Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice

Brain Research

Volumn 753, Issue 1, 1997, Pages 8-17

  Lauritzen, Inger ^a   De Weille, Jan ^a   Adelbrecht, Christine ^b   Lesage, Florian ^a   Murer, Gustavo ^b   Raisman Vozari, Rita ^b   Lazdunski, Michel ^a  

^a CNRS   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

cell death; immunohistochemistry; in situ hybridization; inward rectifier K+ channel; weaver

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CEREBELLUM; GENE EXPRESSION; HOMOZYGOSITY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; MUTANT; MUTATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; CEREBELLUM; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; REFERENCE VALUES; RNA, MESSENGER;

EID: 0030900140     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01491-6     Document Type: Article

References (29)

1. Altman, J., Postnatal development of the cerebellar cortex in the rat. III. Maturation of the components of the granule layer, J. Comp. Neurol., 145 (1972) 465-513.
2. + channel: expression cloning and molecular properties, Proc. Natl. Acad. Sci. USA, 90 (1993) 10235-10239.
3. + channel activity of neuronal and cardiac G-protein-activated inward rectifiers, Biochem. Biophys. Res. Commun., 212 (1995) 657-663.
4. Gao, W.-Q., Liu, X.-L. and Hatten, M.E., The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation, Cell, 68 (1992) 841-854.
5. Goldowitz, D., The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: evidence from homozygous weaver chimeras, Neuron, 2 (1989) 1565-1575.
6. Goldowitz, D. and Mullen, R.J., Granule cell as a site of gene action in the weaver mouse cerebellum: evidence from heterozygous mutant chimeras, J. Neurosci., 2 (1982) 1474-1485.
7. + channel subunit that permits GIRK1 expression of I-KACh currents in oocytes, Neuron, 16 (1996) 423-429.
8. Hess, E.J., Identification of the weaver mouse mutation: the end of the beginning, Neuron, 16 (1996) 1073-1076.
9. + channel mRNAs are differentially expressed in the adult rat brain, J. Neurosci., 16 (1996) 3559-3570.
10. + channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain, Biochem. Biophys. Res. Commun., 208 (1995) 1166-1173.
11. + channels are activated by G-protein β γ subunits and function as heteromultimers, Proc. Natl. Acad. Sci. USA, 92 (1995) 6542-6546.
12. + channel and rescue of weaver granule cells, Neuron, 16 (1996) 941-952.
13. Kubo, Y., Baldwin, T.J., Jan, Y.N. and Jan, L.Y., Primary structure and functional expression of a mouse inward rectifier potassium channel, Nature (London), 362 (1993) 127-133.
14. + channels in the brain, FEBS Lett., 353 (1994) 37-42.
15. + channels, J. Biol Chem., 270 (1995) 28660-28667.
16. Mjaatvedt, A.E., Cabib, D.E., Cole, S.E., Long, L.J., Breitwieser, G.E. and Reeves, R.H., Assessment of a mutation in the H5 domain of GIRK2 as a candidate for the weaver mutation, Genomic Res., 5 (1995) 453-463.
17. + channels, Science, 272 (1996) 1950-1953.
18. Patil, N., Cox, D.R., Bhat, D., Faham, M., Myers, R.M. and Peterson, A.S., A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation, Nature Genet., 11 (1995) 126-129.
19. Roffler-Tarlov, S., Martin, B., Graybiel, A.M. and Kauer, J.S., Cell death in the midbrain of the murine mutation weaver, J. Neurosci., 16 (1996) 1819-1826.
20. Sekiguchi, M., Nowakowski, R.S., Nagato, Y., Tanaka, O., Guo, H., Madoka, M. and Abe, H., Morphological abnormalities in the hippocampus of the weaver mutant mouse, Brain Res., 696 (1995) 262-267.
21. + channels, Neuron, 16 (1996) 321-331.
22. Smeyne, R.J. and Goldowitz, D., Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study, J. Neurosci., 9 (1989) 1608-1620.
23. Smeyne, R.J. and Goldowitz, D., Purkinje cell loss is due to a direct action of the weaver gene in Purkinje cells: evidence from chimeric mice, Dev. Brain Res., 52 (1990) 211-218.
24. + channel (GIRK4) from human hippocampus associates with other GIRK channels, J. Neurosci., 16 (1996) 930-938.
25. + current in cerebellar granule cells, Proc. Natl. Acad. Sci. USA, 93 (1996) 11191-11195.
26. Tong, Y., Wei, J., Zhang, S., Strong, J.A., Dlouhy, S.R., Hodes, M.E., Ghetti, B. and Yu, L., The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2, FEBS Lettt., 390 (1996) 63-68.
27. ir 3.2 allele, FEBS Lett., 390 (1996) 253-257.
28. Wuenschell, C.W. and Tobin, A.J., The abnormal cerebella organization of weaver and reeler mice does not affect the cellular distribution of three neuronal mRNAs, Neuron, 1 (1988) 805-815.
29. Wüllner, U., Löschmann, P.-A., Weller, M. and Klockgether, T., Apoptotic cell death in the cerebellum of mutant weaver and lurcher mice, Neurosci. Lett., 200 (1995) 109-112.