Consensus motifs and peptide ligands of mhc class i molecules

Seminars in Immunology

Volumn 5, Issue 2, 1993, Pages 81-94

  Falk, Kirsten ^a   Rötzschke, Olaf ^a  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

Author keywords

Antigen processing; MHC class I molecules; Natural peptides; Peptide motifs

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; LIGAND; PEPTIDE; TUMOR ANTIGEN;

ALLELE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; REVIEW;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 0027582371     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1993.1012     Document Type: Article

References (130)

1. Zinkernagel RM, Doherty PC (1974) Restriction of m vitro T cell-mediated cytotoxicity in lymphocyte choriomeningitis within a syngeneic or semiallogeneic system. Nature 248:701-702
2. Wabuke-Bunoti MAN, Taku A, Fan DP, Kent S, Webster RG (1984) Cytolytic T lymphocyte and antibody responses to synthetic peptides of influenza virus hemagglutinin. J Immunol 133:2194-2201
3. Townsend ARM, Gotch FM, Davey J (1985) Cytotoxic T cells recognize fragments of the influenza micleoprotein. Cell 42:457-467
4. Townsend ARM, Rothbard J, Gotch FM, Bahadur G, Wraith D, McMichael AJ (1986) The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44:959-968
5. Bjorkman PJ, Saper MA, Samraoui B, Bennet WS, Strominger JL, Wiley DC (1987) Structure of the human class I histocompatibility antigen HLA-A2. Nature 329: 506-512
6. Rotzschke O, Falk K (1991) Naturally occurring peptide antigens derived from the MHC class I-restricted processing pathway. Immunol Today 12:447-455
7. Rotzschke O, Falk K, Wallny HJ, Faath S, Rammensee H-G (1990) Characterisation of naturally occurring minor histocompatibility peptides including H-4 and H-Y. Science 249:283-287
8. Falk K, Rotzschke O, Rammensee H-G (1990) Cellular peptide composition governed by major histocompatibility class I molecules. Nature 348:248-251
9. Rotzschke O, Falk K, Faath S, Rammensee H-G (1991) On the nature of peptides involved in alloreactivity. J Exp Med 174:1059-1071
10. Griem P, Wallny HJ, Falk K, Rotzschke O, Arnold B, Schonrich G, Hammerling G, Rammensee H-G (1991) Uneven tissue distribution of minor histocompatibility proteins versus peptides caused by MHC expression. Cell 65:633-640
11. Sekimata M, Griem P, Egawa K, Rammensee H-G, Takiguchi M (1992) Isolation of human minor histocompatibility peptides. Int Immunol 4:301-304
12. Pamer EG, Wang C-R, Flaherty L, Fischer Lindahl K, Bevan MJ (1992) H-2M3 presents a listeria monocytogenes peptide to cytotoxic T lymphocytes. Cell 70:215-223
13. Demotz S, Grey HM, Sette A (1989) Characterisation of a naturally processed MHC class ITrestricted T cell determinant of hen egg lysozyme. Nature 342:682-684
14. Van Bleek G, Nathenson SG (1990) Isolation of an endogenously processed immunodominant viral peptide from the class I H-2Kb molecule. Nature 348:213-216
15. Jardetzky TS, Lane WS, Robinson RA, Madden DR, Wiley DC (1991) Identification of self peptides bound to purified HLA-B27. Nature 353:326-329
16. Falk K, Rotzschke O, Stevanovic S, Jung G, Rammensee H-G (1991) Allele-specific motifs revealed by self-peptides eluted from MHC molecules. Nature 351:290-296
17. Hunt DF, Henderson RA, Shabanowitz J, Sakakguchi K, Michel H, Sevilier N, Cox AL, Apella E, Engelhard VH (1992) Characterization of peptides bound to Class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255:1261-1263
18. Henderson RA, Michel H, Sakaguchi Kf Shabanowitz J, Appella E, Hunt DF, Engelhard VH (1992) HLA- A2.1-associated peptides from a mutant cell line: A second pathway of antigen presentation. Science 255: 1264-1266
19. Hunt DF, Michel H, Dickinson TA, Shabanowitz J, Cox AL, Sakaguchi K, Appella E, Grey A, Sette A (1992) Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science 256:1817-1820
