Elderly patients with adult-onset growth hormone deficiency are not osteopenic

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 5, 1997, Pages 1462-1466

  Toogood, Andrew A ^a   Adams, Judith E ^b   O'Neill, Paul A ^c   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DEOXYPYRIDINOLINE; GROWTH HORMONE; OSTEOCALCIN; SOMATOMEDIN C;

ADULT; AGE; AGED; ARTICLE; BONE MASS; BONE MINERAL; BONE TURNOVER; CLINICAL ARTICLE; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HIP; HUMAN; LUMBAR SPINE; MALE; OSSIFICATION; OSTEOLYSIS; OSTEOPENIA; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0030918539     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.5.1462     Document Type: Article

References (41)

1. Raisz LG. 1988 Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med. 318:818-828.
2. Smith Jr RW. 1967 Dietary and hormonal factors in bone loss. Fed Proc. 26:1737-1746.
3. Iranmanesh A, Lizarralde G, Veldhuis JD. 1991 Age and relative obesity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 73:1081-1088.
4. Rudman D. 1985 Growth hormone, body composition and aging. J Am Geriatr Soc. 33:800-807.
5. Wémeau J-L. 1995 Calciotropic hormones and ageing. Horm Res. 43:76-79.
6. Wüster C, Blum WF, Schlemilch S, Ranke MB, Ziegler R. 1993 Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis. J Intern Med. 234:249-255.
7. Rosen T, Hansson T, Granhed H, Szucs J, Bengtsson BA. 1993 Reduced bone mineral content in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh). 129:201-206.
8. Bing-You RG, Denis M-C, Rosen CJ. 1993 Low bone mineral density in adults with previous hypothalamic-pituitary tumors: correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor 1, and IGF binding protein 3. Calcif Tissue Int. 52:183-187.
9. Holmes SJ, Economou G, Whitehouse RW, Adams JE, Shalet SM. 1994 Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab. 78:669-674.
10. Johansson AG, Burman P, Westermark K, Ljunghall S. 1992 The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I. J Intern Med. 232:447-452.
11. Beshyah SA, Freemantle C, Thomas E, et al. 1995 Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Clin Endocrinol (Oxf). 42:179-189.
12. O'Halloran DJ, Tsatsoulis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM. 1993 Increased bone density after recombinant human growth hormone therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab. 76:1344-1348.
13. Hyer SL, Rodin DA, Tobias JH, Leiper A, Nussey SS. 1992 Growth hormone deficiency during puberty reduces adult bone mineral density. Arch Dis Child. 67:1472-1474.
14. De Boer H, Blok GJ, Van Lingen A, Teule GJJ, Lips P, Van Der Veen EA. 1994 Consequences of childhood-onset growth hormone deficiency for adult bone mass. J Bone Miner Res. 9:1319-1326.
15. Kaufman J-M, Taelman P, Vermeiden A, Vandeweghe M. 1992 Bone mineral status in growth hormone deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab. 74:118-123.
16. Rosen T, Wilhelmsen L, Landin-Wilhelmsen K, Lappas G, Lindstedt G, Bengtsson B-Å. Increased fracture rate in growth hormone deficient adults. Proc of the 77th Annual Meet of the Am Endocrine Soc. 1995; 353.
17. Johansen JS, Pedersen SA, Jorgensen JOL, et al. 1990 Effects of growth hormone on plasma bone gla protein in GH deficient adults. J Clin Endocrinol Metab. 70:916-919.
18. Schlemmer A, Johansen JS, Pedersen SA, Jorgensen JOL, Hassager C, Christiansen C. 1991 The effect of growth hormone therapy on urinary pyridinoline cross-links in GH-deficient adults. Clin Endocrinol (Oxf). 35:471-476.
19. Holmes SJ, Whitehouse RW, Swindell R, Economou G, Adams JE, Shalet SM. 1995 Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency. Clin Endocrinol (Oxf). 42:627-633.
