Interleukin-12 synthesis is a required step in trehalose dimycolate- induced activation of mouse peritoneal macrophages

Infection and Immunity

Volumn 65, Issue 4, 1997, Pages 1364-1369

  Oswald, Isabelle P ^a   Dozois, Charles M ^a   Petit, Jean François ^b   Lemaire, Genevieve ^b  

^a CEMAGREF   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; NITRIC OXIDE; TREHALOSE;

ANIMAL CELL; ARTICLE; BACTERIAL CELL WALL; FEMALE; GENE EXPRESSION REGULATION; IMMUNOREGULATION; IMMUNOSTIMULATION; INTERFERON PRODUCTION; MACROPHAGE ACTIVATION; MOUSE; MYCOBACTERIUM; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION;

EID: 0030898139     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.4.1364-1369.1997     Document Type: Article

References (63)

1. Abe, M., T. Goto, D. Wolfenbarger, D. T. Weiss, and A. Solomon. 1993. Novel immunization protocol and ELISA screening methods used to obtain and characterize monoclonal antibodies specific for human light chain variable-region subgroups, Hybridoma 12:475-483.
2. Afonso, L. C. C., T. M. Sharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237.
3. Afroun, S., I. P. Oswald, F. Lantier, J. F. Petit, and G. Lemaire. 1991. Stimulation of mouse peritoneal macrophages by priming with trehalose dimycolate (TDM). FEMS Microbiol. Immunol. 7:257-268.
4. Azuma, I. 1992. Synthetic immunoadjuvants: application to non-specific host stimulation and potentiation of vaccine immunogenicity. Vaccine 10:1000-1006.
5. Bermudez, L. E., W. Martin, and L. S. Young. 1995. Interleukin-12-stimulated natural killer cells can activate human macrophages to inhibit growth of Mycobacterium avium. Infect. Immun. 63:4099-4104.
6. Brunda, M. J., L. Luistro, R. R. Warrier, R. B. Wright, B. R. Hubbard, M. Murphy, S. F. Wolf, and M. K. Gately. 1993. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178:1223-1230.
7. Castro, A. G., R. A. Silva, and R. Appelberg. 1995. Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infection in mice. J. Immunol. 155:2013-2019.
8. Chehimi, J., S. E. Starr, I. Frank, A. d'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361-1366.
9. Chong, C., K. L. Bost, and J. D. Clements. 1996. Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect. Immun. 64:1154-1160.
10. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721-1724.
11. Cleveland, M. G., J. D. Gorham, T. L. Murphy, E. Tuomanen, and K. M. Murphy. 1996. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD-14-dependent pathway. Infect. Immun. 64:1906-1912.
12. Cooper, A. M., A. D. Roberts, E. R. Rhoades, J. E. Callahal, D. M. Getzy, and I. M. Orme. 1995. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 84:423-432.
13. D'Andreas, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387-1398.
14. + T cells from human immunodeficiency virus-infected persons. J. Exp. Med. 182:1759-1767.
15. Fallarino, F., C. Uyttenhove, T. Boon, and T. J. Gajewski. 1996. Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J. Immunol. 156:1095-1100.
16. Flesh, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1994. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and on tumor necrosis factor α. J. Exp. Med. 181:1615-1624.
17. Flynn, J. A., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515-2524.
18. Fulton, S. A., J. M. Johensen, S. F. Wolf, D. S. Sieburth, and W. H. Boom. 1996. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect. Immun. 64:2523-2531.
19. Gazzinelli, R. T., S. Hieny, T. A. Wynn, T. A. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115-6119.
20. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
21. Gazzinelli, R. T., S. Bala, R. Stevens, M. Baseler, L. Wahl, J. Kovacs, and A. Sher. 1995. HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines. J. Immunol. 155:1565-1574.
22. Grand-Perret, T., M. Lepoivre, J.-F. Petit, and G. Lemaire. 1986. Macrophage activation by trehalose dimycolate: requirement for an expression signal in vitro for antitumoral activity; biochemical markers distinguishing primed and fully activated macrophages. Eur. J. Immunol. 16:332-338.
23. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, P. C. Familletti, and M. K. Gately. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88:4143-4147.
24. Guillemard, E., M. Geniteau-Legendre, R. Kergot, G. Lemaire, J.-F. Petit, C. Labarre, and A.-M. Quero. 1993. Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon α/β. Antivir. Res. 22:201-231.
25. Heinzel, F. P., R. M. Merko, P. Ling, J. Hakimi, and D. S. Schoenhaut. 1994. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 60:4244-4249.
26. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med 177:1505-1509.
27. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
28. Hunter, C. A., E. Candolfi, C. Subauste, V. Van Cleave, and J. S. Remington. 1995. Studies on the role of IL-12 in murine toxoplasmosis. Immunology 84:16-20.
29. Johnson, W. J., P. A. Marino, R. D. Schreiber, and D. A. Adams. 1983. Sequential activation of murine mononuclear phagocytes for tumor cytolysis: differential expression of markers by macrophages in the several stages of development. J. Immunol. 131:1038-1043.
30. Kato, M. 1970. Site II-specific inhibition of mitochondrial oxidative phosphorylation by trehalose 6-6′-dimycolate (cord factor) of Mycobacterium tuberculosis. Arch. Biochem. Biophys. 140:379-390.