20. Boon T, Van Pel A (1989) T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis. Immunogenet 29:75-79
21. Fetten JV, Roy N, Gilboa E (1991) A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not effect generation of cytotoxic T lymphocyte epitopes. J Immunol 147:2695-2705
22. Townsend A, Bastin J, Gould K, Brownlee G, Andrew M, Coupar B, Boyle D, Chan S, Smith G (1988) Defective presentation to class I-restricted T lymphocytes is overcome by enhanced degradation of protein. J Exp Med 168: 1211-1224
23. Bachmair A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-termmal residue. Science 234:179-186
24. Elvin JG, Cerundolo V, Elliott TJ, Townsend ARM (1991) A quantitative assay of peptide dependent class I assembly. Eur J Immunol 21:2025-2031
25. Del Val M, Schlicht H-J, Ruppert T, Reddehase MJ, Koszinowski UH (1991) Efficient processing of an antigenic sequence for its presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 66:1145-1153
26. Eisenlohr LC, Yewdell JW, Benninck JR (1992) Flanking regions influence the presentation of endogenously synthesized peptides to cytotoxic T lymphocytes. J Exp Med 175:481-487
27. Hahn YS, Braciale VL, Braciale TJ (1991) Presentation of viral antigen to class I major histocompatibility complex- restricted cytotoxic T lymphocytes. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocytes is independent of the position of the site in the hemagglutinin translation product. J Exp Med 174:733-736
28. Fischer Lindahl K, Hermel E, Loveland BE, Richards S, Wang C-R, Yonekawa H (1989) Molecular definition of a mitochondrially encoded mouse minor histocompatibility antigen. Cold Spr Harb Symp Quant Biol 54:563-569
29. Goulmy E, Termijtelen A, Bradley BA, Van Rood JJ (1977) Y-antigen killing by T cells of women is restricted by HLA. Nature 266:544-545
30. Gordon RD, Mathieson BJ, Samelson LE, Boyse EA, Simpson E (1976) The effect of allogeneic presentation on H-Y graft survival and in vitro cell-mediated responses to H-Y antigen. J Exp Med 144:810-820
31. Speiser DE, Ziircher T, Ramseier H, Hengartner H, Staeheli P, Haller O, Zinkernagel RM (1990) Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen. Proc Natl Acad Sci USA 87: 2021-2025
32. Schild H, Rotzschke O, Kalbacher H, Rammensee H-G (1990) Limit of T cell tolerance to self proteins by peptide presentation. Science 247:1587-1589
33. Falk K, Rotzschke O, Rammensee H-G (1992) A self peptide naturally presented by both H-2Kb and H-2Kbml molecules demonstrates MHC-restriction of self-tolerance at the molecular level. Int Immunol 4:321-325
34. Matzinger P, Bevan MJ (1977) Hypothesis: Why do so many lymphocytes respond to major histocompatibility antigens. Cell Immunol 29:1-5
35. Santos-Aguado J, Crimmins MAV, Mentzer SJ, Burakoff SJ, Strominger JL (1989) Alloreactivity studied with mutants of HLA-A2. Proc Natl Acad Sci USA 86: 8936-8940
36. Heath WR, Hurd ME, Carbone FR, Sherman L (1989) Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes. Nature 341:749-752
37. Udaka K, Tsomides TJ, Eisen HN (1992) A naturally occurring peptide recognized by alloreactive CD8 + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69:989-998
38. Aosai F, Ohlen C, Ljundgren H-G, Hoglund P, Franksson L, Ploegh H, Townsend A, Karre K, Stauss HJ (1991) Different types of allo-specific CTL clones identified by their ability to recognize peptide loading defective target cells. Eur J Immunol 21:2767-2774
39. Elliot TJ, Eisen HN (1990) Cytotoxic T lymphocytes recognize a reconstituted class I histocompatibility antigen (HLA-A2) as an allogeneic target molecule. Proc Natl Acad Sci USA 87:5213-5217
40. Ohlen C, Bastin J, Ljundgren H-G, Foster L, Wolpert E, Klein G, Townsend ARM, Karre K (1990) Resistance to H-2-restricted but not to a3Jo-H2-specific graft and cytotoxic T lymphocytes responses in lymphoma mutant. J Immunol 345:52-58
