Regulation of the export of RNA from the nucleus

Seminars in Cell and Developmental Biology

Volumn 8, Issue 1, 1997, Pages 71-78

  Cole, Charles N ^a   Saavedra, Claudio ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Gsp1p; hnRNP; Nuclear export signal; Ran; RNA export; TC4

Indexed keywords

ANIMALIA; EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1; NES;

EID: 0039415382     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.1996.0124     Document Type: Article

References (87)

1. Rout MP, Wente SR (1994) Pores for thought: nuclear pore complex proteins. Trends Cell Biol 4:357-365
2. Rout MP, Blobel G (1993) Isolation of the yeast nuclear pore complex. J Cell Biol 123:771-783
3. Akey CW, Radermacher M (1993) Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryoelectron microscopy. J Cell Biol 122:1-19
4. Hinshaw JE, Carragher BO, Milligan RA (1992) Architecture and design of the nuclear pore complex. Cell 69:1133-1141
5. Dworetzky SI, Feldherr CM (1988) Translocation of RNA-coated gold particles through the nuclear pores of oocytes. J Cell Biol 106:575-584
6. Zasloff M (1983) tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process. Proc Natl Acad Sci USA 80:6436-6440
7. Dingwall C (1991) Transport across the nuclear envelope: enigmas and explanations. BioEssays 13:213-217
8. Iovine MK, Watkins JL, Wente SR (1995) The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor. J Cell Biol 131:1699-1713
9. Kraemer DM, Strambio-de-Castillia C, Blobel G, Rout MP (1995) The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate. J Biol Chem 270:19017-19021
10. Radu A, Moore MS, Blobel G (1995) The peptide repeat domain of the nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell 81:215-222
11. Rexach M, Blobel G (1995) Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83:683-692
12. Schlenstedt G, Wong DH, Koepp DM, Silver PA (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14:5367-5378
13. Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H (1995) Human RanGtPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. Proc Natl Acad Sci USA 92:1749-1753
14. Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A (1995) RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J Biol Chem 270:11860-11865
15. Corbett AH, Koepp DM, Schlenstedt G, Lee MS, Hopper AK, Silver PA (1995) Rnalp, a Ran/TC4 GTPase activating protein, is required for nuclear import. J Cell Biol 130:1017-1026
16. Bischoff FR, Krebber H, Smirnova E, Dong W, Ponstingl H (1995) Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. EMBO J 14:705-715
17. Coutavas E, Ren M, Oppenheim JD, D'Eustachio P, Rush MG (1993) Characterization of proteins that interact with the cellcycle regulatory protein Ran/TC4. Nature 366:585-587
18. Ren M, Villamarink A, Shih A, Coutavas E, Moore MS, LoCurico M, Clarke V, Oppenheim JD, D'Eustachio P, Rush MG (1995) Separate domains of the Ran GTPase interact with different factors to regulate nuclear import and RNA processing. Mol Cell Biol 15:2117-2124
19. Paschal BN, Delphin C, Gerace L (1996) Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97. Proc Natl Acad Sci USA 93:7679-7683
20. Corbett AH, Silver PS (1996) The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivo. J Biol Chem 271:18477-18484
21. Fischer U, Darzynkiewicz E, Tahara SM, Dathan NA, Lurhmann R, Mattaj IW (1991) Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport. J Cell Biol 113:705-714
22. Michaud N, Goldfarb D (1991) Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway. J Cell Biol 112:215-223
23. Chow TY, Ash JJ, Dignard D, Thomas DY (1992) Screening and identification of a gene, PSE1, that affects protein secretion in Saccharomyces cerevisiae. J Cell Sci 101:709-719
24. Aitchison JD, Blobel G, Rout MP (1996) Kap104p: A karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274:624-627
25. Michael WM, Choi M, Dreyfuss G (1995) A nuclear export signal in hnRNP Al: A signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83:415-422
26. Pollard VW, Michael WM, Nakielny S, Siomi M, Wang F, Dreyfuss G (1996) A novel receptor-mediated nuclear protein import pathway. Cell 86:985-994
27. Zachar Z, Kramer J, Mims IP, Bingham PM (1993) Evidence for channeled diffusion of pre-mRNAs during nuclear RNA trans-port in metazoans. J Cell Biol 121:729-742
28. Rosbash M, Singer RH (1993) RNA travel: tracks from DNA to the cytoplasm. Cell 75:399-401
