Regulation of gene expression and nitric oxide production in murine macrophages by the serine/threonine phosphatase inhibitor okadaic acid

Journal of Endotoxin Research

Volumn 3, Issue 1, 1996, Pages 19-27

  Barber, S A ^a,b   Salkowski, C A ^a   Fultz, M J ^a   Perera, P Y ^a   McNally, R ^a   Vogel, S N ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OKADAIC ACID; SERINE; SERINE THREONINE PHOSPHATASE INHIBITOR; THREONINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN;

EID: 0029931873     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/096805199600300103     Document Type: Article

References (55)

1. Weiel J.E., Hamilton T.A., Adams D.O. LPS induces altered phosphate labeling of proteins in murine peritoneal macrophages. J Immunol 1986; 136: 3012-3018.
2. Weinstein S.L., Gold M.R., DeFranco A.L. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci USA 1991; 88: 4148-4152.
3. Dong Z., Qi X., Fidler I.J. Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J Exp Med 1993; 177: 1071-1077.
4. Novogrodsky A., Vanichkin A., Patya M., Gazit A., Osherov N., Levitzki A. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 1994; 264: 1319-1322.
5. Barber S.A., Perera P-Y., McNally R., Vogel S.N. The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide. J Immunol 1995; 155: 1404-1410.
6. Cohen P. The structure and regulation of protein phosphatases. Annn Rev Biochem 1989; 58: 453-508.
7. Cohen P., Holmes C.F.B., Tsukitani Y. Okadaic acid: a new probe for the study of cellular regulation. TIBS 1990; 15: 98-102.
8. Suganuma M., Fujiki H., Furuya-Suguri H., et al. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. Cancer Res 1990; 50: 3521-3525.
9. Cohen P., Cohen P.T.W. Protein phosphatases come of age. J Biol Chem 1989; 264: 21435-21438.
10. Sung S-J., Walters J.A., Fu S.M. Stimulation of tumor necrosis factor a production in human monocytes by inhibitors of protein phosphatase 1 and 2A. J Exp Med 1992; 176: 897-901.
11. Guy G.R., Cao X., Chua S.P., Tan Y.H. Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1. J Biol Chem 1991; 267: 1846-1852.
12. Tebo J.M., Hamilton T.A. Okadaic acid stimulates inflammatory cytokine gene transcription in murine peritoneal macrophages. Cell Immunol 1994; 153: 479-491.
13. Mossman T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-173.
14. Vogel S.N., Hogan M.M. The role of cytokines in endotoxin-mediated responses. In: Oppenheim J.J., Shevach E., eds. Immunophysiology: Role of Cells and Cytokines. Immunity and Inflammation. New York: Oxford University Press, 1990; 238-258.
15. McIntire F.C., Dievert H.W., Barlow G.H., Finley R.A., Lee W.Y. Chemical, physical and biologic properties of a lipopolysaccharide from Escherichia coli K235. Biochemistry 1967; 6: 2363-2372.
16. Manthey C.L., Brandes M.E., Perera P-Y., Vogel S.N. Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages. J Immunol 1992; 149: 2459-2465.
17. Barber S.A., Fultz M.J., Salkowski C.A., Vogel S.N. Differential expression of IRF-1, IRF-2, and ICSBP genes in LPS-responsive and LPS-hyporesponsive macrophages. Infect Immun 1995; 63: 601-608.
18. Manthey C.L., Perera P-Y., Qureshi N., Stütz P.L., Hamilton T.A., Vogel S.N. Modulation of lipopolysaccharide-induced macrophage gene expression by Rhodobacter sphaeroides lipid A and SDZ 880.431. Infect Immun 1993; 61: 3518-3526.
19. Svetic A., Finkelman F.D., Jian Y.C. et al. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J Immunol 1991; 147: 2391-2397.
20. Manthey C.L., Perera P-Y., Salkowski C.A., Vogel S.N. Taxol provides a second signal for murine macrophage tumoricidal activity. J Immunol 1994; 152: 825-831.
21. Wynn T.A., Eltoum I., Oswald I.P., Cheever A.W., Sher A. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J Exp Med 1994; 179: 1551-1561.
22. Salkowski C.A., Neta R., Wynn T.A., Strassman G., van Roojen N., Vogel S.N. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol 1995; 155: 3168-3179.
23. Lorsbach R.B., Murphy W.J., Lowenstein C.J., Snyder S.H., Russell S.W. Expression of the nitric oxide synthase gene in mouse macrophage activated for tumor cell killing. J Biol Chem 1993; 268: 1908-1912.
24. Henricson B.E., Benjamin W.R., Vogel S.N. Differential cytokine induction by doses of lipopolysaccharide and monophosphoryl lipid A that result in equivalent early endotoxin tolerance. Infect Immun 1990; 58: 2429-2437.