41. Klein J (1990) 7: The major histocompatibility complex, in Immunology, pp 183-185. BlackweU Science
42. Gammon G, Sercarz E, Bertichou G (1991) The specificity of the autoreactive T cell repertoire: The dominant self and the cryptic self, Immunol Today 12:193-195
43. van der Bruggen P, Traversal C, Chomez P, Lurquin C, De Piaen £, Van den Eynde B Knuth A, Boon T (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:3643-1647
44. De Plaen E, Lurquin C, Van Pel A, Mariame B, Szikorra J-P, Wolfe! T, Sibille C, Chomez P, Boon T (1988) Immunogenic (turn”) variants of mouse tumor P815: Cloning of the gene of turn” antigen P91A and the identification of the turn” mutation. Proc Natl Acad Sci USA 85:2274-2278
45. Sibille C, Chomez Widmann C, Van Pel A, De Plaen E, Maryanski J L, de Bergeyck V, Boon T (1990) Structure of the turn” transplantation antigen P19S: A point mutation generates a new antigenic peptide. J Exp Med 172:35-45
46. Kast WM, Offringa Rf Peters PJ, Voordouw AC, Meloen RH, van der Eb AJ, Melief CJM (1989) Eradication of adenovirus El-induced tumors by ElA-spectfic cytotoxic T cells. Cell 59:603-614
47. Cerundolo V, Elliot* T, Eivin J, Bastin J, Rammensee H- G, Townsend A (1991) The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules. Eur J Immunol 21:2069-2075
48. Rotzschke O, Falk K, Deres K, Schild H, Norda M, Metager J, Jung G, Rammensee H-G (1990) Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252-254
49. Fajk K, Rotzschke O, Deres K, Mei2ger Jf Jung G, Rammensee H-G (1991) Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. J Exp Medl 74:425-434
50. Rotzschke O, Falk K, Stevanovic S, Jung G, Walden P, Rammensee H-G (1991) Exact prediction of a natural T cell epitope. Eur J Immunol 21:2891-2894
51. Wallny H-J, Deres K, Faath S, Jung G, Van Pel A, Boon T, Rammensee H-G (1992) Identification and quantification of a naturally presented peptide as recognized by cytotoxic T lymphocytes specific for an immunogenic tumor variant. Int Immunol 4:1085-1090
52. 2-microglobulin in peptide binding by class I molecules, Science 250:1423-1426
53. Christinc-k ER, Luscher MA; Barber BH, Williams DB (1991) Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL-lysis. Nature 352:67-70
54. Cox JH, Yewdell JW, Eisenlohr LC, Johnson PR, Bemunk JR (1990) Antigen presentation requires transport of MHC class 1 molecules from the endoplasmic reticulum. Science 247:735-718
55. del Val M, Hengei H, Hacker H, Hartlaub U, Ruppert T, Lucin P, Koszinowski UH (1992) Cytomegalovirus prevents antigen presentation by blocking the transport of peptide- loaded major histocompatibility complex class I molecules into themedial-Golgi compartment. J Exp Med 176:729-738
56. Sonnenwinh AC, McGee ZA, Davis BO (1980) 43: Other pathogenic microorganisms; L-phase variants, in Microbiology; including Immunology and Molecular Genetics, 3rd edn (Davis BD, Dulbecco R, Eisen HN, Ginsberg HS, eds), pp 799-800. Harper and Row, Philadelphia
57. Harty JT, Bevan MJ (1992) CD8 + T cells specific fo single nonarner epitope of listeria monocytogenes i protective in viva. J Exp Med 175:1531-1538
58. Romero P (1992) Malaria vaccines. Curr Opin lmmun 4:432-441
59. Maryanski JL, Verdini AS, Weber PC, Salemme FR Corradin G (1990) Competitor analogs for define T cell antigens: Peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Cell 60: 63-72
60. Pircher H, Moskophidis D, Rohrer U, Burki K, Hengartner H, Zinckernagel RM (1990) Viral escape by selection of cytotoxic T ceil-resistant virus variants vivo. Nature 346:629-633
61. Meyerhans A, Dadaglio G, Vartanian J-P, Langlade- Demoyen P, Frank R, Asjo B, Plata F, Wain-Hobson S (1991) In vivo persistence of a HIV-i-encoded HLA- B27-restricted cytotoxic T-iymphocyte epitope despite specific in vitro reactivity, Eur J Immunol 23:2637-2640
62. Phillips R, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Fivin JG, Rothbard JA, Bangham CRM, Rizza CR, McMichael AJ (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453-459
