The effect of low dose recombinant human growth hormone replacement on indices of bone remodelling and bone mineral density in hypopituitary growth hormone-deficient adults

Endocrinology and Metabolism, Supplement

Volumn 3, Issue 1, 1996, Pages 55-61

  Weaver, Jola U ^a,c   Monson, John P ^a   Noonan, Kate ^a   Price, Christopher ^a   Edwards, Ann ^b   Evans, Katherine A ^b   James, Ian ^b   Cunningham, John ^c  

^a Depts Endocrinol Clin Biochem   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; PLACEBO; RECOMBINANT GROWTH HORMONE;

ADULT; ARTICLE; BONE MINERAL; BONE REMODELING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOPITUITARISM; MALE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029914497     PISSN: 1074939X     EISSN: 20935978     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Wuster C, Slenczka E, Ziegler R. Erhote Pravalenz von Osteoporose und Arteriosklerose bei Konventionell substitnierter hypophysenvardrhappen Insuffiens: Bedarf einer Zusatzlichen Wachestumhormonsubstitution? Klin. Wochenschrift. 1991; 69: 769-773.
2. Beshyah SA, Thomas E, Skinner E, Sharp P, Johnston DG. Total body and spine bone mineral density in women with hypopituitarism. In: Ring EFJ, editor, Current Research in Osteoporosis and Bone Mineral Measurement II. London: The British Institute of Radiology, 1992: 17-18.
3. Harris WH, Heaney RP. Skeletal renewal and metabolic bone disease. New Engl. J. Med. 1969; 280: 253-259.
4. Diamond T, Nery L, Posen S. Spinal and peripheral bone densities in acromegaly: the effects of excess growth hormone and hypogonadism. Ann. Int. Med. 1989; 111: 567-573.
5. Risteli L, Risteli J. Biochemical markers of bone metabolism. Ann. Med. 1993; 25: 385-393.
6. Beardsworth LJ, Eyer DR, Dickson IR. Changes with age in the urinary excretion of lysyl- and hydroxylyspyridinoline, two new markers of bone collagen turnover. J. Bone Min. Res. 1990; 5: 671-676.
7. Vandeweghe M, Taelman P, Kaufman J-M. Short and long effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone deficient males. Clin. Endocrinol. 1993; 39: 409-415.
8. James I, Perrett D, Thompson PW. Rapid assay for hard tissue collagen crosslinks using isocratic ion-paired reversed phase liquid chromatography. J. Chromatogr. 1990; 525: 43-57.
9. Garnero P, Delmas PD. Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J. Clin. Endocrinol. Metab. 1993; 77: 1046-1053.
10. Johansen JS, Pedersen SA, Jorgensen JOL, Riis BJ, Christiansen C, Skakkbeaek NE. Effects of growth hormone (GH) on plasma bone Gla protein in GH deficient adults. J. Clin. Endocrinol. Metab. 1990; 70: 916-919.
11. Schlemmer A, Johansen JS, Jorgensen JO, Hassager C, Christiansen C. The effect of growth hormone (GH) therapy on urinary pyridinoline cross-links in GH deficient adults. Clin. Endocrinol. 1991; 35: 471-476.
12. Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG. The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Clin. Endocrinol. 1994; 40: 383-391.
13. Degerblad M, Eligindy N, Hall K, Sjoberg HE, Thoren M. Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with hypopituitarism. Acta Endocrinol. 1992; 126: 387-393.
14. Whitehead HM, Boreham C, Mcllrath EM, Sheridan B, Kennedy L, Atkinson AB, Hadden DR. Growth hormone treatment of adults with growth hormone deficiency: results of a 13-months placebo controlled cross-over study. Clin. Endocrinol. 1992; 36: 45-52.
15. O'Halloran DJ, Tsatsoullis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM. Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J. Clin. Endocrinol. Metab. 1993; 76: 1344-1348.
16. Mazess RB, Barden HS, Bisek JP, Hanson J. Dual-energy X-ray absorptiometry for total-body and mineral and soft tissue composition. Am. J. Clin. Nutr. 1990; 51: 1106-1112.
17. Wark JD. Osteoporosis: pathogenesis, prevention and management. In: Burger HG, editor, Bailliere's Clinical Endocrinology and Metabolism. London: Baillière Tindall, 1993; 7(1): 151-181.
18. Risteli L, Risteli J, Moniz C. Measuring collagen degradation. Eur. J. Clin. Invest. 1993; 23: 339-340.
19. Partiff AM. Growth hormone and adult bone remodelling. Clin. Endocrinol. 1991; 35: 467-470.