25. Bakouche O., Moreau J.L., Lachman L.B. Secretion of IL-1: role of protein kinase C. J Immunol 1992; 148: 84-91.
26. Lee J.C., Laydon J.T., McDonnell P.C. et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-746.
27. Tannenbaum C.S., Koerner T.J., Jansen M.M., Hamilton T.A. Characterization of lipopolysaccharide-induced macrophage gene expression. J Immunol 1988; 140: 3640-3645.
28. Suganuma M., Fujiki H., Suguri H. et al. Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. Proc Natl Acad Sci USA 1988; 85: 1768-1771.
29. Hibbs Jr J.B., Taintor R., Vavrin Z., Rachlin E. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 1988; 157: 87-94.
30. Steuhr D.J., Nathan C.T. Nitric oxide: a macrophage product responsible for cytostasis and respiration inhibition in tumor target cells. J Exp Med 1989; 169: 1543-1555.
31. Russell S.W., Doe W.F., McIntosh T. Functional characterization of a stable noncytolytic stage of macrophage activation in tumors. J Exp Med 1977; 146: 1511-1520.
32. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051-3064.
33. Xie Q-W., Nathan C. The high-outout nitric oxide pathway: role, and regulation. J Leukocyte Biol 1994; 56: 576-582.
34. Hogan M.M., Vogel S.N. Lipid A-associated proteins provide an alternate 'second signal' in the activation of recombinant interferon-γ-primed, C3H/HeJ macrophages to a fully tumoricidal state. J Immunol 1987; 139: 3697-3702.
35. Matsuyama T., Kimura T., Kitagawa M. et al. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 1993; 75: 83-97.
36. Martin E., Nathan C., Xie Q-W. Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp, Med 1994; 180: 977-984.
37. - synthase induction in macrophages. Science 1994; 263: 1612-1615.
38. Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995; 80: 225-236.
39. Tan Y.H. Yin and yang of phosphorylation in cytokine signaling. Science 1993; 262: 376-377.
40. Sun S-C., Maggirwar S.B., Harhaj E. Activation of NF-κB by phosphatase inhibitors involves the phosphorylation of IκBa at phosphatase 2A-sensitive sites. J Biol Chem 1995; 270: 18437-18351.
41. r = 29,000 protein by IL-1 is susceptible to partial down-regulation after endothelial cell activation. J Immunol 1991; 146: 3772-3778.
42. Ohmori Y., Strassman G., Hamilton T.A. cAMP differentially regulates expression of mRNA encoding IL-1α and IL-1β in murine peritoneal exudate macrophages. J Immunol 1990; 145: 3333-3339.
43. Tannenbaum C.S., Hamilton T.A. Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP. J Immunol 1989; 142: 1274-1280.
44. + exchange potentiates lipopolysaccharide-induced gene expression in murine peritoneal macrophages. J Cell Phys 1991; 148: 96-105.
45. Li Z-Y., Manthey C.L., Perera P-Y., Sher A., Vogel S.N. Toxoplasma gondii soluble antigen induces a subset of lipopolysaccharide-inducible genes and tyrosine phosphoproteins in peritoneal macrophages. Infect Immun 1994; 62: 3434-3440.
46. Perera P-Y., Barber S.A., Ching L-M., Vogel S.N. Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthone-4-acetic acid in primary murine macrophages. J Immunol 1994; 153: 4684-4693.
47. d) macrophages. J Immunol 1994; 153: 2653-2663.
48. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995; 13: 251-276.
49. Moore K.W., O'Garra A., de Waal Malefyt R., Vieira P., Mossmann T. Interleukin-10. Annu Rev Immunol 1993; 11: 165-190.
50. Schönthal A., Tsukitani Y., Feramisco J.R. Transcriptional and post-transcriptional regulation of c-fos expression by the tumor promoter okadaic acid. Oncogene 1991; 6: 423-430.
51. Cao X., Mahendran R., Guy G.R., Tan Y.H. Protein phosphatase inhibitors induce the sustained expression of the egr-1 product and the hyperphosphorylation of its gene product. J Biol Chem 1992; 267: 12991-12997.
52. McVicar D.W., Mason A.T., Bere E.W., Ortaldo J.R. Activation of peripheral large granular lymphocytes with the serine/threonine phosphatase inhibitor, okadaic acid. Eur J Immunol 1994; 24: 165-170.
53. Marcinkiewicz J., Grabowska A., Chain B. Nitric oxide upregulates the release of inflammatory mediators by mouse macrophages. Eur J Immunol 1995; 25: 947-951.
54. - at work. Cell 1994; 78: 919-925.
55. Albina J.E., Cui S., Mateo R.B., Reicher J.S. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J Immunol 1993; 150: 5080-5085.