63. Littau RA, Oldstone MBA, Takeda A, Debouck C, Wong JT, Carmelita UT, Moss B, Kievits F, Frarjcis AE (1991) An HLA-C-restricted CD8 + cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag. Virol 65:4051-4056
64. Schendd DJ, Reinhardt C, Nelson PJ, Maget B, Pullen L, Bornkamm GW, Steinle A (1992) Cytotoxic T lymphocytes show HLA-C restricted recognition of Epstein-Ban virus bearing cells and allorecognition of HLA class I molecules presenting self-peptides. J Immunol 149:2406-2414
65. Colonri&M, Spies T, Strominger JL, Ciccone E, Moretta A, Moretta L, Pende D, Viale O (1992) AHoarttigen recognition by human natural killer cells is associated with HLA-C or a closely linked gene. Proc Natl Acad Sci USA 89:7983-7985
66. Ciccone E, Pende D, Viale O, Than A, Di Donata C, Orengo AM, Biassoni R, Verdiani MS, Amoroso A, Moretta A, Moretta L (1992) Involvement of HLA class 1 alleles in natural killer (NK) cell-specific functions: Expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). J Exp Med 176:963-971
67. Loveland B, Wang C-R, Yonekawa H, Hermel E, Fisher Lindahl K (1990) Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mUochondrally encoded protein, Cell 60:971-980
68. Shawar SM, Vyas JM, Rodgers JR, Cook RG, Rich RR (1993) Specialized functions of major histocompatibility complex class I molecules, II. Hmt hinds N-formylated peptides of mitochondrial and prokaryotic origin. J Exp Med 174:941-944
69. Kuriander RJ, Shawar SM, Brown ML, Rich RR (1992) Specialised role for a murine class I-b MHC molecule in prokaryotic host defenses. Science 257:678-679
70. Imani F, Soloski MJ (1991) Heat shock proteins can regulate expression of the Tla region-endoded class Ib molecule Qa-1. Proc Natl Acad Sci USA 88:10475-10479
71. Hershberg R, Eghtasadi P, Sydora 8, Borson K, Cheroutre H, Modlin R, Kronenberg M (1990) Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc Natl Acad Sci USA 87:9727-9731
72. Wu M, Van Kaer L, Itohara S, Tonegawa S (1991) Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J Exp Med 174: 213-218
73. Flaherty L, Elliott E, Tine JA, Walsh AC, Waters JB (1990) Immunogenetics of the Q and TL regions of the mouse. Crit Rev Immunol 10:131-175
74. Hermel E, Grigorenko E, Fischer Lindahl K (1991) Expression of medial class I histocompatibility antigens on RMA-S mutant cells. Int Immunol 3: 407-412
75. Attaya M, Jameson S, Martinez CK, Hermel E, Aldrich C, Forman J, Fischer Lindahl K, Bevan MJ, Monaco JJ (1992) Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature 355:647-649
76. Carbone FR, Bevan MJ (1989) Induction of ovalbumin- specific cytotoxic T cells by in vivo peptide immunization. J Exp Med 169:603-619
77. Pamer EG, Harty JT, Bevan MJ (1991) Precise prediction of a dominant class I MHC-restricted epitope of listeria monocytogenes. Nature 353:852-855
78. Garret TPJ, Saper MA, Bjorkman PJ, Strominger JL, Wiley DC (1989) Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342:692-697
79. Saper MA, Mjorkman PJ, Wiley DC (1991) Refined structure of the human histocompatibility antigen HLA- A2 at 2.6 A resolution. J Mol Biol 219:277-319
80. Madden DR, Gorga JC, Strominger JL, Wiley DC (1991) The structure of HLA-B27 reveals nonamer self-peptides bound in extended conformation. Nature 353:321-325
81. Fremont DH, Matsumura M, Stura EA, Peterson PA, Wilson IA (1992) Crystal structures of two viral peptides in complexes with murine MHC class I H-2Kb. Science 257:919-927
82. Matsumura M, Fremont DH, Peterson P, Wilson IA (1992) Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257:927-934
83. Zhang W, Young ACM, Imara M, Nathenson SG, Sacchetti JC (1992) Crystal structure of the histocompatibility complex class I H-2Kb molecule containing a single viral peptide: Implications for peptide binding and T cell receptor recognition. Proc Natl Acad Sci USA 89:8403-8407