29. Dreyfuss G, Mantunis JJ, Piñol-Roma S, Burd CG (1993) HnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62:289-321
30. Flach J, Vogel J, Bossie M, Corbett A, Jinks T, Willins D, Silver PA (1994) A yeast RNA binding protein shuttles between the nucleus and the cytoplasm. Mol Cell Biol 12:8399-8407
31. Lee M, Henry M, Silver PA (1996) Np13p, a protein that shuttles between nucleus and cytoplasm, is an important mediator of mRNA export. Genes Dev 10:1233-1246
32. Showman RM, Wells DE, Anstrom J, Hursch DA, Raff RA (1982) Message-specific sequestration of maternal histone mRNA in the sea urchin egg. Proc Natl Acad Sci USA 79:5944-5947
33. DeLeon DV, Cox KH, Angerer LM, Angerer RC (1983) Most early-variant histone mRNA is contained in the pronucleus of sea urchin eggs. Dev Biol 100:197-208
34. Beltz GA, Flint SJ (1979) Inhibition of Hela cell protein synthesis during adenovirus infection: restriction of cellular mRNA sequences to the nucleus. J Mol Biol 131:353-373
35. Leppard KN, Shenk T (1989) The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO 8:2329-2336
36. Lu Y, Qian XY, Krug RM (1994) The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev 8:1817-1828
37. Pilder S, More M, Logan J, Shenk T (1985) Transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol 6:470-476
38. Qian XY, Alonso-Caplen F, Krug RM (1994) Two functional domains of the influenza virus NSl protein are required for regulation of nuclear export of mRNA. J Virol 68:2433-2441
39. Qiu Y, Nemeroff M, Krug R (1995) The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing. RNA 1:304-316
40. Chang DD, Sharp PA (1989) Regulation by HIV Rev depends upon recognition of splice sites. Cell 59:789-795
41. Izaurralde E, Mattaj IW (1995) RNA Export. Cell 81:153-159
42. Legrain P, Rosbash M (1989) Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Cell 57:573-583
43. Bray M, Prasad S, Dubay JW, Hunter E, Jeang K-T, Rekosh D, Hammarskjöld M-L (1994) A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication. Rev-independent. Proc Natl Acad Sci USA 91:1256-1260
44. Cullen BR, Malim MH (1991) The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators. Trends Biochem Sci 16:346-350
45. Fischer U, Huber J, Boelens WC, Mattaj IW, Lührmann R (1995) The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82:475-483
46. Meyer BE, Meinkoth J, Malim M (1996) Nuclear transport of HIV type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals. J Virol 70:2350-2359
47. Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82:463-473
48. Stutz F, Rosbash M (1994) A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation. EMBO J 17:4096-4104
49. Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR (1996) Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. Proc Natl Acad Sci USA 93:2936-2940
50. Fritz CC, Zapp ML, Green MR (1995) A human nucleoporinlike protein that specifically interacts with HIV Rev. Nature 376:530-533
51. Stutz F, Neville M, Rosbash M (1995) Identification of a novel nuclear pore-associated protein as a functional target of the HIV-I Rev protein in yeast. Cell 82:495-506
52. Davis LI (1995) The nuclear pore complex. Annu Rev Biochem 64:865-896
53. Doye V, Hurt EC (1995) Genetic approaches to nuclear pore structure and function. Trends Genet 11:235-241
54. von Lindern M, van Baal S, Wiegant JAR, Hagemeijer A, Grosveld G (1992) Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene. Mol Cell Biol 12:3346-3355
55. Kraemer D, Wozniak RW, Blobel G, Radu A (1994) The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc Natl Acad Sci USA 91:1519-1523
56. Gorsch LC, Dockendorff TC, Cole CN (1995) A conditional allele of the novel repeat-containing yeast nucleoporin Rat7/ NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes. J Cell Biol 129:939-955
57. Bogerd HP, Fridell RA, Madore S, Cullen BR (1995) Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82:485-494
58. Jarmolowski A, Boelens WC, Izaurralde E, Mattaj IW (1994) Nuclear export of different classes of RNA is mediated by specific factors. J Cell Biol 124:627-635
59. Fridell RA, Bogerd HP, Cullen BR (1996) Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Proc Natl Acad Sci USA 93:4421-4424
60. Fritz CC, Green MR (1996) HIV Rev uses a conserved cellular protein export pathway to the nucleocytoplasmic transport of viral RNAs. Curr Biol 6:848-854