20. Johannsson G, Rosén T, Bosaeus I, Sjöström L, Bengtsson B-Å. 1996 Long term growth hormone treatment increases bone mineral content and density in patients with adult-onset growth hormone deficiency. J Clin Endocrinol Metab. 81:2865-2873.
21. Shalet SM. 1996 Growth hormone deficiency and replacement in adults. Br Med J. 313:314.
22. Toogood AA, O'Neill PA, Shalet SM. 1996 Beyond the somatopause: growth hormone deficiency in adults over the age of 60 years. J Clin Endocrinol Metab. 81:460-465.
23. Toogood AA, Adams JE, O'Neill PA, Shalet SM. 1996 Body composition in growth hormone deficient adults over the age of 60 years. Clin Endocrinol (Oxf). 45:399-405.
24. Theintz G, Buchs B, Rizzoli R, et al. 1992 Longitudinal monitoring of bone mass accumulation in healthy adolescents: evidence for a marked reduction after 16 years of age at the levels of lumbar spine and femoral neck in female subjects. J Clin Endocrinol Metab. 75:1060-1065.
25. Bonjour J-P, Theintz G, Buchs B, Slosman D, Rizzoli R. 1991 Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 73:555-563.
26. Hall ML, Heavens J, Cullum ID, Ell PJ. 1990 The range of bone density in normal British women. Br J Radiol. 63:266-269.
27. Rodin A, Murby B, Smith MA, et al. 1990 Premenopausal bone loss in the lumbar spine and neck of femur: a study of 225 Caucasian women. Bone. 211:1-5.
28. Corpas E, Harman SM, Blackman MR. 1993 Human growth hormone and human aging. Endocr Rev. 14:20-39.
29. Ernst M, Froesch ER. 1988 Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochem Biophys Res Commun. 151:142-147.
30. Schlechter NL, Russell SM, Spencer EM, Nicoll CS. 1986 Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc Natl Acad Sci. 83:7932-7934.
31. Scheven BAA, Hamilton NJ, Fakkeldij TMV, Duursma SA. 1991 Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regul. 1:160-167.
32. Nicolas V, Prewett A, Bettica P, et al. 1994 Age-related decreases in insulin-like growth factor-I and transforming growth factor-β in femoral cortical bone from both men and women: implications for bone loss with aging. J Clin Endocrinol Metab. 78:1011-1016.
33. Sartorio A, Conti A Monzani M. 1993 New markers of bone and collagen turnover in children and adults with growth hormone deficiency. Postgrad Med J. 69:846-850.
34. Garnero P, Sornay-Rendu E, Chapuy M-C, Delmas PD. 1996 Increased bone turnover in late postmenopausal women is a major determinent of osteoporosis. J Bone Miner Res. 11:337-349.
35. Davies MC, Hall ML, Jacobs HS. 1990 Bone mineral loss in young women with amenorrhoea. Br Med J. 301:790-793.
36. Reid IR. 1989 Pathogenesis and treatment of steroid osteoporosis. Clin Endocrinol (Oxf). 30:83-103.
37. Eastell R. 1995 Management of corticosteroid-induced osteoporosis. J Intern Med. 237:439-447.
38. Peacey SR, Guo C-Y, Robinson AM, et al. Glucocorticoid replacement therapy: are patients over treated and does it matter? Clin Endocrinol (Oxf). In press.
39. Sartorio A, Conti A, Monzani MB. 1993 New markers of bone and collagen turnover in children and adults with growth hormone deficiency. J Clin Endocrinol Metab. 69:846-850.
40. Thorén M, Soop M, Degerblad M, Sääf M. 1993 Preliminary study of the effects of growth hormone substitution therapy on bone mineral density and serum osteocalcin levels in adults with growth hormone deficiency. Acta Endocrinol (Copenh). 128(Suppl 2):41-43.
41. Weaver JU, Monson JP, Noonan K, et al. 1996 The effect of low dose recombinant human growth hormone replacement on indices of bone remodelling and bone mineral density in hypopituitary growth hormone deficient adults. Endocrinol Metab. 3:55-61.