84. Latron F, Pazmany L, Morrison J, Moots R, Saper MA, McMichael A, Strominger JL (1992) A critical role for conserved residues in the cleft of HLA-A2 in presentation of a nonapeptide to T cells. Science 257:964-967
85. Rudensky AY, Preston-Hurlburt P, Hong S-C, Barlow A, Janeway Jr CA (1991) Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622-627
86. d. Science 256:1817-1820
87. Kropshofer H, Max H, Müller CA, Hesse F, Stcvanovic S, Jung G, Kaibacher H (1992) Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif. J Exp Med 175:1799-1803
88. Chicz RM, Urban RG, Lane WS, Gorga JC, Stern LJ, Vignalli DAA, Strominger JL (1992) Predominant naturally processed peptides bound to HLA-DRl are derived from MHC-related molecules and are heterogenous in size. Nature 358:764-768
89. Latron F, Moots R, Rothbard JB, Garret TPJ, Strominger JL, McMichael A (1991) Positioning of a peptide in the cleft of HLA-A2 by complementing amino acid changes. Proc Natl Acad Sci USA 88:11325-11329
90. Parham P (1990) Transporters of delight. Nature 348: 674-675
91. Robertson M (1991) Proteasomes in the pathway. Nature 353:300-301
92. Spies T, DeMars R (1991) Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 351:323-324
93. Powis SJ, Townsend ARM, Deverson EV, Bastin J, Butcher GW, Howard JC (1992) Restoration of antigen presentation to the mutant cell line RMA-S by an MHC- linked transporter. Nature 354:528-531
94. Powis SJ, Deverson EV, Coadwell J, Ciruela A, Huskisson NS, Smith H, Butcher GW, Howard JC (1992) Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature 357:211-215
95. Levy F, Gabathuler R, Larsson R, Kvist S (1991) ATP is required for in vitro assembly of MHC class I antigens but not for transfer of peptides across the ER membrane. Cell 67:265-274
96. Koppelman B, Zimmerman DL, Walter P, Brodsky FM (1992) Evidence for peptide transport across microsomal membranes. Proc Natl Acad Sci USA 89:3908-3912
97. Martinez CK, Monaco JJ (1991) Homology of proteasome subunits to a major histocompatibility complex linked LMP gene. Nature 353:664-667
98. Ortiz-Navarrete V, Seelig A, Gernold M, Frentzel S, Klötzel P, Hammerling GJ (1991) Subunit of the ‘20S’ proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 353:662-664
99. Wallny HJ, Rötzschke O, Falk K, Hämmerling G, Rammensee H-G (1992). Gene transfer experiments imply instructive role of major histocompatibility class I molecules in cellular peptide processing. Eur J Immunol 22:655-659
100. Falk K, Rötzschke O, Rammensee H-G (1992) Specificity of antigen processing for MHC class I restricted presentation is conserved between mouse and man. Eur J Immunol 22:655-659
101. Stauss HJ, Davies H, Sadovinikova E, Chain B, Horowitz N, Sinclair C (1992) Induction of T lymphocytes in vitro: Identification of candidate T-cell epitopes in human papilloma virus. Proc Natl Acad Sci USA 89:7871-7875
102. Flynn GC, Pohl J, Flocco MT, Rothman JE (1991) Peptide-binding of the molecular chaperone BIP. Nature 353:726-730
103. Degen E, Wiliams DB (1991) Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules. J Cell Biol 112:1099-1115
104. Monaco JJ (1992) A molecular model of MHC class I restricted antigen processing. Immunol Today 13:173-179
105. Seglen PO, Bohley P (1992) Autophagy and other vacuolar protein degradation mechanisms. Experientia 48:158-172
106. Huet S, Nixon DF, Rothbard JB, Townsend A, Ellis SA, McMichael AJ (1990) Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with IILA B27. Int Immunol 2:311-316
107. Cerundolo V, Tse AGD, Salter RD, Parham P, Townsend A (1991) CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1. Proc R Soc Lond B 244:169-177
108. Braciale TJ, Sweetser MT, Morrison LA, Kittlesen DJ, Braciale VL (1988) Class I major histocompatibility complex restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin. Proc Natl Acad Sci USA 86:277-281
