Do neuroleptic drugs hasten cognitive decline in dementia?

BMJ

Volumn 314, Issue 7091, 1997, Pages 1411-

  Holmes, C ^a   Fortenza, O ^a   Powell, J ^a   Lovestone, S ^a   Tobiansky, Robert ^b   Blanchard, Martin ^c   Bentham, P W ^d   Goh, S E ^d   Gregg, E M ^d   Madeley, P ^d   Patel, A R A ^d   Taylor, A P ^d   Mcshane, Rupert ^e   Hope, Tony ^e   Jacoby, Robin ^e   Keene, Janet ^e   Fairburn, Christopher ^e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b E HMHNHST Woodlands   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

^d QUEEN ELIZABETH PSYCHIATRIC HOSPITAL   (United Kingdom)

^e WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CHOLINERGIC RECEPTOR BLOCKING AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; RISPERIDONE; SULPIRIDE;

ALZHEIMER DISEASE; COGNITIVE DEFECT; DEMENTIA; DRUG CHOICE; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0030975987     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.314.7091.1411     Document Type: Letter

References (8)

1. McShane R, Keene J, Gedling K, Fairburn C, Jacoby R, Hope T. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up BMJ 1997; 314: 266–270. (25 January.)
2. Holmes C. The Camberwell dementia case register. Int J Geriatr Psychiatry 1996; 11: 369–375.
3. Holmes C, Levy R, McLoughlin DM, Powell JF, Lovestone S. Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease. J Neurol Neurosurg Psychiatry 1996; 61: 580–583.
4. Van Duijn CM. Epidemiology of the dementias: recent developments and new approaches J Neurol Neurosurg Psychiatry 1996; 60: 478–488.
5. McShane R, Keene J, Gedling K, Fairburn C, Jacoby R, Hope T. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up BMJ 1997; 314: 266–270. (25 January.)
6. Bartus RT, Dean RL, Beer B, Lippas AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982; 217: 408–414.
7. Perry EK. The cholinergic hypothesis 10 years on. Br Med Bull 1986; 42: 63–69.
8. McShane R, Keene J, Gedling K, Fairburn C, Jacoby R, Hope T. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up BMJ 1997; 314: 266–270. (25 January.)