Apolipoprotein E: Non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease

Journal of Neurology Neurosurgery and Psychiatry

Volumn 61, Issue 6, 1996, Pages 580-583

  Holmes, Clive ^a   Levy, Raymond ^a   McLoughlin, Declan M ^a   Powell, John F ^a   Lovestone, Simon ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Apoliprotein E; Cognitive decline; Depression

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; COGNITION; DEPRESSION; DISEASE COURSE; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MENTAL DISEASE; ONSET AGE; PRIORITY JOURNAL; REGISTER; SYMPTOMATOLOGY; UNITED KINGDOM;

EID: 0030462762     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.61.6.580     Document Type: Article

References (27)

1. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
2. Kuusisto J, Koivisto K, Kervinen K, Mykkanen L, Helkala EL, Vanhanen M, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study. BMJ 1994;309:636-8.
3. Ohm TG, Kirca M, Bohl J. Scharnagl H, Groß W, Marz W. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience 1995;66:583-7.
4. Henderson AS, Easteal S, Jorm AF, Mackinnon AJ, Korten AE, Christensen H, et al. Apolipoprotein E allele e4, dementia and cognitive decline in a population sample. Lancet 1995;346:1387-90.
5. Frisoni GB, Govoni S, Geroldi C, Bianchetti A, Calabresi L, Franceschini G, et al. Gene dose of the e4 allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease. Ann Neurol 1995;37: 596-604.
6. Basun H, Grut M, Lannfelt L. Apolipoprotein e4 allele and disease progression in patients with late-onset Alzheimer's disease. Neurosci Lett 1995;183:32-4.
7. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed, revised (DSM-III-R). Washington, DC: APA, 1987;103-7.
8. The International Classification of Diseases Volume 10. Classification of mental and behavioural disorders. Geneva: World Health Organisation; 1992;45-6.
9. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadian EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group. Neurology 1984;34:939-44.
10. Steele C, Rouner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placements of patients with Alzheimer's disease. Am J Psychiatry 1990;147:1048-51.
11. Holmes C, Cooper B, Levy R. Dementia known to mental health services: first findings of a case register for a defined elderly population. International Journal of Geriatric Psychiatry 1995;10:875-81.
12. Holmes C. The Camberwell dementia case register. International Journal of Geriatric Psychiatry 1996;11: 369-75.
13. Mölsa PK, Marttila, RJ, Rinne UK. Epidemiology of dementia in a Finnish population. Acta Neurol Scand 1982;65:541-552.
14. Kokmen, E, Chandra V, Schoenberg, BS. Trends in incidence of dementing illness in Rochester, Minnesota, in three quinquennial periods, 1960-1974. Neurology 1988; 38:975-80.
15. Roth M, Huppert FA, Tym E, Mountjoy CQ. CAMDEX: the Cambridge examination for mental disorders of the elderly. Cambridge, UK: Cambridge University Press, 1988.
16. Hope T, Fairburn CG. The Present behavioural examination (PBE): the development of an interview to measure current behavioural abnormalities. Psychol Med 1992;22: 223-30.
17. Meer B, Baker JA. The Stockton geriatric rating scale. J Gerontol 1966;21:392-403.
18. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
19. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
20. Becker JT, Huff FJ, Nebes RD, Holland A, Boller F. Neuropsychological function in Alzheimer's disease: pattern of impairment and rates of progression. Arch Neurol 1984;45:263-8.
21. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell scale for depression in dementia. Biol Psychiatry 1988;23:271-84.
22. Wenham PR, Price WH, Blundell, G. Apolipoprotein E genotyping by one-stage PCR. Lancet 1991;337: 1158-9.
23. Savitz DA, Olshan AO. Multiple comparisons and related issues in the interpretation of epidemiologic data. Am J Epidemiol 1995;142:204-8.
24. Liddell M, Williams J, Bayer A, Kaiser F, Owen M. Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease. J Med Genet 1994;31:197-200.
25. Schächter F, Faure-Delanef L, Guénot F, Herve R, Froguel P, Leseur-Ginot L, et al. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet 1994;6:29-32.
26. Morgan RS, Palinkas LA, Barrett-Connor EL, Wingard DL. Plasma cholesterol and depressive symptoms in older men. Lancet 1993;341:75-9.
27. Utermann G, Steinmetz A. Polymorphism of apolipoprotein E and occurrence of dybetalipoproteinaemia in man. Nature 1977;269:604-7.