109. Gould KG, Scotney H, Brownlee GG (1991) Characterization of two distinct major histocompatibility complex class I Kk-restricted T-cell epitopes within the influenza A/PR/8/34 virus hemagglutinin. J Virol 65:5401-5409
110. Sweetser MT, Morrison LA, Braciale VL, Braciale TJ (1989) Recognition of pre-processed endogenous antigen by class I but not by class II MHC-restricted T cells. Nature 342:180-182
111. Morrison J, Eivin J, Latron F, Moots R, Strominger JL, McMichael A (1992) Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA-A2 in its recognition by cytotoxic T lymphocytes. Eur J Immunol 22:903-907
112. Bednarek MA, Sauma SY, Gammon MC, Porter G, Tamhankar S, Wiliamson AR, Zweerink H (1991) The minimum peptide epitope from the influenza virus matrix protein. J Immunol 147:4047-4053
113. Deckhut A, Lippolis JD, Tevethia SS (1992) Comparative analysis of core amino acid residues of H-2Derestricted cytotoxic T-Iymphocyte recognition epitopes. J Virol 66:440-447
114. Schulz M, Aichele P, Schneider R, Hansen TH, Zinkernagel RM, Hengartner H (1991) Major histocompatibility complex binding and T cell recognition of a viral nonapeptide contain a minimal tetrapeptide. Eur J Immunol 21:1181-1185
115. Kast WM, Melief CJM (1991) Fine peptide specifity of cytotoxic T lymphocytes directed against adenovirus- induced tumours and peptide-MHC binding. Int J Cancer 6:90-94
116. Kast WM, Roux L, Curren J, Blom HJJ, Voordouw AC, Meloen RH, Kolakofsky D, Melief CJM (1991) Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc Natl Acad Sci USA 88:2283-2287
117. Deres K, Schumacher TNM, Wiesmuller K-H, Stevanovic S, Greiner G, Jung G, Ploegh HL (1992) Preferred size of peptides that bind to H-2Kb is sequence dependent. Eur J Immunol 22:1603-1608
118. van Binnendijk RS, van Baalen CA, Poelen MCM, de Vries P, Boes J, Cerundolo V, Osterhaus DME, UytdeHaag FGCM (1992) Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition. J Exp Med 175:119-128
119. Oldstone MBA (1991) Moleculer anatomy of viral persistence. J Virol 65:6381-6386
120. Romero P, Corradin G, Luescher IF, Maryanski JL (1991) H-2Kd-restricted antigenic peptides share a simple binding motif. J Exp Med 174:603-612
121. Maryanski JL, Pala P, Cerottini J-C, Corradin G (1988) Synthetic peptides as antigens and competitors in recognition by H-2-restricted cytolytic T cells specific for HLA. J Exp Med 167:1391-1405
122. Traversari C, van der Brüggen P, Luescher IF, Lurquin C, Chomez P, Van Pel A, De Plaen E, Amar-Costesec A, Boon T (1992) A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by CTL directed against tumor antigen MZ2-E. J Exp Med 176:1453-1457
123. Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zürcher G, Ziemiecki A (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 11:2057-2065
124. Wallny H-J (1992) Untersuchungen zur Rolle der MHC- Klasse-I-Moleküle bei der Prozessierung von Neben- histokompatibilitätsantigenen. Ph.D. Thesis, University of Tübingen
125. Wei ML, Cresswell P (1992) HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence- derived peptides. Nature 356:443-446
126. Hartmann E, Rapoport TA, Prehn S (1992) Signal sequence identified. Nature 358:198
127. Corr M, Boyd LF, Frankel SR, Kozlowski S, Padlan EA, Margulies DH (1992) Endogenous peptides of a soluble MHC class I molecule H-2Lds: Sequence motif, quantitative binding, and molecular modelling of the complex. J Exp Med 176:1681-1692
128. Rötzschke O, Falk K, Stevanovic S, Jung G, Rammensee H-G (1992) Peptide motifs of closely related HLA class I molecules encompass substantial differences. Eur J Immunol 22:2453-2456
129. Bjorkman PJ, Parham P (1990) Structure, function and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem 59:253-288
130. Klein J (1986) Natural History of the Major Histocompatibility complex. Wiley, New York.