJ, Case J, Sporn MB, Roberts AB, Wilder R. Transforming growth factor-β production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats: Studies on secretion by synovial fibroblast-like cells and immunohistologic localization. J Immunol 143:1142-1148;1989.
5. Siepl C, Malpiero U, Fontana A. Transforming growth factor-β (TGF-β)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-β receptors. J Immunol 146:3063-3067;1991.
6. Yoo YD, Ueda H, Park K, Flanders KC, Lee Y, Jay G, Kim S-J. Regulation of transforming growth factor-β1 expression by the hepatitis B virus (HBV) X transcactivator. JCI 97: 388-395;1996.