31. Lemaire, G., J.-P. Tenu, J.-F. Petit, and E. Lederer. 1986. Natural and synthetic trehalose diesters as immunomodulators. Med. Res. Rev. 6:243-274.
32. Lepoivre, M., J.-P. Tenu, G. Lemaire, J.-F. Petit, and E. Lederer. 1982. Antitumor activity and hydrogen peroxide release by macrophages elicited by trehalose diesters. J. Immunol. 129:860-866.
33. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
34. Mountford, A. P., S. Anderson, and R. A. Wilson. 1996. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant. J. Immunol. 156:4739-4745.
35. Orbach-Arbouys, S., J.-P. Tenu, and J.-F. Petit. 1983. Enhancement of in vitro and in vivo antitumor activity by cord factor (6-6′-dimycolate of trehalose) administered suspended in saline. Int. Arch. Allergy Appl. Immunol. 71:67-73.
36. Oswald, I. P., S. Afroun, D. Bray, J.-F. Petit, and G. Lemaire. 1992. Low response of BALB/c macrophages to priming and activating signals, J. Leukocyte Biol. 52:315-322.
37. Oswald, I. P., P. Caspar, D. Jankovic, T. A. Wynn, E. J. Pearce, and A. Sher. 1994. IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J. Immunol. 153:1707-1713.
38. + T cell clones from HIV-infected patients. J. Clin. Invest. 96:1677-1682.
39. Parant, M., F. Parant, L. Chedid, J. C. Drapier, J. F. Petit, J. Wietzerbin, and E. Lederer. 1977. Enhancement of nonspecific immunity to bacterial infection by cord factor (6, 6′-trehalose dimycolate). J. Infect. Dis. 135:771-777.
40. Raddassi, K., J.-F. Petit, and G. Lemaire. 1993. LPS induced activation of primed murine peritoneal macrophages is modulated by prostaglandins and cyclic nucleotides. Cell. Immunol. 149:50-64.
41. Rao, J. B., S. A. Chamberlain, Y. Bronte, M. W. Caroll, K. R. Irvine, B. Moss, S. A. Rosenberg, and N. P. Restifo. 1996. IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines. Enhancement by simultaneous B7-1 expression. J. Immunol. 156:3357-3365.
42. Rawling, D. J., and D. C. Kaslow. 1992. Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens. J. Exp. Med. 176:1483-1487.
43. Ruco, L. P., and M. S. Meltzer. 1978. Macrophage activation for tumor cytotoxicity: tumoricidal activity by macrophages from CH3/HeJ mice requires at least two activation stimuli. Cell. Immunol. 41:35-51.
44. Sazaki, K., I. Yoshida, and M. Azuma. 1992. Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6-6′ dimycolate. Microbiol. Immunol. 36:1061-1075.
45. Schijns, V. E. C., B. L. Haagmans, and M. C. Horzinek. 1995. Interleukin-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-γ receptor deficient mice. J. Immunol. 155:2525-2532.
46. Sedegah, M., F. Finkelman, and S. L. Huffman. 1994. Interleukin 12 induction of interferon-γ-dependent protection against malaria. Proc. Natl. Acad. Sci. USA 91:10700-10702.
47. Sharma, A., and S. N. Upadhyay, 1993. Cellular immune responsiveness in rabbits with Setaria digitata filarial antigen and TDM adjuvant. Int. J. Immunopharmacol. 15:395-400.
48. Sieling, P. A., X. Wang, M. K. Gately, J. L. Oliveros, T. McHugh, P. F. Barnes, S. F. Wolf, L. Golkar, M. Yamamura, Y. Yogi, K. Uyemura, T. H. Rea, and R. L. Modlin. IL-12 regulates T helper type 1 cytokine response in human infectious disease. J. Immunol. 153:3639-3647.
49. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler, 1996. Regulation of murine IL-12 production. Activation of macrophages in vivo, restimulation in vitro and modulation by other cytokines. J. Immunol. 156:1196-1206.
50. Skeiky, Y., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Rubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527-1537.
51. Stevenson, M. M., M. F. Tam, S. F. Wolf, and A. Sher. 1995. IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism. J. Immunol. 155:2545-2556.
52. Sypek, J., C. L. Chung, S. H. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797-1802.
53. + αβ cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis. J. Immunol. 156:3366-3373.
54. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridges innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-254.
55. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukocyte Biol. 59:505-511.
56. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725-3729.
57. Viera, L. Q., B. D. Hondowicz, L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1994. Infection with Leishmania major induces interleukin 12 in vivo. Immunol. Lett. 40:157-161.
58. Wang, Z. E., S. Zheng, D. B. Corry, D. K. Dalton, R. A. Seder, S. L. Reiner, and R. M. Locksley. 1994. Interferon γ-independent effects of interleukin 12 administrated during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 91:12932-12936.
59. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430-1440.
60. Wynn, T. A., A. W. Cheever, D. Jankovic, R. P. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594-596.
61. Wysocka, M., M, Kubin, L. Vieira, L. Ozwen, G. Garrotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672-676.
62. Zhan, Y., Z. Liu, and C. Cheers. 1996. Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms. Infect. Immun. 64:2782-2786.
63. Zitvogel, L., T. Hideaki, P. D. Robbing, W. J. Storkus, M. R. Clarke, M. A. Nalesnik, and M. T. Lotze. 1995. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J. Immunol. 155:1393-1403.