61. Murphy R, Wente SR (1996) An RNA-export mediator with an essential nuclear export signal. Nature 383:357-360
62. Del Priore V, Snay CA, Bahr A, Cole CN (1996) Identification of RSS1, a high-copy extragenic suppressor of the rat7-1 temperature-sensitive allele of the Saccharomyces cerevisiae RAT7/ NUP159 nucleoporin. Mol Biol Cell 7:1601-1621
63. Görlich D, Vogel F, Mills AD, Hartmann E, Laskey RA (1995) Distinct functions for the two importin subunits in nuclear protein import. Nature 377:246-248.
64. Chi NC, Adam EJ, Adam SA (1995) Sequence and characterization of cytoplasmic nuclear protein import factor p97. J Cell Biol 130:265-274
65. Moroianu J, Hijikata M, Blobel G, Radu A (1995) Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci USA 92:6532-6566
66. Yano R, Oakes M, Yamaghishi M, Dodd JA, Nomura M (1992) Cloning and characterization of SRP1, a suppressor of temperature-sensitive RNA polymerase I mutations, in Saccharomyces cerevisiae. Mol Cell Biol 12:5640-5651
67. Tani T, Derby RJ, Hiraoka Y, Spector DL (1995) Nucleolar accumulation of poly(A) + RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport. Mol Biol Cell 6:1515-1534
68. Saavedra C, Tung K-S, Amberg DC, Hopper AK, Cole CN (1996) Regulation of mRNA export in response to stress in Saccharomyces cerevisiae. Genes Dev 10:1608-1620
69. Goldstein AL, Snay CA, Heath CV, Cole CN (1996) Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Mol Biol Cell 917-934
70. Heath CV, Copeland CS, Amberg DC, Del Priore V, Snyder M, Cole CN (1995) Nuclear pore complex clustering and nuclear accumulation of poly(A) + RNA associated with mutations of the Saccharomyces cerevisiae RAT2/NUP120 gene. J Cell Biol 131:1677-1697
71. Dockendorff TC, Heath CV, Goldstein AL, Snay CA, Cole CN (1997) C-terminal truncations of the yeast nucleoporin Nup145p produce conditional mRNA export defects and alterations to nuclear structure. Mol Cell Biol 17:906-920
72. Kadowaki T, Schneiter R, Hitomi M, Tartakoff AM (1995) Mutations in nucleolar proteins lead to nucleolar accumulation of polyA + RNA in Saccharomyces cerevisiae. Mol Biol Cell 6:1103-1110
73. Schneiter R, Kadowaki T, Tartakoff AM (1995) mRNA transport in yeast: time to reinvestigate the functions of the nucleolus. Mol Biol Cell 6:357-370
74. Yost HJ, Lindquist S (1991) Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae. Mol Cell Biol 11:1062-1068
75. Yost HJ, Lindquist S (1986) RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis. Cell 45:185-193
76. Kay RJ, Russnak RH, Jones D, Mathias C, Candido EP (1987) Expression of intron-containing C. elegans heat shock genes in mouse cells demonstrates divergence of 3′ splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus. Nucl Acids Res 15:3723-3741
77. Amberg DA, Goldstein AL, Cole CN (1992) Isolation and characterization of RAT1, an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA. Genes Dev 6:1173-1189
78. Amberg DC, Fleischmann M, Stagljar I, Cole CN, Aebi M (1993) Nuclear PRP20 protein is required for mRNA export. EMBO J 12:233-241
79. Forrester W, Stutz F, Rosbash M, Wickens M (1992) Defects in mRNA 3′-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: Possible coupling of mRNA processing and chromatin structure. Genes Dev 6:1914-1926
80. Koepp DM, Wong DH, Corbett AH (1996) Dynamic localization of the nuclear import receptor and its interactions with transport factors. J Cell Biol 133:1163-1176
81. Schlenstedt G, Saavedra C, Loeb JDJ, Cole CN, Silver PA (1995) The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A) + RNA in the cytoplasm. Proc Natl Acad Sci USA 92:225-229
82. Azuma Y, Tabb MM, Vu L, Nomura M (1995) Isolation of a yeast protein kinase that is activated by the protein encoded by SRP1 (Srplp) and phosphorylates Srplp complexed with nuclear localization signal peptides. Proc Natl Acad Sci USA 92:5159-5163
83. Fleischmann M, Stagljar I, Aebi M (1996) Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Mol Gen Genet 250:614-625
84. G-dimethylarginine in nuclear protein fractions. Biochem Biophys Res Commun 74:969-976
85. Liu Q, Dreyfuss G (1995) In vivo and in vitro arginine methylation of RNA-binding proteins. Mol Cell Biol 15:2800-2808
86. Henry M, Silver P (1996) A novel arginine methyltransferase (HMT1) modifies a poly(A) RNA-binding protein. Mol Cell Biol 16:3668-3678
87. Cheng Y, Dahlberg JE, Lund E (1995) Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transport. Science 267:1807-1810